EKS-OTG-00003
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00003
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph515.22.2E-155634893260
StatusUnreviewed
Ensembl ProteinENSOGAP00000013158
UniProt AccessionH0XBR1;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB2
Gene Synonyms/Alias EPHB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000014678ENSOGAP00000013158ENSOGAT00000014690
OrganismOtolemur garnettii
Functional Description
Protein Length1040
Protein Sequence
(FASTA)
LDTGYTAPNL LALVHPAQII KLIVSSAWKF IETLMDSTTA TAELGWMVHP PSGWEEVSGY 60
DENMNTIRTY QVCNVFESSQ NNWLRTKFIR RRGAHRIHVE MKFSVRDCSS IPSVPGSCKE 120
TFNLYYYEAD YDSATKTFPN WMENPWVKVD TIAADESFSQ VDLGGRVMKI NTEVRSFGPV 180
SRSGFYLAFQ DYGGCMSLIA VRVFYRKCPR IIQNGAIFQE TLSGAESTSL VAARGSCIAN 240
AEEVDVPIKL YCNGDGEWLV PIGRCMCKAG FEAVENGTIC RGCPSGTFKA NQGDEACTHC 300
PINSRTTSEG ATNCVCRNGY YRADLDPLDM PCTTIPSAPQ AVISSVNETS LMLEWTPPRD 360
SGGREDLVYN IICKSCGSGR GACTRCGDNV QYAPRQLGLT EPRIYISDLL AHTQYTFEIQ 420
AVNGVTDQSP FSPQFASVNI TTNQAAPSAV SIMHQVSRTV DSITLSWSQP DQPNGVILDY 480
ELQYYEKELS EYNATAIKSP TNTVTVQGLK AGAIYVFQVR ARTVAGYGRY SGKMYFQTMT 540
EDPEYQTSIQ EKLPLIIGSS AAGLVFLIAV VVIAIVCNRR RGFERADSEY TDKLQHYTSG 600
HMTPGMKIYI DPFTYEDPNE AVREFAKEID ISCVKIEQVI GAGEFGEVCS GHLKLPGKRE 660
IFVAIKTLKS GYTEKQRRDF LSEASIMGQF DHPNVIHLEG VVTKSTPVMI ITEFMENGSL 720
DSFLRQNDGQ FTVIQLVGML RGIAAGMKYL ADMNYVHRDL AARNILVNSN LVCKVSDFGL 780
SRFLEDDTSD PTYTSALGGK IPIRWTAPEA IQYRKFTSAS DVWSYGIVMW EVMSYGERPY 840
WDMTNQDVIN AIEQDYRLPP PMDCPSALHQ LMLDCWQKDR NHRPKFGQIV NTLDKMIRNP 900
NSLKAMAPLS SGINLPLLDR TIPDYTSFNT VDEWLEAIKM GQYKESFANA GFTSFDVVSQ 960
MMMEDILRVG VTLAGHQKKI LNSIQVMRAQ MNQIQSVEGQ PPARRPRAAE EPSSAPATRC 1020
HQEHMQFKRR KKKGMGGKRK 1040
Nucleotide Sequence
(FASTA)
CTTGACACTG GGTACACTGC CCCTAATCTC CTAGCCCTAG TACATCCAGC CCAGATCATC 60
AAACTAATTG TTTCAAGTGC CTGGAAGTTT ATAGAAACCT TAATGGACTC CACTACAGCG 120
ACGGCTGAGC TGGGCTGGAT GGTGCATCCT CCATCAGGGT GGGAAGAGGT GAGTGGCTAC 180
GATGAGAACA TGAACACGAT CCGCACGTAC CAGGTGTGCA ACGTGTTTGA GTCAAGCCAG 240
AACAACTGGC TACGGACCAA GTTCATCCGG CGCCGTGGCG CCCACCGCAT CCACGTGGAG 300
ATGAAGTTCT CGGTGCGTGA CTGCAGCAGC ATCCCCAGCG TGCCTGGCTC CTGCAAGGAG 360
ACCTTCAACC TCTATTACTA TGAGGCTGAT TATGACTCGG CCACCAAGAC CTTCCCCAAC 420
TGGATGGAGA ATCCGTGGGT GAAGGTGGAT ACCATTGCGG CTGACGAGAG CTTCTCCCAG 480
GTGGACCTGG GGGGCCGGGT CATGAAAATC AACACTGAGG TACGGAGCTT CGGACCCGTG 540
TCCCGCAGTG GCTTCTACCT GGCCTTCCAG GACTACGGTG GCTGCATGTC CCTCATCGCT 600
GTGCGTGTTT TCTACCGTAA GTGCCCCCGC ATCATCCAGA ATGGCGCCAT CTTCCAGGAG 660
ACGCTGTCAG GGGCTGAAAG CACATCACTG GTGGCTGCCC GGGGCAGCTG CATCGCCAAT 720
GCTGAAGAAG TGGATGTACC CATCAAGCTC TACTGTAATG GGGACGGCGA GTGGCTGGTG 780
CCCATTGGGC GTTGCATGTG CAAAGCGGGG TTTGAAGCCG TGGAGAATGG CACCATCTGC 840
CGAGGTTGTC CATCTGGAAC CTTCAAGGCC AACCAAGGGG ATGAGGCCTG CACCCACTGT 900
CCCATCAACA GCCGCACCAC TTCAGAAGGG GCCACCAACT GTGTCTGCCG CAATGGCTAT 960
TACAGAGCAG ACCTGGACCC CCTGGACATG CCCTGCACAA CCATCCCCTC CGCACCCCAG 1020
GCTGTGATTT CCAGTGTCAA CGAGACCTCC CTCATGCTGG AGTGGACTCC TCCCCGGGAC 1080
TCCGGAGGCC GTGAGGATCT CGTCTACAAC ATCATCTGCA AAAGCTGTGG CTCAGGCCGG 1140
GGCGCCTGCA CCCGCTGTGG GGACAACGTG CAGTACGCAC CGCGCCAGTT GGGCCTGACC 1200
GAGCCCCGCA TCTACATCAG CGACCTGCTG GCCCACACCC AGTACACCTT TGAGATCCAG 1260
GCCGTGAACG GCGTCACTGA CCAGAGCCCC TTCTCACCTC AGTTCGCCTC CGTGAACATC 1320
ACCACCAACC AAGCAGCTCC GTCGGCCGTG TCCATCATGC ATCAGGTGAG CCGCACAGTG 1380
GACAGCATCA CCCTGTCGTG GTCCCAGCCA GACCAGCCCA ATGGTGTGAT CCTGGACTAT 1440
GAGCTGCAGT ACTATGAGAA GGAGCTCAGT GAGTACAACG CCACAGCCAT AAAAAGCCCC 1500
ACCAACACGG TCACTGTGCA GGGCCTCAAA GCCGGCGCCA TCTATGTCTT CCAGGTGCGG 1560
GCACGCACCG TGGCAGGCTA CGGGCGCTAC AGTGGCAAGA TGTACTTCCA GACCATGACA 1620
GAAGATCCCG AGTACCAGAC AAGCATCCAG GAGAAGCTGC CACTGATCAT CGGCTCCTCG 1680
GCCGCTGGCC TGGTCTTCCT CATTGCTGTG GTTGTCATCG CCATTGTGTG TAACAGAAGA 1740
CGGGGGTTTG AGCGTGCTGA CTCGGAGTAC ACAGACAAGC TGCAGCACTA CACCAGCGGC 1800
CACATGACCC CAGGCATGAA AATCTACATC GACCCTTTCA CCTACGAGGA CCCCAACGAG 1860
GCAGTGAGGG AGTTTGCCAA GGAAATTGAC ATCTCCTGTG TCAAGATTGA GCAGGTGATC 1920
GGAGCAGGAG AGTTTGGTGA GGTCTGCAGT GGCCACCTGA AGCTGCCAGG CAAGAGAGAG 1980
ATCTTCGTGG CCATCAAGAC ACTCAAGTCG GGCTACACTG AGAAGCAGCG CCGGGACTTC 2040
CTGAGCGAGG CCTCCATCAT GGGCCAGTTT GACCACCCCA ATGTCATCCA CCTGGAAGGT 2100
GTTGTCACCA AGAGCACACC CGTGATGATC ATCACAGAGT TCATGGAGAA TGGCTCCCTG 2160
GACTCCTTTC TACGGCAAAA TGATGGGCAG TTCACAGTCA TCCAGCTGGT AGGCATGCTG 2220
AGGGGCATTG CGGCTGGCAT GAAGTACCTG GCAGACATGA ACTACGTACA CCGGGACCTG 2280
GCTGCCCGCA ATATCCTCGT CAACAGCAAC CTGGTCTGCA AGGTGTCTGA CTTTGGGCTC 2340
TCACGCTTCC TGGAAGATGA CACCTCAGAC CCCACCTACA CCAGTGCCCT GGGGGGGAAG 2400
ATCCCCATCC GCTGGACAGC CCCAGAAGCC ATCCAGTACC GGAAGTTCAC CTCAGCCAGT 2460
GACGTGTGGA GCTACGGCAT CGTCATGTGG GAGGTGATGT CCTATGGGGA GCGGCCCTAC 2520
TGGGACATGA CCAACCAGGA TGTAATCAAC GCCATTGAGC AGGACTATCG GCTGCCGCCA 2580
CCCATGGACT GCCCAAGCGC CCTGCACCAA CTCATGCTGG ACTGCTGGCA GAAGGACCGC 2640
AACCACCGGC CCAAGTTTGG CCAAATAGTC AACACGCTAG ACAAGATGAT CCGCAACCCA 2700
AACAGCCTCA AAGCCATGGC TCCCCTCTCC TCTGGTATTA ACCTGCCGCT GCTGGACCGT 2760
ACGATCCCCG ATTACACCAG CTTTAACACA GTGGATGAGT GGCTGGAGGC CATAAAGATG 2820
GGGCAGTACA AGGAGAGCTT CGCCAACGCT GGCTTCACCT CCTTCGATGT CGTGTCTCAG 2880
ATGATGATGG AGGACATTCT CCGGGTCGGG GTCACTTTGG CTGGCCACCA GAAAAAAATC 2940
CTGAACAGTA TCCAGGTGAT GCGGGCACAG ATGAACCAGA TTCAGTCTGT GGAGGGTCAG 3000
CCACCTGCCA GGAGGCCACG GGCAGCAGAA GAACCAAGCA GTGCTCCAGC CACGAGATGT 3060
CACCAAGAAC ACATGCAATT CAAACGACGG AAAAAAAAGG GAATGGGGGG AAAAAGAAAA 3120
TAG 3123
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp
Q: 634   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  693
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm
Q: 694   NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  753
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y
Q: 754   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  813
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml
Q: 814   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML  873
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rpkf qiv++l
Q: 874   DCWQKDRNHRPKFGQIVNTL  893
         *****************975
Domain Sequence
(FASTA)
VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60
NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPSALHQLML 240
DCWQKDRNHR PKFGQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00004
EKS-CAF-00005
EKS-CAP-00004
EKS-CIS-00001
EKS-DAR-00002
EKS-EQC-00005
EKS-GAG-00005
EKS-GAA-00006
EKS-GOG-00004
EKS-HOS-00006
EKS-ICT-00004
EKS-LOA-00005
EKS-MEG-00004
EKS-MOD-00005
EKS-MUM-00005
EKS-MUP-00004
EKS-MYL-00005
EKS-ORN-00004
EKS-ORC-00004
EKS-ORL-00005
EKS-PAT-00005
EKS-PES-00010
EKS-PEM-00001
EKS-POA-00013
EKS-PTV-00003
EKS-RAN-00005
EKS-SAH-00004
EKS-SUS-00004
EKS-TAG-00009
EKS-TAR-00006
EKS-TEN-00005
EKS-TUT-00002
EKS-XIM-00002
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013