EKS-OTG-00153

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00153

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	554.5	3.1E-167	448	724	277

Status

Unreviewed

Ensembl Protein

ENSOGAP00000013169

UniProt Accession

H0XBR9;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000014695	ENSOGAP00000013169	ENSOGAT00000014703

Organism

Otolemur garnettii

Functional Description

Protein Length

792

Protein Sequence
(FASTA)

AQPWGAPVEV ESLLVHPGDL LQLRCRLRDD VQIINWLRDG VQLVESNRTR ITGAEVEVRD 60

SVPADSGLYA CVTSSPSGSD TTYFSVNVSD ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP 120

VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS NGTPYPTLRW LKNGKEFKPD HRIGGYKVRY 180

ATWSIIMDSV VPSDKGNYTC IVENEYGSIN HTYQLDVVER SPHRPILQAG LPANKTVALG 240

SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN 300

VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE ALEERPAAMA SPLYLEIIIY CTGAFLISCM 360

VGSVIICKMK SSTKKSDFHS QMAVHKLAKS IPLRRQVTVS ADSSASMNSG VLLVRPSRLS 420

SSGTPMLAGV SEYELPEDPR WELPRDRLVL GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK 480

VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK HKNIINLLGA CTQDGPLYVI VEYASKGNLR 540

EYLQARRPPG LEYCYNPRHS PEEQLSSKDL ISCAYQVARG MEYLASKKCI HRDLAARNVL 600

VTEDNVMKIA DFGLARDIHH IDYYKKTTNG RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL 660

WEIFTLGGSP YPGVPVEELF KLLKEGHRMD KPSNCTNELY MMMRDCWHAV PSQRPTFKQL 720

VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH 780

PPQLANGGLK PR 792

Nucleotide Sequence
(FASTA)

GCCCAGCCCT GGGGAGCCCC TGTGGAAGTG GAGTCCCTCC TGGTCCACCC TGGTGACCTG 60

CTGCAGCTTC GCTGCCGGCT GCGGGACGAT GTGCAGATCA TCAACTGGCT GCGGGACGGG 120

GTACAGCTGG TGGAAAGCAA TCGCACCCGC ATCACAGGGG CAGAGGTGGA GGTGCGGGAC 180

TCCGTGCCCG CGGACTCCGG CCTCTACGCT TGCGTGACCA GCAGCCCCTC AGGCAGCGAC 240

ACCACCTACT TCTCCGTCAA TGTTTCAGAT GCTCTCCCCT CCTCTGAGGA TGATGATGAC 300

GATGATGACT CCTCTTCAGA GGAGAAAGAG ACAGATAACA CCAAACCAAA CCGTATGCCT 360

GTAGCTCCAT ATTGGACATC CCCAGAAAAG ATGGAAAAGA AATTGCATGC CGTGCCAGCT 420

GCCAAGACAG TGAAGTTTAA ATGCCCTTCC AATGGGACAC CTTACCCCAC ACTGCGCTGG 480

TTGAAAAATG GCAAAGAATT CAAACCTGAC CACAGGATTG GAGGCTACAA AGTCCGTTAC 540

GCCACCTGGA GCATCATAAT GGACTCCGTC GTGCCCTCTG ACAAGGGCAA CTACACCTGC 600

ATTGTGGAAA ATGAGTATGG CAGCATTAAC CACACCTACC AGCTCGACGT CGTCGAGCGA 660

TCCCCACACC GCCCCATCTT GCAGGCAGGG CTGCCTGCCA ACAAGACAGT GGCCCTGGGC 720

AGCAACGTGG AGTTCATGTG CAAGGTGTAC AGTGACCCCC AGCCTCACAT CCAGTGGCTG 780

AAGCACATCG AGGTGAACGG GAGCAAGATT GGTCCCGACA ACCTGCCTTA TGTCCAGATC 840

CTGAAGACTG CCGGAGTTAA TACCACCGAC AAAGAGATGG AAGTGCTTCA CTTAAGGAAT 900

GTCTCCTTTG AGGACGCTGG GGAGTATACG TGCTTGGCGG GTAACTCTAT CGGACTCTCC 960

CACCACTCTG CATGGCTGAC CGTTCTGGAA GCCCTGGAGG AGAGGCCGGC GGCGATGGCG 1020

TCGCCCCTGT ACCTGGAGAT CATCATCTAC TGCACGGGGG CCTTCCTCAT CTCCTGCATG 1080

GTGGGCTCCG TCATCATCTG CAAGATGAAG AGCAGCACCA AGAAGAGCGA CTTCCACAGC 1140

CAGATGGCCG TGCACAAGCT GGCCAAGAGC ATCCCCCTGC GCAGACAGGT AACAGTGTCA 1200

GCCGACTCCA GTGCCTCCAT GAACTCTGGG GTTCTGCTGG TCCGGCCCTC ACGACTGTCC 1260

TCCAGTGGGA CACCCATGCT TGCTGGCGTC TCTGAGTATG AGCTCCCCGA AGACCCTCGC 1320

TGGGAGCTGC CTCGGGACAG ACTGGTCTTA GGCAAACCCC TGGGAGAGGG CTGCTTTGGG 1380

CAGGTGGTGT TGGCCGAGGC CATTGGGCTG GACAAGGACA AACCCAACCG TGTGACCAAA 1440

GTGGCTGTGA AGATGTTGAA GTCCGATGCA ACAGAGAAAG ACCTGTCAGA CCTGATCTCA 1500

GAAATGGAGA TGATGAAGAT GATCGGAAAG CACAAGAACA TCATCAACCT GCTGGGAGCC 1560

TGCACACAGG ACGGTCCACT GTACGTCATC GTGGAATACG CCTCCAAGGG CAACCTGCGG 1620

GAGTACCTGC AGGCCCGCAG GCCTCCGGGG CTGGAGTACT GCTACAACCC CCGCCACAGT 1680

CCGGAGGAGC AGCTGTCCTC CAAGGACCTG ATCTCTTGTG CCTACCAGGT GGCCCGAGGC 1740

ATGGAATACC TCGCCTCCAA GAAGTGTATA CACCGAGACC TGGCTGCCAG GAACGTCCTG 1800

GTGACAGAGG ACAATGTGAT GAAGATCGCA GACTTCGGGC TGGCCCGGGA CATTCACCAT 1860

ATCGACTACT ATAAAAAAAC TACGAATGGC CGGCTGCCCG TGAAGTGGAT GGCTCCTGAG 1920

GCGCTGTTTG ACCGGATCTA CACCCACCAG AGTGATGTGT GGTCTTTCGG GGTGCTCCTG 1980

TGGGAGATCT TCACTCTGGG TGGCTCCCCG TATCCTGGTG TGCCCGTGGA GGAGCTTTTC 2040

AAGCTGCTGA AGGAGGGTCA TCGCATGGAC AAGCCCAGTA ACTGCACCAA TGAACTGTAC 2100

ATGATGATGC GGGACTGCTG GCACGCTGTG CCCTCGCAGA GACCCACCTT CAAGCAGCTG 2160

GTGGAAGACC TGGACCGCAT TGTAGCCTTG ACTTCCAACC AGGAGTATCT GGACCTGTCG 2220

ATGCCCTTGG ACCAGTACTC CCCCAGCTTT CCTGACACCC GGAGCTCCAC CTGCTCCTCG 2280

GGGGAGGATT CCGTCTTTTC TCATGAGCCA TTGCCTGAGG AGCCCTGTCT GCCCCGACAC 2340

CCACCCCAGC TTGCCAATGG CGGACTCAAA CCACGCTGA 2379

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 448   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  507

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++++++eeql++

Q: 508   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPRHSPEEQLSS  567

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdl+s+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 568   KDLISCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  627

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 628   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  687

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 688   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  724

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP RHSPEEQLSS 120

KDLISCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013