EKS-OTG-00470

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00470

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.6	4.6E-125	26	321	296

Status

Unreviewed

Ensembl Protein

ENSOGAP00000013344

UniProt Accession

H0XC62;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000014897	ENSOGAP00000013344	ENSOGAT00000014903

Organism

Otolemur garnettii

Functional Description

Protein Length

426

Protein Sequence
(FASTA)

MSKSKVDNQF YSVEVGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAVLDR NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMVR HKILFPGRDY IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRNYV ENRPKYAGLT FPKLFPDSLF PADSEHNKLK ASQARDLLSK 300

MLVIDPAKRI SVDDALQHPY INVWYDPAEV EAPPPQIYDK QLDEREHTIE EWKELIYKEV 360

MNSEEKTKNG VVKGQPSPSG AAVNSSESLP PSSSVNDISS MSTDQTLASD TDSSLEASAG 420

PLGCCR 426

Nucleotide Sequence
(FASTA)

ATGAGCAAAA GCAAAGTGGA CAACCAGTTC TACAGTGTGG AAGTGGGAGA TTCAACCTTC 60

ACAGTTCTCA AGCGCTACCA GAATCTAAAG CCTATTGGCT CTGGGGCTCA GGGAATAGTT 120

TGTGCTGCGT ATGATGCTGT CCTTGACAGA AATGTGGCCA TTAAGAAGCT CAGCAGACCC 180

TTTCAGAACC AAACACATGC CAAGAGAGCA TACCGGGAGC TGGTCCTCAT GAAGTGTGTG 240

AACCATAAAA ACATTATTAG TTTATTAAAC GTCTTCACAC CCCAGAAAAC GCTGGAGGAG 300

TTCCAAGATG TTTACTTAGT AATGGAACTG ATGGATGCCA ACTTATGTCA GGTGATTCAG 360

ATGGAATTAG ACCATGAGCG AATGTCTTAC CTGCTATACC AAATGCTGTG TGGCATCAAG 420

CACCTCCACT CTGCTGGAAT TATTCACAGG GATTTAAAAC CTAGTAACAT TGTAGTCAAG 480

TCAGATTGCA CATTGAAAAT CCTGGACTTT GGACTGGCCA GGACAGCAGG CACAAGCTTC 540

ATGATGACTC CGTATGTGGT GACACGTTAT TACAGAGCCC CTGAAGTCAT CCTGGGAATG 600

GGCTACAAGG AGAACGTGGA TATATGGTCT GTGGGGTGCA TCATGGGAGA AATGGTTCGC 660

CACAAAATCC TCTTTCCAGG AAGGGACTAT ATTGACCAGT GGAATAAGGT AATTGAACAA 720

CTAGGAACAC CATGTCCGGA ATTCATGAAG AAATTGCAAC CCACAGTAAG AAACTATGTG 780

GAGAATCGGC CCAAGTACGC GGGACTCACC TTCCCCAAGC TTTTTCCAGA TTCCCTCTTC 840

CCAGCGGACT CCGAGCACAA TAAACTCAAA GCCAGCCAAG CCAGGGACTT GTTGTCAAAG 900

ATGCTAGTGA TTGACCCAGC AAAAAGGATA TCAGTGGACG ACGCCTTACA GCATCCCTAC 960

ATCAACGTCT GGTACGACCC TGCTGAAGTG GAGGCGCCTC CACCTCAGAT ATATGACAAA 1020

CAGTTGGATG AAAGAGAGCA CACCATTGAA GAATGGAAAG AACTTATCTA CAAGGAAGTA 1080

ATGAATTCAG AAGAAAAGAC TAAAAATGGC GTAGTAAAAG GCCAGCCTTC TCCTTCAGGT 1140

GCAGCAGTGA ACAGCAGCGA GAGTCTCCCT CCATCCTCAT CCGTCAACGA CATCTCCTCC 1200

ATGTCCACCG ACCAGACCCT GGCATCCGAC ACTGACAGCA GCCTGGAAGC TTCGGCAGGG 1260

CCCCTGGGTT GTTGCAGGTG A 1281

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 202   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 261   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013