EKS-OTG-00330

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00330

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	322.8	1.5E-96	17	274	258

Status

Unreviewed

Ensembl Protein

ENSOGAP00000013826

UniProt Accession

H0XD93;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K1

Gene Synonyms/Alias

MAP4K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000015436	ENSOGAP00000013826	ENSOGAT00000015444

Organism

Otolemur garnettii

Functional Description

Protein Length

833

Protein Sequence
(FASTA)

MDFTDPDIFN KDPRDHYDLL QRLGGGTYGE VFKARDKVSG DLVALKMVKM EPDDDVSTLQ 60

KEILMLKTCR HANIVAYHGS YLWWLQKLWI CMEFCGAGSL QDIYQVTGSL SELQISYVCR 120

EVLQGLAYLH SQKKIHRDIK GANILINDAG EVRLADFGIS AQIGATLARR LSFIGTPYWM 180

APEVAAVALK GGYNELCDIW SLGITAIELA ELQPPLFDVH PLRVLFLMTK SGYQPPRLKE 240

KGKWSAAFHN FVKVTLTKSP KKRPSATKML SHQLLAQPGL NRGLILDLLD KLRNPGKGAL 300

TGEIEDEEPE LPPAIPRRIK STHRSSSLGV PDADCCRRHM EFRKLRGLET RPPVDTARLQ 360

PPKDFWSSPR RHLSESDDDD YDDVDIPTPA EDIPPPLPPK PKFRSPSDEG PGGPRDEGQL 420

SPGVLVRCAS GPPPRTPRPR PPPATGSPHL TAHSEPSLWN PASQEPDQPP LLPPKKEKMK 480

RKLDLPPGPV WPAQGCALLV KLFNGCPLRI HSTAAWTHPS TKDQHLLLGA EEGIFILNRN 540

DQEATLEMLF PSRTTWVYSI NNVLMSLSGK TPHLYSHSIL GLLERKETRA GSPIAHISPH 600

RLLARKNMVS TKIQDTKGCR ACCVAEGATS GGPFLCGALE TSVVLLQWYQ PMNKFLLVRQ 660

VLFPLPTPLP VFALLTGPGS ELPAVCIGVS PGRPAKSVLF HTVRFGALSC WLGEMSTEHK 720

GPVQVTQVEE DMVMVLMDGS LKLVTPEGAP VRGLRTHEIP MTEAVEAVAM VRGQLQAFWK 780

HGVQVWALGS DQLLQELRDP TLTFRLLGSP KPVVVETRPA DDPTAPSNLY IQE 833

Nucleotide Sequence
(FASTA)

ATGGACTTTA CAGACCCCGA CATTTTTAAT AAGGACCCCC GTGACCATTA CGACCTGTTG 60

CAGCGGCTGG GTGGCGGCAC CTATGGGGAA GTCTTCAAGG CTCGAGACAA GGTGTCGGGG 120

GACCTGGTGG CATTGAAGAT GGTGAAAATG GAGCCTGATG ACGATGTCTC CACCCTTCAG 180

AAGGAAATCC TCATGCTGAA AACTTGCCGG CATGCCAACA TCGTGGCCTA CCATGGGAGT 240

TATCTCTGGT GGTTGCAGAA GCTCTGGATC TGCATGGAAT TCTGTGGGGC TGGTTCTCTC 300

CAGGACATCT ACCAAGTGAC AGGCTCCCTG TCAGAGCTCC AGATTAGCTA TGTGTGCCGG 360

GAAGTGCTGC AGGGACTGGC CTACCTGCAC TCACAGAAGA AGATACACAG AGACATCAAG 420

GGAGCCAACA TCCTCATCAA TGATGCTGGG GAGGTCAGAC TAGCTGACTT TGGCATCTCA 480

GCCCAGATTG GGGCAACGCT GGCTAGACGC CTCTCTTTCA TTGGGACACC CTACTGGATG 540

GCTCCAGAAG TGGCGGCCGT GGCCCTGAAG GGGGGATACA ATGAGCTATG TGACATCTGG 600

TCCCTGGGCA TCACAGCTAT TGAACTAGCC GAGCTGCAGC CGCCACTCTT TGATGTGCAC 660

CCCCTGAGAG TTCTCTTCCT CATGACCAAG AGTGGCTACC AGCCTCCTCG GCTAAAGGAA 720

AAAGGCAAAT GGTCTGCTGC CTTCCACAAC TTTGTCAAAG TCACCCTCAC TAAGAGCCCC 780

AAGAAACGAC CAAGCGCCAC CAAGATGCTC AGTCATCAAC TGTTAGCCCA GCCTGGGCTG 840

AACAGAGGCC TGATTCTAGA TCTTCTTGAC AAACTGAGGA ATCCTGGAAA GGGGGCCCTC 900

ACTGGGGAGA TCGAGGATGA GGAGCCTGAG CTACCTCCTG CCATCCCTCG GCGTATCAAA 960

TCTACCCACC GGTCCAGCTC TCTGGGGGTC CCAGATGCAG ACTGCTGTCG GCGGCACATG 1020

GAGTTCAGGA AGCTCAGAGG ACTGGAGACC AGACCCCCAG TCGACACAGC TCGCTTACAG 1080

CCCCCCAAAG ACTTCTGGAG CAGCCCCAGG CGGCACCTGT CAGAGTCGGA TGATGATGAC 1140

TATGATGACG TGGACATCCC CACCCCTGCT GAGGACATAC CTCCTCCACT GCCCCCCAAG 1200

CCCAAGTTCC GTTCTCCATC AGATGAGGGT CCTGGGGGGC CAAGGGATGA AGGGCAGCTG 1260

AGCCCAGGGG TGCTGGTCCG GTGTGCCAGT GGACCTCCTC CACGCACTCC ACGTCCTAGG 1320

CCTCCCCCAG CCACTGGCAG CCCCCACCTC ACTGCCCATT CAGAACCCTC ACTCTGGAAC 1380

CCAGCTTCCC AGGAGCCTGA CCAGCCCCCA CTACTGCCCC CCAAGAAGGA AAAGATGAAG 1440

AGGAAGCTGG ATCTGCCGCC TGGCCCTGTG TGGCCTGCTC AGGGATGTGC CCTTCTGGTA 1500

AAGTTGTTCA ATGGCTGCCC ACTCCGGATC CACAGCACAG CTGCCTGGAC ACACCCCTCC 1560

ACCAAGGACC AGCACCTGCT CCTGGGTGCA GAAGAAGGCA TCTTCATCTT GAACCGGAAT 1620

GACCAGGAGG CTACACTGGA GATGCTCTTT CCTAGCCGGA CTACCTGGGT GTACTCCATC 1680

AACAATGTCC TCATGTCTCT CTCAGGAAAG ACTCCCCACC TGTATTCTCA TAGCATCTTG 1740

GGCCTGCTGG AACGGAAAGA GACCAGAGCA GGAAGCCCCA TCGCTCACAT TAGCCCCCAC 1800

CGGCTACTGG CAAGGAAGAA CATGGTCTCC ACCAAGATCC AGGACACCAA AGGCTGCCGG 1860

GCGTGCTGTG TGGCGGAGGG TGCGACCTCC GGGGGCCCTT TCCTGTGCGG GGCACTGGAG 1920

ACATCTGTGG TCCTCCTTCA GTGGTATCAG CCTATGAACA AGTTCCTGCT CGTCCGGCAG 1980

GTGCTGTTCC CACTACCGAC GCCTCTGCCA GTGTTCGCGC TGCTGACCGG GCCCGGCTCT 2040

GAACTGCCCG CCGTGTGCAT CGGCGTCAGT CCCGGGCGGC CGGCGAAGTC GGTGCTCTTC 2100

CACACCGTGC GCTTCGGCGC GCTGTCCTGC TGGCTGGGCG AGATGAGCAC CGAGCACAAG 2160

GGACCAGTGC AGGTGACCCA GGTAGAGGAA GATATGGTAA TGGTGTTGAT GGATGGCTCT 2220

CTGAAGCTGG TGACCCCGGA GGGAGCACCA GTCCGGGGCC TTCGCACACA TGAGATCCCT 2280

ATGACCGAGG CAGTGGAAGC TGTGGCTATG GTCCGGGGTC AGCTTCAAGC TTTTTGGAAA 2340

CATGGAGTGC AGGTGTGGGC TCTAGGCTCT GACCAGCTGC TGCAGGAGCT GAGAGATCCC 2400

ACTCTCACCT TTCGTCTGCT TGGCTCTCCC AAGCCTGTAG TGGTGGAGAC ACGCCCAGCA 2460

GATGATCCTA CTGCCCCCAG CAACCTCTAC ATCCAGGAAT GA 2502

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ll+++g G++g+v++ar+k +g+lva+k++++e  +++++lqkei +lk+++h niv+

Q: 17    YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILMLKTCRHANIVA  76

         899*********************************************************

S: 61    ylesflk.eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119

         y++s+l   ++lw++me++ +Gsl+d+++  ++ +l+E qi+y++revl++L+ylHs+k+

Q: 77    YHGSYLWwLQKLWICMEFCGAGSLQDIYQ--VTGSLSELQISYVCREVLQGLAYLHSQKK  134

         ******989********************..9****************************

S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYd  178

         iHrdik++niL+++ geV+L+dfg++aq+ +t ++r +++gtpywmAPEv a+  + gY+

Q: 135   IHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVAlKGGYN  194

         ****************************************************998999**

S: 179   ekaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvek  236

         e +DiwslGItaielae +pP++d++pl++l++++k+   pp+lk+k k+s +f++fv+

Q: 195   ELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGyqPPRLKEKGKWSAAFHNFVKV  254

         ***********************************998889*******************

S: 237   clqknpekRpsasellkhkF  256

          l+k+p+kRpsa+++l+h+

Q: 255   TLTKSPKKRPSATKMLSHQL  274

         ******************85

Domain Sequence
(FASTA)

YDLLQRLGGG TYGEVFKARD KVSGDLVALK MVKMEPDDDV STLQKEILML KTCRHANIVA 60

YHGSYLWWLQ KLWICMEFCG AGSLQDIYQV TGSLSELQIS YVCREVLQGL AYLHSQKKIH 120

RDIKGANILI NDAGEVRLAD FGISAQIGAT LARRLSFIGT PYWMAPEVAA VALKGGYNEL 180

CDIWSLGITA IELAELQPPL FDVHPLRVLF LMTKSGYQPP RLKEKGKWSA AFHNFVKVTL 240

TKSPKKRPSA TKMLSHQL 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013