EKS-OTG-00122

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00122

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	356.2	1.1E-106	41	313	273

Status

Unreviewed

Ensembl Protein

ENSOGAP00000013957

UniProt Accession

H0XDK9;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000015576	ENSOGAP00000013957	ENSOGAT00000015587

Organism

Otolemur garnettii

Functional Description

Protein Length

1307

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGSA AARDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDL 60

GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120

LLTELCKGQL VEFLKKSESK GPLSCDAVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180

LSNQGTIKLC DFGSATTISH FPDYSWSAQR RAMVEEEITR NTTPMYRTPE IIDLYSNFPI 240

GEKQDIWALG CILYLLCFQQ HPFEDGAKLR IVNGKYVIPL TDTRYTVFHD LIRAMLKVNP 300

EERLSITEVV RQLQEIAAAR NVNPKSPITE LLEQNGGHGN AVPSRGPLPG GPASSGYSPG 360

LALVEYDQSY SGFLDILRGG TERLFTNIKD TSSKVIQSVA NYAKGDLDIS YITSRIAVMS 420

FPAEGVESAI KNNIEDVRVF LDSRHPGRYA VYNLSARSYR PSKFHSRVSE CGWVARRAPS 480

LHSLYDVCRN MHAWLRQDHR NVCVVHCVDG RAASAVAVCS FLCFCRLFST AEAAVYMFSM 540

KRCPPGIWPS HKRYIEYICD MVAEEPVTPH SKPVLLKAVS MTPVPLFSKQ RTGCRPFCEV 600

YAGGERVAST SQEYDKMRLL LLSSGGREVP WGSSCQSPVC SWVLFCEAQS CGGRVGCSVL 660

ARSWPSTFGL CVVSLTAVCW QQHRYDLDAC DIQEKYPDLF QVNLEVEVEP RDRPSCEALP 720

WENASMKGLN PKILFSSREE QQDILSKFGK PELPRQPGST AQYDAEEGSP EAEPPELDSP 780

PSSSTDTSHF LHTLDWQEEK ESEMGAGNTS PKENQSALVE DRSGSGVSEE EDVPSTGESR 840

MSRAEGDGPG SQDLIFDAGA TALSPEPMPQ EDSVDLLGLH SEADPRPASP TQTCGVSSSN 900

TDLLSCLLGP PEAAPEGPPD DLLGSKAPLL LASPAPPLSV SSTPRGEPPA PADPFDPLLL 960

PSDSDTQPCS KPDLFGEFLN SDSVVAPPAF PATHSAPPPS CSTDFLHLGD LPVEPVKMTA 1020

SSSQPDLLGG WGTWAEATVP GPAPTPATEG PVFSSGGQPA PSGLPANWTK SQSLDPFADL 1080

GDLSSGLQGL PTGSRPVNGG FLPTTTPIPK GGSSWQTNRP LTQGMSWAPQ TKLPPKACAQ 1140

PRPNYAASFS VIGAREERGV RAPGFAPKPK VSENDFEDLL SNQGFSTRPD KKGPKTIAEM 1200

RRQDLVRDTD PLKLKILEWI EGKERNVRAL LSTLHTVLWD GESRWTPVGM ADLVTPAQVK 1260

KHYRRAVLVV HPDKAAGQPY EQYAKMIFME LSDAWSEFES QGSRPLF 1307

Nucleotide Sequence
(FASTA)

ATGTCGCTGC TGCAGTCGGC GCTCGACTTC CTGGCAGGCC CAGGCTCCCT GGGCAGTGCT 60

GCCGCTCGCG ACCAGAGTGA CTTCGTGGGG CAGACGGTGG AACTGGGCGA GCTGCGGCTG 120

CGGGTGCGGC GAGTCCTGGC CGAGGGAGGG TTTGCATTTG TATATGAAGC TCAAGATCTG 180

GGAAGTGGCA GAGAATATGC GTTAAAGAGG CTGTTGTCCA ACGAAGAGGA AAAGAACAGA 240

GCCATCATTC AGGAAGTTTG TTTCATGAAA AAACTTTCTG GCCACCCCAA CATTGTCCAG 300

TTTTGTTCGG CAGCATCAAT AGGAAAAGAA GAGTCGGACA CAGGGCAGGC TGAGTTCCTC 360

CTACTCACAG AGCTCTGCAA AGGGCAGCTG GTGGAATTTT TAAAGAAAAG TGAATCTAAA 420

GGTCCTCTGT CGTGTGATGC GGTTCTGAAG ATCTTTTACC AGACGTGCAG AGCAGTGCAG 480

CACATGCACA GGCAAAAGCC GCCCATCATT CACAGAGACC TCAAGGTTGA AAACTTGCTG 540

CTTAGTAACC AGGGGACCAT TAAGCTATGT GACTTTGGCA GTGCCACAAC CATCTCACAT 600

TTCCCGGACT ACAGCTGGAG CGCGCAGAGA CGAGCCATGG TGGAGGAAGA GATCACAAGG 660

AATACAACAC CCATGTACAG GACACCAGAG ATCATTGACT TGTACTCCAA CTTCCCAATT 720

GGCGAGAAGC AGGACATCTG GGCCCTGGGC TGCATCCTGT ACCTGCTGTG CTTCCAGCAA 780

CACCCTTTTG AGGATGGAGC GAAACTCCGA ATTGTCAACG GGAAGTATGT GATTCCTCTG 840

ACTGACACCC GGTACACCGT CTTCCATGAC CTCATCCGTG CCATGCTGAA GGTCAACCCG 900

GAGGAGCGGC TGTCCATCAC TGAGGTGGTG CGCCAGCTGC AGGAGATCGC AGCTGCCAGG 960

AACGTGAACC CTAAGTCCCC CATCACAGAG CTCCTTGAGC AGAACGGAGG CCATGGAAAT 1020

GCTGTTCCAT CCCGAGGGCC CCTTCCTGGA GGCCCTGCCA GCAGTGGCTA CAGTCCAGGC 1080

CTGGCTCTGG TAGAATATGA CCAGTCCTAC AGCGGCTTCC TGGACATCTT GCGGGGTGGT 1140

ACCGAGCGGC TATTCACCAA CATCAAGGAC ACGTCCTCCA AGGTCATACA GTCAGTTGCT 1200

AATTATGCCA AAGGCGACCT GGACATATCC TACATCACAT CCAGGATCGC TGTGATGTCG 1260

TTCCCAGCAG AGGGCGTGGA GTCGGCGATC AAAAACAATA TAGAAGATGT TCGGGTATTT 1320

CTGGACTCCA GGCACCCGGG GCGCTATGCT GTCTATAACT TGTCGGCACG GAGCTACCGG 1380

CCCTCTAAGT TTCACAGCCG AGTGTCTGAG TGCGGCTGGG TGGCCCGGCG GGCACCCAGC 1440

CTGCACAGCC TGTATGACGT CTGCAGGAAC ATGCATGCCT GGCTCCGGCA GGACCACAGG 1500

AATGTCTGTG TCGTGCACTG CGTGGACGGG AGAGCCGCCT CGGCTGTGGC TGTCTGCTCC 1560

TTCCTGTGCT TCTGCCGGCT CTTTAGCACT GCGGAAGCCG CTGTGTATAT GTTCAGTATG 1620

AAGCGCTGCC CACCAGGCAT TTGGCCATCC CACAAAAGGT ACATTGAGTA CATCTGCGAC 1680

ATGGTGGCAG AGGAGCCCGT CACGCCCCAC AGCAAGCCCG TGCTGCTGAA GGCTGTCTCC 1740

ATGACCCCTG TGCCCCTGTT CAGCAAGCAG AGGACCGGCT GCAGACCCTT CTGTGAAGTC 1800

TATGCAGGTG GTGAGCGCGT GGCCAGCACA TCCCAGGAAT ACGACAAGAT GAGATTGCTT 1860

CTCCTGTCCT CTGGGGGCAG AGAGGTGCCT TGGGGATCTT CGTGTCAGAG TCCTGTGTGC 1920

TCCTGGGTTT TGTTTTGTGA AGCCCAGAGC TGTGGTGGTC GGGTTGGCTG CTCTGTTCTG 1980

GCTCGGAGCT GGCCTTCTAC TTTTGGGCTG TGTGTGGTCT CCCTAACAGC TGTCTGCTGG 2040

CAACAACACA GGTATGACCT AGATGCGTGT GACATCCAAG AGAAGTACCC AGATCTGTTC 2100

CAAGTGAACC TGGAGGTGGA GGTGGAGCCC AGGGACAGGC CAAGCTGCGA GGCCCTGCCA 2160

TGGGAGAACG CAAGCATGAA GGGGCTGAAC CCCAAAATCC TGTTTTCCAG CCGAGAGGAG 2220

CAGCAAGACA TTCTGTCTAA GTTTGGGAAG CCAGAGCTCC CCCGGCAGCC TGGCTCCACA 2280

GCGCAGTATG ATGCTGAGGA GGGGTCCCCG GAAGCTGAGC CCCCTGAGTT GGACTCACCG 2340

CCAAGCAGCA GCACAGACAC CAGCCACTTC CTGCACACGC TGGACTGGCA GGAGGAAAAA 2400

GAATCCGAGA TGGGTGCAGG AAACACCTCT CCCAAAGAGA ACCAGTCTGC CCTGGTGGAG 2460

GACAGAAGCG GGAGTGGGGT GTCAGAGGAG GAGGATGTGC CGAGCACTGG CGAGAGCAGG 2520

ATGTCCAGGG CTGAGGGCGA TGGACCAGGC TCACAGGACC TGATCTTTGA TGCGGGAGCC 2580

ACAGCCCTGT CCCCGGAGCC CATGCCACAG GAGGACAGCG TGGACCTCCT GGGGCTGCAC 2640

TCTGAGGCGG ACCCCAGGCC AGCTTCTCCC ACACAGACCT GCGGGGTCTC CTCCAGCAAC 2700

ACCGACCTCC TCAGCTGCCT CCTTGGACCC CCTGAGGCTG CTCCAGAAGG GCCGCCAGAT 2760

GACCTGCTTG GCAGCAAGGC CCCACTGCTC TTGGCCAGCC CGGCTCCTCC CCTGAGTGTT 2820

TCCAGCACCC CCCGAGGAGA ACCCCCTGCC CCTGCTGACC CATTTGACCC CTTGCTGCTG 2880

CCGTCGGACT CCGACACTCA GCCCTGCTCT AAGCCTGACC TCTTCGGCGA GTTTCTCAAT 2940

TCTGACTCCG TGGTCGCCCC GCCTGCCTTC CCTGCCACCC ACAGCGCCCC GCCCCCGTCC 3000

TGCAGCACTG ACTTCCTGCA CCTGGGGGAT CTGCCAGTGG AGCCTGTTAA GATGACAGCC 3060

TCGTCCAGCC AGCCGGACCT ACTGGGAGGG TGGGGCACCT GGGCTGAAGC CACTGTGCCC 3120

GGGCCAGCCC CTACACCAGC CACTGAAGGC CCTGTCTTCT CTTCTGGAGG CCAGCCGGCC 3180

CCTTCTGGCC TTCCAGCCAA CTGGACCAAG TCTCAGAGCC TGGACCCATT TGCTGACCTT 3240

GGCGACCTCA GCTCCGGCCT CCAAGGCCTG CCCACTGGAT CCCGTCCTGT TAACGGAGGC 3300

TTTCTTCCCA CGACAACTCC TATTCCCAAG GGTGGTAGCT CCTGGCAGAC GAATCGGCCA 3360

CTGACCCAGG GCATGTCATG GGCCCCCCAA ACCAAGCTGC CCCCCAAAGC GTGTGCTCAA 3420

CCAAGGCCTA ACTATGCCGC AAGCTTCAGT GTGATCGGGG CACGAGAAGA GAGGGGGGTC 3480

CGCGCACCTG GCTTTGCTCC AAAGCCAAAA GTCTCAGAGA ACGATTTTGA GGATTTACTG 3540

TCCAATCAAG GCTTCTCCAC CAGGCCTGAC AAGAAGGGGC CGAAGACCAT TGCAGAGATG 3600

AGGAGGCAGG ACCTCGTCAG AGACACTGAT CCGCTGAAGC TGAAGATCCT GGAGTGGATC 3660

GAAGGCAAGG AAAGAAATGT CCGTGCCCTG CTATCCACAC TGCACACAGT GCTGTGGGAC 3720

GGGGAGAGCC GCTGGACGCC TGTGGGCATG GCAGACCTAG TGACACCAGC GCAGGTGAAG 3780

AAGCATTACC GCCGTGCGGT TCTGGTCGTG CACCCTGACA AGGCCGCAGG GCAGCCGTAT 3840

GAACAGTATG CCAAGATGAT CTTCATGGAG CTCAGCGACG CCTGGTCTGA GTTTGAGAGC 3900

CAGGGCTCCC GGCCCCTGTT CTGA 3924

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         r+++vlaeGGfa+vy a+d+ +g++yalKr+l+neee++++i++E+++mkklsgh+niv+

Q: 41    RVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQ  100

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+lll+e+ck g+lv++l+k ++kg ls++ +lki+++++rav

Q: 101   FCsaASIGKEESDTGQAEFLLLTELCK-GQLVEFLKKSESKGPLSCDAVLKIFYQTCRAV  159

         **877888999****************.8*******************************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlkveN+lls++g+++lcD+GSatt+++ ++   s+q++++++eei+

Q: 160   QHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHFPDyswSAQRRAMVEEEIT  219

         ******************************************999999************

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt++yr+PE+idlysn++i+ek+DiWaLGc+lY lcf ++Pfe+++kl+i+ngky iP

Q: 220   RNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFQQHPFEDGAKLRIVNGKYVIP  279

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlell  270

          +++ ++ +++li++ml+v+peeR++i++v+++l

Q: 280   LTDTRYTVFHDLIRAMLKVNPEERLSITEVVRQL  313

         ******************************9875

Domain Sequence
(FASTA)

RVRRVLAEGG FAFVYEAQDL GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ 60

FCSAASIGKE ESDTGQAEFL LLTELCKGQL VEFLKKSESK GPLSCDAVLK IFYQTCRAVQ 120

HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH FPDYSWSAQR RAMVEEEITR 180

NTTPMYRTPE IIDLYSNFPI GEKQDIWALG CILYLLCFQQ HPFEDGAKLR IVNGKYVIPL 240

TDTRYTVFHD LIRAMLKVNP EERLSITEVV RQL 273

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013