EKS-OTG-00319

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00319

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	350.9	4.1E-105	283	534	252

Status

Unreviewed

Ensembl Protein

ENSOGAP00000014106

UniProt Accession

H0XDY1;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK3

Gene Synonyms/Alias

PAK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000015743	ENSOGAP00000014106	ENSOGAT00000015749

Organism

Otolemur garnettii

Functional Description

Protein Length

559

Protein Sequence
(FASTA)

MSDGLDNEEK PPAPPLRMNS NNRDSSALNH SSKPLPMAPE EKNKKARLRS IFPGGGDKTN 60

KKKEKERPEI SLPSDFEHTI HVGFDAVTGE FTPDLYGSQM CPGKLPEGIP EQWARLLQTS 120

NITKLEQKKN PQAVLDVLKF YDSKETVNNQ KYMSFTSGDK SAHGYIAAHP SSTKTASEPP 180

LAPPVSEEED EEEEEEEDDN EPPPVIAPRP EHTKSIYTRS VVESIASPAA PNKEVTPPSA 240

ENANSSTLYR NTDRQRKKSK MTDEEILEKL RSIVSVGDPK KKYTRFEKIG QGASGTVYTA 300

LDIATGQEVA IKQMNLQQQP KKELIINEIL VMRENKNPNI VNYLDSYLVG DELWVVMEYL 360

AGGSLIDVVT ETCMDEGQIA AVCRECLQAL DFLHSNQVIH RDIKSDNILL GMDGSVKLTD 420

FGFCAQITPE QSKRSTMVGT PYWMAPEVVT RKAYGPKVDI WSLGIMAIEM VEGEPPYLNE 480

NPLRALYLIA TNGTPELQNP ERLSAVFRDF LNRCLEMDVD RRGSAKELLQ HPFLKLAKPL 540

SSLTPLIIAA KEAIKNSSR 559

Nucleotide Sequence
(FASTA)

ATGTCTGACG GTCTGGATAA TGAAGAGAAA CCCCCAGCTC CCCCACTGAG GATGAATAGT 60

AACAACCGGG ATTCTTCAGC GCTCAACCAC AGCTCCAAAC CACTTCCCAT GGCCCCTGAA 120

GAGAAGAATA AGAAAGCCAG GCTGCGCTCT ATCTTCCCAG GAGGAGGGGA TAAAACCAAT 180

AAGAAGAAAG AGAAAGAGCG CCCAGAGATC TCTCTTCCTT CAGACTTTGA GCATACGATT 240

CATGTGGGGT TTGATGCAGT CACCGGGGAG TTCACTCCAG ATCTCTATGG CTCACAGATG 300

TGCCCAGGGA AGCTCCCAGA GGGAATTCCT GAGCAGTGGG CACGATTACT CCAAACCTCC 360

AACATAACGA AACTCGAGCA GAAGAAGAAC CCCCAAGCCG TCCTAGATGT TCTCAAATTC 420

TATGATTCCA AAGAAACCGT CAACAACCAG AAATACATGA GCTTTACATC AGGAGATAAA 480

AGCGCACATG GATACATAGC AGCCCATCCT TCGAGTACAA AAACAGCATC TGAGCCTCCT 540

TTGGCTCCTC CTGTGTCTGA AGAAGAAGAT GAAGAAGAGG AAGAAGAAGA AGATGACAAT 600

GAGCCCCCAC CAGTTATTGC ACCAAGGCCA GAGCATACAA AATCCATCTA CACGCGTTCT 660

GTGGTTGAAT CCATTGCTTC ACCAGCAGCA CCAAATAAAG AGGTCACACC ACCTTCCGCT 720

GAGAATGCTA ATTCCAGTAC TTTGTACAGG AACACAGATC GGCAAAGGAA AAAATCCAAG 780

ATGACAGATG AGGAGATCTT AGAGAAGCTA AGAAGCATTG TGAGTGTTGG AGACCCAAAG 840

AAAAAATACA CAAGATTTGA AAAAATCGGT CAAGGGGCGT CAGGTACTGT TTATACAGCA 900

CTAGACATTG CAACAGGACA AGAGGTGGCC ATAAAGCAGA TGAACCTTCA ACAGCAACCA 960

AAAAAAGAAT TAATTATTAA TGAAATCCTA GTCATGAGGG AAAATAAGAA CCCCAATATT 1020

GTTAATTATT TAGATAGCTA CTTAGTGGGT GATGAACTAT GGGTAGTCAT GGAATACTTG 1080

GCTGGTGGCT CATTGATTGA TGTGGTCACA GAAACCTGTA TGGATGAAGG ACAGATAGCA 1140

GCTGTCTGCA GAGAGTGCCT CCAAGCTTTG GATTTCTTGC ACTCAAACCA AGTGATCCAT 1200

AGAGACATAA AGAGTGACAA TATTCTCCTC GGGATGGATG GCTCTGTTAA ATTGACTGAT 1260

TTTGGGTTCT GTGCCCAGAT CACTCCTGAG CAAAGTAAAC GGAGCACGAT GGTGGGAACC 1320

CCTTATTGGA TGGCACCAGA GGTGGTGACT CGAAAAGCTT ATGGTCCGAA AGTTGATATT 1380

TGGTCTCTGG GAATTATGGC AATTGAAATG GTGGAAGGTG AACCCCCTTA CCTTAATGAA 1440

AATCCACTCA GGGCATTATA TCTGATAGCC ACTAATGGAA CCCCAGAGCT CCAGAATCCT 1500

GAGAGACTGT CAGCTGTATT CCGTGACTTT TTAAATCGCT GTCTTGAGAT GGATGTGGAT 1560

AGGCGAGGAT CTGCCAAGGA GCTTTTGCAG CATCCATTTT TAAAATTAGC CAAGCCTCTC 1620

TCCAGCCTGA CTCCTCTGAT CATCGCTGCA AAGGAAGCGA TTAAGAACAG CAGCCGCTAG 1680

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+

Q: 283   YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  342

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         yl+s+l+ +elw+vmeylagGsl d+v+   ++ ++E qia+++re+l+aL++lHs++vi

Q: 343   YLDSYLVGDELWVVMEYLAGGSLIDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVI  399

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 400   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  457

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++++s  f++f+++cl+

Q: 458   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEM  517

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++++R sa+ell+h+Fl

Q: 518   DVDRRGSAKELLQHPFL  534

         ****************7

Domain Sequence
(FASTA)

YTRFEKIGQG ASGTVYTALD IATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60

YLDSYLVGDE LWVVMEYLAG GSLIDVVTET CMDEGQIAAV CRECLQALDF LHSNQVIHRD 120

IKSDNILLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPER LSAVFRDFLN RCLEMDVDRR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013