EKS-OTG-00232

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00232

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	386.3	7.0E-116	69	361	293

Status

Unreviewed

Ensembl Protein

ENSOGAP00000014222

UniProt Accession

H0XE68;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K1

Gene Synonyms/Alias

MAP2K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000015876	ENSOGAP00000014222	ENSOGAT00000015880

Organism

Otolemur garnettii

Functional Description

Protein Length

393

Protein Sequence
(FASTA)

MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 60

GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE 120

CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 180

REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 240

SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY 300

GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF 360

IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV 393

Nucleotide Sequence
(FASTA)

ATGCCCAAGA AGAAGCCGAC GCCCATCCAG CTGAACCCGG CCCCCGATGG CTCCGCGGTT 60

AACGGGACTA GCTCTGCGGA GACCAACCTG GAGGCCTTGC AGAAGAAGCT GGAGGAGCTG 120

GAGCTTGATG AACAGCAGCG GAAGCGCCTT GAGGCCTTCC TTACCCAGAA GCAGAAAGTG 180

GGAGAACTGA AGGATGATGA CTTCGAGAAG ATCAGTGAGC TGGGGGCTGG CAATGGCGGT 240

GTGGTATTCA AGGTCTCCCA CAAGCCTTCT GGTTTGGTCA TGGCCAGAAA GCTAATTCAT 300

CTGGAGATCA AACCCGCAAT CCGGAACCAG ATCATAAGGG AGCTGCAGGT TTTGCATGAG 360

TGTAACTCTC CATACATTGT GGGCTTCTAT GGTGCATTCT ACAGTGATGG CGAGATCAGT 420

ATCTGCATGG AGCATATGGA TGGAGGTTCC TTGGATCAAG TCCTGAAGAA AGCTGGAAGA 480

ATTCCAGAAC AAATTTTAGG AAAAGTTAGC ATTGCTGTAA TAAAAGGCCT AACATATCTG 540

AGGGAGAAGC ACAAGATTAT GCACAGAGAT GTCAAGCCCT CCAACATCCT AGTCAACTCT 600

CGTGGGGAGA TCAAGCTCTG TGACTTTGGG GTCAGTGGGC AGCTCATCGA CTCCATGGCC 660

AACTCCTTCG TGGGCACAAG GTCTTACATG TCGCCAGAAA GACTCCAGGG GACTCATTAC 720

TCTGTGCAGT CGGACATCTG GAGCATGGGG CTCTCTCTGG TGGAGATGGC AGTTGGGAGG 780

TATCCCATCC CTCCTCCAGA TGCCAAGGAG CTGGAGCTGA TGTTTGGGTG TCAAGTGGAA 840

GGAGATGCGG CTGAGACCCC ACCCAGGCCA AGAACCCCTG GGAGGCCCCT CAGCTCATAT 900

GGAATGGATA GCCGACCTCC CATGGCAATT TTTGAATTGT TGGATTACAT AGTCAATGAG 960

CCTCCTCCAA AATTGCCCAG TGGAGTATTC AGTCTGGAAT TTCAAGATTT TGTGAATAAA 1020

TGCTTAATAA AAAACCCTGC GGAGAGAGCA GATTTGAAGC AACTCATGGT TCATGCTTTT 1080

ATCAAGAGAT CTGATGCTGA GGAAGTAGAT TTTGCAGGCT GGCTGTGTTC CACCATTGGC 1140

CTTAACCAGC CCAGCACGCC AACCCACGCG GCAGGTGTCT AA 1182

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         ek++elGaGnggvV kv+hk+sg ++a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 69    EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  127

         799**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlkk    ++ripe++lgk+++av+k+l+yl+ek

Q: 128   GFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREK  183

         *****************************9....8*************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 184   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  242

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lve+a+gryp++++++

Q: 243   QSDIWSMGLSLVEMAVGRYPIPPPDAkelelmfgcqvegdaaetpprprtpgrplssygm  302

         ************************999*********************************

S: 208   .......ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhafi  259

                i+ell++ivne+ppklp+  fs efq+fv+kCl+k+++eR++lk+l+ hafi

Q: 303   dsrppmaIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI  361

         *********************************************************97

Domain Sequence
(FASTA)

EKISELGAGN GGVVFKVSHK PSGLVMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKKA GRIPEQILGK VSIAVIKGLT YLREKHKIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVEMAV GRYPIPPPDA KELELMFGCQ VEGDAAETPP RPRTPGRPLS SYGMDSRPPM 240

AIFELLDYIV NEPPPKLPSG VFSLEFQDFV NKCLIKNPAE RADLKQLMVH AFI 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013