EPS-OTG-00131

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-OTG-00131

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	622.0	1.5E-187	185	496	312

Status

Unreviewed

Ensembl Protein

ENSOGAP00000014316

UniProt Accession

H0XEE7;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000015987	ENSOGAP00000014316	ENSOGAT00000015992

Organism

Otolemur garnettii

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MAMAEGERTE CAEPPRDEPP ADGSLKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPG 60

NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 120

TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDVESM TIEDEYSGPK 180

LEDGKVTITF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC 240

GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 300

RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 360

VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENNL 420

DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLRGSDLR PQFHQFTAVP 480

HPNVKPMAYA NTLLQLGMM 499

Nucleotide Sequence
(FASTA)

ATGGCGATGG CGGAGGGCGA GCGGACTGAG TGTGCTGAGC CCCCCCGGGA CGAGCCCCCA 60

GCTGATGGCT CCCTGAAGCG GGCAGAGGAG CTCAAGACGC AGGCCAACGA CTACTTCAAA 120

GCCAAGGACT ACGAGAACGC GATCAAGTTC TATAGCCAGG CCATCGAGCT GAACCCCGGC 180

AATGCTATCT ACTATGGCAA CCGCAGCCTG GCCTACCTGC GTACCGAGTG CTACGGCTAT 240

GCGTTGGGTG ATGCCACACG GGCCATTGAG CTCGACAAGA AGTACATCAA GGGTTACTAC 300

CGCCGGGCTG CCAGCAACAT GGCACTGGGC AAGTTCCGGG CTGCCCTGCG AGACTACGAG 360

ACGGTGGTAA AGGTGAAGCC CCATGACAAG GACGCCAAAA TGAAATACCA GGAATGCAAC 420

AAGATTGTGA AGCAGAAGGC CTTCGAGCGG GCCATCGCGG GCGATGAGCA CAAGCGCTCA 480

GTCGTGGACT CTCTTGATGT TGAGAGCATG ACCATCGAGG ATGAGTACAG CGGGCCCAAG 540

CTTGAGGACG GCAAAGTGAC AATCACTTTC ATGAAGGAGC TCATGCAGTG GTACAAGGAC 600

CAGAAGAAAC TGCACCGGAA ATGCGCCTAC CAGATTCTGG TACAGGTCAA AGAGGTCCTC 660

TCCAAGCTGA GCACACTTGT GGAAACTACA CTCAAAGAGA CAGAGAAGAT TACAGTGTGC 720

GGGGACACTC ATGGCCAGTT CTATGACCTC CTCAACATAT TCGAGCTCAA CGGTTTACCC 780

TCTGAGACCA ACCCCTATAT ATTTAATGGC GACTTTGTGG ACCGCGGTTC CTTCTCCGTA 840

GAAGTGATTC TCACCCTTTT TGGCTTTAAG CTCCTATATC CAGATCATTT TCACCTATTG 900

CGAGGCAACC ATGAGACAGA CAACATGAAC CAGATATATG GTTTTGAGGG TGAAGTGAAG 960

GCCAAGTACA CAGCTCAGAT GTACGAGCTC TTCAGCGAGG TGTTTGAGTG GCTCCCGTTG 1020

GCACAGTGCA TCAACGGCAA AGTTCTGATC ATGCATGGAG GCTTATTCAG TGAAGATGGC 1080

GTCACCTTGG ATGATATCAG GAAGATTGAG CGGAATCGGC AGCCCCCAGA TTCCGGTCCC 1140

ATGTGTGACC TGCTTTGGTC AGATCCACAG CCACAGAATG GGCGCTCAGT CAGCAAGCGG 1200

GGCGTGAGCT GTCAGTTTGG GCCTGATGTC ACCAAGGCTT TCCTGGAGGA GAACAACCTG 1260

GACTACATCA TCCGCAGCCA CGAGGTCAAG GCCGAGGGCT ATGAGGTTGC ACATGGAGGC 1320

CGCTGCGTCA CTGTCTTCTC TGCTCCCAAC TACTGCGACC AGATGGGGAA CAAAGCCTCC 1380

TATATCCACC TCCGGGGCTC TGACCTGCGG CCCCAGTTCC ACCAGTTCAC AGCAGTGCCT 1440

CATCCCAACG TCAAGCCCAT GGCCTACGCC AACACGCTGC TGCAACTAGG AATGATGTGA 1500

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+i f+k+l++++k++kkl+rk+a++ilv+v++vl+kl++++e+++ke++kitvcGdth

Q: 185   KVTITFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVCGDTH  244

         799*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 245   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  304

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 305   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  364

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleen+ldyii

Q: 365   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENNLDYII  424

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih+r++dlr+++++f+av+hp+v

Q: 425   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLRGSDLRPQFHQFTAVPHPNV  484

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+ll+l

Q: 485   KPMAYANTLLQL  496

         *********997

Domain Sequence
(FASTA)

KVTITFMKEL MQWYKDQKKL HRKCAYQILV QVKEVLSKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENNLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL RGSDLRPQFH QFTAVPHPNV 300

KPMAYANTLL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013