EKS-OTG-00177

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00177

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	456.5	2.9E-137	405	664	260

Status

Unreviewed

Ensembl Protein

ENSOGAP00000014413

UniProt Accession

H0XEN0;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCH

Gene Synonyms/Alias

PRKCH;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000016105	ENSOGAP00000014413	ENSOGAT00000016108

Organism

Otolemur garnettii

Functional Description

Protein Length

733

Protein Sequence
(FASTA)

MKFNGYLRVR IGEAVGLQPT RWSLRHSLFK KGHQLLDPYL TVSVDQVRVG QTSTKQKTNK 60

PTYNEEFCAN VTDGGHLELA VFHETPLGYD HFVANCTLQL QELLRTASSS DTFEGWVDLE 120

PEGKVFVVIT LTGSFTEATL QRDRIFKHFT RKRQRAMRRR VHQINGHKFM ATYLRQPTYC 180

SHCREFIWGV FGKQGYQCQV CTCVVHKRCH HLIITACTCQ NNNNKVDSKI AEQRFGINIP 240

HKFNIHNYKV PTFCDHCGSL LWGIMRQGLQ CKICKMNVHI RCQANVAPNC GVNAVELAKT 300

LAGMGLQPGN ISPTAYRAAK VGGTGWSTEA AALTPPLQDD ADNTAEANSC RGCSELENLI 360

TCQAMSFSHM KLVSRSTLRR QGKDSSKEGN GIGVSSSSRL GIDNFEFIRV LGKGSFGKVM 420

LARIKETGDL YAVKILKKDV ILQDDDVECT MTEKRILSLA RNHPFLTQLF CCFQTPDRLF 480

FVMEFVNGGD LMFHIQKSRR FDEARARFYA AEIISALMFL HEKGIIYRDL KLDNVLLDHE 540

GHCKLADFGM CKEGICDGVA TATFCGTPDY IAPEILQEML YGPAVDWWAM GVLLYEMLCG 600

HAPFEAENED DLFEAILNDD VVYPTWLHED ATGILKSFMT KNPTMRLGSL TQGGEQAILR 660

HPFFKEIDWA QLNHRQLEPP FRPRIKSRED VSNFDPDFIK EEPILTPIDE GHLPMINQEE 720

FRNFSYMSPE LQP 733

Nucleotide Sequence
(FASTA)

ATGAAATTCA ATGGTTATTT GAGGGTCCGC ATCGGCGAGG CGGTGGGGCT GCAGCCCACC 60

CGCTGGTCCC TGCGCCACTC GCTCTTCAAG AAGGGCCACC AGCTTCTGGA CCCCTACCTG 120

ACGGTGAGCG TGGACCAGGT GCGCGTGGGC CAGACCAGCA CCAAGCAGAA GACCAACAAA 180

CCCACGTACA ATGAGGAGTT CTGCGCTAAC GTCACCGACG GCGGCCACCT CGAGCTGGCC 240

GTTTTCCACG AGACTCCCCT GGGCTATGAC CACTTCGTGG CCAACTGCAC TCTGCAGCTC 300

CAGGAGCTGC TGCGGACGGC CAGCTCCTCG GACACCTTCG AAGGCTGGGT GGACCTGGAA 360

CCAGAGGGGA AAGTGTTTGT GGTAATAACC CTAACTGGGA GTTTCACTGA AGCTACTCTC 420

CAGAGAGACC GAATCTTCAA ACATTTTACC AGGAAGCGCC AAAGGGCGAT GCGGAGACGC 480

GTCCACCAGA TCAACGGACA CAAGTTCATG GCCACGTACC TGAGGCAGCC CACCTACTGC 540

TCCCACTGCA GAGAGTTCAT CTGGGGAGTA TTTGGGAAAC AGGGTTATCA ATGCCAAGTG 600

TGCACCTGTG TCGTCCATAA ACGCTGCCAT CATCTCATTA TTACAGCCTG CACTTGCCAA 660

AACAACAACA ACAAAGTGGA TTCGAAGATT GCTGAACAGA GGTTCGGAAT CAACATCCCA 720

CACAAATTCA ACATCCACAA CTACAAAGTG CCAACGTTCT GCGACCACTG TGGCTCCCTG 780

CTCTGGGGGA TAATGCGGCA AGGACTGCAG TGTAAAATCT GTAAAATGAA TGTGCACATC 840

CGATGTCAAG CAAACGTGGC CCCTAACTGT GGGGTGAACG CCGTGGAGCT GGCTAAGACC 900

CTGGCAGGGA TGGGTCTCCA ACCCGGAAAT ATTTCCCCAA CCGCGTACAG GGCTGCAAAA 960

GTGGGTGGGA CTGGATGGTC CACTGAGGCA GCCGCACTCA CTCCCCCTTT GCAGGATGAT 1020

GCTGACAACA CAGCTGAAGC AAACTCATGC AGAGGTTGTT CTGAGTTGGA GAACCTGATC 1080

ACCTGTCAAG CCATGAGTTT TTCCCACATG AAACTGGTTT CCAGATCAAC CCTAAGAAGA 1140

CAGGGAAAGG ACAGCAGCAA AGAAGGAAAT GGGATTGGGG TCAGTTCTTC CAGCCGACTC 1200

GGTATTGACA ACTTCGAGTT CATCCGAGTG CTGGGGAAGG GGAGTTTTGG GAAGGTGATG 1260

CTTGCAAGAA TAAAAGAAAC GGGAGACCTG TATGCCGTGA AGATTCTAAA GAAGGACGTG 1320

ATCCTGCAGG ATGACGACGT GGAGTGTACC ATGACCGAGA AAAGGATCCT GTCTTTGGCC 1380

CGCAATCACC CCTTCCTCAC TCAGCTGTTC TGCTGCTTTC AGACCCCTGA CCGCCTGTTC 1440

TTCGTGATGG AGTTTGTGAA TGGGGGCGAC CTGATGTTCC ACATTCAGAA GTCCCGTCGC 1500

TTTGACGAAG CGAGAGCTCG TTTCTACGCT GCGGAGATCA TTTCCGCGCT CATGTTCCTC 1560

CACGAGAAAG GGATCATCTA TCGAGATCTG AAACTGGACA ATGTCCTGTT GGACCATGAG 1620

GGTCACTGCA AATTGGCAGA CTTTGGCATG TGCAAGGAGG GGATTTGTGA CGGAGTCGCC 1680

ACGGCCACCT TCTGCGGCAC GCCTGACTAC ATTGCTCCAG AGATCCTCCA AGAGATGCTG 1740

TACGGGCCTG CCGTGGACTG GTGGGCCATG GGTGTGCTGC TCTATGAGAT GCTGTGTGGC 1800

CACGCGCCCT TTGAGGCAGA GAATGAAGAT GACCTTTTCG AGGCCATCCT GAATGATGAC 1860

GTGGTCTACC CAACTTGGCT CCATGAAGAT GCCACAGGGA TCCTAAAATC TTTCATGACC 1920

AAGAACCCCA CCATGCGGCT GGGCAGCCTG ACCCAGGGCG GGGAGCAGGC CATCCTGAGA 1980

CATCCTTTCT TTAAGGAGAT CGACTGGGCC CAGCTGAACC ACCGCCAACT AGAGCCGCCT 2040

TTCAGACCCA GAATTAAATC CAGAGAAGAT GTCAGTAATT TTGACCCCGA CTTCATAAAG 2100

GAAGAGCCGA TTTTAACTCC AATCGATGAG GGCCATCTTC CTATGATTAA CCAGGAGGAG 2160

TTTAGAAACT TTTCCTATAT GTCTCCAGAA CTGCAACCAT AG 2202

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         fe+++vlGkGsfgkv+la+ k+t +lya+k+lkkdv+lqdddve+t++ekr+l+la+++p

Q: 405   FEFIRVLGKGSFGKVMLARIKETGDLYAVKILKKDVILQDDDVECTMTEKRILSLARNHP  464

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+qlf+cfqt drlffv+e+vnGGdlmfhiqk+r+++e+rarfyaaeii+al+flhekg

Q: 465   FLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHEKG  524

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGh+kladfG+cke+i++g  t+tfcGtPdyiaPeil+e+ yg +

Q: 525   IIYRDLKLDNVLLDHEGHCKLADFGMCKEGICDGVATATFCGTPDYIAPEILQEMLYGPA  584

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyeml+g++Pfe+e+ed+lfe+il+++v+yP++l+++a+ ilk+++tk+p+

Q: 585   VDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDDVVYPTWLHEDATGILKSFMTKNPT  644

         ************************************************************

S: 241   krlGvk.eegeedikehaff  259

         +rlG+  + ge++i +h+ff

Q: 645   MRLGSLtQGGEQAILRHPFF  664

         *****65999*********9

Domain Sequence
(FASTA)

FEFIRVLGKG SFGKVMLARI KETGDLYAVK ILKKDVILQD DDVECTMTEK RILSLARNHP 60

FLTQLFCCFQ TPDRLFFVME FVNGGDLMFH IQKSRRFDEA RARFYAAEII SALMFLHEKG 120

IIYRDLKLDN VLLDHEGHCK LADFGMCKEG ICDGVATATF CGTPDYIAPE ILQEMLYGPA 180

VDWWAMGVLL YEMLCGHAPF EAENEDDLFE AILNDDVVYP TWLHEDATGI LKSFMTKNPT 240

MRLGSLTQGG EQAILRHPFF 260

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013