EKS-OTG-00112
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00112
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec469.91.6E-141363613251
StatusUnreviewed
Ensembl ProteinENSOGAP00000014803
UniProt AccessionH0XWD5;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000016539ENSOGAP00000014803ENSOGAT00000016543
ENSOGAG00000016539ENSOGAP00000020428ENSOGAT00000029615
OrganismOtolemur garnettii
Functional Description
Protein Length620
Protein Sequence
(FASTA)
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGCIELSRI 60
KCVEIVKSDI IIPCHYKYPF QVVHDNHLLY VFAPDRESRQ RWVLALKEET RNNNSLVPMY 120
HPNFWMDGRW RCCSQLEKLA TGCAQYDPTK NASKKPLPPT PEDNRRSLPE HEETVVIALY 180
DYQTNDPQEL ALRCNEEYCL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLKTYEWY 240
NENISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTLSVFTK AIISENNPCI KHYHIKETND 300
NPKRFYVAEK FVFDSIPLLI NYHQHNGGGL VTRLRYPVCS WRQKAPIKAG LRYGKWVIDP 360
SELTFVQEIG SGQFGLVHLG YWLDKDKVAI KTIQEGAMSE EDFIEEAEIM MKLSHPKLVQ 420
LYGVCLEQAP ICLVFEFMEH GCLSDYLRSQ RGLFAADTLL GMCLDVCEGM AYLEEACVIH 480
RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540
VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASSHVYQI MNYCWKERPE 600
DRPAFSRLLG QLAEIAESGL 620
Nucleotide Sequence
(FASTA)
ATGAACAACT TTATCCTTCT GGAAGAACAG CTCATCAAGA AATCCCAACA AAAGAGAAGA 60
ACATCTCCAT CGAACTTCAA AGTTCGCTTC TTCGTTTTAA CCAAAGCCAG CCTAGCATAC 120
TTCGAAGATC GTCATGGGAA AAAGCGTACG TTGAAGGGCT GCATTGAACT CTCCCGGATC 180
AAATGTGTGG AGATTGTGAA AAGTGACATT ATCATCCCCT GCCACTACAA ATACCCATTT 240
CAGGTAGTGC ATGACAACCA CCTCCTGTAT GTGTTTGCTC CAGACCGAGA GAGCCGGCAG 300
CGCTGGGTGC TGGCCCTTAA AGAAGAAACG AGGAATAATA ACAGTTTGGT GCCCATGTAT 360
CATCCTAATT TTTGGATGGA TGGGAGATGG AGATGCTGCT CTCAGCTGGA GAAGCTTGCA 420
ACAGGCTGTG CCCAGTATGA TCCAACCAAA AATGCTTCAA AGAAGCCTCT TCCTCCCACT 480
CCTGAAGACA ACAGGCGATC ACTTCCAGAG CATGAAGAAA CCGTGGTCAT TGCCTTGTAT 540
GATTACCAAA CGAACGACCC TCAGGAACTC GCCCTGCGCT GCAATGAAGA ATACTGCCTG 600
CTGGACAGTT CTGAGATTCA CTGGTGGCGA GTTCAAGACA GGAATGGGCA TGAAGGATAC 660
GTACCAAGCA GTTATCTGGT GGAAAAATCT CCAAATAACC TGAAAACCTA TGAGTGGTAC 720
AATGAGAATA TCAGCCGGGA CAAAGCTGAA AAACTTCTTT TGGACACAGG TAAAGAAGGA 780
GCCTTCATGG TACGAGATTC CAGGACTCCA GGAACTTACA CCCTGTCTGT TTTCACCAAG 840
GCTATCATAA GCGAGAATAA TCCCTGTATA AAGCACTATC ACATCAAAGA AACAAATGAC 900
AATCCCAAGC GATTCTATGT GGCTGAAAAG TTTGTGTTTG ACTCCATCCC TCTTCTCATC 960
AATTACCACC AACACAACGG AGGAGGCCTG GTCACTCGAC TCCGGTATCC AGTTTGTTCC 1020
TGGAGGCAGA AAGCTCCCAT CAAGGCAGGG CTGAGATATG GAAAATGGGT GATTGATCCC 1080
TCAGAACTCA CTTTTGTGCA GGAGATTGGC AGCGGACAGT TTGGGTTGGT GCATCTTGGC 1140
TACTGGCTTG ACAAGGACAA GGTGGCCATC AAAACCATTC AGGAAGGTGC TATGTCAGAA 1200
GAGGACTTCA TAGAAGAGGC TGAAATCATG ATGAAACTCT CTCATCCCAA ACTGGTCCAG 1260
CTCTATGGGG TGTGTCTGGA GCAAGCCCCC ATCTGCCTGG TGTTTGAGTT CATGGAGCAC 1320
GGCTGCCTGT CGGACTACCT GCGCAGCCAG CGGGGACTCT TTGCTGCGGA TACCCTGCTG 1380
GGCATGTGTC TGGACGTGTG TGAGGGCATG GCCTACCTGG AAGAGGCGTG CGTCATCCAC 1440
AGGGACTTGG CTGCCCGAAA TTGTTTGGTG GGAGAAAACC AAGTCATCAA GGTGTCAGAC 1500
TTTGGCATGA CAAGGTTCGT TCTTGATGAC CAATATACCA GTTCCACAGG CACCAAATTC 1560
CCAGTGAAGT GGGCATCCCC AGAAGTTTTC TCTTTCAGTC GCTACAGCAG CAAGTCGGAT 1620
GTGTGGTCAT TTGGTGTGCT GATGTGGGAG GTCTTCAGTG AAGGCAAAAT CCCATATGAA 1680
AACCGGAGCA ACTCAGAGGT GGTGGAAGAC ATCAGTACTG GGTTTCGGTT ATACAAGCCC 1740
CGACTGGCCT CCTCACATGT CTACCAGATC ATGAATTACT GCTGGAAAGA GAGACCAGAA 1800
GACCGTCCAG CCTTCTCCAG ACTGCTGGGT CAACTGGCTG AAATCGCAGA ATCGGGACTT 1860
TAG 1863
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w  k++vaik+i+egamseedfieea++mmklshpklvqly
Q: 363   LTFVQEIGSGQFGLVHLGYWLDKDKVAIKTIQEGAMSEEDFIEEAEIMMKLSHPKLVQLY  422
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++ +++++ll mc dvcegm+yle++++ihrd
Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAADTLLGMCLDVCEGMAYLEEACVIHRD  482
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las++vy++m+ cwke+pe+r
Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASSHVYQIMNYCWKERPEDR  602
         ************************************************************
S: 241   ptfkellsale  251
         p+f++ll +l+
Q: 603   PAFSRLLGQLA  613
         *******9986
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LDKDKVAIKT IQEGAMSEED FIEEAEIMMK LSHPKLVQLY 60
GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG LFAADTLLGM CLDVCEGMAY LEEACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASSHVYQIMN YCWKERPEDR 240
PAFSRLLGQL A 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-CIS-00119
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013