EKS-OTG-00231

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00231

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	392.6	8.5E-118	66	331	266

Status

Unreviewed

Ensembl Protein

ENSOGAP00000014875

UniProt Accession

H0XFS0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K4

Gene Synonyms/Alias

MAP2K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000016618	ENSOGAP00000014875	ENSOGAT00000016623

Organism

Otolemur garnettii

Functional Description

Protein Length

363

Protein Sequence
(FASTA)

MQGKRKALKL NFANPPFKST ARFTLNPNPT GVQNPHIERL RTHSIESSGK LKISPEQHWD 60

FTAEDLKDLG EIGRGAYGSV NKMVHKPSGQ IMAVKRIRST VDEKEQKQLL MDLDVVMRSS 120

DCPYIVQFYG ALFREGDCWI CMELMSTSFD KFYKYVYSVL DDVIPEEILG KITLATVKAL 180

NHLKENLKII HRDIKPSNIL LDRSGNIKLC DFGISGQLVD SIAKTRDAGC RPYMAPERID 240

PSASRQGYDV RSDVWSLGIT LYELATGRFP YPKWNSVFDQ LTQVVKGDPP QLSNSEEREF 300

SPSFINFVNL CLTKDESKRP KYKELLKHPF ILMYEERTVE VACYVCKILD QMPATPSSPM 360

YVD 363

Nucleotide Sequence
(FASTA)

ATGCAGGGTA AACGCAAAGC ACTGAAGTTG AATTTTGCAA ATCCACCTTT CAAATCTACA 60

GCAAGGTTTA CTCTGAATCC CAATCCTACA GGAGTTCAAA ACCCACACAT AGAGAGACTG 120

AGAACACACA GCATTGAGTC ATCAGGAAAA CTGAAGATCT CCCCTGAACA ACACTGGGAT 180

TTCACTGCAG AGGACTTGAA AGACCTTGGA GAGATTGGAC GAGGAGCTTA TGGTTCTGTC 240

AACAAAATGG TCCACAAACC AAGTGGGCAA ATAATGGCAG TTAAAAGAAT TCGGTCTACA 300

GTGGATGAAA AAGAACAAAA GCAGCTTCTT ATGGATTTGG ATGTAGTGAT GCGGAGTAGT 360

GATTGCCCAT ACATTGTTCA GTTTTATGGT GCACTCTTCA GAGAGGGTGA CTGTTGGATC 420

TGTATGGAGC TCATGTCTAC CTCGTTTGAT AAGTTTTACA AATATGTATA TAGTGTATTA 480

GATGATGTTA TTCCAGAAGA AATTTTAGGC AAAATCACTT TAGCAACTGT GAAAGCACTA 540

AACCACTTAA AAGAAAACTT GAAAATTATT CACAGAGATA TCAAACCTTC CAACATTCTT 600

CTGGACAGAA GTGGAAATAT TAAACTCTGT GACTTCGGTA TTAGTGGACA GCTTGTGGAC 660

TCCATCGCCA AGACAAGAGA TGCTGGGTGT AGGCCGTATA TGGCTCCTGA AAGAATAGAC 720

CCAAGTGCAT CACGACAAGG ATATGATGTC CGCTCTGATG TCTGGAGTTT GGGGATCACA 780

TTGTATGAGT TGGCCACAGG CCGATTTCCT TATCCAAAGT GGAATAGTGT ATTTGATCAA 840

CTAACACAAG TCGTGAAAGG AGATCCTCCA CAGCTGAGTA ATTCTGAGGA GAGGGAGTTC 900

TCCCCAAGTT TCATCAACTT TGTCAATTTG TGCCTTACAA AGGATGAATC CAAAAGGCCA 960

AAGTATAAAG AACTTCTGAA ACATCCCTTT ATTTTGATGT ACGAGGAACG TACCGTTGAG 1020

GTCGCATGCT ATGTTTGTAA AATCCTGGAT CAAATGCCAG CTACTCCCAG CTCTCCCATG 1080

TATGTCGATT GA 1092

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 66    LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYI  125

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk

Q: 126   VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSVlDDVIPEEILGKITLATVKALNHLK  184

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL++++G++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 185   ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  244

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   efs++f

Q: 245   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSeerEFSPSF  304

         9***********************************************988788******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+kde++Rpk+kellkh+fi

Q: 305   INFVNLCLTKDESKRPKYKELLKHPFI  331

         **************************7

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSGQIMAVK RIRSTVDEKE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSVLDDVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSNS EEREFSPSFI 240

NFVNLCLTKD ESKRPKYKEL LKHPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013