EKS-OTG-00479

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00479

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	329.2	2.0E-98	22	312	291

Status

Unreviewed

Ensembl Protein

ENSOGAP00000014920

UniProt Accession

H0XFV4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000016663	ENSOGAP00000014920	ENSOGAT00000016671

Organism

Otolemur garnettii

Functional Description

Protein Length

588

Protein Sequence
(FASTA)

MAEKGDCIAN VYGYDLGGRF VDFQPLGFGV NGLVLSAVDS RACRKVAVKK ITLSDSRSMK 60

HALREIKIIR RLDHDNIVKV HEVLGPKGAD LQGELFKFSV AYIVQEYMET DLARLLEQGT 120

LTEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYCSPRLL LSPNNYTKAI DMWAAGCILA EMLTGKMLFA GAHELEQMQL 240

ILETIPVVRE EDKDELLRVM PSFVSSTWEV KRPLRKLLPD VDSEAIDFLE KILTFNPMDR 300

LTAEMGLQHP YMSPYACPED EPTSQHPFRI EDEIDDIVLM AANQSQLSNW DRTCAPCRYP 360

VSLSSDLEWR PDRCQDASEV QLDPRAGSAP LSEDVQVDPR KDSQSSSGRF LEQSHSSMER 420

AFEADYGRSC DYKVGSPSYL DKLLWRDNKP HHYSEPKLIL DLSHWKQAAG APPTAAVAAD 480

AVAREDEPAS LFLEIAQWVK STQGGPELAS PPRDGSEHLS ASPPGCPAPV DGGASPQFDL 540

DVFISRALKL CTKPEDLPDN KRGDLNGACI SEHPGDLVQT EAFSKERW 588

Nucleotide Sequence
(FASTA)

ATGGCCGAGA AGGGCGACTG CATCGCCAAT GTTTATGGGT ATGACCTCGG TGGGCGCTTT 60

GTTGACTTCC AGCCCCTGGG CTTTGGTGTC AATGGGCTGG TGCTGTCAGC TGTGGACAGC 120

CGGGCTTGCC GGAAGGTAGC CGTGAAGAAG ATCACCCTGA GTGACTCCCG CAGCATGAAG 180

CACGCGCTCC GGGAGATCAA GATCATCCGG CGCCTGGACC ACGACAACAT CGTCAAGGTG 240

CACGAGGTGC TGGGTCCCAA GGGCGCCGAC CTGCAGGGCG AGCTGTTCAA GTTCAGCGTG 300

GCTTACATCG TCCAGGAGTA CATGGAGACC GACCTGGCAC GCCTGCTGGA GCAGGGCACA 360

CTGACAGAGG AGCACGCCAA GCTCTTCATG TACCAGCTGC TCCGCGGCCT CAAATACATC 420

CACTCTGCCA ACGTGCTGCA CAGGGACCTG AAGCCCGCCA ACATCTTCAT CAGCACAGAG 480

GACCTCGTGC TCAAAATCGG CGATTTTGGG TTGGCAAGGA TCGTTGATCA GCATTATTCA 540

CACAAGGGTT ATCTGTCAGA AGGGTTGGTG ACAAAGTGGT ACTGCTCCCC ACGATTGCTT 600

CTGTCGCCCA ACAACTACAC CAAAGCCATC GACATGTGGG CCGCTGGCTG CATCCTGGCT 660

GAGATGCTCA CAGGGAAAAT GCTCTTTGCT GGGGCTCACG AGCTGGAGCA GATGCAGCTC 720

ATCCTGGAGA CCATCCCCGT GGTCCGGGAG GAAGACAAGG ACGAGCTGCT CAGAGTGATG 780

CCCTCCTTCG TCAGCAGCAC CTGGGAGGTG AAGCGGCCGC TGCGCAAGCT GCTCCCCGAT 840

GTGGACAGTG AAGCCATCGA CTTTCTGGAG AAGATCCTGA CCTTTAACCC CATGGATCGC 900

CTGACAGCTG AGATGGGGCT GCAGCACCCC TACATGAGCC CATACGCGTG CCCCGAGGAC 960

GAGCCCACCT CGCAGCACCC CTTCCGCATC GAGGACGAGA TTGACGACAT TGTGCTGATG 1020

GCCGCCAACC AGAGCCAGCT TTCCAACTGG GACAGAACTT GTGCACCTTG CAGGTACCCG 1080

GTGAGCCTGT CATCGGACCT GGAGTGGCGG CCCGACCGGT GCCAGGACGC GAGCGAGGTG 1140

CAGCTCGACC CACGCGCGGG CTCTGCGCCG CTGTCCGAGG ACGTGCAAGT GGATCCGCGC 1200

AAGGACTCGC AGAGCAGCTC CGGCCGCTTC CTGGAGCAGT CGCACTCGTC CATGGAGCGC 1260

GCCTTCGAGG CCGACTACGG GCGCTCCTGC GACTACAAGG TGGGCTCGCC GTCCTACCTG 1320

GACAAGCTGC TGTGGCGCGA CAACAAGCCG CATCACTACT CCGAGCCCAA GCTCATCCTG 1380

GACCTGTCGC ACTGGAAGCA GGCGGCCGGC GCCCCCCCCA CGGCCGCGGT GGCGGCGGAC 1440

GCGGTGGCCC GCGAGGACGA GCCAGCCAGC CTCTTCCTGG AGATCGCTCA GTGGGTCAAG 1500

AGCACGCAAG GCGGCCCCGA GCTCGCCAGC CCGCCGCGCG ACGGGTCCGA GCACCTGTCT 1560

GCCTCTCCCC CCGGCTGCCC GGCACCAGTC GACGGGGGCG CTAGCCCCCA GTTCGACCTG 1620

GATGTGTTCA TCTCCCGCGC CCTAAAGCTC TGCACCAAGC CAGAGGACCT GCCAGACAAT 1680

AAACGCGGCG ACCTCAATGG CGCGTGCATC TCTGAGCACC CTGGCGACCT CGTGCAGACA 1740

GAGGCCTTTT CCAAAGAAAG GTGGTGA 1767

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + +plg G +g+v+savd+r+ ++va+kk++  ++++ s+k++lRE+k++++l+h+Ni+k

Q: 22    DFQPLGFGVNGLVLSAVDSRACRKVAVKKIT--LSDSRSMKHALREIKIIRRLDHDNIVK  79

         6799**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         + +v+ p+      el +++  Y+v+e+metdL++++++ +l++eh+kl++yq+lrglky

Q: 80    VHEVLGPKGadlqgELFKFSVAYIVQEYMETDLARLLEQGTLTEEHAKLFMYQLLRGLKY  139

         *******9988888999*******************************************

S: 118   lHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wY +P++

Q: 140   IHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYCSPRL  199

         ******************8765169**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltgk+lf+g++e++q+++ile+++ ++ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGKMLFAGAHELEQMQLILETIPVVREEDKDELLRV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + ++++s+++ k+ ++++l+p+ ++ea+d+lek+L+++p++R+++e+ L+hpY+

Q: 260   -MPSFVSSTWEVKR-PLRKLLPDVDSEAIDFLEKILTFNPMDRLTAEMGLQHPYM  312

         .9*******99988.9**************************************7

Domain Sequence
(FASTA)

DFQPLGFGVN GLVLSAVDSR ACRKVAVKKI TLSDSRSMKH ALREIKIIRR LDHDNIVKVH 60

EVLGPKGADL QGELFKFSVA YIVQEYMETD LARLLEQGTL TEEHAKLFMY QLLRGLKYIH 120

SANVLHRDLK PANIFISTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYCSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGKMLFAG AHELEQMQLI LETIPVVREE DKDELLRVMP 240

SFVSSTWEVK RPLRKLLPDV DSEAIDFLEK ILTFNPMDRL TAEMGLQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013