EKS-OTG-00406
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00406
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR582.72.7E-175610943334
StatusUnreviewed
Ensembl ProteinENSOGAP00000014945
UniProt AccessionH0XFX5;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000016694ENSOGAP00000014945ENSOGAT00000016703
OrganismOtolemur garnettii
Functional Description
Protein Length993
Protein Sequence
(FASTA)
KLLKKKKKKK KYFTVLFSAM TFGAITNQDQ PVLKCILIYH QNNDSSVGKS SSYPTVSESP 60
EDLGCALRSK SSGTAYEAAT VEVDVFASIT LQVLVNTPGN ISCLWVFKHS SLNCQPHFDL 120
QNRGVVSMVI LKMTETQAGE YLLFIQSEAT NYTILFTVSI RNTLLYTLRR PYFRKMENQD 180
ALVCISESVP EPVVEWVFCD SQGESCKEES PAVVKKEEKV LRELFGTDIR CCARNELGRE 240
CTKLFTIDLN QTPQTKLPQL FLKVGEPLWI RCKAVHVNHG FGLTWELENK ALDEGSSFEM 300
STYSTNRTMI RILFAFVSSV GRNDTGYYTC SSSKHPSQSA LVTIVEKGFI NATYSSDDYE 360
IDQYEEFCFS VRFKAYPQIR CTWTFSQKSF PCEQRGLDDG YSISKFCNHK HQPGEYIFHA 420
ENDDAKFTKM FTLNIRRKPQ VLVEEASASK ASCSSDGYPL PSWTWRKCSD KSLNCHCCLA 480
GPGQRKANRK VYGQWVSSST LNMSEAVRGF LVKCCAYNSV GTSCETILLN SPGSFPFIQD 540
NVSFYATIGL SLLFIVVLTV LICHKYKKQF RYESQLQMVQ VTGSLDNEYF YVDFREYEYD 600
LKWEFPRENL EFGKVLGSGA FGKVMNATAY GISKTGVSIQ VAVKMLKEKA DSSEREALMS 660
ELKMMTHLGN HENIVNLLGA CTLSGPIYLI FEYCCYGDLL NYLRSKREKF HRTWTEIFKE 720
HNFSFYPTFQ SQPNSSMPGS REVQIHQDSD QVSGLHGNSF HSEDEIEYEN QKRLEEEEDL 780
NVLTFEDLLC FAYQVAKGME FLEFNSCVHR DLAARNVLVT HGKVVKICDF GLARDIMSDS 840
NYVVRGNARL PVKWMAPESL FEGIYTIKSD VWSYGILLWE IFSLGVNPYP GIPVDANFYK 900
LIQSGFKMDQ PFYATEEIYF IMQSCWAFDS RKRPSFPNLA SFLECQLADA EAAMYQNMDG 960
RITERSSTYQ NRRPYSREMD SRPPSPPNQV EDS 993
Nucleotide Sequence
(FASTA)
AAATTGCTAA AAAAAAAAAA AAAAAAAAAA AAATATTTTA CAGTTCTTTT TTCAGCAATG 60
ACATTTGGGG CTATCACAAA TCAAGATCAG CCTGTGCTCA AGTGCATTTT AATCTATCAT 120
CAGAACAATG ATTCATCAGT GGGGAAGTCA TCATCATATC CCACGGTGTC AGAATCACCA 180
GAAGACCTTG GGTGCGCTTT GAGATCCAAG AGCTCCGGGA CAGCATACGA AGCTGCCACG 240
GTGGAAGTGG ACGTGTTTGC GTCCATCACA CTGCAAGTCC TGGTCAACAC GCCGGGGAAC 300
ATATCGTGTC TCTGGGTGTT TAAGCACAGC TCCCTGAACT GCCAGCCACA CTTTGATTTA 360
CAGAACAGAG GAGTTGTTTC CATGGTCATT TTGAAAATGA CAGAAACCCA AGCTGGAGAA 420
TACCTACTTT TTATTCAGAG CGAAGCTACC AATTACACAA TCTTGTTTAC AGTGAGTATA 480
AGAAATACAC TGCTTTACAC ATTAAGAAGA CCTTACTTTA GAAAAATGGA AAATCAGGAC 540
GCCCTGGTCT GCATATCTGA GAGTGTCCCA GAGCCGGTGG TGGAATGGGT GTTTTGTGAT 600
TCGCAGGGTG AAAGCTGTAA AGAAGAAAGT CCAGCTGTTG TGAAAAAGGA GGAAAAGGTA 660
CTTCGTGAAT TATTTGGAAC AGACATAAGG TGCTGTGCAA GAAATGAACT GGGCAGGGAA 720
TGTACCAAGC TGTTCACCAT AGATCTAAAT CAAACCCCTC AGACTAAACT GCCACAATTA 780
TTTCTTAAAG TGGGGGAACC TTTGTGGATA AGATGTAAAG CCGTCCATGT GAACCATGGA 840
TTCGGGCTCA CGTGGGAGTT AGAAAACAAA GCCCTCGATG AGGGCAGCTC CTTTGAGATG 900
AGTACCTATT CAACAAACAG AACTATGATA CGGATTCTGT TTGCTTTTGT ATCATCAGTG 960
GGAAGAAACG ACACTGGGTA TTATACTTGT TCCTCTTCCA AGCATCCCAG TCAGTCAGCT 1020
CTGGTTACCA TCGTAGAAAA GGGATTTATA AATGCTACCT ATTCAAGTGA CGATTATGAA 1080
ATTGACCAAT ATGAAGAGTT TTGCTTTTCT GTCAGGTTCA AAGCGTATCC ACAAATCAGA 1140
TGCACGTGGA CTTTCTCTCA AAAATCGTTT CCTTGTGAAC AAAGGGGTCT TGATGATGGA 1200
TACAGCATAT CCAAGTTTTG CAACCATAAG CACCAGCCAG GAGAATATAT ATTCCATGCA 1260
GAAAATGATG ATGCCAAATT CACCAAAATG TTCACACTGA ACATAAGAAG GAAACCTCAA 1320
GTGCTAGTAG AAGAAGCATC AGCAAGCAAG GCATCTTGCT CCTCGGATGG ATACCCGTTA 1380
CCATCTTGGA CCTGGAGGAA GTGTTCTGAC AAGTCTCTCA ATTGTCATTG TTGTTTGGCA 1440
GGCCCAGGCC AGAGAAAAGC TAACAGAAAA GTATATGGAC AGTGGGTATC CAGCAGTACT 1500
CTAAACATGA GTGAGGCTGT GAGAGGCTTC CTCGTCAAGT GCTGTGCCTA CAATTCCGTT 1560
GGCACGTCCT GTGAAACCAT CCTTTTAAAC TCCCCAGGTT CCTTCCCTTT CATCCAAGAC 1620
AACGTCTCAT TCTATGCAAC AATTGGGCTT AGTCTTCTCT TCATTGTCGT TTTAACCGTG 1680
CTCATATGTC ACAAGTACAA AAAGCAATTT AGGTATGAGA GCCAGCTGCA GATGGTGCAG 1740
GTGACTGGCT CCTTGGATAA TGAGTACTTC TACGTCGACT TCAGAGAATA CGAATATGAT 1800
CTCAAATGGG AATTTCCACG AGAAAATTTA GAGTTCGGGA AGGTGCTAGG ATCGGGCGCT 1860
TTTGGAAAGG TGATGAATGC GACCGCTTAT GGAATCAGTA AAACAGGAGT CTCAATCCAG 1920
GTTGCAGTCA AAATGCTGAA AGAAAAAGCA GACAGTTCTG AAAGAGAGGC CCTCATGTCA 1980
GAACTCAAAA TGATGACTCA TCTGGGAAAC CACGAGAACA TCGTGAATCT GCTGGGGGCT 2040
TGCACACTGT CAGGACCAAT TTACTTGATC TTTGAATATT GTTGCTATGG TGATCTTCTC 2100
AACTATCTAA GAAGTAAAAG AGAGAAATTT CACAGGACAT GGACAGAGAT TTTCAAGGAA 2160
CACAATTTCA GTTTTTACCC AACTTTCCAA TCACAACCAA ATTCCAGTAT GCCTGGTTCA 2220
AGAGAAGTTC AAATACATCA GGATTCGGAT CAGGTCTCAG GGCTCCATGG GAATTCATTT 2280
CATTCTGAAG ATGAAATTGA ATATGAAAAC CAAAAAAGGC TGGAGGAGGA AGAGGACTTG 2340
AATGTACTTA CATTTGAAGA TCTTCTTTGC TTTGCATATC AAGTTGCCAA AGGAATGGAA 2400
TTTCTGGAAT TTAACTCATG TGTTCACAGG GACCTGGCAG CCAGGAATGT GCTCGTCACC 2460
CACGGGAAGG TGGTGAAGAT ATGTGATTTT GGATTGGCTC GAGATATCAT GAGTGACTCC 2520
AACTACGTCG TGAGGGGCAA TGCACGTCTG CCTGTGAAGT GGATGGCTCC GGAAAGCTTG 2580
TTTGAAGGGA TCTACACAAT TAAGAGTGAT GTCTGGTCCT ACGGAATATT ACTCTGGGAA 2640
ATCTTCTCAC TTGGTGTGAA TCCTTACCCT GGCATTCCAG TTGATGCTAA CTTCTATAAA 2700
CTCATTCAGA GTGGGTTTAA AATGGATCAG CCGTTTTATG CTACAGAAGA AATATACTTT 2760
ATAATGCAAT CCTGCTGGGC TTTTGACTCT AGGAAACGGC CATCTTTCCC TAACCTGGCT 2820
TCATTTTTAG AATGTCAGCT GGCAGATGCA GAAGCGGCGA TGTATCAGAA CATGGATGGC 2880
CGTATCACAG AACGTTCTTC CACCTACCAA AACAGGAGAC CTTATAGCAG AGAGATGGAC 2940
TCAAGGCCAC CGTCTCCACC CAATCAGGTC GAAGATTCAT AG 2982
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk+++hlG
Q: 610   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTHLG  669
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 670   NHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  728
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s+e v++++d+++vs  + ++++se++ +++++++   +eeed
Q: 729   ------FQSQPNSSMPGSRE-VQIHQDSDQVSGLHGNSFHSEDEIEYENQKRL--EEEED  779
         ......9*************.**************************999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++ +cvhrdlaarnvl+t+GkvvkicdfGlardim+d
Q: 780   LNVLTFEDLLCFAYQVAKGMEFLEFNSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD  839
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvv+Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 840   SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  899
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 900   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLASFL  943
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTHLG 60
NHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSQPNSSMPG SREVQIHQDS DQVSGLHGNS FHSEDEIEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFNSCVH RDLAARNVLV THGKVVKICD FGLARDIMSD SNYVVRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFPNL ASFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013