EKS-OTG-00471

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00471

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.3	5.8E-125	26	321	296

Status

Unreviewed

Ensembl Protein

ENSOGAP00000015111

UniProt Accession

H0XGB5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK9

Gene Synonyms/Alias

MAPK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000016875	ENSOGAP00000015111	ENSOGAT00000016879

Organism

Otolemur garnettii

Functional Description

Protein Length

424

Protein Sequence
(FASTA)

MSDSECDGQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI NVAVKKLSRP 60

FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIH 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ 240

LGTPSAEFMK KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESERDKIK TSQARDLLSK 300

MLVIDPDKRI SVDEALRHPY ITVWYDPTEA EAPPPQIYDA QLEEREHAIE EWKELIYKEV 360

MDWEERSKNG VVKDQTSDAA VSSNATPSQS SSINDISSMS TEQTLASDTD SSLDASTGPL 420

EGCR 424

Nucleotide Sequence
(FASTA)

ATGAGTGACA GTGAATGTGA CGGTCAGTTT TACAGCGTAC AAGTGGCAGA CTCAACCTTC 60

ACTGTCCTAA AACGCTACCA GCAGCTGAAA CCAATTGGCT CTGGGGCCCA AGGGATTGTT 120

TGTGCTGCAT TTGATACAGT TCTTGGGATA AATGTTGCAG TCAAGAAACT AAGCCGTCCT 180

TTTCAGAATC AAACTCATGC AAAGAGAGCT TATCGTGAAC TTGTCCTCTT AAAATGTGTC 240

AATCACAAAA ATATAATAAG TTTGTTAAAT GTGTTTACAC CACAAAAAAC TCTAGAAGAA 300

TTTCAAGATG TGTATTTGGT TATGGAATTA ATGGATGCCA ACTTGTGTCA GGTTATTCAT 360

ATGGAGTTGG ACCATGAAAG AATGTCCTAC CTTTTGTACC AGATGCTTTG CGGTATTAAA 420

CATCTGCATT CAGCTGGTAT AATTCATAGA GATTTAAAGC CCAGCAACAT TGTAGTGAAA 480

TCGGACTGCA CCCTTAAGAT CCTTGACTTT GGCCTGGCCC GGACAGCATG CACCAACTTC 540

ATGATGACCC CCTATGTGGT AACACGGTAC TATCGGGCAC CAGAAGTCAT CCTGGGGATG 600

GGCTACAAAG AGAACGTTGA TATCTGGTCA GTGGGTTGCA TCATGGGAGA GCTGGTGAAA 660

GGTTGTGTGA TATTCCAAGG CACTGACCAT ATTGATCAGT GGAATAAAGT TATTGAGCAG 720

CTAGGAACAC CATCAGCAGA GTTTATGAAG AAACTTCAAC CAACTGTAAG AAATTATGTA 780

GAAAACAGAC CAAAGTATCC TGGAATCAAA TTTGAAGAAC TCTTTCCGGA TTGGATATTC 840

CCATCAGAAT CTGAACGAGA CAAAATAAAA ACAAGTCAAG CCAGAGATCT GTTATCAAAA 900

ATGTTAGTGA TTGATCCTGA CAAGCGGATC TCTGTAGACG AGGCCTTGCG TCACCCCTAT 960

ATTACTGTTT GGTACGACCC CACTGAAGCA GAAGCACCAC CACCTCAAAT TTATGATGCC 1020

CAGTTGGAAG AAAGAGAACA TGCAATTGAA GAATGGAAAG AGCTAATTTA CAAAGAAGTA 1080

ATGGATTGGG AAGAAAGAAG CAAGAATGGC GTTGTAAAAG ATCAGACTTC AGATGCAGCA 1140

GTAAGTAGCA ACGCCACTCC TTCTCAGTCG TCATCTATCA ATGACATTTC ATCCATGTCC 1200

ACTGAGCAGA CACTGGCCTC AGACACAGAC AGCAGTCTCG ATGCGTCGAC GGGACCCCTT 1260

GAAGGTTGTC GATGA 1275

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  + +va+kklsrpfq++t+akr++REl llk+++h+Ni

Q: 26    YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFM--MTPYVVTRYYRAPEVILG-MG  201

         ********************************99976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++El++g ++f+g+d+idq++k++e+lgtps+ef+kk++  ++rny+

Q: 202   YKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +feelfp+            ++++a+dLl+k+Lv+dpdkRisv+eaL+hpY

Q: 261   ENRPKYPGIKFEELFPDwifpseserdkiKTSQARDLLSKMLVIDPDKRISVDEALRHPY  320

         *****************************9******************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQQLKPIGSG AQGIVCAAFD TVLGINVAVK KLSRPFQNQT HAKRAYRELV LLKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIHMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART ACTNFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GELVKGCVIF QGTDHIDQWN KVIEQLGTPS AEFMKKLQPT VRNYVENRPK 240

YPGIKFEELF PDWIFPSESE RDKIKTSQAR DLLSKMLVID PDKRISVDEA LRHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013