EKS-OTG-00098

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00098

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	408.6	2.0E-122	2691	3009	319

Status

Unreviewed

Ensembl Protein

ENSOGAP00000015450

UniProt Accession

H0XH60;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM

Gene Synonyms/Alias

ATM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000017247	ENSOGAP00000015450	ENSOGAT00000017252

Organism

Otolemur garnettii

Functional Description

Protein Length

3051

Protein Sequence
(FASTA)

MSLALNDLLI CCRHLEHDKA TERKKEIEKF KQLIRDTETV KHLDRHSDSK QGKYLNWDAV 60

FRFLQKYIQK ETECLRTGRP NVSASTQASR QKKMQEISSL VKYFIKCANK RAPRLKCQEL 120

LNYIMDIVKD SSNGAIYGAD YSNILLKDIL SVRKYWCEIS QQQWLELFSV YFRLYLKPSQ 180

DVYRVLVARI IHTVTKGCCS QTDALNSKFL EFFPKAIQYA RQEKSSAGLN HILAALIIFL 240

KTLAVNFRIQ VCELGDEILP NLLYIWSQHR LNDSLKEVII ELFQLQIYIH HPKGAKTQEI 300

GAYESIKWQS ILYNLYDLLV NEINHIGSRG KYSSGYRNIA VKENLIELMA DICHQVFKED 360

TRSLEISQSY TTTQRESGDY SVPCKRKKIE LGWEVIKDHL QKSQNDFDLV PWLQITAQLI 420

SKYPVSLPTC ELFPLLMILY QLLPQQRRGE RTPYVLRCLM EVALCQAKKS DLESSQKSDL 480

LKLWNKIWSI TFRGLSSEQI QAESFGLVGA IIQGGLVEVD KEFWKLFTGS ACRPSCPAVH 540

CLTLALTVSI VPEMVKMGIE QNICEINRSF SLKESIMKWL LLYQLEDGLE DSTELPPILH 600

SNFPHLVVEK ILVSLTMKNC KAAMNFFQSG PICEHHQKGK EEPSFSEVEE LFLQTTFDKV 660

DFLTYVEESS TEEHQSSIGF SVHQNLKESL DHYLLGLSEQ LLNYYSSEIT NSDMLVRCSR 720

LLVGVLGCYC YVGIIAEEEA YKSELFQKAK SLMQCTGEII TLFKNKTSEE STVDTLRNMM 780

HLCTSCLCNC TKRNPNKIAS GFFLRLLTSK LMNDMADICK NSASFIKKPF ARGEVESMEE 840

DTNRNLMEVE DQSSMNLFND NPASNVNDAN EPGESLSIIG AMNPLAEEYL SKQDLLFLDM 900

LKFLCVCVTT AQTNTVSFRA ADIRRKLLML IDISTLDPTK FLHLHMYLVL LKELPGEQHH 960

LPMEDVVELL KPLSNVCSLY RRDQDVCKTI LNHVLHIVTN LGQGSVGSEN TRDAQGQFLT 1020

VIGAFWHLTK EGKCTSSVRM ALVKCLKTLL EADPYSKWAI LNVKGKDFAV NEVFPQFLAD 1080

DHHQVRMLAA ESANRLFLDM KQGDSSMLLK ALPWKLQQAA FENAHLIALE GIKEVSHSAE 1140

NAQLLDEIYN RKSVLLMLIA VILYCSPICE KQALFALCKS VKENGLEPHL VKKVLEKISE 1200

TFGYRHLEDF MASHLDYLVL EWLNLQDTDE YSLSSFPFIL LNYTKVEDFY RSCYKVLIPH 1260

LVIRSHFDEV KSIANQIQED WKSLLIDCFP KILVNILPYF AYECSEDSGM AQQRETASKV 1320

YDMLKSENLL GKQIDHLFIS NLPEIVVELL MTLHEPANSG ASQSTDISDF LGDLDPAPNP 1380

PHFPSHVIKA TFAYISNCHK TKFKSILEIL SRSPDSYQKI LLAICEQAET NNVYKKHRIL 1440

KIYHLFVSLL LKDIKTGLGG AWAFVLRDVI YTLIHYINKR PSRLTDVALR SFSLCCDLLS 1500

RVCQTAVTNC KDALENHLHV IVGTLIPLVD DQEVQEQVLD LLKYLVIGNK DNENLYLTIK 1560

LLDPFPDHVV FKDLRITQQK IKYSRGPFSL LEEINHFLSV SVYDALPLTR LEGLKDLRRQ 1620

LEQHKDQMMD LMRASQGNPQ DGMVKLVVNL LQLSKMAINH TGEREVLEAV GSCLGEVGPI 1680

DFSTIAIQHS KDTSYTKALE LFEDKELQWT FIMLTYLNNT LVEDSVKVRS AAVACLKNIL 1740

ATKTGHRFWE IYKMTTDPML TYIQPFRTSR KKFLEVPRFD NENPLEYLDD TNLWIPQNEN 1800

HDTWIKTLTR AFLNSGGTKS EILQLLKPMC EVKADFCQTV LPYLIHDILL QDTDESWRNL 1860

LSTHVQGFFT SCFRHVSQMS RSTTPRNLDS ESEHVFRCCL DKKSQRTMLA VVDYMRRQKR 1920

PSLGTVFDDA FWLDLNYLEV AKVAQSCAAH FTALLYAEIY ADKKSMEDQE KRSLTFEDGS 1980

QSTTISSLSE KSKEETGISL QDLLLEIYRS IGEPDSLYGC GGGKMLQPLT RLRTYEHEAM 2040

WGKALVTYDV ETAISSSTRQ AGIIQALQNL GLCHILSIYL KGLDYENKEW CAELQELHYQ 2100

AAWRSMQWDH CLPLKEIEGT SYHKSLYSAL QSLRDREFST FYESLKYARV KEVEELCKGS 2160

LESVYSLYPT LSRLQAIGEL ENIGELFSRS VTGRQLSEVY IKWRKHSQLL KDSDFSFQEP 2220

IMALRTVILE ILIEKEMENS QKECFKDILT KHLVEFSTLA RTFKNTQLPE RAIFQIKQYN 2280

SASCGVSEWQ LEEAQVFWAK KEQSLALSIL KQMIRKLDVS CTEKKLCFKI LFISGMSPTT 2340

PSPVFSCKYN LNGCVFLKAV EVAGNCDGES NDELRNGKMK AFLSLARFSD TQYQRIENYM 2400

KSSEFENKQA LLKRAKEEVG LLREHKIQTS RYTVKVQREL ELDECALHAL REDRKRFLCK 2460

AVENYINCLL SGEEHDMWVF RLCSLWLENS GVSEVNGMMK ANGMKIPSYK FLPLMYQLAA 2520

RMGTKMMGGL GFHEVLNNLI SRISMDHAHH TLFIILALAN ANKDEFLTKP EAARRSRMTK 2580

SAPKQSSQLD EDRMEAANKI IRTIRSRRPQ MVRSVEALCD AYIILANLDA TQWKTQRKGI 2640

SIPTDQPITK LKNLEDVVVP TMEIKVDPTG EYKNLVTIHS FKAEFRLAGG LNLPKIIDCV 2700

GSDGKERRQL VKGRDDLRQD AVMQQVFQMC NTLLQRNTET RKRKLTICTY KVVPLSQRSG 2760

VLEWCTGTVP IGEFLVNNED GAHKRYRPQD FSAYQCQKIM MEVQKKSFEE KYETFMHICQ 2820

NFQPVFRYFC MEKFLDPAVW FERRLAYTRS VATSSIVGYI LGLGDRHVQN ILINEQSAEL 2880

VHIDLGVAFE QGKILPTPET VPFRLSRDIV DGMGITGVEG VFRRCCEKTM EVMRSSQETL 2940

LTIVEVLLYD PLFDWTMNPL KALYLQQRPE DETELHSTLN ADDQECKQNL SDIDQSLNKV 3000

AERVLMRLQE KLKGVEEGTV LSVGGQVNLL IQQAMDPKNL SRLFPGWKAW V 3051

Nucleotide Sequence
(FASTA)

ATGAGTCTGG CACTTAATGA TCTGCTTATT TGCTGCCGTC ATCTAGAACA TGATAAAGCT 60

ACAGAACGAA AGAAAGAAAT TGAGAAATTT AAGCAGCTGA TTCGAGATAC TGAAACAGTT 120

AAACATTTAG ATCGGCATTC AGATTCCAAA CAAGGGAAAT ATTTAAATTG GGATGCTGTT 180

TTTCGATTTT TACAGAAATA TATTCAGAAA GAAACAGAAT GTCTGAGAAC AGGAAGACCA 240

AATGTATCAG CTTCAACACA AGCCTCCAGG CAAAAGAAGA TGCAAGAAAT CAGTAGTTTG 300

GTCAAATACT TCATCAAATG TGCAAATAAA AGAGCACCTA GGCTAAAATG TCAAGAACTG 360

TTGAATTATA TTATGGATAT AGTGAAAGAT TCATCTAATG GTGCCATTTA TGGAGCTGAT 420

TATAGCAACA TTCTGCTCAA AGACATCCTT TCTGTGAGAA AATATTGGTG TGAAATATCT 480

CAACAACAGT GGCTAGAATT ATTCTCTGTG TACTTCAGGC TGTATCTCAA ACCTTCGCAA 540

GATGTTTATA GAGTTTTAGT GGCTAGAATA ATTCATACTG TGACCAAAGG ATGTTGTTCA 600

CAAACTGATG CATTAAATTC CAAATTTTTG GAGTTTTTCC CCAAGGCCAT TCAGTATGCA 660

AGACAAGAAA AGAGCTCTGC AGGTCTGAAT CATATCTTAG CAGCGCTTAT TATCTTCCTC 720

AAGACTTTGG CTGTCAACTT TCGAATTCAA GTGTGTGAAT TAGGAGATGA AATTCTTCCT 780

AACTTGCTTT ATATTTGGTC TCAACATAGA CTTAATGATT CCTTAAAAGA AGTAATAATT 840

GAATTATTTC AACTGCAAAT TTATATCCAT CATCCAAAAG GAGCCAAAAC CCAAGAAATA 900

GGTGCTTATG AATCAATAAA ATGGCAAAGT ATTTTATACA ACTTATACGA TCTGCTGGTA 960

AATGAGATAA ATCATATAGG AAGTAGAGGA AAATATTCTT CAGGATATCG TAATATTGCT 1020

GTCAAGGAAA ATTTGATTGA ATTGATGGCA GATATTTGTC ACCAGGTTTT TAAGGAAGAT 1080

ACCAGATCCT TGGAGATTTC TCAGTCTTAT ACTACTACAC AAAGAGAATC TGGTGATTAT 1140

AGTGTACCTT GCAAAAGGAA GAAAATAGAA CTAGGCTGGG AAGTAATAAA AGATCATCTT 1200

CAGAAGTCAC AGAATGATTT CGATCTGGTG CCTTGGCTAC AAATTACAGC TCAATTAATA 1260

TCAAAGTATC CTGTGAGTTT ACCTACCTGT GAGCTATTTC CACTACTGAT GATACTATAC 1320

CAGCTTTTGC CTCAACAGCG ACGTGGGGAG CGCACACCAT ATGTGTTACG ATGCCTTATG 1380

GAAGTTGCAT TGTGTCAAGC CAAGAAATCA GACCTAGAAA GCTCACAAAA GTCAGATTTA 1440

TTGAAACTCT GGAATAAAAT TTGGTCTATT ACCTTTCGTG GTTTAAGTTC TGAACAAATA 1500

CAAGCTGAAA GCTTTGGCTT AGTTGGAGCT ATAATTCAAG GTGGTTTAGT TGAGGTTGAC 1560

AAAGAATTCT GGAAATTATT TACTGGGTCA GCTTGCAGAC CTTCGTGTCC TGCAGTACAC 1620

TGTTTGACTT TGGCACTGAC AGTCAGTATA GTTCCAGAAA TGGTAAAAAT GGGAATAGAG 1680

CAAAACATAT GTGAAATAAA TAGAAGTTTT TCTTTAAAGG AATCAATCAT GAAATGGCTC 1740

TTACTCTATC AGTTAGAGGA TGGCTTAGAA GACAGTACAG AACTGCCTCC AATTCTTCAC 1800

AGTAATTTTC CTCATCTTGT AGTGGAGAAA ATTCTTGTGA GTCTCACTAT GAAAAACTGT 1860

AAAGCTGCAA TGAATTTTTT CCAAAGTGGG CCAATATGTG AACACCACCA AAAAGGTAAA 1920

GAAGAACCTT CCTTCTCAGA AGTAGAAGAA CTGTTTCTTC AGACAACTTT TGACAAGGTG 1980

GACTTTTTAA CCTATGTTGA AGAAAGTAGT ACTGAAGAGC ACCAATCTAG TATTGGCTTT 2040

TCTGTCCACC AGAATCTGAA GGAATCACTG GACCACTATC TTTTGGGATT ATCAGAACAG 2100

CTTCTGAATT ATTACTCATC TGAGATTACA AACTCAGATA TGCTTGTCCG GTGTTCGCGT 2160

CTTTTGGTGG GTGTTCTTGG CTGCTACTGT TATGTGGGTA TAATAGCTGA AGAAGAAGCA 2220

TATAAGTCAG AATTATTCCA GAAAGCCAAG TCTCTAATGC AGTGTACAGG AGAAATTATC 2280

ACTCTGTTTA AAAATAAGAC AAGTGAGGAA TCCACAGTTG ATACATTGAG AAATATGATG 2340

CATCTATGTA CAAGTTGCTT GTGTAACTGT ACCAAGAGGA ATCCAAATAA AATTGCTTCT 2400

GGCTTTTTCC TACGACTGCT AACATCAAAA CTGATGAATG ACATGGCAGA TATTTGTAAA 2460

AATTCAGCAT CCTTTATCAA AAAACCATTT GCCCGTGGAG AAGTAGAATC AATGGAAGAG 2520

GATACTAACA GAAATCTAAT GGAGGTGGAG GATCAGTCAT CCATGAATTT ATTCAATGAT 2580

AATCCTGCTA GTAATGTTAA TGATGCCAAT GAACCTGGAG AGAGCCTGAG TATTATAGGT 2640

GCCATGAATC CATTAGCTGA AGAATATCTG TCAAAGCAAG ATCTACTCTT TTTAGACATG 2700

CTAAAGTTCT TGTGTGTGTG TGTAACTACT GCTCAAACCA ATACTGTGTC ATTTCGGGCA 2760

GCTGATATTC GAAGGAAATT GTTAATGTTA ATTGATATTA GCACACTAGA CCCTACCAAA 2820

TTCCTCCATC TACATATGTA TCTAGTGCTT TTAAAGGAGC TTCCTGGAGA ACAGCATCAC 2880

TTGCCAATGG AAGACGTTGT TGAACTTCTG AAACCACTAT CCAATGTGTG CTCTTTGTAT 2940

CGACGTGACC AAGATGTTTG TAAAACAATT TTAAACCACG TCCTTCACAT AGTGACCAAC 3000

CTAGGTCAAG GCAGCGTGGG CTCTGAGAAC ACAAGAGATG CTCAAGGGCA GTTTCTTACA 3060

GTGATTGGAG CATTTTGGCA TCTAACAAAG GAGGGAAAAT GTACATCCTC TGTGAGAATG 3120

GCACTAGTAA AATGCCTTAA AACTTTGCTT GAGGCTGATC CTTATTCAAA ATGGGCAATT 3180

CTTAATGTAA AGGGAAAAGA CTTTGCTGTC AATGAAGTAT TTCCACAATT TCTTGCTGAT 3240

GATCATCACC AAGTTCGCAT GCTGGCTGCA GAGTCAGCTA ATAGATTATT CCTGGATATG 3300

AAACAAGGAG ATTCTTCCAT GTTATTGAAA GCACTTCCTT GGAAGCTTCA GCAAGCAGCT 3360

TTTGAAAATG CACACTTGAT AGCTTTGGAA GGAATAAAAG AAGTGTCCCA CAGTGCTGAG 3420

AATGCTCAAC TTTTGGATGA GATTTATAAT AGAAAATCTG TTTTACTGAT GTTGATAGCT 3480

GTGATTTTAT ACTGTAGCCC TATTTGTGAA AAACAGGCTT TGTTTGCCTT ATGCAAATCT 3540

GTGAAAGAGA ATGGATTAGA ACCCCACCTT GTGAAAAAGG TTTTAGAGAA AATTTCTGAA 3600

ACTTTTGGAT ATAGACATTT AGAAGACTTC ATGGCTTCTC ATTTAGATTA TCTGGTTTTG 3660

GAATGGCTAA ATCTTCAAGA TACTGATGAA TACAGCTTAT CTTCTTTTCC TTTTATTTTA 3720

TTAAACTACA CAAAAGTTGA AGATTTCTAC AGATCTTGTT ATAAAGTTTT AATTCCACAT 3780

TTGGTAATTA GAAGTCATTT TGATGAAGTG AAGTCTATTG CAAATCAGAT TCAAGAGGAC 3840

TGGAAAAGTC TTCTAATAGA CTGCTTTCCA AAGATTCTTG TAAATATTCT TCCTTATTTT 3900

GCCTATGAGT GTTCAGAAGA CAGTGGAATG GCACAGCAAA GAGAGACCGC TAGTAAGGTC 3960

TATGATATGC TCAAAAGTGA AAACTTACTG GGAAAACAGA TTGATCATTT ATTTATTAGT 4020

AATTTACCCG AGATTGTGGT GGAGTTATTG ATGACATTAC ATGAACCAGC AAATTCTGGT 4080

GCCAGCCAAA GCACTGACAT CTCTGACTTT TTGGGGGATT TGGATCCTGC TCCTAATCCA 4140

CCTCATTTTC CATCACATGT GATTAAAGCA ACATTTGCCT ATATCAGCAA TTGTCATAAA 4200

ACTAAGTTTA AAAGCATTCT AGAAATTCTT TCCAGAAGTC CTGATTCCTA TCAGAAAATT 4260

CTTCTAGCCA TATGTGAGCA AGCAGAGACA AATAATGTTT ATAAAAAGCA CAGAATTCTT 4320

AAAATATATC ATCTATTTGT TAGTTTATTA CTAAAAGATA TAAAAACTGG CTTAGGAGGA 4380

GCTTGGGCCT TTGTTCTTCG AGATGTTATT TACACTTTGA TTCACTATAT CAACAAAAGG 4440

CCTTCCCGTT TAACAGATGT GGCATTACGT AGCTTCTCTC TTTGTTGTGA CCTGTTAAGT 4500

CGTGTTTGTC AGACAGCAGT GACTAACTGC AAGGATGCTT TAGAAAATCA CCTTCATGTT 4560

ATTGTTGGTA CACTTATTCC CCTTGTGGAT GATCAGGAGG TTCAGGAACA GGTATTGGAC 4620

TTGTTGAAAT ACTTAGTGAT TGGCAACAAG GATAATGAAA ACCTCTATCT CACAATTAAA 4680

CTTTTAGATC CTTTTCCTGA CCATGTTGTT TTTAAGGATT TACGTATTAC TCAGCAAAAA 4740

ATCAAATATA GTAGAGGACC CTTTTCACTC TTGGAGGAAA TTAACCATTT TCTCTCAGTC 4800

AGTGTTTATG ATGCACTTCC ATTGACAAGA CTTGAAGGAC TGAAAGATCT TCGAAGACAG 4860

CTGGAGCAAC ATAAAGATCA GATGATGGAT CTTATGAGAG CGTCTCAGGG TAACCCACAA 4920

GATGGCATGG TGAAGCTAGT TGTCAATTTG TTGCAGTTAT CCAAGATGGC AATAAACCAC 4980

ACTGGGGAAA GAGAAGTTTT AGAGGCTGTT GGAAGCTGCT TGGGAGAAGT GGGTCCTATA 5040

GATTTTTCTA CCATAGCTAT ACAACATAGT AAAGATACGT CTTATACCAA GGCCCTTGAG 5100

TTATTTGAAG ATAAAGAACT TCAGTGGACC TTTATAATGC TTACCTATTT GAATAATACA 5160

CTGGTAGAAG ATAGTGTCAA AGTTCGATCA GCTGCTGTTG CCTGTTTGAA AAACATTTTA 5220

GCCACAAAGA CTGGACATCG TTTCTGGGAG ATATATAAGA TGACAACAGA CCCCATGCTG 5280

ACCTATATAC AGCCTTTTAG AACATCAAGA AAAAAGTTTT TAGAAGTACC TAGATTTGAT 5340

AATGAAAACC CATTAGAATA CCTGGATGAT ACAAATCTGT GGATTCCTCA AAATGAAAAT 5400

CACGACACTT GGATAAAGAC ACTGACTCGT GCTTTTTTGA ACAGTGGAGG CACAAAAAGT 5460

GAAATTCTTC AATTATTAAA GCCAATGTGT GAGGTGAAAG CTGACTTTTG TCAGACTGTG 5520

CTTCCATACT TGATACATGA TATTTTACTC CAAGACACAG ATGAATCCTG GAGAAATCTG 5580

CTTTCTACAC ATGTTCAGGG ATTTTTCACC AGCTGTTTTA GACATGTCTC ACAAATGAGC 5640

CGATCCACAA CGCCTAGAAA CTTGGATTCA GAGTCAGAGC ATGTTTTCCG ATGCTGCTTG 5700

GATAAAAAAT CACAAAGAAC AATGCTTGCT GTTGTGGACT ATATGAGAAG ACAAAAGAGA 5760

CCTTCTTTGG GAACAGTTTT TGATGATGCT TTCTGGCTGG ATTTGAATTA TCTAGAGGTT 5820

GCCAAGGTAG CTCAGTCTTG TGCTGCTCAC TTTACGGCGT TACTCTATGC AGAAATTTAT 5880

GCAGATAAGA AAAGCATGGA GGATCAAGAG AAAAGAAGTC TTACATTTGA AGATGGAAGC 5940

CAAAGTACAA CTATTTCTAG TTTGAGTGAA AAAAGTAAAG AGGAAACTGG AATAAGTTTA 6000

CAGGATCTTC TCTTAGAAAT TTACAGAAGT ATAGGAGAGC CAGATAGTCT GTATGGCTGT 6060

GGTGGAGGGA AAATGTTACA ACCCCTTACC AGACTACGAA CATATGAACA TGAAGCAATG 6120

TGGGGGAAGG CTCTAGTAAC ATATGATGTT GAGACAGCAA TCTCCTCATC AACGCGGCAG 6180

GCAGGAATAA TTCAGGCCTT ACAGAATTTG GGACTCTGCC ATATTCTTTC CATCTATTTA 6240

AAAGGATTAG ATTATGAAAA TAAAGAGTGG TGTGCTGAAC TACAGGAACT GCATTACCAA 6300

GCAGCTTGGA GGAGTATGCA GTGGGACCAT TGTTTACCTC TCAAAGAAAT AGAAGGAACC 6360

AGTTACCACA AATCATTGTA CAGTGCTCTA CAGTCTTTAA GAGACAGAGA ATTCTCCACA 6420

TTTTATGAAA GTCTCAAATA TGCCAGAGTA AAAGAAGTAG AAGAGCTGTG TAAGGGCAGC 6480

CTTGAGTCTG TGTATTCACT GTACCCCACA CTTAGCAGAC TGCAGGCCAT CGGAGAGCTG 6540

GAAAACATTG GGGAACTTTT CTCAAGGTCT GTCACAGGTA GACAACTCTC TGAAGTATAC 6600

ATTAAGTGGC GGAAACACTC CCAGCTTCTC AAGGACAGTG ATTTTAGTTT TCAGGAGCCT 6660

ATCATGGCTC TACGCACAGT TATTTTGGAG ATTTTGATTG AAAAGGAAAT GGAGAACTCC 6720

CAAAAAGAAT GTTTTAAGGA CATTCTCACC AAGCACCTTG TAGAGTTTTC TACATTGGCC 6780

CGAACTTTCA AGAACACACA GCTTCCTGAA AGGGCAATAT TTCAAATTAA ACAGTATAAT 6840

TCAGCTAGTT GTGGAGTTTC TGAGTGGCAG CTGGAAGAAG CACAAGTATT CTGGGCAAAA 6900

AAGGAGCAGA GTCTTGCCCT GAGTATTCTC AAACAGATGA TCAGGAAGTT GGATGTCAGC 6960

TGTACAGAGA AAAAACTATG CTTTAAAATA CTCTTTATTT CTGGCATGAG CCCTACCACT 7020

CCCAGCCCTG TGTTTAGTTG TAAATATAAT TTAAATGGTT GTGTTTTCTT GAAGGCAGTG 7080

GAAGTTGCTG GAAATTGTGA TGGAGAAAGC AATGATGAGC TAAGAAATGG AAAGATGAAG 7140

GCATTTCTCT CATTAGCCCG GTTCTCAGAT ACTCAGTACC AAAGAATTGA AAACTACATG 7200

AAATCATCAG AATTTGAAAA CAAGCAAGCT CTCCTGAAAA GGGCCAAAGA GGAAGTGGGC 7260

CTCCTCAGAG AACATAAAAT TCAGACCAGC AGATACACAG TAAAAGTTCA GCGAGAGCTG 7320

GAGCTGGATG AATGTGCACT CCATGCGCTG AGAGAGGATC GTAAACGCTT CTTATGTAAA 7380

GCAGTTGAAA ATTACATCAA TTGCTTATTA AGTGGAGAAG AACATGATAT GTGGGTATTT 7440

CGGCTTTGTT CCCTCTGGCT TGAAAATTCT GGAGTTTCTG AAGTCAATGG CATGATGAAG 7500

GCAAATGGAA TGAAGATTCC ATCATATAAA TTTTTGCCTC TTATGTACCA ATTGGCTGCT 7560

AGAATGGGGA CCAAAATGAT GGGAGGCCTA GGATTTCACG AAGTCCTCAA TAATCTCATC 7620

TCTAGAATTT CCATGGATCA CGCCCATCAT ACTTTGTTTA TTATATTGGC CTTAGCAAAT 7680

GCAAACAAAG ATGAATTTTT GACCAAACCA GAGGCAGCAA GAAGGAGTAG AATGACTAAA 7740

AGTGCACCTA AGCAGAGCTC TCAGCTTGAT GAGGACAGAA TGGAGGCTGC AAACAAAATA 7800

ATACGTACAA TCAGAAGTAG GAGACCTCAG ATGGTCAGAA GTGTTGAGGC CCTTTGTGAT 7860

GCTTATATTA TATTAGCAAA CTTAGATGCC ACTCAGTGGA AGACTCAGAG AAAAGGCATA 7920

AGTATTCCAA CAGACCAACC GATTACTAAA CTTAAGAACT TAGAAGATGT CGTCGTGCCT 7980

ACTATGGAAA TTAAGGTGGA TCCCACAGGA GAATATAAAA ATCTGGTGAC TATACATTCA 8040

TTTAAAGCAG AATTTCGTTT AGCAGGAGGT TTAAATTTAC CAAAAATAAT AGATTGTGTA 8100

GGCTCTGATG GCAAGGAAAG AAGACAGCTT GTTAAGGGCC GGGATGACCT GAGACAAGAC 8160

GCTGTCATGC AGCAGGTTTT CCAGATGTGT AATACGCTGC TGCAGAGAAA CACTGAAACT 8220

AGGAAGAGGA AACTGACCAT CTGCACATAC AAGGTGGTGC CCCTCTCTCA GAGAAGTGGT 8280

GTTCTTGAAT GGTGCACAGG AACTGTCCCT ATTGGTGAAT TTCTTGTGAA CAATGAAGAT 8340

GGTGCTCATA AAAGATACAG GCCACAAGAT TTTAGCGCCT ATCAATGTCA AAAGATAATG 8400

ATGGAGGTGC AAAAGAAGTC TTTTGAAGAG AAATATGAAA CCTTCATGCA TATTTGCCAA 8460

AATTTTCAAC CAGTTTTTCG TTACTTCTGC ATGGAAAAAT TCTTGGACCC AGCTGTTTGG 8520

TTTGAGAGGC GATTGGCTTA TACTCGCAGT GTGGCCACTT CTTCCATTGT TGGTTACATA 8580

CTTGGACTTG GTGACAGACA CGTGCAGAAT ATCCTGATAA ATGAGCAGTC AGCAGAACTA 8640

GTACATATAG ATCTAGGTGT TGCTTTTGAA CAGGGTAAAA TCCTTCCTAC TCCTGAGACA 8700

GTCCCTTTTA GACTTAGCAG AGACATTGTG GACGGCATGG GCATTACTGG TGTTGAAGGT 8760

GTCTTCAGAA GGTGCTGTGA GAAAACCATG GAAGTCATGA GAAGCTCTCA GGAAACTCTG 8820

TTAACTATTG TAGAGGTACT TCTGTATGAT CCACTCTTTG ACTGGACCAT GAATCCTTTG 8880

AAAGCTTTGT ATTTACAGCA GAGACCAGAA GATGAAACTG AGCTTCACTC CACTCTAAAT 8940

GCAGATGACC AAGAGTGCAA ACAAAATCTC AGTGATATTG ACCAGAGTCT CAACAAAGTA 9000

GCTGAACGAG TCTTGATGAG ACTGCAAGAG AAACTGAAAG GGGTAGAAGA AGGCACTGTG 9060

CTCAGTGTGG GTGGACAAGT GAATTTGCTC ATTCAGCAGG CCATGGACCC CAAAAATCTC 9120

AGCCGACTTT TCCCCGGATG GAAAGCTTGG GTGTGA 9156

Domain Profile

S: 14    kqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdketsrrkLkirty  73

         ++ pk +   Gsdgke+++Lvkg++Dlrqd++++q+f+++NtlL++++et++rkL+i+ty

Q: 2691  LNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTY  2750

         567999999***************************************************

S: 74    kVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdlstvqarkpklkhl  133

         kVvpls+rsg++ew+++tv+++e+l   v++++++++   +yr++d+s+ q++k +++++

Q: 2751  KVVPLSQRSGVLEWCTGTVPIGEFL---VNNEDGAHK---RYRPQDFSAYQCQKIMMEVQ  2804

         *************************...799*****9...********************

S: 134   kls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvislvgyiLg  189

         k+s    +e f+++++n++p  +++++++ekf++p++wfe+r aytrs+A++s+vgyiLg

Q: 2805  KKSfeekYETFMHICQNFQP--VFRYFCMEKFLDPAVWFERRLAYTRSVATSSIVGYILG  2862

         ********************..9*************************************

S: 190   LgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnalgvtgveGv  249

         Lgdrh++n+li+++++e+vhid+gvafe++k+ l++pe+vPFRL r+iv+++g+tgveGv

Q: 2863  LGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLSRDIVDGMGITGVEGV  2921

         ********************************.***************************

S: 250   frasceavlrvlreskeklltiLevflydplvdwkk......kkktsketeeelaekaka  303

         fr++ce++++v+r+s+e+llti+ev+lydpl+dw++      + ++++e+e+el+++ +a

Q: 2922  FRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMnplkalYLQQRPEDETELHSTLNA  2981

         ******************************************9*****************

S: 304   ealkikkllskvekaenavatrdlllle  331

         +++++k++ls+++++ n+va+r+l++l+

Q: 2982  DDQECKQNLSDIDQSLNKVAERVLMRLQ  3009

         ***********************99987

Domain Sequence
(FASTA)

LNLPKIIDCV GSDGKERRQL VKGRDDLRQD AVMQQVFQMC NTLLQRNTET RKRKLTICTY 60

KVVPLSQRSG VLEWCTGTVP IGEFLVNNED GAHKRYRPQD FSAYQCQKIM MEVQKKSFEE 120

KYETFMHICQ NFQPVFRYFC MEKFLDPAVW FERRLAYTRS VATSSIVGYI LGLGDRHVQN 180

ILINEQSAEL VHIDLGVAFE QGKILPTPET VPFRLSRDIV DGMGITGVEG VFRRCCEKTM 240

EVMRSSQETL LTIVEVLLYD PLFDWTMNPL KALYLQQRPE DETELHSTLN ADDQECKQNL 300

SDIDQSLNKV AERVLMRLQ 319

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0016572	; P:histone phosphorylation
GO:0090399	; P:replicative senescence
GO:0010212	; P:response to ionizing radiation
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR016024	; ARM-type_fold.
IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013