EKS-OTG-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	459.1	8.0E-138	209	522	314

Status

Unreviewed

Ensembl Protein

ENSOGAP00000021113

UniProt Accession

H0XYC0;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000025150	ENSOGAP00000021113	ENSOGAT00000029620

Organism

Otolemur garnettii

Functional Description

Protein Length

588

Protein Sequence
(FASTA)

MGGTARGPGR KDAGPPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVA CNSSEPPLPR 60

RVNITTEQLI RDHTQHFLNG GEIKVEQLFQ EFGSKRSDIL QSDVINDSEK CFPVACQGKS 120

LDNLYSVKSN SSSKAPKVVP LTPEQALKQY KHHLTAYEKL EIINYPEIYF VGPNAKKRHG 180

VVGGPNNGGY DDSDGSYIHV PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV 240

RNEKRFHRQA AEEIRILEHL KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK 300

KNKFQGFSVQ LVRKFAQSIL QSLDALHRNK IIHCDLKPEN ILLKHHGRSA TKVIDFGSSC 360

FEYQKLYTYI QSRFYRAPEI ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC 420

MIELLGMPPP KLLEQAKRAK YFINSRGLPR YCSLTTQADG RIVLMGGRSR RGKKRGPPGS 480

KDWETALKGC DDYLFIEFLK KCLHWDPSAR LTPAQALRHP WISKSVPRPL ATTDKVSGKR 540

AVNPTNAFQG LGSKLPPVVG IANKLKANLM SESSGSIPLC SVLPKLIS 588

Nucleotide Sequence
(FASTA)

ATGGGGGGCA CCGCTCGCGG GCCTGGGCGG AAGGATGCGG GGCCACCCGG GGCCGGGCTC 60

CCGCCCCAGC AGCGGAGATT GGGGGATGGT GTCTATGATA CCTTCATGAT GATAGATGAA 120

ACCAAATGCC CACCCTGTTC AAATGTAGCC TGCAATTCTT CTGAACCACC TCTACCCAGA 180

AGAGTAAATA TCACCACAGA GCAGTTAATA AGAGACCATA CTCAGCACTT TCTGAATGGA 240

GGTGAAATAA AGGTAGAACA GCTATTTCAA GAATTTGGCA GCAAAAGATC TGATATTCTT 300

CAGTCAGATG TTATCAACGA TTCTGAAAAA TGCTTTCCTG TTGCTTGTCA GGGTAAAAGT 360

TTAGATAACT TGTATTCAGT AAAATCCAAC AGTTCATCCA AAGCACCTAA AGTGGTCCCG 420

CTGACTCCAG AGCAAGCACT GAAGCAGTAT AAACACCACC TCACTGCTTA TGAGAAGCTG 480

GAGATTATCA ATTATCCAGA AATCTATTTT GTGGGTCCAA ATGCCAAAAA GAGACATGGA 540

GTTGTTGGTG GCCCCAATAA TGGGGGATAC GATGATTCAG ATGGGTCCTA CATTCACGTA 600

CCTCGAGACC ATCTAGCTTA CCGATATGAG GTGCTGAAAA TTATTGGCAA GGGGAGTTTT 660

GGGCAGGTGG CCCGGGTCTA TGATCACAAA CTTCGACAGT ACGTGGCCCT AAAAATGGTG 720

CGAAATGAGA AGCGCTTCCA TCGTCAAGCA GCTGAGGAGA TCCGGATTTT GGAGCACCTG 780

AAAAAACAGG ATAAAACCGG TAGCATGAAT GTCATCCACA TGTTGGAAAG TTTCACATTT 840

CGGAACCACG TCTGCATGGC CTTTGAATTG CTAAGCATAG ACCTTTATGA GCTAATCAAA 900

AAAAACAAGT TTCAAGGTTT TAGCGTACAA TTAGTACGCA AGTTTGCTCA ATCCATCTTG 960

CAATCCTTGG ATGCTCTCCA CAGAAATAAG ATTATTCACT GTGACCTGAA GCCAGAAAAC 1020

ATTCTCCTGA AACACCATGG GCGCAGTGCA ACCAAGGTCA TTGACTTTGG GTCCAGCTGT 1080

TTCGAGTACC AGAAGCTTTA TACGTATATC CAGTCTCGGT TCTACAGAGC TCCCGAGATC 1140

ATCTTAGGAA GCCGCTACAG CACCCCTATT GACATATGGA GTTTCGGCTG CATCCTTGCG 1200

GAACTTTTAA CGGGACAGCC TCTCTTTCCT GGAGAGGATG AAGGTGACCA GTTGGCCTGC 1260

ATGATAGAGC TGTTAGGGAT GCCACCACCC AAACTCCTGG AGCAAGCCAA ACGTGCCAAG 1320

TACTTTATCA ACTCCAGGGG CCTCCCTCGC TATTGCTCTT TGACCACCCA GGCAGACGGG 1380

AGGATTGTGC TTATGGGGGG TCGCTCACGA AGGGGTAAAA AGCGGGGTCC CCCAGGCAGC 1440

AAAGACTGGG AGACAGCACT GAAAGGGTGT GATGACTACT TGTTTATAGA GTTTTTGAAA 1500

AAGTGTCTTC ACTGGGACCC CTCTGCCCGT CTGACCCCAG CTCAAGCATT AAGACACCCT 1560

TGGATTAGCA AGTCAGTACC CAGACCGCTT GCCACCACAG ACAAAGTGTC AGGGAAGCGG 1620

GCAGTCAATC CCACAAATGC TTTCCAGGGA CTGGGTTCCA AGCTGCCTCC AGTTGTTGGA 1680

ATAGCCAATA AGCTTAAAGC TAACCTGATG TCAGAGAGCA GTGGCAGTAT ACCTCTGTGC 1740

AGTGTCTTGC CAAAACTGAT TAGCTAA 1767

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV++++d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 209   YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS  268

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c+ fells++Lyel+kknkf+g+s++lvrk+aq+il++L++L++

Q: 269   MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHR  328

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs+ kviDFGss+++ qk +ytyiqsrfYraPEiilg +y+

Q: 329   NKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQK-LYTYIQSRFYRAPEIILGSRYS  387

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iD+WS+Gc+laEl+tG+pLfpGe+e dqla+++e+lg+pp+klle+ak+ak+f+++++

Q: 388   TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLGMPPPKLLEQAKRAKYFINSRG  447

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

          p+y+  t+++d + +l+ ++++++kkr +p+sk++++alk ++d+lf+++lk++l++dp

Q: 448   LPRYCSLTTQADGRIVLMGGRSRRGKKRGPPGSKDWETALKGCDDYLFIEFLKKCLHWDP  507

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 508   SARLTPAQALRHPWI  522

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVARVYD HKLRQYVALK MVRNEKRFHR QAAEEIRILE HLKKQDKTGS 60

MNVIHMLESF TFRNHVCMAF ELLSIDLYEL IKKNKFQGFS VQLVRKFAQS ILQSLDALHR 120

NKIIHCDLKP ENILLKHHGR SATKVIDFGS SCFEYQKLYT YIQSRFYRAP EIILGSRYST 180

PIDIWSFGCI LAELLTGQPL FPGEDEGDQL ACMIELLGMP PPKLLEQAKR AKYFINSRGL 240

PRYCSLTTQA DGRIVLMGGR SRRGKKRGPP GSKDWETALK GCDDYLFIEF LKKCLHWDPS 300

ARLTPAQALR HPWI 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013