EKS-OTG-00154

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00154

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	553.8	5.2E-167	474	750	277

Status

Unreviewed

Ensembl Protein

ENSOGAP00000021689

UniProt Accession

H0XZZ6;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR3

Gene Synonyms/Alias

FGFR3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000025157	ENSOGAP00000021689	ENSOGAT00000029547

Organism

Otolemur garnettii

Functional Description

Protein Length

808

Protein Sequence
(FASTA)

MGTPACALVF CVAVAVVAGV ASEPPGTEQR VAGKAAEGPG LDSGQQEQLV FSSGDIVELS 60

CHPPGGGPVG PTVWDKDGMG LVPSERVLVG PRRLQVLNAS QEDAGAYSCR QRLTRRLLCN 120

FSVRVTDAPS SGDDEDGEDE AEDAGVCPLA GAPYWTRPER MDKKLLAVPA ANTVRFRCPA 180

AGNPTPSISW LKNGKEFRGE HRIGGIKLRH QQWSLVMESV VPSDRGNYTC VVENKFGSLR 240

QTYTLDVLER SPHRPILQAG LPANQTAVLG SDVEFHCKVY SDAQPHIQWL KHVEVNGSKV 300

GPDGTPYVTV LKTAGANTTD KELEVLSLRN VTFEDAGEYT CLAGNSIGFS HHSAWLAVLP 360

AEEELAEAGE ASSVYTGVLS YGAGFFLFIL VVAAVTLCRL RSPPKKGLGS PTVHKISRFP 420

LKRQVSLESN SSMSSNTPLV RIARLSSGEG PTLADVSELE LPADPKWELP RARLTLGKPL 480

GEGCFGQVVM AEAIGIDKDR AAKPVTVAVK MLKDNATDKD LSDLVSEMEM MKMIGTHKNI 540

INLLGACTQG GPLYVLVEYA AKGNLREYLR ARRPPGMDYS FDTCKLPEEQ LTFKDLVSCA 600

YQVARGMEYL ASQKCIHRDL AARNVLVTED NVMKIADFGL ARDVHNLDYY KKTTNGRLPV 660

KWMAPEALFD RVYTHQSDVW SFGVLLWEIF TLGGSPYPGV PVEELFKLLK EGHRMDKPAN 720

CTHDLYMIMR ECWHAAPSQR PTFKQLVEDL DRILTVTSTD EYLDLSVPFE QYSPGGQDTP 780

SSSSSGDDSV FAHELLPPAL PSSGGPRT 808

Nucleotide Sequence
(FASTA)

ATGGGCACCC CGGCCTGCGC CCTCGTGTTC TGCGTGGCCG TGGCCGTGGT GGCCGGTGTC 60

GCCTCAGAGC CCCCGGGCAC GGAGCAGCGC GTCGCTGGGA AAGCGGCAGA GGGCCCGGGG 120

CTGGATTCTG GCCAGCAGGA ACAGCTGGTG TTCAGCAGTG GGGACATCGT GGAGCTGAGC 180

TGCCACCCAC CTGGAGGTGG TCCTGTGGGG CCCACTGTCT GGGACAAGGA TGGCATGGGG 240

CTGGTGCCCT CAGAGCGTGT CCTGGTGGGG CCACGGCGGC TGCAGGTGCT GAACGCCTCC 300

CAGGAGGACG CTGGGGCGTA CAGCTGCCGG CAGCGGCTCA CCCGGCGCCT GCTCTGCAAC 360

TTCAGTGTGC GTGTGACAGA TGCTCCATCC TCAGGAGATG ATGAAGATGG TGAGGATGAA 420

GCTGAAGACG CAGGTGTGTG TCCTCTGGCA GGGGCCCCTT ACTGGACTAG GCCTGAGCGG 480

ATGGACAAAA AGCTGCTGGC TGTGCCGGCC GCCAACACTG TCCGCTTCCG CTGCCCAGCT 540

GCTGGCAACC CCACTCCTTC CATCTCCTGG CTGAAGAATG GCAAGGAGTT CCGTGGCGAG 600

CATCGCATCG GGGGCATCAA GCTTCGGCAC CAGCAGTGGA GCCTGGTCAT GGAGAGCGTG 660

GTACCCTCGG ACCGGGGCAA CTACACCTGT GTGGTGGAAA ACAAGTTCGG CAGCCTGCGG 720

CAGACATACA CGCTGGATGT GCTGGAGCGC TCTCCACACC GTCCCATCCT GCAGGCGGGG 780

CTGCCAGCCA ACCAGACAGC AGTGCTTGGC AGTGACGTGG AGTTCCACTG CAAGGTGTAT 840

AGTGATGCGC AGCCGCACAT CCAGTGGCTG AAGCACGTGG AGGTGAATGG CAGCAAGGTG 900

GGCCCCGACG GCACGCCCTA CGTCACTGTG CTTAAGACGG CGGGCGCTAA CACCACCGAC 960

AAAGAGCTAG AGGTTTTGTC CTTGCGCAAT GTTACCTTTG AGGACGCCGG GGAGTACACC 1020

TGCCTGGCGG GCAATTCTAT CGGGTTTTCC CATCACTCTG CGTGGCTGGC GGTGCTGCCA 1080

GCTGAGGAGG AGCTGGCAGA AGCCGGCGAG GCCAGCAGCG TGTACACGGG TGTCCTCAGC 1140

TACGGGGCGG GCTTCTTCCT GTTCATCTTG GTGGTGGCAG CCGTGACACT CTGCCGCCTG 1200

CGCAGCCCCC CAAAGAAGGG CCTGGGCTCA CCCACCGTGC ACAAGATCTC ACGTTTCCCA 1260

CTGAAGCGAC AGGTGTCCTT GGAGTCCAAC TCGTCCATGA GCTCCAACAC GCCGCTGGTC 1320

CGCATTGCCC GCCTGTCCTC AGGAGAGGGC CCCACACTAG CCGATGTCTC TGAGCTCGAG 1380

CTGCCAGCTG ACCCCAAGTG GGAGCTGCCC CGGGCCAGGC TCACGCTGGG CAAGCCTCTG 1440

GGGGAAGGAT GCTTCGGCCA GGTGGTCATG GCAGAGGCCA TCGGCATTGA CAAGGACCGA 1500

GCTGCCAAGC CTGTCACCGT GGCTGTGAAG ATGCTGAAAG ACAATGCCAC TGACAAGGAC 1560

CTGTCGGACT TGGTATCGGA GATGGAGATG ATGAAGATGA TCGGCACGCA CAAGAACATC 1620

ATCAACCTGC TGGGGGCCTG CACACAGGGT GGGCCCTTGT ACGTGTTGGT GGAGTATGCG 1680

GCCAAGGGCA ACCTGCGTGA GTACCTGCGG GCACGGCGGC CCCCGGGCAT GGACTACTCC 1740

TTTGACACTT GCAAGCTGCC GGAGGAGCAG CTCACCTTCA AGGACCTGGT GTCCTGTGCC 1800

TACCAGGTGG CCCGAGGCAT GGAGTACCTG GCCTCCCAGA AGTGCATTCA CAGGGACTTG 1860

GCCGCCCGCA ACGTGCTTGT GACTGAGGAC AACGTGATGA AGATCGCAGA CTTCGGCCTG 1920

GCTCGAGACG TGCACAACCT GGACTACTAT AAAAAGACCA CAAACGGCCG GCTGCCTGTG 1980

AAGTGGATGG CGCCTGAGGC CCTGTTTGAC CGTGTCTACA CCCACCAGAG TGATGTCTGG 2040

TCCTTTGGGG TCCTGCTCTG GGAGATCTTC ACGCTAGGAG GCTCACCCTA TCCTGGTGTC 2100

CCTGTTGAGG AGCTCTTCAA GCTGCTGAAA GAAGGCCACC GCATGGACAA GCCAGCCAAC 2160

TGCACACATG ACCTGTACAT GATCATGCGT GAGTGCTGGC ATGCTGCGCC CTCTCAGAGG 2220

CCCACCTTCA AGCAGTTGGT GGAGGACCTG GACCGCATAC TCACTGTGAC ATCCACCGAT 2280

GAATACCTGG ACCTGTCAGT GCCCTTTGAG CAGTACTCCC CGGGTGGCCA GGACACCCCC 2340

AGCTCCAGCT CCTCTGGGGA TGACTCTGTG TTTGCCCATG AGCTGCTGCC CCCGGCCCTG 2400

CCCAGCAGCG GGGGCCCGAG GACGTGA 2427

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aeaig+dkd+++k vtvavkmlk++atdkdl+dlvseme++k+

Q: 474   LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDNATDKDLSDLVSEMEMMKM  533

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iG hkniinllGactq+Gplyv+veyaakGnlre+lrarrp+g+++s d++k +eeqlt+

Q: 534   IGTHKNIINLLGACTQGGPLYVLVEYAAKGNLREYLRARRPPGMDYSFDTCKLPEEQLTF  593

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyykkt

Q: 594   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT  653

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 654   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  713

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl

Q: 714   RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL  750

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA IGIDKDRAAK PVTVAVKMLK DNATDKDLSD LVSEMEMMKM 60

IGTHKNIINL LGACTQGGPL YVLVEYAAKG NLREYLRARR PPGMDYSFDT CKLPEEQLTF 120

KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPANCTH DLYMIMRECW HAAPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013