EKS-OTG-00248

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00248

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	365.7	1.1E-109	49	300	252

Status

Unreviewed

Ensembl Protein

ENSOGAP00000016369

UniProt Accession

H0XJS9;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK3

Gene Synonyms/Alias

SIK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000026497	ENSOGAP00000016369	ENSOGAT00000026415

Organism

Otolemur garnettii

Functional Description

Protein Length

1353

Protein Sequence
(FASTA)

GGAGPAGRLL PPPAPGPPAA PAAVSPAAGP PRPPAPASRG PMPARIGYYE IDRTIGKGNF 60

AVVKRATHLV TKAKVAIKII DKTQLDEENL KKIFREVQIM KMLCHPHIIR LYQVMETERM 120

IYLVTEYASG GEIFDHLVAH GRMAEKEARR KFKQIVTAVY FCHCRNIVHR DLKAENLLLD 180

ANLNIKIADF GFSNLFTPGQ LLKTWCGSPP YAAPELFEGK EYDGPKVDIW SLGVVLYVLV 240

CGALPFDGST LQNLRARVLS GKFRIPFFMS TECEHLIRHM LVLDPNKRLS MEQICRHKWM 300

KLGDADPNFD RLIAECQQLK EDRETDSLNE DVLLAMEDMG LDKERTLQSL RSDAYDHYSA 360

IYSLLCDRHK RHKTLRLGAL PSMPRAMAFQ APVNIQVGNN SITQGVRVSY CSLTLVSSFL 420

TFLTSLHCHL SIRGEEPSPE ALVRYLSMRR HTVGVADPRT EVMEDLQKLL PGFPGVNPQA 480

PFLQVAPNMN FMHNLLPMQN LQPTGQLEYK EQSLLQPPTL QLLNGMGPLG RRASDGGANI 540

QLHAQQLLKR PRGPSPLVTM TPAVPAVTPV DEESSDGEPD QEAVQRYLAN RSKRHTLAMT 600

NPTAEIPPDL QRQLGQQPFR SRVWPPHLVP DQHRSTYKDS NTLHLPTERF SPVRRFSDGA 660

ASIQAFKAHL EKMGNNSSIK QLQQECEQLQ KMYGGQIDER TLEKTQQQHM LYQQEQHHQI 720

LQQQIQDSIC PPQPSPPLQT ACENQPTLLT HQLQRLRIQP SSPPPNHPNN HLFRQPSNSP 780

PPMTSAMIQS HGAASPSQFQ GLSSRSTIFH QQPENCSPPP SVALTCLGLQ QPTQSQQVTI 840

QVQEPVDMLS NMPSAGSTGR GLSISPSASP IQMQHRTNLM ATFSYGHRPL SKQLSADSAE 900

AHSLNVNRFS PANYDQAHLH PHLFLDQSRG SPSSYSPSTG VGFPPTQALK VPPLDQFPTF 960

PPSAHQQPSH YTTSALQQAL LSPTPPDYTR HQQVPHILQG LLSPRHSLTG HSDIRLPPAE 1020

FAQLIKRQQQ QRQQQQQQQQ QQQHDYQELF RHMNQGDAGS LAPSLGGQSM TEHQALSYQN 1080

ADSYHHHHTS PQHLLQIRAQ ECISQVSSPT PTHGYVHQPT LMHSESMEED CSREGAQDGF 1140

PDSKSSSTLT KVCRDSPLLL STGGPGDPES LLGTVSHAQE LGIHPYGHQP AAAFSRNKVP 1200

SRESVIGNCM DRSSPGQAME LPGHNGFGYP ARPSVHEHHR PRTLQRHHTI QNSDDAYVQL 1260

DNLPGMSLVA GKALSSARMS DAVLSQSSLM GSQQFQDGED EECGASLGGH EHPDLSDGSQ 1320

HLNSSCYPST CITDILLSYK HPEVSFSMEQ AGV 1353

Nucleotide Sequence
(FASTA)

GGGGGAGCCG GGCCGGCGGG CCGCCTGCTG CCTCCTCCCG CCCCCGGGCC CCCGGCTGCC 60

CCCGCTGCTG TGTCCCCGGC GGCTGGCCCG CCGCGTCCCC CAGCCCCGGC CTCCCGCGGA 120

CCAATGCCCG CCCGCATCGG GTACTACGAG ATCGACCGCA CCATCGGCAA GGGCAACTTC 180

GCTGTGGTCA AGCGGGCCAC GCACCTCGTC ACCAAGGCCA AGGTTGCTAT CAAGATCATA 240

GATAAGACCC AGTTGGATGA AGAAAACTTG AAGAAGATTT TCCGAGAGGT TCAAATTATG 300

AAGATGCTTT GCCACCCCCA TATCATCAGG CTTTACCAGG TTATGGAGAC AGAGCGGATG 360

ATTTATCTGG TGACAGAATA TGCTAGTGGA GGGGAAATAT TTGACCACCT CGTGGCTCAT 420

GGTAGAATGG CAGAAAAGGA GGCCCGTCGG AAGTTTAAAC AGATCGTCAC AGCCGTCTAT 480

TTTTGTCACT GTCGGAACAT TGTTCATCGC GATTTAAAAG CTGAAAATTT GCTTCTGGAT 540

GCCAATCTGA ATATCAAAAT AGCAGATTTT GGCTTTAGTA ACCTCTTCAC TCCTGGGCAG 600

CTGCTGAAGA CCTGGTGTGG TAGCCCTCCT TATGCTGCAC CCGAACTCTT TGAAGGAAAA 660

GAATATGATG GGCCCAAAGT GGACATCTGG AGCCTTGGAG TTGTCCTCTA TGTGCTTGTG 720

TGTGGTGCCC TGCCATTTGA TGGGAGCACA CTGCAGAATC TGCGGGCCCG GGTGCTGAGT 780

GGAAAGTTCC GCATCCCATT TTTTATGTCC ACAGAATGTG AGCACTTGAT CCGCCACATG 840

CTGGTGTTGG ACCCGAATAA GCGCCTCTCC ATGGAGCAGA TCTGCAGGCA CAAGTGGATG 900

AAGCTCGGGG ACGCGGACCC CAACTTTGAC AGGTTAATCG CTGAGTGTCA ACAACTAAAA 960

GAAGACAGAG AGACGGACTC CCTGAATGAG GATGTTCTCC TGGCCATGGA GGACATGGGA 1020

CTGGACAAAG AGCGGACATT ACAGTCATTA AGGTCAGATG CCTATGATCA CTATAGTGCA 1080

ATCTACAGCC TCCTGTGTGA TCGACATAAG AGACATAAAA CCCTGCGTCT CGGAGCACTT 1140

CCTAGCATGC CCCGAGCCAT GGCCTTTCAA GCACCAGTCA ATATCCAGGT GGGCAATAAC 1200

TCCATAACAC AGGGGGTGAG GGTTAGCTAT TGCTCACTAA CCCTGGTTAG CAGCTTCCTG 1260

ACCTTCCTTA CATCTCTCCA TTGTCATCTC TCCATCAGAG GAGAAGAGCC TTCCCCTGAA 1320

GCGCTGGTCC GCTATTTGTC AATGAGGAGG CACACAGTGG GTGTGGCTGA CCCACGCACG 1380

GAAGTCATGG AAGACCTGCA GAAGCTCCTA CCTGGCTTTC CTGGAGTCAA CCCGCAGGCT 1440

CCATTCCTCC AGGTGGCCCC TAACATGAAC TTCATGCACA ACCTGTTGCC CATGCAAAAT 1500

TTGCAACCAA CAGGGCAGCT TGAGTACAAG GAGCAGTCTC TACTACAGCC GCCTACCCTG 1560

CAGCTACTCA ATGGAATGGG CCCCCTCGGC CGGAGGGCAT CAGATGGAGG AGCCAACATC 1620

CAGCTGCATG CCCAGCAGCT ACTGAAGCGC CCACGGGGAC CCTCCCCACT TGTCACCATG 1680

ACACCAGCAG TGCCAGCAGT TACCCCTGTG GACGAGGAGA GCTCAGATGG GGAGCCAGAT 1740

CAGGAAGCTG TGCAGAGGTA CTTGGCTAAT AGGTCCAAAA GACATACACT GGCCATGACC 1800

AACCCTACAG CTGAGATTCC ACCGGACCTA CAGCGGCAGC TAGGACAGCA GCCTTTCCGT 1860

TCCCGGGTCT GGCCTCCTCA CCTGGTACCT GATCAGCATC GCTCTACCTA CAAGGACTCC 1920

AACACCCTGC ACCTCCCTAC GGAGCGTTTC TCCCCCGTGC GCCGGTTCTC AGATGGGGCT 1980

GCAAGCATCC AGGCCTTCAA AGCTCACCTG GAAAAAATGG GCAACAACAG CAGCATCAAA 2040

CAGTTGCAGC AGGAGTGTGA GCAGCTGCAG AAGATGTACG GGGGGCAGAT CGATGAGAGA 2100

ACCCTGGAGA AGACCCAGCA GCAGCATATG CTATACCAGC AGGAGCAGCA CCATCAAATT 2160

CTCCAGCAAC AAATTCAAGA TTCTATCTGT CCTCCTCAGC CTTCTCCACC TCTTCAGACG 2220

GCTTGTGAAA ATCAGCCAAC CCTTCTTACC CACCAGCTCC AGAGGTTAAG GATTCAGCCT 2280

TCAAGCCCAC CCCCCAACCA CCCCAACAAC CATCTCTTCA GGCAACCCAG TAATAGTCCT 2340

CCCCCCATGA CCAGTGCCAT GATCCAGTCT CACGGTGCTG CGTCTCCTTC GCAGTTTCAA 2400

GGCCTGTCCT CCCGCAGCAC AATCTTCCAT CAGCAGCCTG AAAACTGCTC CCCTCCACCC 2460

AGCGTGGCAC TAACCTGCTT GGGCCTGCAG CAGCCTACCC AGTCACAGCA GGTGACCATT 2520

CAAGTACAAG AGCCTGTTGA CATGCTCAGC AACATGCCCT CCGCAGGCTC CACTGGGCGG 2580

GGCCTCTCCA TCAGCCCCAG TGCCAGTCCG ATTCAGATGC AGCACCGTAC CAACCTAATG 2640

GCCACCTTCA GCTATGGGCA CCGGCCCTTG TCCAAGCAGC TGAGCGCTGA CAGTGCAGAG 2700

GCTCACAGCT TGAACGTGAA TCGGTTCTCC CCTGCTAACT ACGACCAGGC GCATTTACAC 2760

CCCCATCTGT TTTTGGACCA GTCCCGGGGT TCCCCCAGCA GCTACAGCCC TTCAACAGGA 2820

GTGGGGTTCC CTCCAACCCA AGCCCTGAAA GTCCCTCCAC TTGACCAATT CCCCACCTTC 2880

CCTCCCAGTG CACATCAGCA GCCGTCACAC TATACCACAT CGGCACTACA GCAGGCCCTG 2940

CTGTCCCCCA CGCCTCCAGA CTACACAAGA CACCAGCAGG TACCTCACAT CCTTCAAGGA 3000

CTGCTGTCTC CCCGGCATTC GCTCACTGGC CATTCGGACA TTCGGCTGCC CCCAGCAGAG 3060

TTTGCACAAC TCATTAAAAG GCAGCAGCAA CAGCGCCAGC AGCAGCAGCA GCAACAGCAA 3120

CAGCAGCAGC ACGATTACCA AGAATTGTTC AGGCACATGA ACCAAGGGGA CGCGGGGAGT 3180

CTGGCTCCCA GTCTTGGGGG ACAGAGCATG ACAGAGCACC AGGCTTTATC GTATCAAAAT 3240

GCTGACTCGT ATCACCACCA TCACACCAGC CCCCAGCATC TGCTACAAAT CAGGGCACAA 3300

GAATGTATCT CCCAGGTTTC CTCCCCCACC CCGACCCACG GGTACGTTCA TCAGCCGACA 3360

CTGATGCATT CAGAGAGTAT GGAAGAGGAC TGCTCACGTG AGGGGGCCCA GGATGGCTTT 3420

CCAGACAGTA AGAGCTCAAG TACACTGACC AAAGTTTGCC GTGATAGCCC CCTGCTCTTG 3480

AGCACTGGTG GACCTGGGGA CCCTGAATCT TTGCTAGGAA CTGTGAGTCA TGCCCAGGAA 3540

TTGGGGATAC ATCCCTACGG ACATCAGCCG GCTGCTGCAT TCAGTAGAAA TAAGGTGCCC 3600

AGCAGAGAGT CTGTCATAGG GAACTGCATG GATAGAAGTT CTCCAGGACA AGCAATGGAA 3660

CTGCCAGGCC ACAATGGGTT CGGGTACCCA GCACGTCCCT CAGTACATGA GCACCACAGG 3720

CCTCGGACCC TCCAGAGACA CCACACGATC CAGAACAGCG ACGACGCCTA CGTACAGCTG 3780

GATAACTTGC CAGGAATGAG TCTCGTGGCT GGGAAAGCGC TCAGTTCTGC CCGGATGTCA 3840

GATGCAGTTC TCAGTCAGTC TTCACTCATG GGCAGCCAGC AGTTTCAGGA TGGGGAAGAT 3900

GAGGAGTGTG GGGCAAGTCT GGGAGGTCAT GAGCACCCAG ACCTGAGTGA TGGCAGCCAG 3960

CATTTAAACT CCTCTTGCTA TCCATCTACG TGTATTACAG ACATTCTGCT CAGCTACAAG 4020

CACCCTGAGG TCTCCTTCAG CATGGAGCAG GCGGGCGTGT AA 4062

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +t+G+g+f+ Vk a+h  tk kva+Kii+k++l+ee+l+ki+rE++i+k+l hp+i

Q: 49    YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHI  108

         999*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         i+l++v+et++++ylv+eyasgge+fd+++++gr+ ekear+ fkq+v+av ++h ++iv

Q: 109   IRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIV  168

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld++ nikiaDFG++nlf++g+ll+t+cGsppYaaPel++gk+Y+gpkvD

Q: 169   HRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVD  228

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +WslGvvLy+lv+g+lPfd+++l++l++++l+gk++ip+ +s+e+e+L+r++Lv dp+kR

Q: 229   IWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKR  288

         ************************************************************

S: 241   atieeilkhewl  252

         +++e+i +h+w+

Q: 289   LSMEQICRHKWM  300

         ***********8

Domain Sequence
(FASTA)

YEIDRTIGKG NFAVVKRATH LVTKAKVAIK IIDKTQLDEE NLKKIFREVQ IMKMLCHPHI 60

IRLYQVMETE RMIYLVTEYA SGGEIFDHLV AHGRMAEKEA RRKFKQIVTA VYFCHCRNIV 120

HRDLKAENLL LDANLNIKIA DFGFSNLFTP GQLLKTWCGS PPYAAPELFE GKEYDGPKVD 180

IWSLGVVLYV LVCGALPFDG STLQNLRARV LSGKFRIPFF MSTECEHLIR HMLVLDPNKR 240

LSMEQICRHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013