EKS-OTG-00375

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00375

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	424.7	1.0E-127	237	486	250

Status

Unreviewed

Ensembl Protein

ENSOGAP00000015643

UniProt Accession

H0XHQ3;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000026548	ENSOGAP00000015643	ENSOGAT00000032860

Organism

Otolemur garnettii

Functional Description

Protein Length

501

Protein Sequence
(FASTA)

MGLVSSKKQV KEKGKGRWSP SKVSTPSKTL PTRPAMVLFG HLTPPPPEED CPDEEEHFVV 60

ALYDYTAVND RDLQMLKGEK LQVLKGTGDW WLAKSLVTGR EGYVPSNFVA RVESLEVEKW 120

FFRSISRKET ERQLLAPINK AGSFLIRESE TNKGAFSLSV KDVTAQGEIV KHYKIRSLEE 180

GGYYISPRIT FPSLQALVQH YSKKGDGLCQ KLTVPCVSLA SQNPWAPDEW EIPRQSLKLV 240

RKLGSGQFGE VWMGYYKNNM KVAVKTLKEG TMSPEAFLGE ANMMKTLQHE RLVRLYAVVT 300

KEPIYIVTEY MARGCLLDFL KTDEGSSLPL PRLIDMAAQI AEGMAYIEHM NSIHRDLRAA 360

NILVSETLCC KIADFGLARI IDSEYTAQEG AKFPIKWTAP EAIHFGVFTI KADVWSFGIL 420

LMEIVTYGRV PYPGMSNPEV IRNLERGYRM PRPDTCPPEL YRGVIAECWR SRPEERPTFE 480

FLQSVLEDFY TATEQQYELQ P 501

Nucleotide Sequence
(FASTA)

ATGGGACTGG TGAGCAGCAA GAAGCAGGTG AAGGAGAAGG GCAAGGGCCG ATGGAGCCCG 60

TCGAAGGTCA GCACCCCAAG CAAGACGCTC CCAACGAGAC CAGCTATGGT CCTCTTCGGC 120

CACCTCACTC CTCCACCTCC CGAGGAGGAC TGCCCAGATG AAGAAGAGCA CTTTGTGGTG 180

GCCCTGTACG ACTACACTGC CGTCAACGAC CGGGACCTGC AGATGCTCAA GGGGGAGAAA 240

CTGCAGGTCC TGAAGGGAAC CGGAGACTGG TGGTTGGCCA AGTCGCTGGT CACCGGAAGA 300

GAAGGCTACG TGCCCAGCAA CTTTGTGGCC CGAGTAGAGA GCCTAGAGGT TGAAAAATGG 360

TTCTTTAGAT CAATCAGCCG GAAGGAGACC GAGAGGCAGC TTCTGGCCCC AATCAACAAG 420

GCAGGCTCCT TTCTTATCAG GGAGAGTGAA ACAAATAAAG GTGCCTTCTC CTTGTCTGTG 480

AAGGATGTCA CGGCCCAAGG GGAGATAGTC AAGCACTATA AGATCCGCTC CCTGGAGGAA 540

GGCGGCTATT ACATCTCCCC TCGGATCACC TTCCCCTCGC TCCAGGCCTT GGTGCAGCAC 600

TATTCCAAGA AGGGGGACGG TTTGTGTCAG AAGCTGACGG TGCCCTGTGT GAGCCTGGCT 660

TCTCAGAACC CCTGGGCCCC AGACGAGTGG GAAATTCCCC GGCAGTCTCT CAAGCTGGTC 720

AGGAAACTTG GATCTGGGCA GTTTGGCGAA GTCTGGATGG GTTATTACAA AAACAACATG 780

AAGGTGGCCG TCAAGACCCT GAAGGAGGGA ACAATGTCTC CAGAAGCCTT CCTGGGCGAG 840

GCCAACATGA TGAAGACCCT CCAGCACGAG AGGCTGGTCC GGCTCTACGC TGTGGTCACC 900

AAGGAGCCCA TCTACATTGT CACTGAGTAC ATGGCCAGAG GATGCTTGCT GGACTTCTTG 960

AAGACAGATG AAGGGAGCAG TCTGCCCCTC CCAAGACTGA TCGACATGGC AGCCCAGATT 1020

GCAGAAGGGA TGGCATACAT AGAGCACATG AATTCCATTC ACCGCGACCT CCGCGCAGCC 1080

AACATCCTGG TGTCTGAGAC CTTGTGCTGC AAAATCGCTG ACTTCGGTTT GGCCAGGATC 1140

ATCGACAGTG AATACACTGC CCAAGAGGGG GCCAAGTTCC CCATCAAGTG GACTGCCCCA 1200

GAAGCCATCC ACTTTGGGGT GTTCACCATC AAGGCAGACG TGTGGTCGTT CGGCATCCTC 1260

CTGATGGAAA TCGTCACTTA CGGGCGGGTG CCGTACCCAG GGATGAGCAA CCCAGAGGTC 1320

ATCCGCAACC TGGAGCGTGG TTACCGCATG CCGCGCCCCG ACACGTGCCC GCCCGAGCTG 1380

TACCGCGGCG TCATCGCAGA GTGCTGGCGC AGCCGGCCGG AGGAGCGGCC CACCTTCGAG 1440

TTCCTGCAGT CAGTGCTGGA GGACTTCTAC ACGGCCACCG AGCAGCAGTA TGAGCTGCAG 1500

CCCTAG 1506

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv+klG+GqfGevw+g++k+++kvavktlkegt+speafl ea+++k+l+he+lv+ly

Q: 237   LKLVRKLGSGQFGEVWMGYYKNNMKVAVKTLKEGTMSPEAFLGEANMMKTLQHERLVRLY  296

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+ma+G+lldflk++eg++l+lp+l+d+aaq+aeGmay+e++n ihr

Q: 297   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSSLPLPRLIDMAAQIAEGMAYIEHMNSIHR  355

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l++k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv

Q: 356   DLRAANILVSETLCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  414

         **************************.899******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239

         WsfGill+eivt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe

Q: 415   WSFGILLMEIVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRgVIAECWRSRPE  474

         ************************************************9***********

S: 240   erPtfetlqevl  251

         erPtfe+lq+vl

Q: 475   ERPTFEFLQSVL  486

         ********9986

Domain Sequence
(FASTA)

LKLVRKLGSG QFGEVWMGYY KNNMKVAVKT LKEGTMSPEA FLGEANMMKT LQHERLVRLY 60

AVVTKEPIYI VTEYMARGCL LDFLKTDEGS SLPLPRLIDM AAQIAEGMAY IEHMNSIHRD 120

LRAANILVSE TLCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180

FGILLMEIVT YGRVPYPGMS NPEVIRNLER GYRMPRPDTC PPELYRGVIA ECWRSRPEER 240

PTFEFLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013