EKS-OTG-00476

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00476

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	364.0	4.7E-109	15	305	291

Status

Unreviewed

Ensembl Protein

ENSOGAP00000015846

UniProt Accession

H0XIA6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK15

Gene Synonyms/Alias

MAPK15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000027991	ENSOGAP00000015846	ENSOGAT00000033587

Organism

Otolemur garnettii

Functional Description

Protein Length

545

Protein Sequence
(FASTA)

MCAAEVDHNV ARRYLLKRRL GKGAYGIVWK AVDRRTGEVV AIKKIFDAFR DKTDAQRTFR 60

EIMLLQEFGN HPNIIRLLDL MRAENDRDIY LVFEFMDTDL HAVIRKGGLL KDVHRRYIFY 120

QLLRATNFIH SARVIHRDLK PSNILLDANC VVKLCDFGLA RSLSSLPEGT KGQALTEYVA 180

TRWYRAPEVL LSSSWYSPGV DMWSLGCVLG EMLRGQPLFP GTSTLHQLQL ILETIPPPLA 240

EDLPALGSGY SASVLHSLGS GPQQTLDTIL PPDTPPEALD LLRLLLVFAP HKRLTAAQAL 300

QHPYVQRFHC PDCDQTGGVD VQLLAQDGVR LSATEYRSHI YQMILEQRGN GCVPKKEGLR 360

GAPPGAEPRA SRSQAHLLKP RASPQLALGP PAQIPGLRPQ SSPSLDPEHE APRTAKNILR 420

RNPASLPQPG TPGVEAEHPS PPSWLKHNIR GANLSLTTQA AAQVANQALI RKDWSQCCGV 480

RAAGPHLVPP QLPPDPRPGR RMFSSSASQG ALGAARTMLG GYSQAYGTIC HSALGHLPLL 540

QGPRA 545

Nucleotide Sequence
(FASTA)

ATGTGCGCCG CGGAAGTGGA CCACAACGTG GCCCGGAGAT ACCTACTCAA GCGGCGGCTC 60

GGAAAAGGGG CCTACGGTAT TGTGTGGAAG GCAGTGGACC GGAGAACTGG TGAGGTTGTT 120

GCCATCAAGA AAATCTTTGA TGCCTTTAGA GATAAGACAG ATGCCCAGAG AACATTCCGG 180

GAAATCATGC TGCTCCAGGA GTTTGGGAAC CATCCCAACA TCATCCGCCT CCTCGACCTG 240

ATGCGGGCAG AGAATGACAG GGACATTTAC CTGGTATTTG AGTTTATGGA CACTGACCTG 300

CATGCCGTCA TCAGGAAGGG TGGGCTGCTG AAGGATGTCC ACAGGCGCTA CATCTTCTAC 360

CAGCTCCTGC GGGCCACCAA CTTCATCCAC TCAGCCCGGG TCATCCACCG GGACCTGAAG 420

CCATCTAATA TCCTCCTGGA TGCCAACTGT GTGGTGAAGC TCTGTGACTT TGGCCTGGCC 480

CGCTCTCTGA GCAGCCTTCC TGAGGGGACC AAGGGCCAGG CCCTGACTGA ATACGTAGCC 540

ACACGCTGGT ACCGAGCTCC AGAGGTTCTG CTGTCCTCAA GCTGGTACTC CCCTGGGGTG 600

GACATGTGGA GTCTGGGCTG TGTCCTGGGG GAGATGCTGC GGGGGCAGCC CTTGTTCCCA 660

GGCACGTCCA CACTCCACCA GCTGCAACTA ATCCTGGAGA CCATTCCACC TCCACTGGCG 720

GAGGACCTCC CAGCTCTCGG CTCAGGCTAC AGCGCCTCCG TCCTGCACAG CTTGGGATCC 780

GGGCCACAGC AGACGCTAGA CACCATCCTG CCACCAGACA CACCTCCAGA GGCTCTGGAC 840

CTTCTCAGGC TGCTCCTGGT ATTTGCCCCC CACAAGCGGC TCACTGCAGC CCAGGCCCTA 900

CAACACCCCT ACGTGCAGAG GTTCCACTGC CCTGACTGTG ATCAGACTGG GGGGGTGGAT 960

GTGCAGCTCC TGGCGCAGGA TGGAGTCCGG CTATCTGCCA CCGAGTATCG CAGCCACATC 1020

TATCAGATGA TCTTGGAGCA GAGAGGCAAT GGCTGTGTCC CCAAAAAGGA GGGCCTGAGG 1080

GGTGCCCCCC CGGGGGCAGA GCCCAGGGCT TCCAGGTCCC AGGCGCACCT GCTCAAGCCC 1140

AGAGCCAGCC CCCAGCTCGC CTTGGGGCCG CCTGCACAGA TCCCTGGACT CAGGCCTCAG 1200

AGTAGCCCTA GTCTGGATCC AGAGCACGAA GCCCCCAGAA CAGCTAAGAA CATTCTCAGG 1260

CGGAACCCAG CCTCTTTGCC CCAACCTGGG ACCCCTGGGG TGGAGGCGGA GCACCCCTCC 1320

CCCCCATCAT GGCTGAAGCA CAACATAAGA GGGGCAAACC TCTCCCTGAC CACTCAGGCT 1380

GCAGCCCAGG TGGCCAATCA GGCCCTGATC CGCAAGGACT GGTCCCAGTG CTGTGGGGTG 1440

AGGGCAGCTG GCCCACACCT GGTCCCTCCT CAGCTTCCCC CAGACCCCCG GCCTGGACGG 1500

AGGATGTTCA GCTCTTCTGC TTCACAGGGG GCGCTGGGGG CTGCCCGGAC CATGCTCGGG 1560

GGCTACTCTC AGGCCTATGG TACCATATGC CACTCAGCAC TGGGCCACCT GCCCCTGCTC 1620

CAAGGACCAC GTGCATGA 1638

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheNi  60

           +++lg+Gayg+v++avd+rt+e vaikk++++f+++t+a+rt+RE++ll+e+ +h+Ni

Q: 15    LLKRRLGKGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREIMLLQEFgNHPNI  74

         56789*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i+lld +++e+     +d+Ylv+e+m+tdL++vi++   l+d h ++++yq+lr++ ++H

Q: 75    IRLLDLMRAEN----DRDIYLVFEFMDTDLHAVIRKGgLLKDVHRRYIFYQLLRATNFIH  130

         ********999....9********************999*********************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPeil  175

         sa+viHrDlKPsN+l++++c +k++dFGlars ++  e +    lteyvatrwYraPe+l

Q: 131   SARVIHRDLKPSNILLDANCVVKLCDFGLARSLSSLPEGTkgqaLTEYVATRWYRAPEVL  190

         ********************************887766556778****************

S: 176   lslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiesee  235

         ls++ y+  vD+Ws+GC+l+E+l+g+plfpg+++++ql++ile+++ p +e+l ++ s

Q: 191   LSSSWYSPGVDMWSLGCVLGEMLRGQPLFPGTSTLHQLQLILETIPPPLAEDLPALGSGY  250

         ************************************************************

S: 236   arnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289

          +++++sl + +++++++++p  + +ealdLl+ lLv++p+kR+++++aL+hpY+

Q: 251   SASVLHSLGSGPQQTLDTILPPdTPPEALDLLRLLLVFAPHKRLTAAQALQHPYV  305

         *******************9875889****************************7

Domain Sequence
(FASTA)

LLKRRLGKGA YGIVWKAVDR RTGEVVAIKK IFDAFRDKTD AQRTFREIML LQEFGNHPNI 60

IRLLDLMRAE NDRDIYLVFE FMDTDLHAVI RKGGLLKDVH RRYIFYQLLR ATNFIHSARV 120

IHRDLKPSNI LLDANCVVKL CDFGLARSLS SLPEGTKGQA LTEYVATRWY RAPEVLLSSS 180

WYSPGVDMWS LGCVLGEMLR GQPLFPGTST LHQLQLILET IPPPLAEDLP ALGSGYSASV 240

LHSLGSGPQQ TLDTILPPDT PPEALDLLRL LLVFAPHKRL TAAQALQHPY V 291

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013