EKS-OTG-00282

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00282

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.6	3.2E-137	185	472	288

Status

Unreviewed

Ensembl Protein

ENSOGAP00000018849

UniProt Accession

H0XRV7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000029484	ENSOGAP00000018849	ENSOGAT00000028876

Organism

Otolemur garnettii

Functional Description

Protein Length

483

Protein Sequence
(FASTA)

MSAPKFPAAL QCACTSCLQA NYTCETDGAC MVSIFNLDGM EHHVRTCIPK VELVPAGKPF 60

YCLSSEDLRN THCCYTDFCN KIDLRVPSGH LKEPEHSSMW GPVELVGIIA GPVFLLFLII 120

IIVFLVINYH QRVYHNRQRL DMEDPSCEMC LSKDKTLQDL VYDLSTSGSG SGLPLFVQRT 180

VARTIVLQEI IGKGRFGEVW RGRWRGGDVA VKIFSSREER SWFREAEIYQ TVMLRHENIL 240

GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTIE GMIKLALSAA SGLAHLHMEI 300

VGTQGKPGIA HRDLKSKNIL VKKNGMCAIA DLGLAVRHDA VTDTIDIAPN QRVGTKRYMA 360

PEVLDETINM KHFDSFKCAD IYALGLVYWE IARRCNSGGV HEEYQLPYYD LVPSDPSIEE 420

MRKVVCDQKL RPNIPNWWQS YEALRVMGKM MRECWYANGA ARLTALRIKK TLSQLSVQED 480

VKI 483

Nucleotide Sequence
(FASTA)

ATGTCTGCTC CCAAATTCCC TGCAGCTCTA CAGTGTGCGT GCACCAGCTG CCTACAGGCC 60

AACTACACAT GTGAAACAGA TGGGGCCTGC ATGGTTTCCA TTTTCAACCT GGATGGGATG 120

GAGCATCATG TGCGCACCTG CATCCCCAAA GTGGAACTGG TCCCCGCCGG GAAGCCCTTC 180

TACTGCCTGA GCTCGGAGGA TCTGCGCAAC ACACACTGCT GCTATACTGA CTTCTGCAAC 240

AAGATCGACC TGAGGGTGCC CAGTGGTCAC CTCAAGGAGC CTGAGCACTC TTCCATGTGG 300

GGCCCTGTGG AGCTGGTAGG CATTATTGCC GGCCCAGTGT TCCTTCTATT TCTCATCATC 360

ATCATTGTTT TCCTTGTCAT TAACTATCAT CAGCGTGTCT ATCACAACCG CCAGAGACTG 420

GATATGGAGG ATCCCTCATG TGAGATGTGT CTCTCCAAAG ACAAGACGCT CCAGGATCTT 480

GTCTACGATC TCTCCACTTC AGGGTCTGGC TCAGGGTTAC CCCTCTTTGT CCAGCGCACA 540

GTGGCCCGAA CCATCGTTTT ACAGGAGATT ATTGGCAAAG GTCGTTTTGG GGAAGTATGG 600

CGTGGGCGCT GGAGGGGTGG TGACGTAGCT GTGAAAATTT TCTCATCTCG TGAAGAACGG 660

TCTTGGTTCC GGGAAGCAGA GATATACCAG ACGGTCATGT TGCGCCACGA AAACATTCTT 720

GGATTTATTG CTGCTGACAA TAAAGATAAT GGCACCTGGA CACAGCTGTG GCTTGTCTCG 780

GACTATCATG AGCATGGCTC CTTGTTTGAT TATCTTAACC GATACACAGT GACAATTGAG 840

GGGATGATCA AGCTGGCCTT ATCCGCTGCT AGTGGGCTGG CACACCTGCA CATGGAGATT 900

GTGGGCACAC AAGGGAAGCC TGGAATTGCT CACCGAGACT TAAAGTCAAA GAATATCTTG 960

GTAAAGAAAA ATGGCATGTG TGCCATCGCA GATCTGGGCC TGGCTGTCCG TCATGATGCA 1020

GTAACTGACA CCATCGACAT TGCCCCAAAC CAGAGGGTGG GGACCAAACG ATACATGGCC 1080

CCTGAAGTAC TTGATGAAAC CATTAACATG AAACATTTTG ACTCCTTTAA ATGTGCTGAT 1140

ATCTATGCCC TCGGGCTGGT ATATTGGGAG ATTGCTCGAA GATGCAATTC TGGAGGAGTC 1200

CATGAAGAGT ATCAGCTGCC ATATTATGAT TTAGTGCCCT CTGACCCTTC CATTGAAGAA 1260

ATGCGAAAGG TCGTATGTGA CCAGAAGCTA CGTCCCAACA TCCCCAACTG GTGGCAGAGT 1320

TATGAGGCGT TACGGGTGAT GGGGAAGATG ATGCGGGAGT GTTGGTATGC CAATGGTGCA 1380

GCCCGCCTGA CTGCTCTGCG CATCAAGAAG ACCCTCTCAC AGCTCAGTGT GCAGGAAGAT 1440

GTGAAGATCT AA 1452

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 185   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  244

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 245   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  304

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 305   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  362

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 363   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  421

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 422   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  472

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013