EKS-OTG-00477

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00477

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	346.4	1.1E-103	20	316	297

Status

Unreviewed

Ensembl Protein

ENSOGAP00000020101

UniProt Accession

H0XVF9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000030786	ENSOGAP00000020101	ENSOGAT00000034222

Organism

Otolemur garnettii

Functional Description

Protein Length

722

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANVLE 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL SVIPVYIRND MTEPHKPLTQ LLPGISREAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 360

QFSEHDWPIH NNFDIDEVQL DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTNYS 420

TEPCWQYPDH HENKYCDLEC SHTCNYKTRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCERNGL VKAQIALEEA SQHLAEKERE KNQGFDFDSF IAGTIQLSSQ 540

HEPSDVVDKL NDLNSSVSQL ELKSLISKSV SQEKQEKGMA NLAQLEALYQ SSWDSQFVSG 600

GEDCFLINQF CCEVRKDEQV EKENTYTSYL DKFFSRKEDT EMLETEPIED GKLGERGNEA 660

GFLNNSGEFL FNKQLESIGI PQFHSPVGSP LKSIQATLTP SAMKSSPQIP HKTYSSILKH 720

LN 722

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG CTCTAGGTAT 60

ATGGACTTAA AACCATTGGG TTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 120

GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTAA CTGATCCCCA GAGTGTCAAA 180

CATGCTCTAC GTGAAATCAA AATTATTAGA AGACTTGACC ACGATAACAT TGTGAAAGTG 240

TTTGAAATTC TTGGTCCCAG TGGAAGCCAG TTAACAGATG ATGTGGGCTC TCTTACTGAA 300

CTGAACAGTG TCTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCGAA CGTGCTGGAG 360

CAAGGCCCTT TACTGGAAGA GCATGCCAGG CTTTTCATGT ATCAGCTGCT ACGGGGGCTC 420

AAGTATATTC ACTCTGCAAA CGTACTGCAC AGAGATCTCA AACCAGCTAA TCTTTTCATT 480

AATACCGAAG ACTTGGTGCT GAAGATAGGT GACTTTGGTC TTGCACGGAT CATGGATCCT 540

CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CTAAGTGGTA CAGATCTCCA 600

CGTCTTTTAC TTTCTCCTAA TAATTATACT AAAGCCATTG ACATGTGGGC TGCAGGCTGC 660

ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTTTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGTTGA TTTTAGAATC TATCCCTGTC GTTCATGAGG AAGATCGTCA GGAGCTTCTC 780

AGTGTAATTC CAGTTTACAT TAGAAATGAC ATGACTGAGC CACACAAACC TTTAACTCAG 840

CTGCTTCCGG GAATTAGTCG AGAAGCACTG GATTTCCTGG AACAAATTTT GACATTTAGC 900

CCCATGGATC GGTTGACGGC AGAAGAAGCG CTCTCCCATC CTTACATGAG CATATATTCT 960

TTTCCGATGG ATGAACCAAT TTCCAGTCAT CCTTTCCATA TTGAAGATGA AGTTGATGAT 1020

ATTTTGCTTA TGGATGAAAC ACATAGTCAC ATTTATAACT GGGAAAGGTA CCATGATTGT 1080

CAGTTTTCAG AGCATGACTG GCCTATACAT AACAACTTTG ATATTGATGA AGTTCAGCTT 1140

GACCCAAGAG CTCTGTCTGA TGTCACTGAT GAAGAAGAAG TACAAGTTGA TCCTCGAAAA 1200

TATTTAGATG GAGATCGGGA AAAGTATCTA GAGGATCCTG CTTTCGATAC CAATTACTCT 1260

ACGGAGCCTT GCTGGCAGTA CCCAGATCAT CACGAAAACA AATATTGTGA TCTGGAATGT 1320

AGCCATACTT GTAACTACAA AACGAGGTCA TCATCATATT TAGATAACTT AGTTTGGAGA 1380

GAGAGCGAAG TTAACCATTA CTATGAACCC AAGCTTATTA TAGATCTTTC CAACTGGAAA 1440

GAACAAAGTA AAGAAAAATC TGATAAGAAA GGCAAGTCAA AATGTGAAAG GAATGGATTG 1500

GTTAAAGCCC AGATAGCTCT GGAAGAAGCA TCACAGCACC TGGCTGAGAA GGAAAGGGAA 1560

AAGAATCAGG GATTTGATTT TGATTCCTTT ATTGCAGGAA CTATTCAGCT TAGTTCACAG 1620

CACGAGCCTA GCGATGTTGT TGATAAATTA AATGACTTGA ATAGCTCAGT GTCCCAGCTA 1680

GAATTGAAAA GTTTGATATC AAAATCTGTA AGCCAAGAAA AACAGGAAAA AGGAATGGCA 1740

AATCTAGCTC AGTTAGAAGC CTTATACCAA TCTTCTTGGG ATAGCCAGTT TGTGAGTGGC 1800

GGGGAGGACT GTTTTCTCAT AAATCAGTTT TGTTGTGAGG TAAGGAAGGA TGAACAAGTT 1860

GAGAAGGAAA ATACTTACAC TAGTTACTTG GACAAGTTTT TTAGCAGGAA AGAAGATACT 1920

GAAATGCTAG AAACTGAGCC AATAGAAGAT GGTAAGCTTG GGGAGAGAGG AAATGAGGCA 1980

GGATTTCTAA ACAACAGTGG GGAGTTCCTC TTTAACAAGC AGCTTGAATC CATAGGCATC 2040

CCACAGTTCC ACAGTCCAGT TGGGTCACCG CTTAAGTCCA TACAGGCCAC ATTAACACCT 2100

TCTGCCATGA AATCTTCCCC TCAAATTCCT CATAAAACGT ACAGCAGCAT TCTGAAACAT 2160

CTGAACTAA 2169

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rvaikk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el++vY+v+e+metdL++v+++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yi++ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAIK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNSVYIVQE YMETDLANVL EQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LSVIPVYIRN DMTEPHKPLT QLLPGISREA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013