EPS-OTG-00058

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-OTG-00058

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	257.8	6.6E-77	1	151	151

Status

Unreviewed

Ensembl Protein

ENSOGAP00000018538

UniProt Accession

H0XQZ6;

Protein Name

Protein Synonyms/Alias

Gene Name

PTEN

Gene Synonyms/Alias

PTEN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000031772	ENSOGAP00000018538	ENSOGAT00000024405

Organism

Otolemur garnettii

Functional Description

Protein Length

369

Protein Sequence
(FASTA)

MGFPAERLEG VYRNNIDDVV RFLDSKHKNH YKIYNLCAER HYDTAKFNCR VAQYPFEDHN 60

PPQLELIKPF CEDLDQWLSE DDNHVAAIHC KAGKGRTGVM ICAYLLHRGK FLKAQEALDF 120

YGEVRTRDKK GVTIPSQRRY VYYYSYLLKN HLDYRPVALL FHKMMFETIP MFSGGTCNPQ 180

FVVCQLKVKI YSSTSGPTRR EDKFMYFEFP QPLPVCGDIK VEFFHKQNKM LKKDKMFHFW 240

VNTFFIPGPE ETSEKVENGS LCDQEIDSIC SIERADNDKE YLVLTLTKND LDKANKDKAN 300

RYFSPNFKVK LYFTKTVEEP SNPEASSSTS VTPDVSDNEP DHYRYSDTTD SDPENEPFDE 360

DQHTQITKV 369

Nucleotide Sequence
(FASTA)

ATGGGATTTC CTGCAGAAAG ACTTGAAGGC GTATACAGGA ACAATATTGA TGATGTAGTA 60

AGGTTTTTGG ATTCAAAGCA TAAAAACCAT TACAAGATAT ACAATCTATG TGCTGAAAGA 120

CATTATGACA CCGCCAAATT TAACTGCAGA GTTGCACAGT ATCCTTTTGA AGACCATAAC 180

CCACCACAGC TAGAACTTAT CAAACCCTTT TGTGAAGATC TTGACCAATG GCTAAGTGAA 240

GATGACAATC ATGTGGCAGC AATTCACTGT AAAGCTGGAA AGGGACGAAC TGGTGTAATG 300

ATTTGTGCAT ATTTATTACA TCGGGGCAAA TTTTTAAAGG CACAAGAGGC CCTAGATTTC 360

TATGGGGAAG TAAGGACCAG AGACAAAAAG GGAGTAACTA TTCCCAGTCA AAGGCGCTAT 420

GTGTATTATT ATAGCTACCT GCTAAAGAAT CATCTGGATT ATAGACCAGT GGCACTGTTG 480

TTTCACAAGA TGATGTTTGA AACTATTCCA ATGTTCAGTG GCGGAACTTG CAATCCTCAG 540

TTTGTGGTCT GCCAGCTAAA GGTGAAGATA TATTCCTCCA CTTCAGGACC CACACGACGA 600

GAAGACAAGT TCATGTATTT CGAGTTCCCT CAGCCGTTGC CTGTATGTGG TGACATCAAA 660

GTAGAGTTCT TCCACAAACA GAACAAGATG CTAAAAAAGG ATAAAATGTT TCATTTTTGG 720

GTAAATACGT TCTTCATACC AGGACCAGAG GAAACCTCAG AAAAAGTAGA AAATGGAAGT 780

CTATGTGATC AAGAAATTGA TAGCATTTGT AGTATAGAGC GTGCAGATAA TGACAAAGAG 840

TATCTAGTAC TTACTTTAAC AAAAAATGAT CTTGACAAAG CAAATAAAGA CAAGGCCAAC 900

CGATATTTTT CTCCAAATTT TAAGGTGAAG CTGTACTTCA CAAAAACAGT AGAGGAGCCA 960

TCAAATCCAG AGGCTAGCAG TTCAACTTCT GTAACGCCAG ATGTTAGTGA CAATGAACCT 1020

GATCATTATA GATATTCTGA CACCACTGAC TCTGATCCAG AGAATGAACC TTTTGATGAA 1080

GATCAGCATA CACAAATTAC AAAAGTCTGA 1110

Domain Profile

S: 22    vsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltklnakvaefgiedln  81

         ++fPae+ e+vyrnn+++vvr+ldskh+n+yk+ynlc+er+yd++k+n++va++++ed+n

Q: 1     MGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHN  60

         89**********************************************************

S: 82    aPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayllaseisakadealdt  141

         +P+le ++++c++ld+Wlsedd++v+++hck+gkgr+Gv++cayll++++++ka+eald+

Q: 61    PPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDF  120

         ************************************************************

S: 142   fgerrtredkvagvkqPsqrryvsyfsqllkgs  174

         +ge+rtr++k  gv++Psqrryv+y+s+llk++

Q: 121   YGEVRTRDKK--GVTIPSQRRYVYYYSYLLKNH  151

         **********..******************986

Domain Sequence
(FASTA)

MGFPAERLEG VYRNNIDDVV RFLDSKHKNH YKIYNLCAER HYDTAKFNCR VAQYPFEDHN 60

PPQLELIKPF CEDLDQWLSE DDNHVAAIHC KAGKGRTGVM ICAYLLHRGK FLKAQEALDF 120

YGEVRTRDKK GVTIPSQRRY VYYYSYLLKN H 151

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0016314	; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800	; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0046855	; P:inositol phosphate dephosphorylation
GO:0030336	; P:negative regulation of cell migration
GO:0008285	; P:negative regulation of cell proliferation
GO:0051895	; P:negative regulation of focal adhesion assembly
GO:0051898	; P:negative regulation of protein kinase B signaling cascade
GO:0035335	; P:peptidyl-tyrosine dephosphorylation
GO:0046856	; P:phosphatidylinositol dephosphorylation
GO:0031647	; P:regulation of protein stability

KEGG

InterPros

IPR017361	; Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR014019	; Phosphatase_tensin-typ.
IPR014020	; Tensin_phosphatase_C2-dom.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00782	; DSPc; 1.
PF10409	; PTEN_C2; 1.

SMARTs

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS00383	; TYR_PHOSPHATASE_1; 1.

Prints

Created Date

20-Feb-2013