EKS-OTG-00288

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00288

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.4	1.5E-122	203	490	288

Status

Unreviewed

Ensembl Protein

ENSOGAP00000018789

UniProt Accession

H0XRP7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000032563	ENSOGAP00000018789	ENSOGAT00000025957

Organism

Otolemur garnettii

Functional Description

Protein Length

525

Protein Sequence
(FASTA)

AAAIGARSVV LSPGGTGSGR GEAETRECIY YNANWELERT NQSGLERCEG EQDKRLHCYA 60

SWRNSSGTIE LVKKGCWLDD FNCYDRQECV ATEENPQVYF CCCEGNFCNE RFTHLPEAGG 120

PEVTYEPPPT APTLLTVLAY SLLPIGGLSL IVLLAFWMYR HRKPPYGHVD IHEVRLSWLG 180

QALALSQDPG PPPPSPLVGL KPLQLLEIKA RGRFGCVWKA QLMNDFVAVK IFPLQDKQSW 240

QSEREIFSTP GMKHENLLQF IAAEKRGSNL EVELWLITAF HDKGSLTDYL KGNIITWNEL 300

CHVAETMSRG LSYLHEDVPW CRGEGHKPSI AHRDFKSKNV LLKSDLTAVL ADFGLAVRFE 360

PGKPPGDTHG QVGTRRYMAP EVLEGAINFQ RDAFLRIDMY AMGLVLWELV SRCKAADGPV 420

DEYMLPFEEE IGQHPSLEEL QEVVVHKKMR PTIKDHWLKH PGLAQLCVTI EECWDHDAEA 480

RLSAGCVEER VSLIRRSVNG TTSDCLVSLV TSVTNVDLPP KESSI 525

Nucleotide Sequence
(FASTA)

GCTGCAGCCA TAGGGGCACG CTCAGTGGTT CTCTCTCCTG GGGGCACAGG CTCTGGGCGT 60

GGGGAGGCTG AGACTCGGGA GTGCATCTAC TACAACGCCA ACTGGGAGCT GGAGCGGACC 120

AACCAGAGTG GCCTGGAGCG CTGCGAGGGC GAGCAGGACA AGCGGCTGCA CTGCTATGCC 180

TCCTGGCGCA ACAGCTCCGG CACCATCGAG CTTGTCAAGA AAGGCTGCTG GTTGGATGAC 240

TTCAACTGCT ATGACAGGCA GGAGTGTGTG GCCACCGAGG AGAACCCACA AGTGTACTTC 300

TGCTGCTGTG AAGGCAACTT CTGCAACGAG CGCTTCACCC ATTTGCCAGA AGCTGGGGGC 360

CCAGAAGTCA CGTACGAGCC ACCCCCGACA GCCCCCACCC TGCTCACGGT GCTGGCCTAC 420

TCGCTGCTGC CCATCGGGGG CCTTTCCCTC ATCGTCCTGC TGGCCTTCTG GATGTACCGG 480

CATCGCAAGC CACCATATGG CCATGTGGAC ATCCATGAGG TGAGACTGTC CTGGCTTGGG 540

CAAGCCCTTG CTCTTTCCCA GGATCCTGGG CCTCCACCCC CATCCCCTCT AGTGGGCCTG 600

AAACCACTGC AACTGCTGGA GATCAAGGCT CGGGGGCGCT TTGGCTGTGT CTGGAAGGCT 660

CAGCTCATGA ATGACTTTGT GGCTGTCAAG ATCTTCCCAC TCCAGGACAA GCAGTCATGG 720

CAGAGTGAAC GGGAGATCTT CAGCACACCT GGCATGAAGC ATGAGAACCT GCTACAGTTC 780

ATCGCTGCTG AGAAGCGAGG CTCCAACCTT GAAGTGGAGC TGTGGCTCAT CACAGCCTTC 840

CACGACAAGG GCTCCCTCAC GGATTACCTC AAGGGGAACA TCATCACATG GAATGAATTG 900

TGTCATGTGG CAGAGACGAT GTCACGAGGC CTCTCGTACC TGCATGAGGA TGTGCCCTGG 960

TGCCGTGGTG AGGGCCACAA GCCGTCTATT GCTCACAGGG ACTTCAAAAG CAAGAATGTA 1020

TTGCTGAAGA GCGACCTCAC GGCTGTGCTG GCTGACTTTG GCCTGGCTGT TCGGTTTGAG 1080

CCAGGGAAAC CTCCAGGGGA CACCCATGGG CAGGTGGGCA CAAGACGGTA CATGGCCCCT 1140

GAGGTGCTGG AGGGAGCCAT CAACTTCCAG AGAGATGCAT TCCTGCGCAT TGATATGTAT 1200

GCCATGGGGC TGGTGCTGTG GGAACTTGTG TCTCGCTGCA AGGCTGCAGA TGGACCTGTG 1260

GATGAGTACA TGCTGCCTTT TGAAGAAGAG ATTGGCCAGC ACCCTTCTCT GGAAGAGCTG 1320

CAGGAAGTGG TTGTGCACAA GAAGATGAGG CCCACCATTA AGGATCATTG GCTGAAGCAC 1380

CCGGGCCTGG CCCAGCTCTG TGTGACCATC GAGGAATGCT GGGACCATGA TGCAGAAGCT 1440

CGCCTGTCTG CAGGCTGTGT GGAAGAGCGG GTGTCCCTGA TCCGGAGGTC GGTCAACGGC 1500

ACTACCTCGG ACTGTCTTGT CTCCCTGGTG ACCTCTGTCA CCAATGTGGA CCTGCCCCCT 1560

AAAGAGTCAA GCATCTAA 1578

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+++ vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 203   LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA  262

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 263   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR  322

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +Kp+iaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 323   GeGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  380

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Pslee

Q: 381   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE  439

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP+i+++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 440   LQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  490

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEELQE 240

VVVHKKMRPT IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013