EKS-OTG-00277
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-OTG-00277
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK438.21.8E-131111431321
StatusUnreviewed
Ensembl ProteinENSOGAP00000022135
UniProt AccessionH0Y192;
Protein Name
Protein Synonyms/Alias
Gene NameDYRK1B
Gene Synonyms/Alias DYRK1B;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSOGAG00000032823ENSOGAP00000022135ENSOGAT00000030419
OrganismOtolemur garnettii
Functional Description
Protein Length629
Protein Sequence
(FASTA)
MAIPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV DLIKTYKHIN 60
EVYYAKKKRR AQQAPPQDSS TKKEKKVLNH GYDDDNHDYI VRSGERWLER YEIDSLIGKG 120
SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK YYIVHLKRHF 180
MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL 240
KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG 300
CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAPMLDQA PKARKYFERL PGGGWTLRRT 360
KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR MLEYEPAARI 420
SPLGALQHGF FRRTADEATN TGPAGSSAST SPAPLDTCPS SSTASSISSS GGSSGSSSDN 480
RTYRYSNRYC GGPGPPITDC EMNSPQVPPS QPLRPWAGGD VPHKTHQAPT SASSLPGTGA 540
QLPTQPRCLG HPPSPTSPPP PELMDVSLVG GPPDCSPPHP APAPQHPTAS ALRTRMTGGR 600
PPLPPPDDPA TLGPRLGLRG VPQSTAASS 629
Nucleotide Sequence
(FASTA)
ATGGCCATCC CACCAGGCCA TGGTCCCTTC TCTGGCTTCC CAGGGCCCCA AGAGCACACA 60
CAGGTATTGC CTGATGTGCG GCTCCTGCCA CGGAGGCTGC CCTTGGCCTT CCGGGATGCA 120
ACCTCGGCCC CATTGCGCAA GCTCTCTGTG GACCTCATCA AGACCTACAA GCACATCAAT 180
GAGGTATACT ATGCGAAGAA GAAGCGCCGG GCCCAGCAGG CGCCACCCCA GGACTCGAGC 240
ACCAAGAAGG AGAAGAAGGT CCTGAACCAT GGTTATGATG ACGACAACCA TGACTATATT 300
GTGCGCAGTG GCGAGCGCTG GCTGGAGCGC TATGAGATTG ACTCGCTCAT TGGCAAAGGC 360
TCCTTTGGCC AGGTGGTGAA AGCCTATGAC CATCAAACCC AGGAGCTGGT GGCCATCAAG 420
ATCATCAAGA ACAAAAAGGC CTTCCTGAAC CAGGCCCAGA TTGAGTTGCG GCTGCTGGAG 480
CTGATGAACC AGCATGACAC AGAAATGAAA TACTACATAG TGCACCTGAA GCGACACTTC 540
ATGTTCCGGA ACCACCTGTG CCTGGTGTTC GAGCTGCTGT CCTACAACCT GTATGACCTC 600
CTGCGCAACA CGCACTTCCG TGGCGTCTCG CTGAACCTTA CCCGGAAGCT GGCGCAGCAG 660
CTCTGCACTG CGCTGCTATT CCTGGCCACA CCTGAACTCA GCATCATTCA TTGTGACCTC 720
AAGCCTGAGA ACATCCTGCT CTGCAACCCC AAGCGCAGTG CCATCAAGAT CGTGGACTTT 780
GGCAGCTCCT GCCAGCTTGG CCAACGGATC TACCAGTATA TCCAGAGTCG CTTCTACCGC 840
TCGCCTGAGG TGCTCCTGGG CACACCCTAT GACCTAGCCA TTGACATGTG GTCCCTGGGC 900
TGCATCCTTG TGGAGATGCA CACCGGAGAG CCTCTTTTCA GCGGCTCCAA CGAGGTGGAC 960
CAGATGAACC GCATTGTGGA GGTGCTGGGC ATCCCACCGG CCCCCATGCT GGACCAGGCA 1020
CCCAAGGCTC GCAAGTACTT TGAACGGCTG CCTGGGGGTG GCTGGACCTT ACGAAGGACA 1080
AAGGAACTCA GGAAGGATTA CCAGGGCCCC GGGACACGGC GGCTGCAGGA GGTGCTGGGC 1140
GTGCAGACGG GCGGGCCCGG GGGCCGGCGG GCGGGGGAGC CGGGCCACAG CCCCGCCGAC 1200
TACCTCCGCT TCCAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 1260
AGCCCTCTGG GGGCTCTCCA ACACGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 1320
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCCGCAC CCCTTGACAC CTGCCCCTCC 1380
TCCAGCACCG CCAGCTCCAT CTCCAGCTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 1440
CGGACCTACC GCTACAGCAA CCGATACTGT GGGGGCCCTG GGCCCCCTAT CACTGACTGT 1500
GAGATGAACA GCCCCCAGGT CCCACCCTCC CAGCCGCTGC GCCCCTGGGC AGGGGGTGAT 1560
GTGCCCCACA AGACACATCA AGCCCCTACC TCTGCCTCGT CACTGCCGGG GACTGGGGCC 1620
CAGTTACCCA CCCAACCCCG ATGCCTTGGC CATCCCCCAT CACCAACCTC ACCACCACCT 1680
CCGGAGCTGA TGGATGTGAG CCTGGTGGGC GGCCCTCCAG ACTGCTCACC ACCTCACCCA 1740
GCACCTGCCC CCCAGCACCC GACTGCCTCA GCCCTCCGGA CTCGGATGAC AGGAGGTCGT 1800
CCACCTCTCC CACCCCCCGA TGACCCTGCC ACTCTGGGGC CTCGCCTGGG CCTCCGTGGT 1860
GTACCCCAGA GCACGGCAGC CAGCTCATGA 1890
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         ye++++igkGsfgqVvka+d++t+e vaikiiknkk+f++qaq+E+++Le +n++d+e+k
Q: 111   YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK  170
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119
         y++v+l+++f+frnhlclvfells+nLy+ll++++f+g+sl+l+rklaqq+++aL +L+ 
Q: 171   YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAt  230
         **********************************************************99
S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++
Q: 231   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGTP  289
         99*************************************.********************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238
         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq++ ivevlg+pp+ +l++a ka+k+f++
Q: 290   YDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAPMLDQAPKARKYFER  349
         ************************************************************
S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288
              ++l+++          ++r+ ++vl+v++ +     p+ +++ge+ ++ +d+l f
Q: 350   LPGGGWTLRRTkelrkdyqgPGTRRLQEVLGVQTGG-----PGGRRAGEPGHSPADYLrF  404
         ********9997888888777778888888887777.....99*****************
S: 289   kdllkrmleldpakRitpkealkhpfv  315
         +dl+ rmle++pa+Ri+p  al+h f+
Q: 405   QDLVLRMLEYEPAARISPLGALQHGFF  431
         *************************97
Domain Sequence
(FASTA)
YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK 60
YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT 120
PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY 180
DLAIDMWSLG CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAPMLDQA PKARKYFERL 240
PGGGWTLRRT KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR 300
MLEYEPAARI SPLGALQHGF F 321
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00254
EKS-ANC-00260
EKS-BOT-00271
EKS-CAJ-00277
EKS-CAF-00279
EKS-CAP-00306
EKS-DIO-00022
EKS-EQC-00266
EKS-FEC-00257
EKS-HOS-00277
EKS-ICT-00254
EKS-LOA-00282
EKS-MAM-00273
EKS-MOD-00268
EKS-MUM-00302
EKS-MUP-00270
EKS-MYL-00273
EKS-NOL-00251
EKS-PAT-00257
EKS-PES-00242
EKS-POA-00262
EKS-PRC-00022
EKS-RAN-00288
EKS-SUS-00233
EKS-SCP-00047
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013