EKS-OTG-00006

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-OTG-00006

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	509.1	1.7E-153	639	898	260

Status

Unreviewed

Ensembl Protein

ENSOGAP00000017746

UniProt Accession

H0XNQ5;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHB3

Gene Synonyms/Alias

EPHB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000032936	ENSOGAP00000017746	ENSOGAT00000033819

Organism

Otolemur garnettii

Functional Description

Protein Length

1004

Protein Sequence
(FASTA)

MARARPPPPP PPPGLLPLLP PLLLPPLLLL PLLLPIGCRA LEETLMDTKW VTSELAWTAH 60

PESGWEEVSG YDEAMNPIRT YQVCNVRESS QNNWLRTGFI WRRDVQRVYV ELKFTVRDCN 120

SIPNIPGSCK ETFNLFYYEA DSDVASASSP FWMENPYVKV DTIAPDESFS RLDAGRVNTK 180

VRSFGPLSKA GFYLAFQDQG ACMSLISVRA FYKKCASTTA GFALFPETLT GAEPTSLVIA 240

PGTCIPNAVE VSVPLKLYCN GDGEWMVPVG ACTCATGHEP AAKESQCRPC PPGSYKAKQG 300

EGPCLPCPPN SRTTSPAASI CTCHNNFYRA DSDSADSACT TVPSPPRGVI SNVNETSLIL 360

EWSEPRDLGG RDDLLYNVIC KKCHGGPGAG GPSTCSRCDD NVEFVPRQLG LTERRVHISH 420

LLAHTRYTFE VQAVNGVSGK SPLPPRYAAV NITTNQAAPS EVPTLRLHSS SGSSLTLSWA 480

PPERPNGVIL DYEMKYFEKS EGIASTVTSQ KNSVQLDGLR PDARYVVQVR ARTVAGYGQY 540

SRPAEFETTS ERGSGAQQLQ EQLPLIVGSA TAGLVFVVAI VVIAIVCLRK QRHGSDSEYT 600

EKLQQYIAPG MKVYIDPFTY EDPNEAVREF AKEIDVSCVK IEEVIGAGEF GEVCRGRLKQ 660

PGRREVFVAI KTLKVGYTER QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMILTEFM 720

ENCALDSFLR LNDGQFTVIQ LVGMLRGIAA GMKYLSEMNY VHRDLAARNI LVNSNLVCKV 780

SDFGLSRFLE DDPSDPTYTS SLGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY 840

GERPYWDMSN QDVINAVEQD YRLPPPMDCP TALHQLMLDC WVRDRNLRPK FSQIVNTLDK 900

LIRNAASLKV IASAQSGMSQ PLLDRTVPDY TTFTTVGDWL DAIKMGRYKE SFVSAGFASF 960

DLVAQMTAED LLRIGVTLAG HQKKILSSIQ DMRLQMNQTL PVQV 1004

Nucleotide Sequence
(FASTA)

ATGGCCAGAG CCCGCCCGCC GCCGCCGCCG CCGCCGCCGG GGCTCCTGCC ACTGCTCCCT 60

CCGCTGCTGC TGCCGCCGCT GCTGCTGCTG CCGCTACTGC TGCCCATCGG CTGCCGGGCG 120

CTGGAAGAGA CCCTCATGGA CACGAAATGG GTAACCTCTG AGTTGGCATG GACAGCTCAT 180

CCGGAAAGTG GGTGGGAGGA GGTGAGTGGC TACGATGAGG CCATGAACCC CATCCGCACG 240

TACCAGGTGT GTAATGTACG AGAGTCAAGC CAGAACAACT GGCTTCGCAC AGGGTTCATC 300

TGGCGGCGAG ATGTGCAGCG GGTCTACGTG GAACTCAAGT TCACTGTGCG TGACTGTAAT 360

AGCATCCCCA ACATCCCTGG CTCCTGCAAG GAGACCTTCA ACCTCTTCTA CTATGAAGCT 420

GACAGTGACG TGGCCTCGGC CTCCTCCCCC TTCTGGATGG AGAACCCCTA TGTGAAAGTG 480

GACACCATTG CACCTGATGA GAGCTTCTCG CGGCTCGATG CTGGCCGTGT GAATACCAAG 540

GTGCGCAGCT TCGGGCCACT TTCCAAGGCT GGCTTCTACC TAGCCTTCCA GGACCAGGGC 600

GCCTGCATGT CACTCATCTC TGTGCGTGCC TTCTACAAGA AATGTGCATC CACCACCGCA 660

GGCTTTGCGC TTTTCCCTGA GACCCTCACT GGGGCAGAGC CCACCTCACT GGTCATTGCT 720

CCTGGCACCT GCATCCCTAA TGCTGTGGAG GTGTCAGTGC CACTCAAGCT CTACTGCAAT 780

GGCGATGGGG AGTGGATGGT GCCTGTGGGC GCCTGCACCT GTGCCACCGG CCATGAGCCA 840

GCTGCCAAGG AGTCCCAGTG CCGCCCCTGT CCCCCTGGGA GCTACAAGGC GAAGCAGGGA 900

GAGGGGCCTT GTCTCCCCTG CCCCCCCAAC AGCCGCACCA CCTCACCAGC TGCCAGCATC 960

TGCACCTGCC ACAATAACTT CTACCGTGCG GACTCAGACT CTGCAGACAG TGCCTGTACC 1020

ACGGTGCCAT CTCCACCCCG GGGTGTGATC TCGAATGTGA ATGAGACCTC ACTGATCCTT 1080

GAGTGGAGTG AGCCCAGGGA CCTGGGTGGC CGCGATGACC TCCTATACAA TGTCATTTGC 1140

AAGAAGTGCC ACGGGGGCCC TGGGGCTGGA GGGCCCTCAA CCTGTTCACG CTGTGATGAC 1200

AATGTGGAGT TTGTGCCTCG GCAGCTGGGC CTGACAGAAC GCCGGGTCCA CATCAGCCAT 1260

CTACTGGCTC ACACACGCTA CACCTTTGAG GTGCAGGCAG TCAATGGTGT CTCGGGCAAG 1320

AGCCCTCTGC CGCCCCGCTA CGCTGCTGTG AATATTACCA CCAACCAGGC CGCCCCATCC 1380

GAAGTGCCTA CACTACGCCT GCACAGCAGC TCAGGCAGCA GCCTGACCCT GTCCTGGGCA 1440

CCCCCGGAAC GGCCCAATGG AGTCATCCTG GACTATGAGA TGAAGTACTT TGAGAAGAGT 1500

GAGGGCATCG CCTCCACAGT GACCAGCCAG AAGAACTCTG TGCAGCTGGA TGGGCTGCGG 1560

CCAGATGCCC GCTATGTGGT CCAGGTCCGT GCCCGTACAG TAGCTGGCTA TGGGCAGTAC 1620

AGCCGCCCAG CTGAGTTTGA GACCACAAGT GAGAGAGGCT CTGGGGCCCA GCAGCTCCAG 1680

GAGCAGCTCC CCCTCATTGT GGGCTCTGCG ACAGCTGGGC TTGTCTTCGT GGTGGCTATC 1740

GTTGTCATTG CTATTGTCTG CCTCAGGAAG CAGCGGCACG GCTCTGACTC AGAGTACACG 1800

GAGAAGCTGC AGCAGTACAT TGCTCCTGGA ATGAAGGTAT ATATTGACCC TTTCACCTAT 1860

GAGGACCCTA ATGAGGCTGT TCGGGAGTTT GCCAAAGAGA TTGATGTGTC CTGTGTCAAG 1920

ATCGAGGAGG TGATTGGAGC TGGGGAGTTT GGGGAAGTAT GCCGTGGTCG GCTGAAACAG 1980

CCTGGCCGCC GGGAAGTGTT TGTGGCCATC AAGACACTGA AGGTGGGCTA CACTGAGAGG 2040

CAGCGGCGGG ACTTCCTGAG TGAAGCCTCC ATCATGGGTC AGTTTGATCA CCCCAACATA 2100

ATCCGGCTAG AGGGTGTGGT CACCAAAAGT CGGCCGGTTA TGATCCTCAC GGAGTTCATG 2160

GAGAACTGCG CCCTAGACTC TTTCCTCCGG CTCAACGATG GGCAGTTCAC AGTCATCCAG 2220

CTGGTGGGCA TGTTGCGGGG CATTGCTGCT GGCATGAAAT ACCTATCTGA GATGAACTAC 2280

GTGCACCGCG ACCTGGCTGC CCGCAACATC CTTGTCAACA GCAACCTGGT CTGCAAAGTC 2340

TCAGACTTTG GCCTCTCTCG CTTCCTGGAA GATGACCCCT CTGATCCTAC CTACACCAGC 2400

TCCCTGGGTG GAAAGATCCC CATTCGCTGG ACTGCCCCGG AAGCCATAGC CTATCGGAAG 2460

TTCACTTCTG CTAGTGATGT CTGGAGCTAT GGAATTGTCA TGTGGGAGGT CATGAGCTAT 2520

GGAGAGCGAC CCTACTGGGA CATGAGCAAC CAGGATGTCA TCAATGCTGT GGAGCAGGAT 2580

TACCGGCTGC CACCACCCAT GGACTGCCCA ACGGCACTGC ACCAGCTCAT GCTGGATTGC 2640

TGGGTGCGGG ACCGGAACCT CAGGCCCAAA TTCTCTCAGA TTGTCAATAC CCTAGACAAG 2700

CTCATCCGCA ATGCTGCCAG CCTCAAGGTT ATCGCCAGTG CCCAGTCTGG CATGTCACAG 2760

CCCCTCTTGG ACCGCACAGT CCCAGATTAT ACAACCTTCA CAACAGTTGG TGATTGGCTG 2820

GATGCCATCA AGATGGGGCG GTACAAGGAG AGCTTTGTCA GTGCAGGGTT TGCATCCTTT 2880

GACCTGGTGG CCCAGATGAC CGCAGAAGAC CTGCTCCGGA TAGGGGTCAC CTTAGCTGGC 2940

CACCAGAAGA AGATCCTCAG CAGTATCCAG GACATGCGGC TGCAGATGAA CCAGACACTG 3000

CCTGTGCAGG TCTGA 3015

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         vkie+viGaGefGevc+Grlk+pg+re+ vaiktlk g+te+qrrdflseasi+Gqfdhp

Q: 639   VKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHP  698

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         niirleGvvtks+pvmi+te+men+aldsflr +dgqftviqlvgmlrGia+gmkyls+m

Q: 699   NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEM  758

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178

         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt+s ggkipirwtapeaiay

Q: 759   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPsDPTYTSSlGGKIPIRWTAPEAIAY  818

         **********************************99*****999****************

S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238

         rkftsasdvwsyGiv+wev+syGerpywdmsnqdvi+a+e++yrlpppmdcp+al+qlml

Q: 819   RKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLML  878

         ************************************************************

S: 239   dcwqkdraerpkfeqivsil  258

         dcw +dr+ rpkf+qiv++l

Q: 879   DCWVRDRNLRPKFSQIVNTL  898

         *****************975

Domain Sequence
(FASTA)

VKIEEVIGAG EFGEVCRGRL KQPGRREVFV AIKTLKVGYT ERQRRDFLSE ASIMGQFDHP 60

NIIRLEGVVT KSRPVMILTE FMENCALDSF LRLNDGQFTV IQLVGMLRGI AAGMKYLSEM 120

NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDPSDPTY TSSLGGKIPI RWTAPEAIAY 180

RKFTSASDVW SYGIVMWEVM SYGERPYWDM SNQDVINAVE QDYRLPPPMD CPTALHQLML 240

DCWVRDRNLR PKFSQIVNTL 260

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013