EPS-OTG-00009

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-OTG-00009

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	151.8	1.1E-44	133	278	146

Status

Unreviewed

Ensembl Protein

ENSOGAP00000018068

UniProt Accession

H0XPM7;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSOGAG00000034721	ENSOGAP00000018068	ENSOGAT00000034152

Organism

Otolemur garnettii

Functional Description

Protein Length

1166

Protein Sequence
(FASTA)

MATGGDPEEE QVVPGEEDEA NIRAVQAHYL RSPSPSQYSM VSDAETESIF MEPIHLSSAI 60

AAKQIINEEL KPRELKADTE CPGLLESAEQ LLVEDLYNRV REKMDDTSLY NTPCILDLQR 120

ALLQDRQETP WNEVDEVWPN VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYT 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL 240

MIFHNMAILE ALMTVRKKRA IYPNDGFLKQ LRALNEKLME EREEDYGGEE GADEAELDQE 300

AGSTIGARVH TLEVEEEDDT TSHLSGSSLG KASQASKPHT LIDEEEEEKL YEEWKKAQGL 360

PTGRVPPGGE DGRSTSSGHG AGELEDEDVE SIVREWQSRN ERYQAEGHRR WAREEDEEEV 420

EDSNAGSFAG SRRRRTLSQS SASESVCSRD IWVLKQQLAA RAQSRGGRRR SDSVSTESTW 480

DMWNERLLEI EREAARTYRS RSRREQADAG SDAAGSDAGS GAPEEDGDSV FSEAPSFYNF 540

CSRNKDKLTA LERWKIKRIQ FGFHKKDLEA GDGSSAHGAE EAAGDKEQPS DVNLTAYQAW 600

KLKHQKKVGS ENKEEVAELC KGEDSALAKK RQRRLELLER SRQTLEESQS MASWEAASSA 660

SGSIPLSAFW SAAPSVSADG DTASVFSTQS HRSHSAQATS NAGGGSTSNP TTPLPNLPVG 720

PGDTVSIASI QNWIAQVVSE TLAQKQNEML LLSRSPSVAS MKAAPAASCL GDDQVSMLGG 780

QSSSSLGGYP LPQSQARLGT DAQSVLSSHT ALSLREEGTG SRVRGTSKPI YSLFADDVNL 840

RELGQKEKEM QMELREKMSE YRMEKLASDN KRSTLFKKKK VKEDENDGVG DRDEDTDSAI 900

GSFRYSSRSN SQRPEADTSS SSLAVCDHYG SGSRAGKELD GSINKWLCGL RTEDKSPPPS 960

DWSGSSRGKY TRSSVLRETE SKSSSYKFSK SQSEEQDTAS YHEANGNSVR STSRFSSSST 1020

SEGREMHKFS RSKFSETSSS RGESPEPYFF RRTPEPSEGE ESPEPQHPHW TGPRDWEDVE 1080

ESSKSDFSEF GAKRKFTQSF MRSEEEGEKE RMENREEGRF ASGRRSQYRR SNDRAEEEEM 1140

DDEAIIAAWR RRQEERRTKL QRRKED 1166

Nucleotide Sequence
(FASTA)

ATGGCGACCG GTGGAGACCC AGAGGAGGAG CAGGTAGTCC CAGGGGAGGA GGATGAAGCC 60

AACATCAGGG CTGTGCAGGC CCACTACCTC CGGAGCCCTT CCCCCAGCCA GTACTCAATG 120

GTCTCAGATG CAGAAACAGA AAGCATTTTC ATGGAGCCCA TTCACCTCTC CTCAGCTATT 180

GCAGCCAAAC AGATCATCAA TGAAGAACTC AAGCCGCGGG AGCTCAAAGC AGACACAGAG 240

TGTCCAGGCT TGCTGGAGTC TGCTGAGCAG CTGCTGGTGG AGGACTTGTA CAACCGCGTC 300

AGGGAGAAGA TGGATGACAC CAGCCTGTAC AACACCCCCT GCATCCTGGA CTTACAGCGG 360

GCCCTGCTTC AGGACCGGCA AGAGACCCCA TGGAACGAGG TAGATGAAGT CTGGCCCAAC 420

GTCTTCATAG CTGAGAAGAG TGTGGCAGTG AACAAGGGTA GGCTGAAGAG GCTGGGAATC 480

ACCCATATCC TGAATGCTGC GCATGGCACA GGCGTTTATA CTGGCCCTGA ATTCTATACT 540

GGCCTGGAGA TCCAGTACCT GGGTGTGGAG GTGGATGACT TTCCTGAGGT GGACATCTCC 600

CAGCATTTCC GAAAGGCTGC TGAGTTCCTT GATGAAGCAC TGCTGACCTA TCGAGGGAAA 660

GTCCTGGTCA GCAGCGAAAT GGGCATCAGC CGCTCGGCGG TGCTGGTGGT GGCCTATCTG 720

ATGATCTTCC ACAACATGGC CATCCTGGAG GCCCTGATGA CCGTGCGCAA GAAGCGCGCC 780

ATCTACCCCA ACGACGGCTT CCTGAAGCAG CTGCGGGCGC TCAATGAGAA GCTGATGGAG 840

GAGAGAGAAG AGGACTACGG TGGGGAGGAG GGGGCGGACG AGGCTGAGCT GGACCAGGAG 900

GCCGGGAGCA CCATCGGGGC CCGAGTGCAC ACCCTGGAGG TGGAGGAGGA GGATGACACC 960

ACCAGCCACC TGAGCGGCTC CTCCCTGGGG AAGGCCAGCC AGGCTTCCAA GCCCCACACT 1020

CTCATTGACG AAGAGGAGGA GGAGAAACTC TACGAGGAGT GGAAGAAGGC CCAGGGCCTC 1080

CCCACGGGCA GGGTCCCCCC CGGGGGAGAG GACGGGCGCT CAACCTCCTC GGGCCACGGC 1140

GCAGGGGAGC TGGAGGACGA GGACGTGGAG AGCATCGTCC GGGAGTGGCA GAGCCGGAAC 1200

GAGCGGTACC AAGCAGAGGG GCACCGGAGG TGGGCTAGGG AGGAGGACGA GGAAGAGGTG 1260

GAGGACAGCA ACGCGGGATC CTTTGCTGGC AGCAGGCGGC GGCGCACGCT GAGCCAGAGC 1320

AGCGCGTCCG AGAGCGTCTG CAGCCGCGAC ATTTGGGTCC TAAAGCAGCA GCTGGCCGCC 1380

AGGGCCCAGA GCCGCGGCGG GCGGCGCCGC TCCGACTCGG TGTCCACAGA GAGCACCTGG 1440

GACATGTGGA ACGAGAGGCT GCTGGAGATC GAGAGGGAGG CGGCCCGCAC GTACCGTTCC 1500

CGGAGCAGGA GAGAGCAGGC AGACGCGGGC TCCGACGCCG CGGGCTCCGA CGCAGGGAGC 1560

GGGGCGCCGG AGGAGGACGG CGACAGTGTG TTCTCCGAGG CCCCCTCCTT CTACAACTTC 1620

TGCAGCAGGA ACAAGGACAA ACTCACTGCC CTGGAACGGT GGAAGATCAA GAGAATCCAA 1680

TTTGGGTTCC ACAAGAAAGA CTTGGAAGCG GGCGACGGCA GCAGTGCGCA CGGAGCGGAG 1740

GAGGCAGCCG GGGACAAGGA GCAACCCTCC GACGTCAACC TGACCGCCTA CCAGGCCTGG 1800

AAGCTCAAAC ACCAGAAGAA GGTGGGGAGT GAGAACAAGG AGGAGGTGGC AGAGCTCTGC 1860

AAGGGGGAGG ACTCGGCCTT AGCCAAGAAG AGGCAGCGGA GGCTGGAGCT GCTGGAGAGG 1920

AGCAGGCAGA CGCTGGAGGA GAGCCAGTCC ATGGCAAGCT GGGAGGCGGC CAGCTCGGCC 1980

AGCGGGAGCA TCCCCCTCTC TGCCTTCTGG TCTGCGGCCC CCTCGGTCAG CGCTGATGGG 2040

GACACAGCGT CCGTGTTCAG CACCCAGAGC CACCGCTCCC ACTCGGCTCA GGCCACAAGC 2100

AACGCAGGGG GAGGCTCGAC CTCCAACCCC ACCACACCCC TGCCTAACCT GCCAGTGGGG 2160

CCTGGAGACA CGGTTTCCAT CGCCAGTATC CAGAACTGGA TTGCCCAGGT AGTCAGTGAG 2220

ACCCTCGCTC AGAAGCAAAA CGAAATGCTG TTACTGTCCC GCTCACCATC CGTGGCAAGC 2280

ATGAAGGCAG CACCAGCAGC CAGCTGCCTA GGGGACGACC AAGTCTCCAT GCTCGGTGGA 2340

CAGAGCAGCT CCTCCCTGGG CGGCTACCCG CTGCCGCAGA GCCAGGCCAG ACTGGGCACC 2400

GACGCACAGT CTGTGTTGTC CTCCCACACC GCGCTGAGCT TGAGGGAGGA AGGCACCGGG 2460

AGCAGAGTGA GGGGGACCAG CAAGCCCATC TACAGCCTCT TCGCTGACGA TGTGAACCTG 2520

AGGGAGCTGG GCCAGAAGGA AAAGGAGATG CAAATGGAGC TGAGGGAGAA GATGTCTGAG 2580

TACAGAATGG AGAAACTGGC CTCAGACAAC AAACGCAGTA CCCTTTTCAA GAAGAAGAAG 2640

GTCAAGGAGG ATGAGAATGA TGGCGTGGGT GATAGAGATG AGGACACTGA CAGTGCCATA 2700

GGGAGCTTCC GATATTCTTC CCGCAGTAAT TCCCAAAGAC CTGAAGCAGA CACCTCCTCT 2760

TCTTCCCTGG CAGTCTGTGA CCACTATGGG AGTGGCAGCA GAGCTGGCAA AGAGCTGGAT 2820

GGCAGTATTA ATAAATGGCT CTGTGGGCTC AGGACAGAGG ACAAATCTCC TCCCCCAAGC 2880

GATTGGTCTG GAAGCTCCAG GGGGAAATAC ACCAGATCAT CCGTGCTCCG AGAAACTGAG 2940

TCTAAATCCT CCAGCTATAA GTTCTCCAAA TCTCAGTCGG AGGAACAGGA CACGGCCTCC 3000

TACCATGAGG CAAATGGCAA CTCTGTAAGA AGCACTTCAC GGTTCTCTTC TTCTTCCACC 3060

AGCGAAGGCA GAGAGATGCA CAAGTTCTCC AGGTCCAAGT TCAGTGAGAC CTCAAGCTCC 3120

CGAGGGGAGA GCCCAGAACC CTACTTCTTC CGCAGGACCC CTGAGCCCTC CGAAGGGGAA 3180

GAGTCCCCAG AGCCACAGCA CCCACATTGG ACTGGGCCCA GGGACTGGGA AGATGTGGAA 3240

GAGTCATCCA AGTCAGACTT TTCTGAATTT GGAGCCAAGA GGAAATTCAC CCAGAGCTTT 3300

ATGAGGTCTG AAGAGGAGGG AGAGAAAGAG AGGATGGAAA ACAGAGAAGA AGGGAGGTTT 3360

GCATCTGGGC GGCGGTCCCA GTATCGGAGA AGCAATGACA GGGCAGAAGA GGAAGAGATG 3420

GATGATGAGG CCATCATTGC AGCTTGGAGA CGCCGGCAAG AAGAAAGGAG GACTAAGCTG 3480

CAGAGAAGGA AGGAAGATTG A 3501

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 133   EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++G+sRSa+lv+aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pn+gfl+QL++l++kl

Q: 252   LMTVRKKR-AIYPNDGFLKQLRALNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGISRS AVLVVAYLMI FHNMAILEAL 120

MTVRKKRAIY PNDGFLKQLR ALNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013