EKS-ORN-00340

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00340

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	413.7	3.7E-124	38	290	253

Status

Unreviewed

Ensembl Protein

ENSONIP00000000232

UniProt Accession

I3IUE2;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000000179	ENSONIP00000000232	ENSONIT00000000231

Organism

Oreochromis niloticus

Functional Description

Protein Length

582

Protein Sequence
(FASTA)

MSAGVAKPAN PMPHVDPKSA TLKEIPDVLV DPRTMRRYTR GRFLGKGGFA KCYEITDVET 60

KQVFAGKIVP KSLILKQHQR EKMTSEISIH QSLNHPNVVG FHGFFEDDDF VFVVLEICRR 120

RSLLELHKRR KAVTEPEARY YMTQLLKGVQ YLHNNKVIHR DLKLGNIFLN DDMDVKIGDF 180

GLATKIEFDG ERKKTLCGTP NYIAPEVLCK KGHSYEVDVW SLGCILYTLL VGKPPFETSC 240

LKETYNRIKK NNYTIPWHIN PAATALIKRM LHADPTQRPT IAELQADEFI TSGYIPLRLP 300

TTCLTVPPRF SIAPSTSTEL SQRRPLTAIN NKVGTEKVEM KDEPAPREVE PSENHLRDML 360

QQLNTIIAAK PSEKAVVRQE EAEDPACIPI FWISKWVDYS DKYGLGYQLC DNSVGVLFND 420

YTRLIMYADG DSLQYIDKTA TESYMSVRSF PSTLNKKITL LKYFRNYMSE HLLKAGANIA 480

RREGDELARL PYLSLWFRTK SAIVLHLTNG TVQINFFQDH TKLILCPLMA AVTYIDEKRD 540

FRTYKLSLLE EFGCSKELAS RIRYAKLMVE KLLDSKPSPA AH 582

Nucleotide Sequence
(FASTA)

ATGAGCGCTG GTGTTGCAAA GCCGGCGAAC CCGATGCCGC ACGTCGACCC AAAATCGGCC 60

ACTCTAAAAG AAATCCCTGA TGTTCTGGTC GACCCACGCA CCATGAGACG ATACACGAGG 120

GGGAGATTCC TCGGGAAAGG TGGATTTGCA AAATGCTACG AAATCACAGA CGTGGAGACA 180

AAGCAGGTTT TCGCCGGAAA GATCGTGCCC AAATCGCTGA TCCTGAAGCA GCACCAGAGG 240

GAGAAGATGA CTTCGGAAAT CTCCATTCAC CAAAGCCTCA ACCACCCCAA CGTCGTGGGC 300

TTCCACGGGT TCTTCGAGGA CGATGATTTT GTGTTTGTCG TCCTGGAAAT CTGCAGGAGA 360

AGGTCCCTGC TGGAGTTGCA CAAGCGTCGT AAGGCTGTCA CAGAGCCCGA GGCCCGATAC 420

TACATGACTC AGCTGCTCAA GGGTGTCCAG TACCTGCACA ACAACAAAGT GATCCACAGA 480

GACCTGAAAC TGGGCAACAT CTTCCTCAAC GACGACATGG ACGTCAAGAT AGGGGATTTT 540

GGCCTTGCCA CAAAGATTGA GTTTGATGGT GAGCGGAAGA AGACCTTGTG TGGAACACCT 600

AACTACATAG CTCCTGAAGT GCTCTGCAAG AAAGGCCACA GCTATGAAGT GGATGTCTGG 660

TCACTTGGGT GTATATTGTA CACTTTGTTG GTGGGCAAGC CTCCATTTGA GACCTCCTGT 720

CTGAAGGAGA CCTACAACCG CATCAAGAAA AACAACTACA CCATCCCCTG GCACATCAAC 780

CCAGCAGCGA CCGCCCTCAT CAAAAGGATG CTGCATGCCG ATCCCACCCA GAGGCCCACC 840

ATTGCTGAGC TGCAAGCGGA TGAGTTCATC ACGTCCGGCT ACATCCCCTT GCGCCTGCCC 900

ACGACTTGTC TCACGGTGCC CCCGCGGTTC TCTATTGCCC CTTCCACAAG TACCGAGCTC 960

AGCCAGAGGC GCCCGTTGAC AGCTATAAAT AACAAAGTAG GGACAGAGAA GGTGGAGATG 1020

AAGGACGAGC CTGCACCACG GGAGGTTGAA CCGTCGGAGA ACCACCTCAG AGACATGCTG 1080

CAGCAGCTCA ACACCATCAT TGCTGCCAAG CCTTCTGAGA AGGCAGTCGT CCGCCAAGAG 1140

GAGGCAGAGG ATCCTGCATG CATCCCCATC TTCTGGATCA GCAAATGGGT GGACTACTCT 1200

GATAAATATG GACTGGGATA TCAGCTGTGT GACAACAGCG TTGGCGTTCT GTTTAACGAT 1260

TACACCCGTC TGATCATGTA CGCTGACGGA GACAGCCTGC AGTACATCGA CAAAACGGCA 1320

ACTGAATCCT ACATGAGTGT GCGCTCTTTC CCTTCCACTC TTAACAAGAA GATAACATTG 1380

CTGAAATACT TCCGCAATTA CATGAGCGAG CACCTGCTGA AGGCTGGCGC AAACATAGCA 1440

CGTCGGGAAG GAGATGAGCT GGCACGACTG CCGTACCTTT CCCTCTGGTT CAGAACCAAA 1500

AGCGCCATTG TGCTGCACCT CACTAACGGC ACGGTTCAGA TCAATTTCTT CCAGGACCAC 1560

ACCAAGCTGA TCCTGTGTCC GCTGATGGCT GCGGTGACCT ACATAGATGA GAAACGAGAC 1620

TTCCGCACCT ACAAGCTGTC TCTCCTGGAG GAGTTCGGTT GCAGTAAGGA GCTGGCGAGC 1680

CGCATTCGTT ACGCCAAGCT CATGGTGGAG AAACTGTTGG ACAGCAAGCC CTCTCCCGCT 1740

GCACATTAG 1749

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rg++lGkGgfakcye++d+etk+vfa k+vpksl+ k++qrek+++ei+ih+sl+h+n

Q: 38    YTRGRFLGKGGFAKCYEITDVETKQVFAGKIVPKSLILKQHQREKMTSEISIHQSLNHPN  97

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v ++ ffed+++v++vle+c+rrsl el+krrka+tepe+ryy++q+++g++ylh++++

Q: 98    VVGFHGFFEDDDFVFVVLEICRRRSLLELHKRRKAVTEPEARYYMTQLLKGVQYLHNNKV  157

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgn+fln++++vkigdfGlat++e ++erkktlcGtPnyiaPevl kkghs+ev

Q: 158   IHRDLKLGNIFLNDDMDVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSYEV  217

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGcilytllvGkPPfet++lkety++ikk++y++P +++++a+ li+++l+++P++

Q: 218   DVWSLGCILYTLLVGKPPFETSCLKETYNRIKKNNYTIPWHINPAATALIKRMLHADPTQ  277

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp++ e+  def+

Q: 278   RPTIAELQADEFI  290

         *******999985

Domain Sequence
(FASTA)

YTRGRFLGKG GFAKCYEITD VETKQVFAGK IVPKSLILKQ HQREKMTSEI SIHQSLNHPN 60

VVGFHGFFED DDFVFVVLEI CRRRSLLELH KRRKAVTEPE ARYYMTQLLK GVQYLHNNKV 120

IHRDLKLGNI FLNDDMDVKI GDFGLATKIE FDGERKKTLC GTPNYIAPEV LCKKGHSYEV 180

DVWSLGCILY TLLVGKPPFE TSCLKETYNR IKKNNYTIPW HINPAATALI KRMLHADPTQ 240

RPTIAELQAD EFI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013