EKS-ORN-00595

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00595

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	342.1	3.0E-102	20	316	297

Status

Unreviewed

Ensembl Protein

ENSONIP00000000234

UniProt Accession

I3IUE3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000000180	ENSONIP00000000234	ENSONIT00000000233
ENSONIG00000000180	ENSONIP00000000233	ENSONIT00000000232

Organism

Oreochromis niloticus

Functional Description

Protein Length

749

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGYGG SGLVFSAVDT DCDKRVAVKK IILTDPQSVK 60

HALREIKIIR RLDHDNIVKV FETLGPNGCR LTEDVVSLTE VNSVYIVQEY METDLCQLLE 120

RGLLSEDHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFV NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV LRDEDRQELH SVIPVFIRND MTKPHTPLAK LLPDVSPQAL DFLEKILTFN 300

PMDRLTAEEA LAHPYMADYS FPLDEPVSLH PFHIEDEVDD ILLMDQSHSH TCDSIRYHES 360

QFSEADWHLH STHDPDEVQV DPRALSDVTD EEVVQVDPRK YADGDREKFL DKPSFDYSTP 420

FPLERSWQDD HHENKYCDLQ CSHTCNYKAV SPSYLDNLIW RDSEVNHYYE PKLIIDLSNW 480

KEQQSKEKAD RKSKSKCEKN GLVKAQIALQ EAEKSPVEKD KVQQNQGFDF DSFIASTIKL 540

SLQPEPCQEV TLLNDVELLN EVGLLNELNF SVSQLEAPRS TSMSKSISQE KEEKCLVNLA 600

QLGGGGLGVV GGDCVWPARP WESSGDTVGE NGILIDEACW DIGKEDHLQK ESPYTSYLDH 660

LFSRREEAVS ETASPQIGSP VVRELDESFL DRSTEIVLNM QLDSLALPGF DSTDDLPLKS 720

IQASLTPCAV KCSPQIAHKT YSNIFKHLN 749

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AGTTTGAGTC ACTGATGAAC ATCCACGGCT TTGACCTGGG TTCTCGCTAC 60

ATGGACTTGA AGCCTCTGGG CTACGGAGGG AGTGGCCTCG TGTTCTCAGC AGTTGACACT 120

GACTGTGACA AGCGTGTAGC CGTGAAGAAA ATTATCTTGA CTGACCCCCA GAGCGTCAAG 180

CACGCCCTCC GGGAAATCAA GATTATCAGA CGCCTCGACC ATGACAACAT TGTCAAGGTG 240

TTTGAGACGT TGGGCCCCAA CGGTTGCAGG CTAACAGAGG ATGTGGTGTC TCTTACGGAG 300

GTCAACTCCG TCTACATTGT GCAAGAGTAC ATGGAGACTG ATTTGTGTCA GCTACTGGAG 360

AGGGGCCTTC TCTCTGAGGA TCACGCCCGG CTCTTCATGT ACCAGCTCCT CAGGGGCCTT 420

AAATACATCC ACTCTGCCAA TGTGCTGCAC CGTGACCTCA AGCCTGCCAA CCTGTTTGTC 480

AACACGGAGG ACCTGGTACT TAAAATCGGG GACTTTGGAC TGGCACGCAT TATGGACCCT 540

CACTACTCTC ACAAGGGCCA TCTCTCTGAA GGTCTCGTCA CAAAGTGGTA CAGATCTCCT 600

CGCCTGCTGC TTTCTCCTAA CAACTACACC AAAGCCATCG ACATGTGGGC TGCTGGCTGC 660

ATCTTTGCTG AGATGCTCAC AGGGAAAACC CTGTTTGCAG GAGCCCATGA ACTGGAACAG 720

ATGCAGCTGA TCCTGGAGTC AATCCCTGTA CTACGAGACG AAGACCGCCA GGAGCTCCAT 780

AGCGTAATTC CCGTCTTTAT CCGCAATGAC ATGACCAAGC CTCACACACC ATTGGCCAAA 840

CTGCTGCCTG ATGTCAGTCC GCAGGCCCTT GATTTCCTGG AGAAGATCCT GACCTTTAAC 900

CCCATGGATC GTCTGACTGC GGAAGAGGCC CTGGCACACC CCTATATGGC TGACTACTCG 960

TTCCCCCTGG ATGAGCCTGT GTCTCTGCAC CCCTTTCACA TTGAGGATGA GGTAGATGAT 1020

ATCCTGCTCA TGGACCAGAG CCACAGCCAC ACTTGTGACA GCATTAGGTA TCATGAGAGC 1080

CAGTTCTCAG AAGCTGACTG GCACTTGCAC AGCACCCATG ACCCAGACGA AGTTCAGGTT 1140

GACCCAAGGG CACTCTCTGA TGTAACGGAC GAAGAGGTCG TCCAGGTGGA TCCTCGTAAA 1200

TATGCTGATG GAGATCGAGA GAAGTTCCTG GACAAGCCGT CCTTCGACTA CTCAACCCCA 1260

TTCCCACTGG AGCGATCTTG GCAGGATGAC CACCACGAGA ACAAATACTG TGACTTGCAG 1320

TGTAGCCACA CCTGTAACTA CAAGGCTGTG TCGCCCTCCT ACCTGGACAA CCTCATCTGG 1380

AGAGACAGTG AAGTCAACCA CTACTACGAA CCCAAGCTTA TCATCGACCT CTCCAACTGG 1440

AAGGAGCAGC AGAGCAAGGA GAAGGCAGAC CGCAAGTCCA AGAGCAAATG CGAGAAGAAC 1500

GGGCTGGTAA AGGCTCAGAT CGCATTGCAG GAGGCAGAGA AGAGCCCTGT AGAGAAGGAC 1560

AAAGTCCAGC AGAACCAGGG CTTTGACTTT GACTCCTTCA TTGCCAGCAC CATCAAGCTG 1620

AGCCTGCAGC CGGAGCCCTG TCAGGAGGTG ACCCTGCTCA ACGATGTGGA GCTCCTGAAT 1680

GAGGTGGGCC TCCTGAACGA GCTCAACTTT TCTGTCTCCC AGCTCGAGGC TCCTCGCTCA 1740

ACCTCTATGT CCAAGTCCAT AAGTCAGGAG AAGGAGGAGA AGTGCCTGGT AAATCTCGCC 1800

CAGCTAGGTG GCGGAGGGCT GGGAGTAGTC GGCGGGGACT GTGTCTGGCC TGCTCGCCCC 1860

TGGGAGAGCT CTGGGGACAC GGTCGGAGAG AACGGCATTT TGATAGATGA AGCGTGCTGG 1920

GACATTGGCA AAGAGGACCA CCTCCAGAAG GAAAGCCCTT ACACCAGCTA CCTGGACCAC 1980

CTGTTCAGCC GGAGGGAGGA AGCCGTCTCC GAGACTGCCA GCCCGCAGAT TGGGTCCCCG 2040

GTGGTGAGAG AGCTAGACGA GAGCTTCCTC GACAGGAGCA CGGAGATTGT GCTCAATATG 2100

CAGCTGGACT CTCTGGCCCT TCCTGGCTTT GACAGCACTG ATGACTTGCC TCTAAAATCC 2160

ATCCAGGCGT CCCTCACCCC CTGCGCTGTC AAATGCTCCC CACAAATTGC CCACAAAACA 2220

TACAGCAACA TCTTCAAACA TCTTAATTAA 2250

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G  g+v+savd+++++rva+kk+   +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGYGGSGLVFSAVDTDCDKRVAVKKII--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++ + p+         +l+e+++vY+v+e+metdL++++++  ls++h++l++yq+l

Q: 78    VKVFETLGPNGcrltedvvSLTEVNSVYIVQEYMETDLCQLLERGLLSEDHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl+vn++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFVNTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++  ++e+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVLRDEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +++s  +  +i++ ++k+++++++l+p+ s++ald+lek+L+++p++R+++eeaL+hpY+

Q: 258   ELHSV-IPVFIRNDMTKPHTPLAKLLPDVSPQALDFLEKILTFNPMDRLTAEEALAHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGYG GSGLVFSAVD TDCDKRVAVK KIILTDPQSV KHALREIKII RRLDHDNIVK 60

VFETLGPNGC RLTEDVVSLT EVNSVYIVQE YMETDLCQLL ERGLLSEDHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF VNTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VLRDEDRQEL 240

HSVIPVFIRN DMTKPHTPLA KLLPDVSPQA LDFLEKILTF NPMDRLTAEE ALAHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013