EKS-ORN-00205

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00205

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	508.0	5.5E-153	358	616	259

Status

Unreviewed

Ensembl Protein

ENSONIP00000000465

UniProt Accession

I3IV24;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

Ola.8570

Gene Synonyms/Alias

Ola.8570;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000000369	ENSONIP00000000464	ENSONIT00000000463
ENSONIG00000000369	ENSONIP00000000465	ENSONIT00000000464

Organism

Oreochromis niloticus

Functional Description

Protein Length

668

Protein Sequence
(FASTA)

MSDLEDDFAK ILLLKEERIR DLERRLADRE DEIQELKRKL HKCQSVLPSA QLIGPRTRRA 60

QGISAEPQTH QDLSRQAFRK YAKSDWSKEL IKEAILDNDF MKNLELSQIQ EIVDCMYPVE 120

YGKDSCIIKE GDVGSLVYVM EDGKVEVTKE SLKLCTMGPG KVFGELAILY NCTRTATVKT 180

LTNVKLWAID RQCFQTIMMR TGLIKHTEYM EFLKSVPSFH GLQEDILSKL ADVLEETHYE 240

DGEYIIRQGA RGDTFFIISK GKVNVTREDL PNGEPVYLRS LGKGDWFGEK ALQGEDIRTA 300

SVMAAGAVTC LVIDRDSFKH LIGGLEDVSS KGHEDADAKA KYEAENAFFF NLNLADFNII 360

DTLGVGGFGR VELVQLKSDE NKTFAMKILK KRHIVDTRQQ EHIRSEKLIM QEAHSDFIVR 420

LYRTFKDSKY LYMLMEACLG GELWTILRDR GSFEDSTTRF YTACVVEAFA YLHSKGIIYR 480

DLKPENLILD HRGYAKLVDF GFAKKIGFGK KTWTFCGTPE YVAPEIILNK GHDISADYWS 540

LGILMFELLT GSPPFSGPDP MKTYNIILRG IDMIEFPKKI TKNAANLIKK LCRDNPSERL 600

GNLKNGVKDI QKHKWFEGFN WEGLKKGTLT PPIIPNVTSA VDTSNFDSFP EDNEDPPPDD 660

NSGWDVDF 668

Nucleotide Sequence
(FASTA)

ATGAGTGATT TGGAGGACGA CTTTGCCAAG ATCCTGCTGC TAAAAGAGGA GAGAATACGG 60

GACTTGGAGA GGCGGCTTGC CGATCGGGAA GACGAGATTC AAGAACTGAA GAGAAAATTA 120

CACAAATGTC AGTCTGTTCT GCCAAGCGCT CAACTTATTG GACCCAGGAC CCGCAGGGCG 180

CAGGGCATCT CCGCGGAACC TCAAACGCAC CAGGACCTGT CAAGGCAGGC GTTTCGGAAA 240

TATGCCAAGT CCGACTGGTC CAAGGAACTG ATCAAGGAGG CCATCTTGGA CAATGACTTC 300

ATGAAGAACC TGGAGCTGTC GCAGATCCAA GAGATCGTGG ACTGCATGTA TCCTGTCGAG 360

TACGGGAAGG ACAGCTGCAT CATTAAGGAG GGCGATGTAG GCTCGCTGGT GTACGTCATG 420

GAAGATGGGA AGGTGGAGGT GACGAAGGAG AGCCTGAAGC TCTGCACCAT GGGGCCAGGA 480

AAGGTGTTTG GAGAGCTGGC TATTCTGTAC AACTGCACCA GGACTGCTAC TGTCAAGACT 540

CTAACAAATG TGAAATTGTG GGCCATTGAC CGACAATGTT TTCAGACGAT CATGATGAGG 600

ACGGGTTTAA TCAAGCACAC AGAGTATATG GAGTTTCTGA AAAGCGTCCC CTCATTCCAC 660

GGCCTACAGG AAGATATTCT GAGCAAGCTC GCTGATGTCC TTGAGGAGAC ACATTATGAA 720

GACGGAGAAT ACATCATCAG ACAGGGGGCC AGAGGAGACA CCTTCTTCAT CATCAGTAAA 780

GGAAAGGTTA ATGTAACCAG AGAAGACTTG CCCAACGGAG AGCCTGTCTA CCTCCGCAGC 840

CTCGGAAAAG GAGACTGGTT TGGAGAGAAA GCACTGCAAG GGGAGGACAT CAGGACGGCC 900

AGTGTCATGG CTGCAGGCGC AGTCACCTGT CTAGTCATCG ATCGAGATTC ATTCAAGCAC 960

CTGATTGGGG GTTTGGAGGA TGTATCCAGC AAAGGCCATG AGGATGCTGA TGCCAAAGCC 1020

AAGTATGAAG CAGAGAATGC GTTTTTCTTC AATCTGAACC TAGCTGACTT TAACATCATT 1080

GACACTCTGG GGGTTGGTGG CTTTGGACGC GTTGAGCTGG TTCAGCTCAA GAGTGATGAG 1140

AACAAAACGT TTGCCATGAA AATCCTCAAG AAGCGGCACA TTGTCGACAC GAGACAGCAA 1200

GAGCACATTC GCTCAGAAAA GCTCATCATG CAAGAGGCCC ACTCTGACTT CATTGTTAGA 1260

CTGTACAGAA CCTTCAAGGA CAGCAAATAC CTCTACATGT TGATGGAAGC ATGTTTAGGC 1320

GGAGAACTGT GGACCATTCT TAGAGACCGG GGTTCATTTG AGGACTCGAC CACCAGGTTT 1380

TACACAGCCT GTGTAGTTGA GGCTTTTGCT TACCTGCATT CCAAAGGCAT TATCTACAGA 1440

GACCTTAAAC CAGAGAACCT TATATTGGAC CACAGGGGTT ATGCCAAACT GGTGGACTTT 1500

GGCTTTGCCA AGAAGATTGG GTTTGGGAAG AAAACGTGGA CCTTCTGTGG GACACCAGAG 1560

TATGTAGCAC CAGAGATCAT TCTGAACAAG GGCCACGACA TCTCAGCTGA CTACTGGTCT 1620

CTAGGAATCC TTATGTTTGA GCTCCTAACT GGCAGTCCTC CATTCTCTGG CCCTGATCCT 1680

ATGAAAACCT ACAACATCAT CTTGAGAGGA ATCGACATGA TTGAGTTTCC AAAGAAAATT 1740

ACCAAAAATG CTGCCAACCT AATCAAAAAG CTATGCAGGG ATAATCCTTC TGAAAGACTG 1800

GGAAACTTGA AAAACGGTGT CAAAGACATC CAAAAGCACA AATGGTTTGA GGGCTTTAAC 1860

TGGGAAGGTT TGAAGAAGGG GACACTGACA CCACCTATTA TCCCTAATGT CACATCAGCA 1920

GTTGACACGA GTAATTTTGA CAGTTTCCCA GAGGACAATG AAGACCCACC TCCTGATGAC 1980

AACTCCGGCT GGGACGTTGA TTTTTGA 2007

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ksde+k+fa+kilkk+hivdt+qqeh++sek i++ea+sdf

Q: 358   NIIDTLGVGGFGRVELVQLKSDENKTFAMKILKKRHIVDTRQQEHIRSEKLIMQEAHSDF  417

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 418   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  477

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 478   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  537

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil++elltg+ppfsg+dp+ktyn+il+gid++e+p+kitk+a++likklcrdnp+

Q: 538   YWSLGILMFELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKITKNAANLIKKLCRDNPS  597

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 598   ERLGNLKNGVKDIQKHKWF  616

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SDENKTFAMK ILKKRHIVDT RQQEHIRSEK LIMQEAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMFE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKITKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00220	; S_TKc; 1.

Prosites

PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013