EPS-ORN-00073

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORN-00073

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	297.6	5.5E-89	16	186	171

Status

Unreviewed

Ensembl Protein

ENSONIP00000000488

UniProt Accession

I3IV47;

Protein Name

Protein Synonyms/Alias

Gene Name

PTEN (1 of 2)

Gene Synonyms/Alias

PTEN (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000000386	ENSONIP00000000487	ENSONIT00000000486
ENSONIG00000000386	ENSONIP00000000488	ENSONIT00000000487

Organism

Oreochromis niloticus

Functional Description

Protein Length

443

Protein Sequence
(FASTA)

ATMSSIIKEM VSRNKRRYQE DGFDLDLTYI YPNIIAMGFP AERLEGVYRN NIDDVVRFLD 60

SKHKNHYKIY NLCAERHYDT AKFNCRVAQY PFEDHNPPQL ELIKPFCEDL DQWLSEDDNH 120

VAAIHCKAGK GRTGVMICAY LLHRGKFQEA QEALDFYGEV RTRDKKGVTI PSQRRYVYYY 180

SYLLKHQLEY KPVALLFHKM VFETLPMFSG GTCNPQFVVY QLKVKIHTSN PAHTRREDKH 240

MFFEFPQPLP VCGDIKVEFF HKQNKMLKKD KMFHFWVNTF FIPGPEESGD KMENGAVNSL 300

ESQQGPPGQG LPGQGPGPGR PGQGQLQSAE CKDNWRENYR EEKKESSKES DRDKDYLILT 360

LNKNDLDKAN KDKANRYFSP NFKVKLYFTK TVEEPNSEAS TSTSVTPDVS DNEPDHYRYS 420

DTTDSDPENE PFDEEQHTQI TKV 443

Nucleotide Sequence
(FASTA)

GCTACAATGT CGTCGATTAT AAAAGAAATG GTCAGTCGGA ACAAAAGGAG ATACCAAGAG 60

GATGGTTTCG ACCTGGACTT AACATATATT TACCCAAATA TCATTGCAAT GGGCTTTCCA 120

GCAGAGAGAC TTGAAGGCGT GTACAGAAAC AATATAGATG ATGTAGTACG GTTTTTGGAT 180

TCAAAGCATA AAAACCACTA CAAAATCTAC AACCTCTGTG CAGAAAGACA CTACGATACT 240

GCCAAATTTA ACTGCAGAGT TGCACAGTAC CCCTTCGAAG ACCATAACCC TCCTCAGCTG 300

GAGCTAATTA AGCCGTTTTG TGAAGACCTG GACCAGTGGC TCAGTGAGGA TGACAATCAC 360

GTGGCGGCCA TCCACTGTAA GGCCGGGAAG GGCCGCACCG GAGTCATGAT CTGCGCGTAT 420

CTCCTCCATC GTGGGAAATT CCAGGAGGCC CAAGAAGCAC TTGACTTTTA TGGGGAGGTC 480

AGGACAAGGG ACAAGAAGGG AGTAACGATC CCGAGCCAGC GCCGCTACGT CTACTACTAC 540

AGCTACCTAC TGAAGCACCA GCTGGAGTAC AAGCCTGTGG CATTGCTCTT CCATAAAATG 600

GTGTTTGAGA CTCTCCCTAT GTTCAGCGGG GGCACCTGCA ATCCCCAGTT TGTGGTGTAC 660

CAGCTGAAAG TGAAGATTCA CACGTCGAAC CCCGCTCACA CACGGCGCGA GGACAAGCAT 720

ATGTTTTTTG AATTTCCCCA GCCGCTCCCA GTCTGCGGAG ACATCAAAGT GGAGTTCTTC 780

CATAAACAAA ATAAGATGTT GAAGAAGGAC AAAATGTTTC ATTTTTGGGT GAACACTTTC 840

TTCATCCCTG GACCAGAGGA GAGTGGGGAC AAGATGGAGA ACGGGGCAGT GAACAGTTTA 900

GAGAGCCAGC AGGGGCCACC AGGGCAGGGT CTTCCGGGAC AGGGACCTGG ACCAGGCCGA 960

CCGGGACAGG GCCAACTGCA AAGTGCCGAG TGCAAGGACA ACTGGAGAGA AAACTACAGG 1020

GAGGAGAAGA AGGAAAGCAG CAAAGAAAGC GACAGGGACA AGGACTATCT CATCCTGACA 1080

CTTAATAAGA ACGACTTGGA CAAGGCCAAC AAAGACAAAG CTAACCGCTA CTTCTCACCA 1140

AACTTCAAAG TGAAGTTGTA CTTTACGAAA ACCGTGGAGG AGCCGAACTC CGAGGCTAGT 1200

ACTTCAACAT CAGTCACCCC CGACGTTAGC GACAATGAGC CAGACCATTA TCGATACTCT 1260

GACACCACTG ACTCAGATCC GGAAAATGAA CCTTTTGATG AAGAGCAGCA CACGCAAATC 1320

ACAAAAGTGT GA 1332

Domain Profile

S: 1     rrltedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcse  60

         rr++edgfdldlty++++iia++fPae+ e+vyrnn+++vvr+ldskh+n+yk+ynlc+e

Q: 16    RRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAE  75

         79**********************************************************

S: 61    rrydltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGv  120

         r+yd++k+n++va++++ed+n+P+le ++++c++ld+Wlsedd++v+++hck+gkgr+Gv

Q: 76    RHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGV  135

         ************************************************************

S: 121   ivcayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkg  173

         ++cayll+++++ +a+eald++ge+rtr++k  gv++Psqrryv+y+s+llk

Q: 136   MICAYLLHRGKFQEAQEALDFYGEVRTRDKK--GVTIPSQRRYVYYYSYLLKH  186

         *******************************..*****************985

Domain Sequence
(FASTA)

RRYQEDGFDL DLTYIYPNII AMGFPAERLE GVYRNNIDDV VRFLDSKHKN HYKIYNLCAE 60

RHYDTAKFNC RVAQYPFEDH NPPQLELIKP FCEDLDQWLS EDDNHVAAIH CKAGKGRTGV 120

MICAYLLHRG KFQEAQEALD FYGEVRTRDK KGVTIPSQRR YVYYYSYLLK H 171

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0016314	; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800	; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0046855	; P:inositol phosphate dephosphorylation
GO:0030336	; P:negative regulation of cell migration
GO:0008285	; P:negative regulation of cell proliferation
GO:0051895	; P:negative regulation of focal adhesion assembly
GO:0051898	; P:negative regulation of protein kinase B signaling cascade
GO:0035335	; P:peptidyl-tyrosine dephosphorylation
GO:0046856	; P:phosphatidylinositol dephosphorylation
GO:0031647	; P:regulation of protein stability

KEGG

InterPros

IPR017361	; Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR014019	; Phosphatase_tensin-typ.
IPR014020	; Tensin_phosphatase_C2-dom.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00782	; DSPc; 1.
PF10409	; PTEN_C2; 1.

SMARTs

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS00383	; TYR_PHOSPHATASE_1; 1.

Prints

Created Date

20-Feb-2013