EKS-ORN-00478

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00478

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	435.2	8.7E-131	182	432	251

Status

Unreviewed

Ensembl Protein

ENSONIP00000000590

UniProt Accession

I3IVF0;

Protein Name

Protein Synonyms/Alias

Gene Name

HCK

Gene Synonyms/Alias

HCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000000464	ENSONIP00000000590	ENSONIT00000000589

Organism

Oreochromis niloticus

Functional Description

Protein Length

447

Protein Sequence
(FASTA)

ESIAMALYDY EAIHEGDLGF KKGDKLKILE ESGEWWRAML ISTGQEGYIP SNYVAKDTLE 60

AEEWFFKGVS RKDAERQLLA PGNKIGSFMI RDSETTKGSY SLSVRDNDPQ SGDTVKHYKI 120

RTLDNGGFYI SPRITFTTLQ ELVSHYKKQG DGLCQSLTNP CLSPKPEKPW EKDAWEIPRS 180

SLKLDKRLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE AFMMEANLMK TLQHDKLVRL 240

HAVVSKEEPI YIITEFMEKG SLLDFLKSDE GNRVQLPKLI DFSAQIAEGM AYIEQRNYIH 300

RDLRAANILV NKALVCKIAD FGLARIIEDN EYTAREGAKF PIKWTAPEAI NYGSFTIKSD 360

VWSFGILLTE IISYGRTPYP GMTNPEVIRH LEKGYRMQRM DSCPKELYDI MMECWKNKPE 420

DRPTFDYLQS VLEDFYTATE SQYQQQP 447

Nucleotide Sequence
(FASTA)

GAGAGTATTG CCATGGCACT GTACGACTAT GAGGCCATTC ACGAGGGAGA CCTTGGCTTC 60

AAGAAGGGAG ATAAGCTGAA AATCTTAGAA GAATCAGGCG AGTGGTGGAG AGCTATGTTA 120

ATCAGCACAG GTCAGGAAGG CTACATCCCC AGTAACTATG TAGCCAAAGA TACTCTGGAG 180

GCAGAGGAGT GGTTCTTTAA GGGCGTAAGC AGGAAAGATG CTGAGAGGCA GTTGCTGGCC 240

CCTGGGAACA AAATTGGATC CTTCATGATC CGAGACAGTG AGACTACCAA AGGCAGCTAC 300

TCTCTGTCTG TCAGGGACAA TGATCCTCAG TCCGGCGACA CAGTGAAGCA TTATAAGATT 360

CGTACACTGG ATAATGGAGG ATTCTACATC TCTCCCCGCA TCACTTTCAC CACCCTGCAG 420

GAGCTGGTCA GCCATTACAA GAAGCAAGGA GATGGTCTCT GTCAGTCCCT GACCAACCCA 480

TGCTTGAGTC CAAAACCTGA AAAGCCATGG GAGAAGGATG CGTGGGAAAT CCCAAGATCT 540

TCACTCAAAC TGGACAAGAG GCTTGGTGCT GGCCAGTTTG GAGAAGTGTG GATGGCCACA 600

TACAACAAAC ACACCAAGGT AGCAGTGAAG ACCATGAAGC CTGGCAGCAT GTCAGTGGAA 660

GCCTTCATGA TGGAGGCCAA CCTCATGAAG ACTCTACAAC ATGACAAATT GGTTCGACTT 720

CATGCTGTCG TCAGCAAAGA GGAGCCAATC TATATTATCA CAGAGTTCAT GGAGAAAGGT 780

AGTTTATTAG ACTTCTTAAA GAGTGATGAG GGCAACCGAG TCCAGCTTCC AAAGCTCATT 840

GACTTCTCTG CTCAGATTGC AGAGGGGATG GCCTACATTG AGCAGAGGAA CTACATCCAC 900

AGAGACTTGA GAGCTGCCAA CATCCTGGTC AATAAGGCTT TGGTGTGCAA GATTGCCGAC 960

TTTGGCCTGG CTCGTATCAT TGAAGACAAC GAGTACACAG CCAGGGAAGG TGCTAAGTTC 1020

CCCATTAAAT GGACAGCCCC TGAGGCCATA AACTACGGTT CTTTCACAAT CAAATCTGAT 1080

GTCTGGTCCT TTGGCATCTT GCTGACTGAG ATTATCAGCT ATGGGCGTAC ACCATACCCC 1140

GGTATGACCA ATCCAGAAGT GATCCGCCAC TTGGAGAAGG GCTACCGAAT GCAACGTATG 1200

GATAGCTGTC CCAAGGAACT ATATGACATC ATGATGGAGT GCTGGAAGAA CAAACCTGAG 1260

GACCGCCCCA CCTTTGATTA CCTGCAGAGC GTCCTGGAGG ATTTCTACAC AGCCACAGAG 1320

AGCCAGTATC AGCAGCAGCC ATGA 1344

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lkl k+lG+GqfGevw++++++++kvavkt+k+g++s eaf+ ea+++k+l+h+klv+l+

Q: 182   LKLDKRLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFMMEANLMKTLQHDKLVRLH  241

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvs+eePiyi+te+m+kGslldflk++eg++++lpkl+d++aq+aeGmay+e++n+ihr

Q: 242   AVVSKEEPIYIITEFMEKGSLLDFLKSDEGNRVQLPKLIDFSAQIAEGMAYIEQRNYIHR  301

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv++ lv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 302   DLRAANILVNKALVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDV  361

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGilltei+++G++PypGmtn ev++++e+gyr+ r+++cp+ely++++ecwk++pe+

Q: 362   WSFGILLTEIISYGRTPYPGMTNPEVIRHLEKGYRMQRMDSCPKELYDIMMECWKNKPED  421

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 422   RPTFDYLQSVL  432

         ********986

Domain Sequence
(FASTA)

LKLDKRLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FMMEANLMKT LQHDKLVRLH 60

AVVSKEEPIY IITEFMEKGS LLDFLKSDEG NRVQLPKLID FSAQIAEGMA YIEQRNYIHR 120

DLRAANILVN KALVCKIADF GLARIIEDNE YTAREGAKFP IKWTAPEAIN YGSFTIKSDV 180

WSFGILLTEI ISYGRTPYPG MTNPEVIRHL EKGYRMQRMD SCPKELYDIM MECWKNKPED 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013