EKS-ORN-00053

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00053

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RAD53	331.3	5.1E-99	193	455	263

Status

Unreviewed

Ensembl Protein

ENSONIP00000000942

UniProt Accession

I3IWF2;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK2

Gene Synonyms/Alias

CHEK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000000747	ENSONIP00000000942	ENSONIT00000000941

Organism

Oreochromis niloticus

Functional Description

Protein Length

500

Protein Sequence
(FASTA)

MSEEGPPQSQ TQSTLSPSQA KSQSQSQPGS SSSSGPTSAS QSSSGSGTLS SVDTIPVTLA 60

SVPEEPEPQP WGRLLPMVPG FRSHDCIEDQ YLFGRDSRCN YVLEDPNDRN SRKFRIYSKK 120

HFRIYREGSE VFVEDLSNNG TFLDGIPIGK DKKLPLVNNA VISLAEQRNR VFVFIDLMSD 180

DQSSLPRDLQ EKYLLTRRIG IGVCGEVRLA FERSTCRKFA VKIINKKNFQ SEGTATRNAK 240

TEIEILQRVD HPCLIKTEDF YQTEESFYIV LELMEGGELF HRVKSKQQLN ESVAKLYFYQ 300

MLRAVQVSCN GIIHRDLKPE NILLSSQDDV CLIKVTDFNQ SRILEEAVLM RTLCGTPSYL 360

APEVFTHAST TGYGLAVDAW SLGVLLFVCL GGYPPFHESF GHQSVTDQII RGEFTMVQSK 420

WKSVSDQAKD VVRKLLVVDP MKRMSIEEAL QHPWLQDQKM LETAHRLMYP SAEGGGKKPE 480

ETRTRRRRRG ATSRQTKPSP 500

Nucleotide Sequence
(FASTA)

ATGTCTGAAG AGGGGCCACC TCAGTCCCAA ACCCAGTCCA CTCTGTCCCC GTCCCAGGCC 60

AAGTCCCAGT CCCAGTCCCA GCCTGGTTCC AGTTCATCCA GTGGGCCCAC CTCAGCCAGT 120

CAGTCGTCAA GTGGCTCGGG GACTCTGAGC AGCGTGGACA CCATCCCCGT AACGCTCGCG 180

TCCGTCCCAG AGGAGCCCGA GCCGCAACCC TGGGGCCGCC TACTGCCCAT GGTCCCAGGC 240

TTCAGGAGCC ACGACTGCAT AGAGGACCAG TACCTGTTTG GACGGGACTC CAGGTGTAAC 300

TACGTCCTGG AGGATCCAAA TGACCGAAAT TCCAGAAAGT TTAGAATCTA CAGCAAGAAA 360

CACTTCAGGA TCTACAGAGA GGGCTCGGAG GTCTTCGTGG AGGACCTCAG TAATAATGGC 420

ACTTTTCTCG ATGGGATTCC GATCGGGAAA GACAAGAAGC TTCCTCTGGT CAATAACGCC 480

GTCATCTCTC TGGCTGAACA ACGAAACCGA GTGTTTGTCT TCATCGACCT GATGTCGGAC 540

GATCAGTCCA GCTTACCCAG AGACCTACAA GAGAAATACT TACTGACCCG ACGCATTGGC 600

ATAGGAGTGT GTGGCGAGGT CCGGCTGGCT TTCGAGCGAT CCACCTGCAG GAAGTTTGCA 660

GTGAAAATCA TAAACAAGAA GAACTTTCAG TCTGAAGGGA CAGCGACACG AAATGCAAAG 720

ACGGAGATCG AGATCCTGCA GAGGGTCGAC CACCCTTGTC TCATAAAGAC GGAGGACTTC 780

TATCAGACGG AGGAAAGTTT CTACATCGTG TTGGAGCTGA TGGAGGGGGG GGAGCTGTTC 840

CACAGAGTGA AGTCGAAGCA GCAGCTCAAC GAATCTGTTG CCAAACTTTA TTTTTACCAG 900

ATGCTTCGTG CTGTGCAGGT GAGCTGTAAC GGGATCATCC ACAGAGACCT GAAGCCGGAG 960

AACATCCTGC TGTCCTCACA GGACGACGTG TGTCTCATCA AGGTGACGGA CTTTAACCAG 1020

TCTCGGATCC TGGAGGAAGC GGTGCTGATG AGGACTCTGT GTGGGACTCC ATCTTACCTG 1080

GCTCCGGAGG TGTTCACGCA CGCGTCCACC ACGGGTTACG GTCTCGCCGT GGACGCCTGG 1140

AGCCTCGGCG TGCTGCTCTT CGTCTGCCTG GGAGGTTACC CTCCGTTCCA CGAGAGCTTT 1200

GGTCATCAGT CGGTCACCGA TCAGATCATC AGAGGAGAGT TCACCATGGT TCAGTCCAAG 1260

TGGAAGAGCG TCTCGGATCA AGCCAAAGAC GTGGTGAGGA AGCTGCTGGT CGTCGATCCG 1320

ATGAAGAGGA TGAGCATCGA GGAAGCTCTG CAGCACCCCT GGCTACAGGA CCAGAAGATG 1380

TTGGAGACGG CACACAGGCT CATGTACCCG TCTGCAGAGG GAGGGGGGAA GAAACCTGAG 1440

GAAACGAGGA CGAGAAGGAG ACGGCGAGGA GCAACATCCC GCCAAACGAA GCCAAGCCCT 1500

Domain Profile

S: 1     yilskelGkGafgkvklayekktgkkvavkilskrksirssreikkakeveeeveilkkl  60

         y+l +++G G +g+v+la+e++t++k+avki++k++    ++e + +++ ++e+eil+++

Q: 193   YLLTRRIGIGVCGEVRLAFERSTCRKFAVKIINKKN---FQSEGTATRNAKTEIEILQRV  249

         78999*****************************99...56677788999**********

S: 61    shPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavkylh  120

         +hP+++k +d++++ees y+vlel+egGel+++v +k++l+e+++kl+f+q+l av+ +

Q: 250   DHPCLIKTEDFYQTEESFYIVLELMEGGELFHRVKSKQQLNESVAKLYFYQMLRAVQ-VS  308

         ********************************************************9.67

S: 121   ekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvkk  180

          +giihrDlkPeniLls++++ +l+k+tDf ++++l+e  lm+tlCGtpsy+aPev ++

Q: 309   CNGIIHRDLKPENILLSSQDDVCLIKVTDFNQSRILEEAVLMRTLCGTPSYLAPEVFTHA  368

         89**********************************************************

S: 181   graeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkiseea  240

          +++y  +vD WslGv+lfv+l GypPf e+ +++s+++qi +g++++ ++kwk++s++a

Q: 369   STTGYGLAVDAWSLGVLLFVCLGGYPPFHESFGHQSVTDQIIRGEFTMVQSKWKSVSDQA  428

         ************************************************************

S: 241   kdlikklLvvdPeerlsieealnhpWl  267

         kd+++klLvvdP +r+sieeal+hpWl

Q: 429   KDVVRKLLVVDPMKRMSIEEALQHPWL  455

         **************************8

Domain Sequence
(FASTA)

YLLTRRIGIG VCGEVRLAFE RSTCRKFAVK IINKKNFQSE GTATRNAKTE IEILQRVDHP 60

CLIKTEDFYQ TEESFYIVLE LMEGGELFHR VKSKQQLNES VAKLYFYQML RAVQVSCNGI 120

IHRDLKPENI LLSSQDDVCL IKVTDFNQSR ILEEAVLMRT LCGTPSYLAP EVFTHASTTG 180

YGLAVDAWSL GVLLFVCLGG YPPFHESFGH QSVTDQIIRG EFTMVQSKWK SVSDQAKDVV 240

RKLLVVDPMK RMSIEEALQH PWL 263

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000253	; FHA_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR008984	; SMAD_FHA_domain.

Pfam

PF00498	; FHA; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00240	; FHA; 1.
SM00220	; S_TKc; 1.

Prosites

PS50006	; FHA_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013