EKS-ORN-00520
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00520
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/IRAK297.71.2E-88201487287
StatusUnreviewed
Ensembl ProteinENSONIP00000001025
UniProt AccessionI3IWN5;
Protein Name
Protein Synonyms/Alias
Gene NameIRAK1
Gene Synonyms/Alias IRAK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000000806ENSONIP00000001025ENSONIT00000001024
OrganismOreochromis niloticus
Functional Description
Protein Length750
Protein Sequence
(FASTA)
MSGRDPRAVL YFNLPASVDC EFCRIMDGLS NQDWTRFASG ILMDQNDVRL AERQERRTHW 60
VMVKCSNRNI RVGELIDLLE DLQLLRPRDV ILNWGSVLKM SLVPAPAPAP RLPSPSPFSD 120
SQFVPLPKKP GATPIQNTCR VSSIVNKGSP LPRPASPPPG LRSEVQQRHQ PQVMAPVAVS 180
SSIPVMRLSY EEVYAGTNGF SPCLQIGEGG FGVVYRATLK GMKYAVKKFK EDGLLDWALL 240
KKSFQTEVEQ LSRFRHRNIV DLLGFSDGGG SLCLIYSYME NRSLEDQLHN ECALLSWPQR 300
VSVVKDASEA LQFLHCPSEG EKPLIHGDVK SSNILLDSHM TAKLSDFGLA RFVPTGTSAA 360
STTSVGKTTT VRGTLAYLPE EYVRGGELGP KLDVYSFGVV LLEVLTGRRA LEKDGTYEGR 420
YLKDLVEDIK EGPGGSTEAV WKKHLDKRLI SGGTAEPTGS LQLAALACRC LTKLRRKRPV 480
MKDVCASLED VYKMVREPPY QSFPRPPRSL DSNIQQLSKE LSKLGPLENT YQVSQSTKFS 540
SSPSLVTLAP PDPLHSSSSL PPSSIFPPVS SCSFAGPCET DESRGFSQYD LRSQLRSNGT 600
SCRSLSPSTK AQYHCPARLT EVECNQPSVP TEDQYNFPPQ PNSTSFSIAP GPLTGAPTGP 660
ETRGQTTAGA DARLYGFSPA GSLKSTSPEP SIQINSSKQR LLEKKTQYEE GRIRTPELLS 720
SEDIYEEKSS GDIRGPEESD ELDYLPTKNK 750
Nucleotide Sequence
(FASTA)
ATGTCGGGAA GAGACCCGAG GGCCGTATTG TACTTCAACC TGCCCGCCTC CGTTGACTGT 60
GAGTTCTGCC GCATCATGGA CGGGCTGTCA AACCAGGACT GGACCCGCTT TGCCTCTGGG 120
ATCCTGATGG ATCAGAACGA CGTGCGATTG GCTGAGAGGC AGGAAAGGCG GACCCACTGG 180
GTGATGGTCA AATGCTCGAA CAGGAACATT CGAGTCGGAG AGCTGATCGA CCTGCTGGAG 240
GACCTGCAGC TGTTACGCCC CCGTGATGTC ATCTTGAATT GGGGGAGTGT ATTGAAGATG 300
TCTCTGGTTC CTGCTCCTGC TCCTGCTCCT CGTCTTCCTT CTCCGTCTCC TTTTTCTGAC 360
TCTCAGTTTG TCCCCCTTCC CAAAAAGCCT GGGGCCACAC CCATACAGAA CACCTGTAGA 420
GTGAGCTCAA TAGTAAATAA AGGAAGTCCA TTACCCAGAC CTGCATCGCC CCCCCCGGGG 480
CTGCGCTCTG AAGTGCAACA ACGCCACCAG CCGCAGGTGA TGGCGCCGGT GGCGGTGAGC 540
AGCAGCATCC CAGTGATGCG CTTGTCATAT GAAGAGGTGT ATGCTGGGAC AAATGGGTTC 600
TCCCCCTGCC TGCAGATAGG GGAGGGGGGA TTTGGAGTCG TGTACAGAGC GACTCTGAAG 660
GGCATGAAGT ACGCCGTCAA GAAATTCAAA GAGGACGGGC TGCTGGACTG GGCTCTGCTG 720
AAGAAGAGCT TCCAGACTGA AGTGGAGCAA CTGTCAAGAT TCAGACATCG CAACATTGTG 780
GATCTTTTAG GGTTCAGTGA CGGAGGAGGT TCATTGTGTC TGATTTACAG CTACATGGAA 840
AACAGATCTC TGGAGGACCA GCTGCACAAC GAGTGTGCGT TGCTCTCGTG GCCTCAGAGA 900
GTCAGTGTTG TTAAAGACGC ATCAGAAGCT CTGCAGTTTC TCCACTGCCC ATCTGAAGGC 960
GAAAAGCCGC TGATCCACGG AGACGTGAAA AGCTCCAACA TTTTGTTGGA CAGTCACATG 1020
ACGGCGAAGC TTTCAGACTT CGGTCTGGCT CGGTTTGTAC CCACCGGCAC CTCGGCAGCT 1080
AGCACGACAT CTGTGGGTAA AACAACAACA GTGAGAGGAA CGCTGGCTTA TCTGCCGGAG 1140
GAATACGTGA GGGGCGGAGA GCTGGGACCC AAACTGGACG TTTACAGCTT CGGAGTGGTG 1200
CTGCTCGAGG TGCTGACTGG ACGTCGAGCT CTGGAGAAAG ATGGGACGTA TGAAGGGAGA 1260
TACCTGAAGG ACCTGGTGGA GGATATCAAG GAAGGTCCAG GTGGCTCAAC TGAAGCAGTT 1320
TGGAAAAAGC ATCTTGACAA ACGGCTGATT TCAGGGGGCA CGGCTGAGCC TACTGGTAGC 1380
CTGCAACTGG CGGCTCTGGC CTGCAGGTGT CTGACAAAAC TCAGGAGGAA GAGACCGGTA 1440
ATGAAAGATG TGTGTGCATC TCTTGAGGAC GTATATAAAA TGGTGAGGGA GCCCCCCTAC 1500
CAGTCCTTCC CCAGACCTCC CCGCTCTCTG GACTCTAATA TACAACAGCT TTCCAAGGAG 1560
CTGAGTAAAC TGGGACCACT GGAGAATACC TACCAAGTGT CACAGTCAAC CAAATTTTCT 1620
TCCTCTCCCT CTTTGGTCAC CCTCGCCCCT CCTGACCCAC TTCACTCATC GTCATCTCTT 1680
CCCCCGTCAT CCATTTTCCC TCCTGTGTCC TCCTGTTCGT TCGCTGGTCC GTGTGAAACC 1740
GACGAGAGTC GAGGTTTCTC CCAGTACGAC CTTCGCTCTC AATTGAGATC AAACGGGACC 1800
AGCTGCAGGT CTTTATCTCC TTCCACCAAA GCCCAGTATC ACTGTCCAGC TAGGCTCACA 1860
GAGGTTGAGT GCAACCAGCC TTCGGTGCCC ACTGAGGACC AGTACAATTT CCCTCCCCAG 1920
CCCAATAGCA CCAGTTTCAG TATAGCACCC GGACCACTGA CAGGGGCCCC AACAGGACCA 1980
GAGACTAGAG GGCAAACCAC AGCAGGGGCC GATGCAAGAC TCTACGGCTT CTCTCCTGCA 2040
GGGTCCCTGA AGTCAACATC TCCAGAGCCC TCAATTCAGA TAAATTCCAG CAAACAGCGA 2100
CTCCTGGAGA AGAAAACTCA GTACGAGGAA GGAAGGATTC GTACTCCTGA GCTGCTGTCG 2160
TCTGAAGACA TCTATGAAGA GAAGAGTTCT GGGGACATCA GAGGACCAGA GGAGAGCGAT 2220
GAGCTGGATT ATCTTCCCAC TAAAAACAAG TGA 2253
Domain Profile
S: 2     sednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnil  61
         s   +igeGgfg+vyr++lk++++avkk+ke   l++  lk+sf+tE+++l+rfrH ni+
Q: 201   SPCLQIGEGGFGVVYRATLKGMKYAVKKFKEDGLLDWALLKKSFQTEVEQLSRFRHRNIV  260
         55679*******************************************************
S: 62    ellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeas  121
         +llg+s  +++lcL+Y+ym+n sLed+L+  ++++ LsWpqR+s++  +++a++fLH  s
Q: 261   DLLGFSDGGGSLCLIYSYMENRSLEDQLH--NECALLSWPQRVSVVKDASEALQFLHCPS  318
         ***************************96..789***********************654
S: 122   p...slihgdiksaNiLLDekltpKlgDfglarfap..esekqsstvlrtskvrgtlaYl  176
         +   +lihgd+ks+NiLLD ++t+Kl+Dfglarf p  +s+++++ v +t +vrgtlaYl
Q: 319   EgekPLIHGDVKSSNILLDSHMTAKLSDFGLARFVPtgTSAASTTSVGKTTTVRGTLAYL  378
         33359****************************665115666777799************
S: 177   peefirvgqltvkvDvySfGiVllEvltGlra..vdedrktkyLkdllkeeie...eekv  231
         pee++r g+l  k+DvySfG+VllEvltG+ra  +d   + +yLkdl+++  e    ++ 
Q: 379   PEEYVRGGELGPKLDVYSFGVVLLEVLTGRRAleKDGTYEGRYLKDLVEDIKEgpgGSTE  438
         ********************************5444456789*****9554441114566
S: 232   eilekfldkka...gkleeellealielalaclaekakkrPtmsqvlel  277
          + +k+ldk+    g++e++ + +l+ la++cl + ++krP m++v  +
Q: 439   AVWKKHLDKRLisgGTAEPTGSLQLAALACRCLTKLRRKRPVMKDVCAS  487
         99*******97554678****************************9876
Domain Sequence
(FASTA)
SPCLQIGEGG FGVVYRATLK GMKYAVKKFK EDGLLDWALL KKSFQTEVEQ LSRFRHRNIV 60
DLLGFSDGGG SLCLIYSYME NRSLEDQLHN ECALLSWPQR VSVVKDASEA LQFLHCPSEG 120
EKPLIHGDVK SSNILLDSHM TAKLSDFGLA RFVPTGTSAA STTSVGKTTT VRGTLAYLPE 180
EYVRGGELGP KLDVYSFGVV LLEVLTGRRA LEKDGTYEGR YLKDLVEDIK EGPGGSTEAV 240
WKKHLDKRLI SGGTAEPTGS LQLAALACRC LTKLRRKRPV MKDVCAS 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00378
EKS-ANC-00394
EKS-BOT-00406
EKS-CAJ-00411
EKS-CAF-00406
EKS-DAR-00793
EKS-DRM-00191
EKS-EQC-00398
EKS-ERE-00006
EKS-GAG-00345
EKS-GAA-00495
EKS-GOG-00398
EKS-HOS-00412
EKS-ICT-00385
EKS-LAC-00421
EKS-LOA-00415
EKS-MAM-00405
EKS-MEG-00339
EKS-MIM-00062
EKS-MOD-00395
EKS-MUM-00438
EKS-MUP-00400
EKS-MYL-00401
EKS-NOL-00370
EKS-OCP-00086
EKS-ORA-00354
EKS-ORC-00381
EKS-OTG-00408
EKS-PAT-00384
EKS-PES-00362
EKS-POA-00398
EKS-PRC-00006
EKS-PTV-00116
EKS-RAN-00420
EKS-SAH-00376
EKS-SUS-00360
EKS-TAG-00479
EKS-TAR-00515
EKS-TEN-00517
EKS-TUT-00120
EKS-VIP-00063
EKS-XET-00518
EKS-XIM-00510
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007165; P:signal transduction
KEGG
InterPros
IPR000488; Death.
IPR011029; DEATH-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00531; Death; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013