EKS-ORN-00195

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00195

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	616.2	8.3E-186	387	666	280

Status

Unreviewed

Ensembl Protein

ENSONIP00000001215

UniProt Accession

I3IX75;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2 (1 of 2)

Gene Synonyms/Alias

TLK2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000000960	ENSONIP00000001215	ENSONIT00000001214

Organism

Oreochromis niloticus

Functional Description

Protein Length

697

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVAKGSG QNQNESSNQS LCSVGSLSDK ELETPEKKAN 60

DQRVRKRKAD HFDSQGKAGA RGHKISDYFE FAGGSGPGTS PARGIPPVVR SSPQHSLSNP 120

PVMVQQGSPS SVSSNTEHSS CSLKPPSLHM LHKATQSDLT IEKLTAMENN KNSDLEKKEG 180

RIDDLLRANC DLRRQIDEQQ RMLERYKERL NKCVTMSKKL LIEKSKQEKM ACRDKSMQDR 240

LRLGHFTTVR HGASFTEQWT DGYAFQNLIK QQERINSQRE EIERQRKLLA KRKPPSMAQT 300

PPPSLEQNKR KSKANGAESE ALSQAEYHEQ EEIFKLRLGH LKKEEAEIQA ELERLERVRN 360

LHIRELKRIH NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE VYKAFDLTEQ RYVAVKIHQL 420

NKNWRDEKKE NYHKHACREY RIHKELDHPR IVKLYDYFSL DTDSFCTVLE YCEGNDLDFY 480

LKQHKLMSEK EGRSIIMQIV NALKYLNEIR PPIIHYDLKP GNILLVNGTA CGEIKITDFG 540

LSKIMDDDSY NSVDGMELTS QGAGTYWYLP PECFVVGKEP PKISNKVDVW SVGVIFYQCL 600

YGRKPFGHNQ SQQDILQENT ILKATEVQFP PKPVVTPEAK AFIRRCLVYR KEDRIDVHQL 660

ASDPFLMPHI RKSVASSGTS GMAMASTSSS SNSSASN 697

Nucleotide Sequence
(FASTA)

ATGATGGAAG AACTGCATAG CTTGGACCCC CGACGGCAGG AGCTGCTGGA GGCTCGCTTC 60

ACAGGGGTCG GTGTGGCAAA GGGCTCAGGT CAGAATCAAA ATGAGTCATC CAATCAGAGT 120

CTATGCAGTG TGGGCTCGCT CAGTGACAAA GAGCTAGAGA CTCCTGAGAA AAAGGCAAAT 180

GACCAGAGAG TGAGGAAACG CAAAGCAGAC CACTTTGACA GCCAAGGCAA AGCAGGAGCA 240

AGAGGACATA AAATTAGTGA TTATTTTGAG TTTGCGGGAG GTAGCGGTCC TGGTACCAGC 300

CCTGCCAGGG GAATTCCACC AGTGGTCCGC TCTTCCCCAC AGCACTCTCT GTCCAACCCC 360

CCTGTCATGG TGCAGCAAGG AAGCCCGTCA TCCGTCAGCT CCAACACAGA GCACTCCTCT 420

TGTTCACTGA AGCCTCCTTC TCTTCACATG CTCCACAAAG CCACACAGTC TGACCTTACT 480

ATAGAGAAAC TAACAGCAAT GGAGAACAAC AAGAACTCTG ACCTGGAGAA GAAGGAGGGC 540

CGCATAGACG ATTTGTTGCG GGCCAACTGT GATCTGAGGA GGCAAATTGA TGAACAACAG 600

AGAATGCTAG AGCGATACAA GGAACGCTTA AATAAGTGTG TGACCATGTC CAAGAAGCTT 660

CTGATTGAAA AGTCTAAACA AGAGAAGATG GCATGCCGGG ATAAAAGTAT GCAGGATAGG 720

CTTCGACTGG GTCATTTCAC CACAGTGAGA CACGGTGCAT CTTTCACTGA GCAGTGGACA 780

GATGGATATG CTTTCCAAAA TCTTATCAAA CAACAGGAAA GAATCAACTC CCAGCGAGAG 840

GAGATTGAAA GGCAGAGGAA GCTGCTAGCC AAACGCAAGC CGCCCTCCAT GGCTCAGACC 900

CCACCACCAA GCCTTGAGCA AAACAAACGC AAAAGCAAGG CCAATGGAGC AGAAAGTGAA 960

GCGTTATCAC AGGCAGAGTA CCATGAGCAG GAGGAAATCT TTAAGCTAAG ATTAGGCCAT 1020

CTGAAGAAGG AAGAGGCTGA GATCCAAGCA GAGCTAGAGA GATTGGAGCG AGTGCGAAAT 1080

CTTCACATAC GCGAGCTGAA AAGGATCCAT AATGAAGATA ATTCCCAATT CAAAGATCAC 1140

CCTACGCTAA ATGACCGATA CCTGCTACTC CATTTACTTG GACGGGGAGG TTTCAGTGAA 1200

GTTTACAAGG CCTTTGACCT AACAGAGCAA AGGTACGTTG CGGTCAAAAT TCACCAGTTA 1260

AACAAGAACT GGAGGGATGA GAAGAAGGAA AATTATCACA AACATGCTTG CAGAGAATAT 1320

AGAATCCATA AAGAGCTCGA CCACCCACGA ATAGTTAAAC TCTATGACTA CTTTTCACTT 1380

GACACTGACT CGTTCTGCAC AGTCCTGGAA TACTGTGAGG GTAATGACTT GGACTTCTAC 1440

CTGAAGCAGC ACAAGTTAAT GTCAGAGAAA GAGGGCCGCT CCATCATCAT GCAGATCGTT 1500

AATGCCCTCA AGTACCTCAA TGAGATCAGA CCGCCCATTA TCCACTACGA CCTTAAACCC 1560

GGTAACATTC TGTTAGTGAA CGGCACTGCT TGCGGGGAGA TCAAGATCAC AGACTTTGGC 1620

CTGTCAAAGA TCATGGACGA TGACAGCTAC AACTCGGTGG ATGGGATGGA GCTGACTTCA 1680

CAGGGAGCAG GGACGTACTG GTACCTTCCC CCAGAGTGCT TCGTTGTTGG CAAGGAACCA 1740

CCCAAAATCT CCAATAAAGT TGACGTGTGG TCTGTGGGAG TCATTTTCTA CCAGTGTTTG 1800

TATGGCCGCA AGCCCTTTGG CCACAATCAG TCCCAGCAGG ACATTTTACA GGAAAACACC 1860

ATCCTGAAGG CGACAGAAGT TCAGTTTCCC CCTAAACCTG TAGTCACACC TGAAGCTAAG 1920

GCCTTTATAA GGCGCTGTCT AGTCTACCGT AAGGAGGACC GCATCGATGT GCATCAGCTG 1980

GCCAGTGACC CCTTCCTTAT GCCCCACATC CGCAAGTCAG TGGCCTCGTC GGGCACCTCA 2040

GGCATGGCAA TGGCTTCCAC ATCCAGCTCC TCCAACAGCA GCGCTTCAAA CTGA 2094

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 387   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  446

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+seke rsiimqiv+alkyl

Q: 447   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEGRSIIMQIVNALKYL  506

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         nei+ppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 507   NEIRPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  566

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 567   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  626

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrcl yrkedridv+qla+d++l

Q: 627   VQFPPKPVVTPEAKAFIRRCLVYRKEDRIDVHQLASDPFL  666

         *************************************986

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEGRSII MQIVNALKYL 120

NEIRPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LVYRKEDRID VHQLASDPFL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013