EKS-ORN-00085

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00085

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	372.4	1.8E-111	649	941	293

Status

Unreviewed

Ensembl Protein

ENSONIP00000001285

UniProt Accession

I3IXE5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000001015	ENSONIP00000001285	ENSONIT00000001284

Organism

Oreochromis niloticus

Functional Description

Protein Length

1222

Protein Sequence
(FASTA)

MPGSDRHHGT KRKPESSIGG VPHQNQGPTH TSAGDMMSKD GKRKRHKSTK HNRESLAAPD 60

DFTLGDTAPP GVNTVKPLVE YDDISSDSDT FSDPPSSRPF ERGGNRLEPS PDYDRDIGEE 120

EGNRESRGHR HPRKKSKDTN KVRESGNGER GYKKKSSKDR EKVTSGKGKE EASSGSSSKR 180

QVPKESSRSG KSRKDRQQRR EGRGEASRSS SQRSRTDRSH RKSSKSHKSS PKGKSSSRGS 240

PRRKGTSSAL SPSPRRGAGS ESPLGSGYGH QGDDSYSRRR AAQQSPSPYG DVSRRSRQRS 300

DSPYGSRHRS SSFERDSSPY SRRRSMSPYG NRRSSSTSPM SRRSGRSRSR SPLHYSSSRR 360

SSSRSRGKRH TSSSRPASRS PPSSRLPLNS SLGAELTRRK KERLAAEAAA RASGGGSPLP 420

TAQKTSSSSS SRPAKAEALQ PEKDATAVAA SEPQPPPTQQ LSHDVPNADE LMTATLTSSS 480

NNSPAPPPPP PQPSSPAPPN PATQVPPPPQ AETNIQPPTP STVSQAKSPA SVPARSPVRQ 540

TPLHKTSTLP PLPLPPALLG NAQDSPKKST PPQRPSRKDK EGRNRPSIID LPLPPTLLGG 600

DSSPPQLPVR QPPLLPQTAL KKRPKICCPR YGERKHTQSD WGKRCVDKFD IIGIIGEGTY 660

GQVYKAKDKD TGELVALKKV RLDNEKEGFP ITAIREIKIL RQLKHRSVVN MKEIVTDKQD 720

ALDFKKDKGA FYLVFEYMDH DLMGLLESGL VQFSHEHIRS FMRQLMEGLD YCHKNNFLHR 780

DIKCSNILLN NKGQIKLADF GLARLYNSEE SRPYTNKVIT LWYRPPELLL GEERYSPAID 840

VWSCGCILGE LFTKKPIFQA NQELLQLELI SRLCGSPCPA VWPDVIKLPL FNTMKPKKQY 900

RRRLREEFAH LPTPALDLLD RMLTLDPARR CTSEQALFSD FLHDVEPNRM PPPDLPHHQD 960

CHELWSKKRR RARQSGVVED VPVPKVPRKD VTGTSSGENP RPPSSPTGAP PPPPGKPPST 1020

TNIESLASAA EQLNQTELAV LLNLLQGQAD ALPQVAQLLN LPNPETLSQL LSAVSEASDH 1080

QGAPEDQTQA ASRSQPPEPP PEPQEISPTS GDPPLSQEDQ AKLLALLLGQ IIKPQTEEQG 1140

DERHTSDTHS TSSPINTCTI KKNVCCPVTL ITSEQRPPSP PGPPPSTLGN SQQAAPETQP 1200

SQDISPAVAA ALLQLISQQD SE 1222

Nucleotide Sequence
(FASTA)

ATGCCTGGGT CGGACCGACA CCATGGGACC AAGAGGAAGC CGGAATCTAG CATCGGTGGT 60

GTGCCACACC AGAACCAGGG CCCGACTCAT ACCTCTGCGG GAGACATGAT GAGCAAGGAC 120

GGCAAGCGCA AACGGCATAA ATCAACAAAA CATAATCGGG AATCCTTGGC GGCACCTGAC 180

GATTTTACCC TCGGCGATAC GGCGCCTCCT GGTGTCAACA CGGTGAAGCC TCTAGTGGAG 240

TACGACGATA TTAGCTCCGA CTCGGACACC TTCTCGGACC CACCGTCCTC CAGGCCTTTT 300

GAGAGGGGGG GAAATCGACT GGAACCCTCG CCAGACTACG ATAGGGATAT TGGCGAAGAA 360

GAAGGTAATA GAGAGAGCAG GGGGCACAGA CACCCACGAA AAAAGTCCAA GGACACTAAC 420

AAAGTTAGAG AATCTGGAAA TGGAGAACGT GGGTACAAGA AAAAGAGCAG TAAAGATCGC 480

GAGAAAGTGA CTTCTGGAAA GGGCAAGGAG GAGGCCTCGT CAGGCTCCTC ATCTAAACGC 540

CAGGTGCCTA AGGAGAGCAG CCGCTCAGGG AAGTCTCGCA AAGACAGGCA ACAGCGGAGA 600

GAAGGCCGAG GGGAGGCCAG TCGCAGCTCC TCCCAGAGGA GCCGGACAGA TAGAAGCCAT 660

CGCAAGTCCT CTAAGAGCCA CAAGTCAAGC CCGAAGGGGA AGTCTTCAAG TAGGGGTAGC 720

CCACGGAGAA AGGGCACCAG CTCTGCATTG TCGCCGAGTC CCAGAAGAGG GGCCGGCAGT 780

GAGAGTCCAC TGGGCAGTGG GTATGGACAT CAGGGGGATG ACAGCTACTC TAGACGGAGG 840

GCGGCCCAGC AAAGCCCGAG TCCCTATGGT GATGTGTCTC GTCGTAGCAG GCAGAGATCA 900

GACAGCCCCT ACGGCAGCAG ACACAGGTCC TCCAGCTTTG AGAGGGACAG CAGCCCTTAC 960

TCTAGGAGAC GCTCCATGAG CCCCTATGGT AACCGCAGGT CCTCCAGTAC GAGCCCCATG 1020

TCTCGACGCT CGGGCCGCTC CAGGAGTCGC TCCCCTCTGC ACTACTCTTC TTCTCGCCGC 1080

TCCTCCTCTC GTTCCCGCGG TAAGAGGCAC ACCTCCTCTA GCCGGCCAGC TAGCCGCTCT 1140

CCTCCTTCGT CACGTCTGCC CCTCAATTCC AGCTTGGGTG CAGAGTTGAC CCGCAGGAAG 1200

AAGGAACGCC TGGCTGCTGA GGCGGCTGCT CGTGCTAGTG GAGGCGGCTC TCCACTTCCG 1260

ACAGCTCAAA AAACTTCAAG CTCCTCATCC TCACGGCCTG CTAAAGCTGA AGCTCTACAG 1320

CCAGAAAAAG ATGCAACAGC AGTAGCAGCA TCAGAACCTC AGCCCCCACC AACCCAGCAG 1380

TTATCCCATG ATGTTCCCAA TGCTGATGAG CTGATGACTG CAACTCTAAC TTCCTCTTCA 1440

AACAACTCTC CTGCACCACC GCCTCCTCCT CCACAGCCCT CTTCTCCAGC GCCACCCAAT 1500

CCAGCCACAC AGGTTCCACC ACCACCTCAG GCAGAAACAA ATATTCAGCC TCCTACACCC 1560

TCAACCGTAT CACAGGCTAA ATCGCCAGCG TCGGTTCCTG CTCGCAGCCC TGTCCGTCAG 1620

ACCCCACTCC ACAAGACTTC GACTCTTCCT CCCCTGCCTC TACCACCTGC ACTGCTGGGA 1680

AATGCTCAGG ACAGCCCAAA GAAATCCACT CCTCCCCAGA GGCCATCAAG AAAGGACAAA 1740

GAAGGTCGCA ACCGCCCTTC TATCATTGAC CTGCCTTTAC CGCCCACCTT GCTTGGAGGG 1800

GACTCTTCAC CCCCACAGTT ACCTGTCCGC CAGCCTCCTC TCTTACCCCA GACAGCCCTT 1860

AAGAAGAGAC CAAAGATTTG TTGCCCGCGA TATGGCGAGC GCAAACATAC CCAAAGTGAC 1920

TGGGGCAAAC GGTGTGTAGA TAAATTTGAT ATAATTGGCA TCATAGGGGA AGGCACCTAT 1980

GGGCAAGTGT ACAAGGCTAA GGACAAAGAC ACTGGTGAAC TGGTGGCTTT GAAGAAAGTG 2040

CGTTTGGACA ATGAAAAAGA GGGCTTCCCC ATCACAGCTA TCAGAGAGAT TAAGATCTTG 2100

CGGCAGCTCA AACACCGTAG TGTTGTCAAC ATGAAGGAAA TCGTCACTGA CAAGCAGGAT 2160

GCACTTGACT TTAAAAAGGA TAAAGGAGCT TTTTACCTGG TGTTTGAGTA CATGGACCAT 2220

GATCTGATGG GCCTGCTGGA GTCAGGCCTG GTCCAGTTCT CCCATGAGCA CATCCGCAGC 2280

TTCATGCGTC AGCTGATGGA GGGCCTGGAC TACTGCCACA AAAACAACTT CCTGCACAGA 2340

GACATCAAAT GCTCCAACAT ACTGCTAAAT AACAAAGGTC AGATCAAACT GGCTGACTTT 2400

GGTTTGGCTC GTCTTTACAA TTCAGAGGAA AGCCGGCCAT ACACTAATAA AGTAATCACA 2460

CTATGGTATC GTCCCCCTGA GCTTCTGCTG GGAGAGGAGA GATATTCTCC AGCCATTGAT 2520

GTTTGGAGTT GTGGGTGTAT TCTTGGAGAG CTCTTTACGA AGAAGCCCAT CTTCCAGGCT 2580

AACCAGGAAC TTCTGCAACT AGAGCTGATC AGCCGACTGT GTGGGAGTCC CTGTCCGGCC 2640

GTTTGGCCTG ATGTCATTAA ACTTCCATTG TTCAACACAA TGAAACCCAA GAAGCAGTAC 2700

AGACGGCGAC TACGGGAGGA GTTTGCACAT TTACCTACTC CTGCCCTGGA CTTACTGGAC 2760

CGAATGCTGA CCCTTGACCC TGCACGCCGT TGCACATCAG AGCAAGCTCT CTTCAGTGAC 2820

TTCCTGCATG ATGTTGAGCC CAACAGGATG CCACCACCAG ACCTTCCTCA TCATCAAGAC 2880

TGTCACGAGT TGTGGAGTAA GAAGAGAAGG CGTGCACGTC AGAGTGGGGT TGTCGAGGAT 2940

GTGCCTGTGC CCAAAGTGCC CCGTAAAGAT GTGACAGGGA CCTCCAGTGG AGAGAACCCT 3000

CGTCCCCCAA GCAGCCCCAC TGGAGCTCCA CCACCTCCCC CAGGAAAACC ACCCTCCACA 3060

ACCAACATAG AGAGCCTGGC ATCGGCTGCA GAGCAGTTGA ATCAGACAGA GCTGGCAGTG 3120

CTGCTAAACC TTCTCCAGGG ACAGGCAGAC GCCTTGCCCC AGGTTGCTCA GCTCCTCAAC 3180

CTCCCCAATC CAGAGACTCT CAGCCAGTTG TTGTCTGCTG TTAGTGAGGC CTCTGACCAC 3240

CAGGGGGCAC CAGAGGACCA GACCCAGGCA GCTTCCAGGT CTCAGCCCCC AGAGCCGCCT 3300

CCTGAACCCC AAGAGATCTC ACCGACATCT GGAGATCCGC CACTCAGCCA GGAAGACCAG 3360

GCCAAGCTGC TGGCTCTCCT TTTGGGCCAA ATTATAAAGC CACAAACCGA GGAGCAAGGC 3420

GATGAAAGAC ATACGAGTGA CACACATTCA ACATCTTCCC CTATAAACAC CTGTACTATT 3480

AAAAAAAACG TTTGCTGTCC TGTGACCCTG ATAACCAGTG AGCAACGTCC ACCCTCTCCA 3540

CCAGGTCCAC CTCCATCAAC TCTTGGAAAC TCCCAGCAGG CTGCGCCAGA AACGCAACCC 3600

AGCCAGGACA TCAGCCCTGC TGTAGCAGCC GCCTTGCTCC AGCTCATCTC TCAGCAGGAC 3660

TCGGAA 3666

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++lkh+ +

Q: 649   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLKHRSV  708

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s+e+++s+++ql+e

Q: 709   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-QFSHEHIRSFMRQLME  767

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H+n++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 768   GLDYCHKNNFLHRDIKCSNILLNNKGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  827

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Ys a+D+Ws+gcil el+t+kp+fq+++e  qle i++l+g+p  +vwp+v k

Q: 828   LLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAVWPDVIK  887

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         lp +++  pkk+++ +l+e++ +l + aldll+++l+ldp++R+++++al +++

Q: 888   LPLFNTMKPKKQYRrRLREEFAHLPTPALDLLDRMLTLDPARRCTSEQALFSDF  941

         *****7777777777**********99**********************98776

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLKHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVQFSHEHI RSFMRQLMEG 120

LDYCHKNNFL HRDIKCSNIL LNNKGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYSPA IDVWSCGCIL GELFTKKPIF QANQELLQLE LISRLCGSPC PAVWPDVIKL 240

PLFNTMKPKK QYRRRLREEF AHLPTPALDL LDRMLTLDPA RRCTSEQALF SDF 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013