EKS-ORN-00470

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00470

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	453.6	2.1E-136	272	521	250

Status

Unreviewed

Ensembl Protein

ENSONIP00000001686

UniProt Accession

I3IYJ6;

Protein Name

Protein Synonyms/Alias

Gene Name

FYN

Gene Synonyms/Alias

FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000001335	ENSONIP00000001686	ENSONIT00000001685

Organism

Oreochromis niloticus

Functional Description

Protein Length

538

Protein Sequence
(FASTA)

RMGCVQCKDK EAAKLTDDRE TSLSHNSGYR YGSDPTPQHY PSFGVTTIPN YNNFHSAASQ 60

GVTVFGGVHT SSQSGTLRSR GGTGVTLFVA LYDYEARTED DLSFRKGERF QILNSTEGDW 120

WEARSLTTGG TGYIPSNYVA PVDSIQAEDW YFGKLGRKDA ERQLLSNGNA RGTFLIRESE 180

TTKGAYSLSI QDWDDVKGDH VKHYKIRKLD NGGYYITTRA QFETLQQLVQ HYSARAAGLC 240

CRLIVPCHKG MPRLTDLSVK TKDVWEIPRE SLQLIKRLGN GQFGEVWMGT WNGTTKVAVK 300

TLKPGTMSPE SFLEEAQIMK KLRHDKLVQL YAVVSEEPIY IVTEYMSKGS LLDFLKDGEG 360

RGLKLPNLVD MAAQVAAGMA YIERMNYIHR DLRSANILVG DSLVCKIADF GLARLIEDNE 420

YTARQGAKFP IKWTAPEAAL YGKFTIKSDV WSFGILLTEL VTKGRVPYPG MNNREVLEQV 480

ERGYRMPCPQ DCPSSLHELM LQCWKKDPEE RPTFEYLQAF LEDYFTATEP QYQPGDNL 538

Nucleotide Sequence
(FASTA)

AGAATGGGCT GTGTCCAATG TAAGGATAAA GAAGCAGCAA AACTCACTGA TGACCGGGAG 60

ACCAGCCTTT CGCACAACTC GGGCTACCGC TATGGGTCCG ACCCCACTCC GCAGCACTAC 120

CCCAGCTTTG GGGTCACCAC CATTCCCAAC TACAACAACT TCCACAGCGC AGCCTCGCAG 180

GGAGTGACTG TGTTCGGAGG AGTCCACACG TCCTCGCAGT CTGGGACCCT CCGGTCTCGG 240

GGAGGCACAG GGGTGACTCT CTTTGTGGCC CTTTATGATT ATGAAGCCAG GACCGAGGAT 300

GACCTCAGCT TTAGAAAAGG GGAGAGGTTC CAGATCCTCA ACAGCACCGA GGGAGACTGG 360

TGGGAGGCTC GTTCTCTCAC TACAGGTGGA ACTGGATACA TTCCCAGCAA TTACGTAGCT 420

CCCGTGGACT CCATCCAAGC CGAAGACTGG TATTTTGGTA AATTGGGTCG AAAGGACGCA 480

GAGAGGCAAC TGCTCTCCAA CGGCAACGCC AGAGGCACTT TCCTGATCCG TGAGAGCGAA 540

ACAACTAAAG GAGCCTACTC TCTCTCCATC CAGGACTGGG ATGACGTGAA GGGAGATCAC 600

GTTAAACACT ATAAAATCCG CAAACTGGAT AATGGAGGCT ACTACATCAC CACTAGAGCC 660

CAGTTTGAGA CACTCCAGCA GCTAGTGCAG CACTACTCGG CCAGGGCTGC AGGCCTGTGC 720

TGCAGACTGA TCGTGCCGTG CCACAAAGGC ATGCCTCGTC TGACCGACCT GTCTGTCAAA 780

ACCAAAGACG TGTGGGAGAT CCCGCGGGAG TCGCTGCAGC TTATTAAACG CCTCGGCAAT 840

GGCCAGTTCG GAGAAGTCTG GATGGGTACG TGGAACGGCA CCACCAAGGT GGCAGTGAAG 900

ACTCTTAAGC CCGGCACTAT GTCACCTGAG TCCTTCCTGG AGGAAGCTCA GATAATGAAG 960

AAGCTCCGAC ACGATAAGCT GGTGCAGCTC TATGCTGTGG TGTCCGAGGA ACCCATCTAT 1020

ATAGTCACAG AGTACATGAG CAAAGGGAGT TTGCTTGATT TCCTGAAGGA CGGCGAAGGT 1080

CGAGGCCTCA AACTGCCAAA TCTAGTGGAC ATGGCAGCTC AGGTGGCAGC AGGCATGGCT 1140

TATATCGAGA GGATGAACTA CATCCACAGA GACCTGAGAT CTGCCAACAT CCTAGTCGGA 1200

GACAGCCTGG TGTGCAAGAT TGCTGACTTT GGTCTGGCTA GACTCATCGA GGACAACGAA 1260

TACACAGCAA GACAAGGTGC GAAGTTTCCC ATAAAGTGGA CCGCTCCTGA GGCTGCCCTC 1320

TACGGGAAAT TCACCATCAA GTCAGACGTG TGGTCATTTG GTATCCTGCT GACAGAGCTG 1380

GTGACCAAGG GCAGAGTGCC CTATCCAGGT ATGAACAACC GTGAGGTGCT GGAGCAAGTG 1440

GAGCGAGGCT ACCGGATGCC GTGCCCCCAG GACTGCCCCT CGTCCCTGCA TGAGCTAATG 1500

CTACAGTGCT GGAAGAAAGA CCCAGAGGAG AGGCCCACCT TTGAGTACTT GCAAGCCTTT 1560

TTGGAGGACT ACTTCACTGC CACTGAGCCT CAGTATCAGC CAGGGGATAA CCTCTGA 1617

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw+g+w+g++kvavktlk+gt+spe+fleeaqi+kklrh+klv+ly

Q: 272   LQLIKRLGNGQFGEVWMGTWNGTTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLY  331

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk+ eg+ lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 332   AVVSE-EPIYIVTEYMSKGSLLDFLKDGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHR  390

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+++n+lvg+slv+k+adfGlarlied+eyta++gak+PikWtaPea+ +gkftiksdv

Q: 391   DLRSANILVGDSLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGKFTIKSDV  450

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp++l+el+l+cwkkdpee

Q: 451   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPSSLHELMLQCWKKDPEE  510

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 511   RPTFEYLQAFL  521

         *******9876

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMGTW NGTTKVAVKT LKPGTMSPES FLEEAQIMKK LRHDKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKDGEGR GLKLPNLVDM AAQVAAGMAY IERMNYIHRD 120

LRSANILVGD SLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GKFTIKSDVW 180

SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPSSLHELML QCWKKDPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013