EKS-ORN-00049
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00049
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak283.72.1E-849081178271
StatusUnreviewed
Ensembl ProteinENSONIP00000001952
UniProt AccessionI3IZB2;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameTYK2
Gene Synonyms/Alias TYK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000001561ENSONIP00000001952ENSONIT00000001951
OrganismOreochromis niloticus
Functional Description
Protein Length1186
Protein Sequence
(FASTA)
GVMKLCGRRI MGGRSRSSGS FTGLSEPPKD QGIHVYLFWT KDGEKYLSHT TGEVTAEELC 60
ISAAETVGIT ALCHSLFALY NPERHFWYSP NHIFKPEENP SLVLRYCMRY YFRNWHGLNE 120
NEPMMCRYPP KSGSKRGFPL LDTTSLEYLF SQVVFGGFLM ACFYSHNVLV LTNQAKYEFV 180
NEVVQIEDVK TEEEQTRFKN ESLGMAVLHL SYQAIQTQST LQDVASKVSF LDCVPRSFAK 240
HISRDNFLTK LRIQRVFKDF VRSFQQHTVD RGKLCTEEIM YKYIATLEHL APRFGTEIFP 300
VTRLDLRDED DRSGSCSSTT HAQCGSKDNF CGPISHEISV SGTEGIQWRK VSVQRAQANN 360
YMRNGYLNYM RKQKQHSSQP DADTPNDWTF FSEFPEITHI AITDSNVCIS TRDNLCMEVQ 420
MISSQEAHSF VSLLDGYYRL TADAHHYLCH EVAPPRVVWS EANLLHGPMH DEFVLSKLKK 480
EAEDEGTFLA RWSVVDYNCI ILAVLIKNQD SATRSHKQFR VHVKDSMLCL EGLERQFPSM 540
KELTDSLKSF VLKSGSDSFT VKKCCSPKSG ELSNLLVRRH NECDVHAEPL SQTYKTRLMF 600
PQIKDKDIKQ EQHLGRGTRT NIYTGRLLTQ EREENDNDEF NNNSHRGHRV VLKILDQTHE 660
DIALVFFETA SLMCQVSHRH LVFVYGVSVK GSENIMVEEF VDFGPLDVFL RREKNVSPGW 720
KFIVAKQLAS ALDYLETNGL VHGNVCAKNI LLVKNGLEPN TTPFIKLSDP GIALSVLSRE 780
ERLERIPWIA PECIDSGSNI GSHADQWSFG VTVLEIYNNG DLPFNFNTLS EKERFYQQKG 840
HLAEPSSPEL ARFINMCLTY EPEERPSFRK VLRELIELMR KGFVIQSVMP SSEASANTDP 900
TVFHKRYLKQ VRILGEGHFG KVTLYLYDPA NDGKGEQVAV KSLKQENDKI SDGWIKEIEI 960
LKSLYHSNIV KYKGCCTELG GQVVQLIMEY LPLGSLKDYL PKRNLPKSHC LMFAQQICQG 1020
MNYLHSKRYV HRDLAARNVL VENDSLVKIG DFGLTKYIPE GEIYYRVRED GDSPVFWYAI 1080
ECLKESKFSF SSDVWSFGVT LYEILTRCDR RQSPPDKFFE MMKEAQGQMT VVILIKLLEQ 1140
GLRLPCPKDS PHEVKILMER CWSADPSERP DFESLIKKFQ ILRQTY 1186
Nucleotide Sequence
(FASTA)
GGTGTAATGA AGCTGTGCGG AAGAAGAATA ATGGGAGGGA GGTCCAGATC TTCAGGCTCG 60
TTTACAGGCC TGAGCGAGCC TCCGAAGGAT CAGGGCATCC ATGTCTACCT TTTCTGGACA 120
AAAGATGGGG AGAAATATTT GTCTCACACC ACAGGAGAGG TCACAGCGGA GGAGCTGTGT 180
ATCTCTGCAG CAGAGACCGT CGGGATAACC GCTCTGTGCC ATTCACTGTT TGCGCTCTAC 240
AACCCAGAGA GACACTTTTG GTACAGCCCA AACCACATAT TTAAGCCAGA GGAAAACCCG 300
AGCCTTGTAC TTCGCTACTG TATGAGGTAT TACTTTCGGA ACTGGCATGG ACTGAATGAA 360
AACGAGCCCA TGATGTGCCG CTATCCTCCC AAATCTGGTT CAAAACGGGG TTTCCCTTTA 420
CTTGACACAA CTTCACTGGA GTATTTATTT TCCCAGGTTG TTTTTGGGGG GTTTTTAATG 480
GCATGCTTTT ACAGTCATAA TGTTCTTGTC TTGACAAATC AGGCTAAGTA TGAATTTGTG 540
AATGAAGTGG TACAAATAGA AGACGTCAAG ACAGAGGAGG AACAGACTCG CTTCAAAAAT 600
GAGAGTTTGG GAATGGCTGT GCTTCACCTC TCATACCAGG CAATCCAAAC ACAATCAACT 660
TTGCAAGATG TAGCTTCAAA AGTCAGCTTT CTAGACTGCG TTCCAAGATC TTTCGCCAAA 720
CACATTTCCA GAGACAACTT CCTGACTAAA CTCAGGATCC AGCGAGTGTT TAAAGACTTT 780
GTGCGGTCCT TCCAGCAGCA CACAGTGGAT CGGGGCAAGC TGTGCACTGA GGAAATCATG 840
TACAAGTATA TCGCTACTCT CGAGCACTTG GCACCGCGTT TTGGCACTGA GATTTTCCCC 900
GTAACCCGCC TGGATCTGAG GGACGAAGAC GACAGAAGTG GCTCGTGTTC CAGCACCACC 960
CACGCCCAGT GTGGTTCAAA AGACAACTTC TGCGGCCCAA TATCACATGA AATATCGGTG 1020
TCCGGTACTG AGGGGATTCA GTGGAGGAAG GTGTCTGTTC AGAGGGCACA GGCAAATAAT 1080
TACATGAGGA ATGGCTACTT AAACTACATG AGAAAACAAA AACAGCACTC CAGCCAACCA 1140
GATGCAGACA CACCCAATGA CTGGACCTTC TTCAGCGAGT TCCCTGAAAT AACTCACATA 1200
GCCATTACTG ATTCTAATGT GTGCATCAGT ACTCGAGACA ATCTCTGTAT GGAGGTTCAG 1260
ATGATCTCCA GCCAGGAGGC CCATTCCTTC GTCTCCCTCC TAGATGGATA CTACCGACTG 1320
ACTGCAGACG CCCACCACTA TCTTTGTCAT GAAGTGGCTC CCCCAAGGGT AGTGTGGAGT 1380
GAAGCAAATC TACTGCATGG ACCTATGCAT GACGAGTTTG TGCTGTCTAA GCTGAAAAAG 1440
GAGGCAGAGG ATGAGGGAAC TTTCCTCGCT CGTTGGAGTG TTGTTGACTA TAACTGCATC 1500
ATCCTAGCTG TGCTAATCAA GAATCAGGAT AGTGCAACAC GAAGCCACAA GCAGTTTCGT 1560
GTCCACGTAA AGGATTCAAT GCTCTGTCTG GAGGGCTTGG AACGACAGTT CCCCAGCATG 1620
AAGGAGCTCA CCGATAGCCT CAAGTCGTTT GTTCTCAAGT CTGGTTCGGA CAGCTTTACT 1680
GTCAAAAAAT GCTGTTCGCC AAAATCAGGA GAGCTATCCA ACCTTCTGGT GAGGAGACAC 1740
AATGAATGCG ATGTTCATGC TGAGCCCTTA TCCCAAACCT ACAAGACTCG TCTAATGTTC 1800
CCCCAAATCA AGGACAAAGA TATCAAACAG GAACAGCATT TGGGTCGCGG CACCAGAACT 1860
AACATCTACA CAGGACGCCT GTTAACGCAG GAAAGAGAGG AAAATGATAA TGACGAGTTC 1920
AACAACAACT CTCACCGAGG CCACCGAGTC GTTCTTAAGA TTCTGGACCA AACCCATGAA 1980
GATATTGCTC TGGTGTTTTT CGAAACCGCA AGTCTCATGT GCCAGGTATC CCACCGTCAC 2040
CTGGTGTTTG TATATGGCGT GTCTGTCAAA GGATCTGAAA ACATCATGGT GGAGGAATTT 2100
GTGGATTTCG GGCCTTTGGA TGTCTTCCTT CGCAGAGAAA AGAATGTGTC TCCTGGGTGG 2160
AAGTTCATTG TTGCAAAACA GCTTGCCAGT GCCCTCGACT ATCTTGAAAC CAACGGGTTG 2220
GTTCATGGAA ATGTCTGTGC CAAGAACATC CTTTTGGTAA AAAATGGTCT AGAACCTAAC 2280
ACTACTCCTT TCATCAAGCT GAGTGACCCA GGAATTGCTC TGAGTGTTCT TTCACGTGAA 2340
GAGCGCCTGG AACGTATCCC ATGGATTGCC CCTGAGTGCA TTGACAGTGG TTCAAACATA 2400
GGCAGTCATG CTGACCAGTG GAGCTTTGGC GTAACAGTGC TTGAGATCTA CAACAACGGT 2460
GATCTTCCCT TCAACTTCAA CACATTGTCC GAGAAAGAGC GCTTTTATCA GCAAAAGGGC 2520
CACTTAGCTG AACCATCTTC CCCAGAGTTG GCCAGGTTCA TCAACATGTG TTTGACCTAT 2580
GAGCCTGAGG AGAGGCCGTC ATTCCGCAAG GTGCTCAGAG AACTCATAGA ACTCATGAGG 2640
AAAGGTTTTG TCATTCAGTC TGTTATGCCT TCCAGTGAAG CTTCAGCTAA CACAGACCCC 2700
ACTGTGTTCC ATAAACGCTA CCTGAAACAA GTGCGGATCT TAGGAGAGGG TCACTTTGGA 2760
AAGGTGACTC TGTACTTATA TGACCCGGCC AATGACGGGA AGGGAGAGCA GGTGGCTGTG 2820
AAGTCTTTGA AGCAAGAAAA CGACAAAATT TCTGACGGCT GGATAAAGGA GATTGAGATC 2880
CTGAAATCTC TTTATCACAG CAACATTGTG AAATACAAGG GCTGTTGCAC AGAACTGGGA 2940
GGGCAAGTCG TCCAACTAAT AATGGAGTAC CTTCCTCTGG GGAGTCTGAA AGACTACCTC 3000
CCCAAACGTA ACCTTCCGAA GTCTCATTGT CTCATGTTTG CTCAGCAGAT CTGTCAGGGG 3060
ATGAATTACT TGCACTCAAA GCGATACGTC CATCGAGATC TGGCTGCCCG TAATGTCTTG 3120
GTGGAAAACG ACAGTCTGGT AAAGATTGGA GACTTTGGCC TGACGAAGTA CATCCCTGAG 3180
GGAGAGATCT ACTACCGTGT CCGTGAGGAT GGAGACAGTC CAGTGTTCTG GTATGCCATC 3240
GAGTGCTTGA AAGAGAGTAA ATTTTCCTTC TCCTCTGATG TTTGGTCCTT TGGAGTTACA 3300
CTGTATGAGA TCCTGACCCG CTGTGACCGT CGCCAAAGCC CTCCAGATAA GTTCTTTGAA 3360
ATGATGAAGG AAGCTCAAGG GCAGATGACT GTGGTGATAC TGATAAAACT GTTGGAACAA 3420
GGGTTGCGAT TACCTTGTCC TAAGGACAGC CCACATGAGG TGAAAATATT AATGGAGCGG 3480
TGTTGGAGTG CAGATCCTTC AGAACGGCCA GATTTTGAGT CCCTCATTAA AAAGTTTCAG 3540
ATTCTACGCC AAACATAC 3558
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lkq + Lg+g+f+kv ++ +d+ +d ++e+va+k Lk+  ++is ++ +e+eil++l+h 
Q: 908   LKQVRILGEGHFGKVTLYLYDPANDGKGEQVAVKSLKQENDKISDGWIKEIEILKSLYHS  967
         688899******************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk+kg+c++ g +  +l+mey++ GsL++yL+k+  +l+ s  l +a+q++++m+YL+
Q: 968   NIVKYKGCCTELGGQvvQLIMEYLPLGSLKDYLPKR--NLPKSHCLMFAQQICQGMNYLH  1025
         ***********99999*******************9..**********************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         +k++vhrd+aarnvLve++s       vk++d+gl+k ++++  Yy vre++ds+++w+a
Q: 1026  SKRYVHRDLAARNVLVENDSL------VKIGDFGLTKYIPEGeIYYRVREDGDSPVFWYA  1079
         *********************......***************99****************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225
          ecl+e+k +s  sdvWsFgvtlye+lt c++ +sp     ++++ +        +++ll
Q: 1080  IECLKESK-FSFSSDVWSFGVTLYEILTrCDRRQSPpdkfFEMMKEAqgqmtvvILIKLL  1138
         ********.*******************************55554444557788899***
S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailed  264
         e++ rlp+pk +p e+  lm++c+s++ps+rp F+ ++++
Q: 1139  EQGLRLPCPKdSPHEVKILMERCWSADPSERPDFESLIKK  1178
         ***********************************99875
Domain Sequence
(FASTA)
LKQVRILGEG HFGKVTLYLY DPANDGKGEQ VAVKSLKQEN DKISDGWIKE IEILKSLYHS 60
NIVKYKGCCT ELGGQVVQLI MEYLPLGSLK DYLPKRNLPK SHCLMFAQQI CQGMNYLHSK 120
RYVHRDLAAR NVLVENDSLV KIGDFGLTKY IPEGEIYYRV REDGDSPVFW YAIECLKESK 180
FSFSSDVWSF GVTLYEILTR CDRRQSPPDK FFEMMKEAQG QMTVVILIKL LEQGLRLPCP 240
KDSPHEVKIL MERCWSADPS ERPDFESLIK K 271
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00028
EKS-ANC-00027
EKS-BOT-00034
EKS-CAJ-00031
EKS-CAF-00033
EKS-CAP-00033
EKS-DAR-00045
EKS-FEC-00030
EKS-GAM-00233
EKS-GAA-00049
EKS-GOG-00031
EKS-ICT-00028
EKS-MEG-00026
EKS-MOD-00031
EKS-MUM-00034
EKS-MUP-00034
EKS-MYL-00034
EKS-NOL-00030
EKS-OCP-00021
EKS-ORL-00046
EKS-OTG-00034
EKS-PAT-00030
EKS-PRC-00015
EKS-PTV-00032
EKS-RAN-00033
EKS-SAH-00031
EKS-TAR-00049
EKS-TEN-00053
EKS-XET-00032
EKS-XIM-00047
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
PR01827; YKINASETYK2.
Created Date20-Feb-2013