EKS-ORN-00204
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00204
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb392.79.2E-118431687257
StatusUnreviewed
Ensembl ProteinENSONIP00000002167
UniProt AccessionI3IZX7;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000001731ENSONIP00000002167ENSONIT00000002167
OrganismOreochromis niloticus
Functional Description
Protein Length779
Protein Sequence
(FASTA)
LKEDKNMSGD ASDSSEDSDG KTNERACTVK HQITNANLTG HTERVGMENF ELLKVLGTGA 60
YGKVFLVRKN SGHDVGQLYA MKVLKKAAIV QKAKTTEHTR TERQVLEHIR QSPFLVTLHY 120
AFQTQSKLHL ILDYVSGGEM FTHLYQRDHF PEEAVRIYIG EIILALEHLH KLGIVYRDIK 180
LENILLDSDG HVVLTDFGLS KEFLEEDKGR TYSFCGTIEY MAPEIIRGKS GHGKSVDWWS 240
LGILMFELLT GASPFTLEGE RNSQSEVSKR ILRCDPPFPS MIGPIAQDLL KKLLVKDPHK 300
RLGSGPRGAE DIKAHPFFKG LNWDDLAQKK VSSPFKPELK SELDVGNFAE EFTGMDPVYS 360
PASTPPSTDR LFQGYSFIAP SILFNKNAVM GDFVETQIGA DRPASASVQR SAMLQESQFF 420
QHYELCFQGP PLGEGSFSVC RKCKHKQTGH EYAVKIVSRR MEANTQREIA ALKQCESHPN 480
IVKLYDIFTD QYHTYLVMEL LRGGELLERI KRKKLFGEAE ASQLLQSLVS AVSFMHEAGV 540
VHRDLKPENV LFADEGEDSV LKVIDFGFAR LCPAGSAPLQ TPCFTLQYAA PELFESAGYD 600
KSCDLWSLGV ILYTMLSGQV PFQSEQRGMT SSYAADIMQK IKEGDFSLDG EPWKGVSEDA 660
KELVKGLLTV DPESRLKLSD LKENSWLQGG ASMSTTPLCT PDVLESSGPT VRTYVNATYK 720
AFNRGKREGF FLKSVDNAPL AKRRKMKMTS TGVETRWSSS SSSSSSSTSS SASATASKT 779
Nucleotide Sequence
(FASTA)
CTAAAGGAAG ACAAAAATAT GTCTGGGGAC GCATCTGATA GTAGTGAAGA CTCTGATGGA 60
AAAACAAATG AAAGGGCCTG TACTGTCAAG CACCAGATCA CAAATGCTAA CCTCACAGGT 120
CACACTGAAA GAGTCGGCAT GGAGAACTTT GAGCTGCTGA AGGTCTTGGG CACTGGAGCT 180
TACGGGAAAG TGTTTTTGGT CAGGAAGAAC AGCGGCCATG ATGTGGGCCA GCTCTATGCT 240
ATGAAGGTGT TAAAGAAAGC AGCTATCGTT CAGAAGGCAA AGACAACAGA ACATACTCGC 300
ACTGAGAGAC AAGTCCTGGA GCACATCCGC CAGTCTCCCT TCCTGGTTAC TCTTCACTAT 360
GCCTTTCAGA CTCAGAGCAA ACTACATCTC ATCCTGGACT ATGTGAGCGG TGGGGAGATG 420
TTCACTCATT TGTACCAGCG GGATCACTTT CCAGAAGAGG CAGTACGGAT TTATATTGGA 480
GAAATAATTC TGGCTCTAGA ACACTTGCAC AAGCTTGGGA TTGTGTACCG AGACATCAAA 540
TTGGAAAACA TTCTTCTAGA CAGTGATGGC CATGTGGTGT TGACAGATTT CGGGCTCAGC 600
AAAGAGTTTC TGGAAGAAGA TAAGGGGAGG ACCTACTCTT TCTGTGGCAC CATTGAGTAC 660
ATGGCTCCTG AAATCATCAG AGGGAAATCA GGACATGGCA AGTCAGTAGA TTGGTGGAGT 720
CTTGGGATCC TGATGTTTGA GTTGCTGACG GGTGCGTCTC CTTTTACCCT GGAGGGAGAG 780
AGGAACTCCC AAAGCGAGGT GTCAAAACGT ATTTTGCGCT GTGACCCGCC GTTTCCCTCT 840
ATGATTGGAC CCATTGCTCA GGACCTGCTG AAAAAGTTGT TGGTGAAAGA TCCCCACAAG 900
AGGCTGGGAT CTGGACCGCG GGGGGCTGAA GATATCAAGG CACATCCTTT CTTCAAGGGA 960
CTGAACTGGG ATGACTTAGC ACAAAAGAAG GTTTCAAGTC CATTCAAGCC AGAGCTGAAG 1020
AGCGAACTCG ATGTGGGGAA CTTTGCAGAG GAATTCACTG GGATGGATCC TGTTTATTCT 1080
CCAGCCAGCA CACCCCCGAG CACAGATCGT CTGTTCCAGG GCTATTCTTT CATTGCACCC 1140
TCCATCTTGT TCAATAAGAA CGCAGTCATG GGAGACTTTG TTGAAACCCA AATTGGTGCT 1200
GACCGACCAG CTTCTGCTTC TGTCCAACGC AGCGCAATGC TACAGGAATC CCAGTTTTTT 1260
CAGCACTATG AGCTGTGTTT TCAAGGACCA CCTCTAGGCG AGGGTAGTTT CTCTGTGTGC 1320
AGGAAATGCA AACACAAGCA AACTGGCCAT GAGTACGCCG TCAAGATCGT CAGCCGTAGA 1380
ATGGAGGCAA ACACTCAGAG AGAGATTGCT GCCTTGAAGC AGTGTGAGTC TCACCCCAAC 1440
ATCGTCAAGC TGTATGACAT CTTTACTGAT CAGTATCACA CATATTTAGT GATGGAGCTT 1500
CTGCGAGGTG GGGAGTTGTT GGAAAGGATC AAGAGGAAGA AACTGTTTGG CGAAGCAGAG 1560
GCCAGTCAGC TATTACAGAG CCTGGTCTCA GCTGTCAGCT TCATGCACGA GGCTGGAGTC 1620
GTACACAGAG ACCTCAAACC AGAGAACGTG CTGTTTGCAG ATGAGGGGGA GGACTCTGTG 1680
CTGAAAGTAA TAGATTTTGG ATTTGCTCGC CTGTGCCCTG CAGGCAGTGC CCCCCTGCAG 1740
ACTCCCTGCT TCACGCTGCA GTATGCTGCA CCAGAGCTTT TCGAGAGTGC AGGATATGAT 1800
AAATCCTGTG ACCTCTGGAG TCTCGGGGTC ATTCTGTACA CCATGCTCTC AGGCCAGGTG 1860
CCGTTTCAGA GTGAGCAGCG TGGAATGACC TCATCATATG CTGCCGACAT CATGCAAAAA 1920
ATAAAAGAGG GGGATTTCTC ATTGGATGGG GAGCCCTGGA AGGGTGTGTC AGAGGATGCC 1980
AAAGAGCTTG TTAAAGGCCT GCTAACGGTG GATCCAGAGA GCCGTCTCAA ACTCTCTGAT 2040
CTGAAAGAGA ACAGCTGGCT TCAGGGTGGA GCATCCATGT CCACCACTCC TTTGTGCACA 2100
CCAGATGTGC TCGAGTCCAG TGGGCCCACT GTCCGCACTT ATGTCAATGC TACCTACAAG 2160
GCTTTCAACC GAGGTAAGCG AGAAGGCTTC TTTCTGAAAA GTGTCGACAA TGCTCCCCTT 2220
GCAAAACGAC GAAAGATGAA GATGACCAGC ACAGGAGTAG AGACCCGATG GAGTTCATCC 2280
TCTTCATCTT CGTCTTCTTC CACTTCCTCC TCTGCCTCTG CAACAGCATC CAAAACA 2337
Domain Profile
S: 6     dlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvydd  64
         +lG+Gs+svc++c hk+t++e+avki++++ +++t++ei++l+++e+hpniv+l d++ d
Q: 431   PLGEGSFSVCRKCKHKQTGHEYAVKIVSRRmEANTQREIAALKQCESHPNIVKLYDIFTD  490
         69****************************9*****************************
S: 65    gkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkpeni  124
         + ++ylv+ell+GGell+rik+kk f e eas++l++lv+av+++he Gvvhrdlkpen+
Q: 491   QYHTYLVMELLRGGELLERIKRKKLFGEAEASQLLQSLVSAVSFMHEAGVVHRDLKPENV  550
         ************************************************************
S: 125   lyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlwslG  184
         l++de +++  +k+idfGfa+l +a + +l+tpc+tl+++ape+++  Gyd++cdlwslG
Q: 551   LFADEGEDSV-LKVIDFGFARLCPAGSAPLQTPCFTLQYAAPELFESAGYDKSCDLWSLG  609
         *****99887.*************************************************
S: 185   vllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         v+lytml+G+vpf    +  +++ a++i++kikeG+fsl+Ge w++vse+ak+lv++llt
Q: 610   VILYTMLSGQVPFqseqRGMTSSYAADIMQKIKEGDFSLDGEPWKGVSEDAKELVKGLLT  669
         *************877555678899***********************************
S: 241   vdpakrlkleqllkhswl  258
         vdp+ rlkl++l+++swl
Q: 670   VDPESRLKLSDLKENSWL  687
         *****************7
Domain Sequence
(FASTA)
PLGEGSFSVC RKCKHKQTGH EYAVKIVSRR MEANTQREIA ALKQCESHPN IVKLYDIFTD 60
QYHTYLVMEL LRGGELLERI KRKKLFGEAE ASQLLQSLVS AVSFMHEAGV VHRDLKPENV 120
LFADEGEDSV LKVIDFGFAR LCPAGSAPLQ TPCFTLQYAA PELFESAGYD KSCDLWSLGV 180
ILYTMLSGQV PFQSEQRGMT SSYAADIMQK IKEGDFSLDG EPWKGVSEDA KELVKGLLTV 240
DPESRLKLSD LKENSWL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAF-00171
EKS-CAP-00163
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00453
EKS-DRM-00077
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LAC-00165
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
EKS-XIM-00199
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013