EKS-ORN-00024
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00024
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR524.84.8E-15810101278269
StatusUnreviewed
Ensembl ProteinENSONIP00000002266
UniProt AccessionI3J076;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSR (2 of 2)
Gene Synonyms/Alias INSR (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000001811ENSONIP00000002266ENSONIT00000002266
OrganismOreochromis niloticus
Functional Description
Protein Length1370
Protein Sequence
(FASTA)
MRRLTLKLRA QMVLFIMCTC IICQCGLING EICSSKDIRN NVTNLQSLEN CTIIEGHLKI 60
LLMFKTRTED FRGLSYPKLR VVTDYVLLFR VYGLETLSDL FPNLTVIRGN NLFFNYAFVL 120
YEMLQMKEMG LYSLMNITRG AVRIEKNPDL CYLATLDWSK ILDSVEDNFI VANKNERECG 180
DVCPGIAQGQ TICPQSTING HFRGRCWSQN HCQRMCSDNC KHSACTPQGQ CCHDQCLGGC 240
SEPGNASSCV ACRNLQHGSA CVEKCPPGYY IFRGWRCVSF AFCQDLHNQC KQTRKQNQDR 300
DSGCHEYVIH NGACIPECPS GYSSINSTTL TCSRCAGLCP KECVGNKTID SVTSAQALRG 360
CTILKGNMII KIRGGNNIAA ELEASLGQIE EITGYLTIRR AYALVSLSFL RKLRVIRGEQ 420
LEADAYAFYA LDNQNLRELW DWSKHNLTIL RGRTFFHYNS KLCMSEIRKM ETVTGTRDRN 480
QKNDIALRNN GEQASCETKL LNFTLIKTKS NMIILRWEPF WPADFRDLLG FMVLYKEAPY 540
KNVTEFDGQD ACGSNSWVIA DVDPPPRSTE GKKAEDPGYL IRPLKPWTQY AIMVKTQLSA 600
SDEHQVHGAK TEIIYVQTNA SKPSVPLDPI SSSNSSSQII LKWKPPTSPN GNITHYRVVC 660
RKQQEDSDLY KFDYCLQGMK VPSRIPTHLD SEDEQKWNQT DEPTSGGRCC ACPKTDSQLK 720
KEQEEIEYRK TFENYLHNEV FESRPSRRRR SVGVANATQP PLFLTTVPNL QLDSGTISPD 780
GEDQEESKVE QKVFSKESTV ISNLQHFTSY KIEIIACNDP TDPKRCSMAT YISARTMPEE 840
KADDIPEPVT HEIVQGEPPY VLIKWNPPIN PNGLIILYEV FYSKVGDSEV HTTCVSRPAY 900
QKLGGTKLSL VQPGNYSVRV RATSLAGNGS FTEIIYFFMP NPDQGLIWIV MGPVICFILL 960
LLAGGGVFVY FKKRQTEGPL GDLITSPNPE YFSAGDMYVP DEWEVPRDKI ALLRELGQGS 1020
FGMVYEGVAK DIVKGDPETR VAVKTVNESA SLRERIEFLN EASVMKAFSC HHVVRLLGVV 1080
SKGQPTLVVM ELMTHGDLKS YLRSLRPDSE NNPSGSPPPT LKDMLQMAAE IADGMAYLNA 1140
KKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW MAPESLKDGV 1200
FTAHSDCWSF GVVLWEISTL AEQPYQGLSN EQVLKFVMEG GFLDRPENCP ERMHSLMQMC 1260
WQYNPKMRPT FLEIIEMLRD DLDPSFQEVS FFYSDENKVP ETEEFDLDLD NMESIPLDPS 1320
SYSQREESLS RDSGPSVALR GNYEEHVPYT HMNGGKKNGR ILSLPRSSPS 1370
Nucleotide Sequence
(FASTA)
ATGAGGCGGC TGACGCTTAA ACTGCGAGCA CAAATGGTGT TGTTTATCAT GTGCACCTGC 60
ATTATATGCC AATGTGGACT AATAAACGGA GAAATCTGCT CGAGCAAGGA CATCCGGAAT 120
AACGTGACCA ACCTCCAGTC GTTGGAGAAC TGCACCATCA TCGAGGGCCA CCTAAAAATC 180
CTGCTCATGT TTAAGACCAG GACGGAGGAC TTCCGCGGCC TGAGCTACCC GAAACTGCGA 240
GTGGTGACGG ACTACGTGCT GCTCTTCAGG GTCTACGGCC TCGAGACGCT CAGCGATCTG 300
TTCCCCAACC TGACGGTGAT CCGCGGCAAC AACCTCTTCT TCAACTACGC TTTCGTGCTT 360
TATGAGATGC TGCAGATGAA GGAGATGGGC CTGTACAGCC TCATGAACAT CACCCGGGGC 420
GCCGTGAGGA TAGAGAAGAA TCCGGACCTG TGTTACCTGG CCACTCTGGA CTGGTCCAAG 480
ATCCTGGACT CGGTGGAGGA CAACTTCATC GTGGCCAATA AGAATGAGAG GGAGTGTGGA 540
GACGTGTGTC CAGGCATAGC CCAAGGTCAG ACCATCTGCC CTCAGAGCAC CATCAACGGA 600
CACTTCAGGG GACGATGCTG GTCACAGAAT CACTGCCAGA GAATGTGCTC GGACAACTGC 660
AAGCACAGTG CCTGCACCCC CCAAGGCCAG TGCTGCCACG ACCAGTGCCT GGGCGGCTGC 720
TCTGAGCCGG GTAACGCCAG CAGCTGCGTG GCCTGCAGGA ACCTCCAGCA CGGGAGCGCC 780
TGTGTAGAGA AATGTCCTCC TGGATACTAT ATCTTCAGAG GGTGGCGCTG TGTCAGCTTT 840
GCTTTCTGTC AGGACCTCCA CAACCAGTGT AAGCAGACTC GGAAACAAAA CCAGGACCGG 900
GACTCGGGCT GCCATGAATA CGTCATCCAC AATGGAGCCT GTATCCCAGA GTGCCCTTCC 960
GGATATTCCA GTATAAATTC CACTACGCTG ACTTGCTCAC GGTGTGCAGG CTTGTGTCCT 1020
AAAGAGTGTG TGGGAAACAA GACCATCGAC TCGGTAACGT CGGCCCAGGC TTTGAGGGGG 1080
TGCACCATTC TTAAAGGCAA CATGATCATC AAGATTCGAG GAGGCAATAA CATAGCAGCC 1140
GAATTGGAGG CGAGTTTGGG TCAGATTGAA GAGATCACAG GCTATCTGAC CATTCGCAGA 1200
GCTTACGCCC TGGTCTCCCT TTCATTCCTC CGCAAACTAC GTGTCATCAG GGGGGAGCAG 1260
CTTGAGGCAG ATGCCTATGC CTTCTATGCG CTGGACAACC AGAACCTCCG TGAGCTTTGG 1320
GATTGGTCCA AGCACAATCT AACCATCCTG CGTGGTCGCA CATTCTTCCA CTACAACTCT 1380
AAGCTTTGCA TGTCTGAAAT CCGAAAGATG GAGACGGTGA CTGGAACCCG GGATCGAAAC 1440
CAAAAGAACG ACATCGCTTT ACGCAACAAC GGGGAGCAAG CTTCCTGTGA GACGAAGCTG 1500
CTGAACTTCA CTTTGATAAA GACCAAGTCG AATATGATTA TACTGAGGTG GGAGCCATTC 1560
TGGCCAGCAG ACTTTAGGGA CCTGCTGGGA TTCATGGTTC TCTACAAAGA GGCGCCGTAT 1620
AAGAACGTGA CCGAGTTTGA TGGACAGGAC GCCTGCGGCT CTAACAGCTG GGTGATCGCC 1680
GATGTGGATC CGCCGCCTCG TTCCACGGAG GGAAAGAAGG CAGAGGACCC GGGGTACCTG 1740
ATCCGACCGT TGAAGCCCTG GACCCAGTAC GCCATCATGG TCAAAACGCA GCTGTCTGCG 1800
TCTGATGAGC ACCAGGTCCA CGGAGCCAAG ACCGAGATCA TCTACGTTCA GACGAATGCT 1860
TCCAAACCCT CTGTTCCTCT GGACCCCATC TCCTCCTCCA ACTCCTCCTC TCAGATCATC 1920
CTGAAGTGGA AACCGCCCAC CAGTCCCAAT GGCAACATCA CCCACTACCG GGTGGTCTGT 1980
CGAAAGCAGC AGGAGGACAG CGACCTGTAC AAATTCGACT ACTGCTTACA AGGAATGAAA 2040
GTGCCGTCTC GCATCCCGAC CCACCTGGAC AGTGAGGATG AGCAGAAGTG GAACCAAACA 2100
GATGAGCCCA CCTCGGGCGG CAGGTGCTGC GCCTGCCCCA AGACGGACAG CCAGCTAAAG 2160
AAGGAGCAGG AGGAGATAGA GTACCGCAAG ACCTTCGAGA ACTACCTACA CAATGAAGTC 2220
TTTGAGAGCA GACCATCCCG GCGGCGCCGC TCGGTGGGAG TTGCTAATGC CACCCAGCCT 2280
CCTCTCTTCC TTACCACAGT TCCCAATCTG CAGTTGGATT CAGGCACAAT CTCCCCCGAT 2340
GGCGAGGATC AAGAGGAATC CAAGGTGGAA CAAAAGGTGT TCTCAAAGGA GTCGACGGTC 2400
ATCTCCAACC TGCAACACTT TACCAGTTAT AAGATAGAGA TCATAGCCTG CAACGACCCG 2460
ACAGATCCCA AACGCTGCAG CATGGCTACT TATATCAGTG CCCGAACTAT GCCAGAGGAG 2520
AAAGCAGACG ACATCCCAGA GCCCGTGACC CACGAGATCG TGCAAGGCGA GCCTCCCTAT 2580
GTGTTGATTA AGTGGAATCC ACCTATCAAC CCTAATGGGC TCATCATCCT GTACGAGGTC 2640
TTCTACAGCA AGGTTGGAGA CTCAGAGGTT CACACGACCT GTGTGTCACG GCCGGCCTAT 2700
CAGAAGCTAG GTGGCACCAA GCTTTCCCTT GTTCAGCCTG GAAACTACAG CGTGAGGGTT 2760
CGCGCCACCT CGCTGGCAGG AAATGGCTCT TTTACTGAGA TAATTTACTT CTTCATGCCC 2820
AACCCTGATC AAGGTTTGAT TTGGATTGTC ATGGGTCCCG TCATCTGCTT CATCCTGCTG 2880
CTACTCGCGG GAGGTGGAGT GTTTGTGTAC TTCAAAAAAA GGCAAACCGA AGGCCCCTTA 2940
GGAGATCTCA TCACCTCTCC AAACCCCGAG TACTTCAGCG CTGGTGACAT GTACGTTCCT 3000
GATGAGTGGG AGGTGCCCCG GGACAAGATC GCACTGCTCA GAGAGCTCGG TCAGGGCTCC 3060
TTCGGTATGG TGTACGAAGG AGTCGCCAAA GACATCGTCA AAGGCGATCC GGAGACGCGC 3120
GTGGCCGTCA AGACGGTCAA CGAATCGGCC AGCCTGCGAG AGAGGATCGA GTTCCTCAAC 3180
GAAGCCTCCG TCATGAAGGC TTTCAGCTGT CACCACGTGG TACGTCTGCT CGGTGTGGTG 3240
TCCAAAGGTC AGCCCACCCT GGTAGTGATG GAGCTGATGA CCCACGGGGA CCTGAAAAGC 3300
TACCTGAGGA GTCTCAGGCC AGACTCGGAG AACAACCCGT CTGGCTCCCC GCCACCTACT 3360
CTGAAAGACA TGCTCCAGAT GGCTGCAGAA ATCGCAGACG GCATGGCCTA CCTCAATGCC 3420
AAAAAGTTCG TCCACAGAGA CCTCGCAGCC AGGAACTGCA TGGTGGCGGA GGACTTCACC 3480
GTCAAGATCG GAGACTTTGG TATGACACGA GACATCTATG AGACGGACTA CTACCGTAAA 3540
GGAGGGAAGG GCCTGCTTCC TGTCCGGTGG ATGGCACCCG AGTCCCTGAA GGACGGAGTC 3600
TTCACCGCCC ACTCTGACTG CTGGTCGTTC GGTGTTGTGT TGTGGGAGAT CAGCACACTG 3660
GCCGAGCAGC CTTACCAGGG TTTGTCCAAT GAGCAGGTGC TGAAGTTCGT CATGGAAGGA 3720
GGGTTCCTGG ATCGGCCGGA GAACTGCCCT GAGAGGATGC ACAGCCTCAT GCAGATGTGC 3780
TGGCAGTACA ATCCCAAGAT GCGTCCGACG TTCCTCGAGA TCATCGAGAT GCTGCGGGAC 3840
GACCTGGACC CGTCTTTCCA GGAGGTCTCC TTCTTCTACA GCGATGAAAA CAAAGTCCCT 3900
GAGACGGAGG AGTTTGACCT AGATCTGGAC AACATGGAAA GCATCCCCCT GGACCCGTCT 3960
TCTTACTCCC AGAGAGAGGA GAGCTTATCC AGGGACAGCG GGCCCTCGGT GGCCCTGAGG 4020
GGGAACTATG AGGAGCACGT CCCCTACACA CACATGAACG GTGGCAAGAA AAATGGAAGA 4080
ATTTTATCAT TGCCCAGATC CAGCCCTTCC TAA 4113
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+llrelGqGsfGmvyeGvakd+vkg+ etrva+ktvne+as reriefl+easvmk+f+
Q: 1010  IALLRELGQGSFGMVYEGVAKDIVKGDPETRVAVKTVNESASLRERIEFLNEASVMKAFS  1069
         6899********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaa.lappaldkliqmaa  119
         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrp++en+++  +pp+l+++ qmaa
Q: 1070  CHHVVRLLGVVSKGQPTLVVMELMTHGDLKSYLRSLRPDSENNPSgSPPPTLKDMLQMAA  1129
         *****************************************988626699**********
S: 120   eiadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvr  179
         eiadGmayl+akkfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvr
Q: 1130  EIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR  1189
         ************************************************************
S: 180   wmspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpenc  239
         wm+peslkdGvft++sd wsfGvvlwei tlaeqpyqGlsneqvlkfv++gg+l++penc
Q: 1190  WMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMEGGFLDRPENC  1249
         ************************************************************
S: 240   pelltelmrlcwqynpklrpsfleivell  268
         pe+++ lm++cwqynpk+rp+flei+e+l
Q: 1250  PERMHSLMQMCWQYNPKMRPTFLEIIEML  1278
         **************************975
Domain Sequence
(FASTA)
IALLRELGQG SFGMVYEGVA KDIVKGDPET RVAVKTVNES ASLRERIEFL NEASVMKAFS 60
CHHVVRLLGV VSKGQPTLVV MELMTHGDLK SYLRSLRPDS ENNPSGSPPP TLKDMLQMAA 120
EIADGMAYLN AKKFVHRDLA ARNCMVAEDF TVKIGDFGMT RDIYETDYYR KGGKGLLPVR 180
WMAPESLKDG VFTAHSDCWS FGVVLWEIST LAEQPYQGLS NEQVLKFVME GGFLDRPENC 240
PERMHSLMQM CWQYNPKMRP TFLEIIEML 269
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-CAE-00002
EKS-DRM-00003
EKS-GAA-00022
EKS-ORL-00023
EKS-TAR-00027
EKS-TEN-00025
EKS-XIM-00024
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013