EKS-ORN-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	389.6	8.2E-117	118	373	256

Status

Unreviewed

Ensembl Protein

ENSONIP00000002281

UniProt Accession

I3J091;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK1

Gene Synonyms/Alias

TNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000001824	ENSONIP00000002281	ENSONIT00000002281

Organism

Oreochromis niloticus

Functional Description

Protein Length

753

Protein Sequence
(FASTA)

MVMDQDTQWL YQLLAEVQLE KFYLRLRDGL NITRIEHFSY VKEADLEQIG ISKPGQRRLW 60

EALKRYKTSA RGRSWVPKVF SGRGSDGGEQ LTGGGQAQGQ EVGVRALPCL IQDSELILAE 120

RLGSGSFGVV KRGEWHTPTG RVLPVAVKSL RSSMSRQADT LKDFLQEVTV MQSLDHPNII 180

RLYGVVLTQP LKMVTELAAL GSLYDTLRAR QYEYSLVRLW LFATQIVSGM EYLESRRFIH 240

RDLAARNVLL ASKDMVKIGD FGLMRGLNQE KDHYIMSAHR RIPFAWCAPE SLRVGSFSLS 300

SDVWMFGVTL WEMFTYCEEP WFGLSGRQIL WRVEREGERL EKPQDCPQEI YAVMRKCWAC 360

NPTDRPSFAQ LTAMVAEAKP REVQAIREFA EPRKLALLPN DLVTVIDHSL ELSEWRGQNQ 420

RTMAIGWFPA SLTVPSLPSG AAVSSSSSGP NPGGYISTPV KGSLQHTGHG DVNPDHSWGT 480

PVTLDEAGGG WRSGPGREKE GSNLQKMAAM TRSLESVLGG HRPRAQTVGM FRVDQHGKLL 540

PPVMPAHSAV MQQDPRRLSE ASIVPPPRPP PPNLKVLRKI QRRPTINQAQ GNALPQQMVP 600

SALIQTQPQP QQVVGGSNLT KMAQLARSTP QLDEYSDSRE RDRERIRERE KVPQNTREGL 660

IAQVMEAVHG VTTDEVHNAL QRNEWNPVRA EQQLKMEQLY SLSLCSREDC VKILAKYQWN 720

LQMASRYLIR LTASDRAGPP ERDRPLISPE RRV 753

Nucleotide Sequence
(FASTA)

ATGGTGATGG ACCAGGACAC TCAATGGCTA TACCAACTCC TAGCTGAAGT CCAGCTGGAG 60

AAGTTTTACC TGCGCCTCAG AGATGGCCTC AATATCACTC GCATTGAGCA CTTCAGCTAC 120

GTCAAAGAGG CCGATCTGGA GCAGATAGGA ATCAGCAAAC CTGGACAAAG AAGACTATGG 180

GAAGCTCTGA AACGCTACAA GACAAGCGCA CGCGGGCGGT CATGGGTGCC AAAGGTGTTC 240

AGCGGCCGAG GTTCAGATGG CGGAGAGCAG TTAACTGGAG GTGGCCAAGC ACAGGGCCAG 300

GAAGTCGGAG TCCGGGCTCT TCCTTGTCTG ATCCAAGACA GTGAGCTGAT TCTGGCGGAG 360

AGGCTGGGCT CTGGGTCATT TGGGGTGGTG AAGAGGGGAG AGTGGCACAC GCCCACTGGA 420

AGAGTGTTGC CTGTGGCAGT TAAATCGCTG AGGAGCAGTA TGTCGAGGCA GGCGGACACA 480

CTGAAAGACT TTCTTCAAGA AGTAACCGTC ATGCAGTCTT TAGACCACCC CAACATCATA 540

CGACTCTATG GTGTGGTGCT CACACAGCCC CTCAAGATGG TAACAGAGCT GGCCGCCTTG 600

GGCTCGCTTT ACGACACCCT GCGTGCACGT CAGTATGAGT ACTCTCTGGT CCGCCTTTGG 660

CTCTTTGCTA CGCAGATTGT GTCAGGCATG GAGTACCTGG AGAGCAGGAG ATTCATCCAC 720

AGGGATCTGG CTGCAAGAAA TGTACTGCTT GCATCCAAGG ATATGGTGAA GATCGGGGAC 780

TTTGGTCTGA TGCGAGGCCT GAACCAGGAG AAAGATCACT ACATCATGTC GGCACACAGG 840

CGGATACCGT TTGCATGGTG TGCTCCAGAG AGTCTTCGCG TCGGCTCTTT CTCCCTTTCC 900

TCGGACGTGT GGATGTTTGG TGTCACTCTC TGGGAGATGT TTACCTATTG TGAAGAGCCC 960

TGGTTTGGTC TGTCGGGCCG GCAGATATTA TGGCGGGTAG AGCGGGAGGG CGAGCGCCTG 1020

GAGAAGCCAC AAGATTGCCC TCAGGAGATA TACGCTGTAA TGCGAAAGTG CTGGGCATGC 1080

AATCCTACAG ACAGACCCAG CTTTGCCCAG CTCACCGCGA TGGTAGCAGA GGCTAAACCC 1140

AGAGAGGTGC AAGCAATAAG AGAATTTGCC GAACCCAGAA AGCTCGCCCT TTTGCCCAAC 1200

GACCTCGTGA CTGTCATCGA CCACAGTCTG GAGCTGAGTG AGTGGAGGGG GCAGAACCAG 1260

AGGACGATGG CCATCGGCTG GTTTCCCGCA AGCCTCACTG TCCCATCACT CCCCTCAGGT 1320

GCCGCAGTGT CCTCCAGCAG CTCCGGGCCT AACCCTGGTG GCTACATCTC AACCCCAGTA 1380

AAGGGCAGTT TGCAACACAC CGGGCACGGA GACGTCAACC CTGATCACTC CTGGGGAACG 1440

CCTGTGACCC TGGACGAGGC TGGCGGTGGC TGGAGGTCAG GCCCCGGCAG GGAGAAGGAG 1500

GGATCCAATC TGCAGAAAAT GGCAGCTATG ACTAGAAGCC TGGAGTCAGT CTTGGGTGGA 1560

CATCGGCCCC GAGCTCAAAC AGTAGGGATG TTCAGAGTGG ATCAGCACGG CAAACTCCTT 1620

CCTCCTGTGA TGCCGGCTCA CAGTGCGGTG ATGCAACAGG ATCCGCGTCG GTTGAGTGAG 1680

GCTAGTATCG TTCCCCCTCC TCGACCGCCA CCTCCCAACC TGAAAGTGCT TCGAAAAATC 1740

CAGAGGAGAC CTACAATTAA CCAAGCCCAG GGCAATGCAT TGCCCCAGCA AATGGTTCCC 1800

TCTGCTCTGA TACAGACACA ACCTCAGCCT CAGCAGGTTG TCGGGGGTTC CAACCTCACC 1860

AAAATGGCCC AGCTGGCACG CTCTACCCCA CAGCTGGATG AGTACTCAGA CAGCAGAGAG 1920

AGAGATCGGG AGCGAATAAG AGAACGGGAG AAAGTGCCTC AGAACACAAG AGAGGGTCTC 1980

ATTGCACAGG TTATGGAGGC GGTACATGGC GTGACCACAG ATGAGGTTCA CAACGCACTT 2040

CAACGAAATG AGTGGAACCC AGTGCGAGCT GAACAGCAAC TAAAGATGGA GCAGCTGTAC 2100

TCGCTGAGCC TCTGCTCCAG AGAGGACTGC GTCAAGATCC TCGCCAAATA CCAGTGGAAC 2160

CTGCAGATGG CCAGCCGCTA TCTAATCCGA CTGACTGCCA GCGACAGGGC CGGCCCACCT 2220

GAGAGGGATC GGCCTCTGAT CAGCCCGGAA AGAAGGGTCT AA 2262

Domain Profile

S: 3     lleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllklehe  61

         l e+lG+GsfgvvkrgeW++p+g++++vavk+l+s    ++++ +dfl+ev+v+++l+h+

Q: 118   LAERLGSGSFGVVKRGEWHTPTGRVLPVAVKSLRSSMSRQADTlKDFLQEVTVMQSLDHP  177

         7899******************************9998888877****************

S: 62    nlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayles  121

         n++rlyGvvltqplk+vtela lgsl+d+lr+++   ++++ +l+ +a+qi++g++yles

Q: 178   NIIRLYGVVLTQPLKMVTELAALGSLYDTLRARQY--EYSLVRLWLFATQIVSGMEYLES  235

         ********************************999..79999******************

S: 122   krlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrtr  181

         +r++hrdlaarn+llask++vki+dfGl+r l++e+d+y ++ ++++PfaWcaPeslr

Q: 236   RRFIHRDLAARNVLLASKDMVKIGDFGLMRGLNQEKDHYIMSAHRRIPFAWCAPESLRVG  295

         ************************************************************

S: 182   kfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediyslll  241

          fs +sdvW+fGvtlWemf+y eePW glsg qil ++++e+erlekP++cp++iy+++

Q: 296   SFSLSSDVWMFGVTLWEMFTYCEEPWFGLSGRQILWRVEREGERLEKPQDCPQEIYAVMR  355

         ************************************************************

S: 242   kcWakkpadrpkfsalke  259

         kcWa +p drp+f++l++

Q: 356   KCWACNPTDRPSFAQLTA  373

         **************9976

Domain Sequence
(FASTA)

LAERLGSGSF GVVKRGEWHT PTGRVLPVAV KSLRSSMSRQ ADTLKDFLQE VTVMQSLDHP 60

NIIRLYGVVL TQPLKMVTEL AALGSLYDTL RARQYEYSLV RLWLFATQIV SGMEYLESRR 120

FIHRDLAARN VLLASKDMVK IGDFGLMRGL NQEKDHYIMS AHRRIPFAWC APESLRVGSF 180

SLSSDVWMFG VTLWEMFTYC EEPWFGLSGR QILWRVEREG ERLEKPQDCP QEIYAVMRKC 240

WACNPTDRPS FAQLTA 256

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Danio rerio"; ?>Erinaceus europaeus"; ?>Gasterosteus aculeatus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013