EKS-ORN-00336

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00336

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Abl	531.9	3.1E-160	286	540	255

Status

Unreviewed

Ensembl Protein

ENSONIP00000002471

UniProt Accession

I3J0T1;

Protein Name

Protein Synonyms/Alias

Gene Name

ABL2

Gene Synonyms/Alias

ABL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000001974	ENSONIP00000002471	ENSONIT00000002472

Organism

Oreochromis niloticus

Functional Description

Protein Length

1208

Protein Sequence
(FASTA)

MGQQVGRVGE GTSTGLQPPQ PHAPQPHQGK GNRGSGVGRR PREPGSSTGT PPGRTAPVNV 60

PDPGINIFTQ HSVVQRIYAC PFVPEALTEA VRWSSKENLL GAAESDPNLF VALYDFVASG 120

DNTLSITKGE KLRVLGYNQN GEWSEVRSKN GQGWVPSNYI TPVNSLEKHS WYHGPVSRSA 180

AEYLLSSLIN GSFLVRESES SPGQLSISLR YEGRVYHYRI NTATDGKVYV TSESRFATLA 240

ELVHHHSTVP DGLVTTLHYP APKCNKPTVY GVSPIHDKWE MERTDITMKH KLGGGQYGEV 300

YVGVWKKYNL TVAVKTLKED TMEVEEFLKE AAVMKEVKHP NLVQLLGVCT LEPPFYIVTE 360

YMPHGNLLDY LRECERDEVN AVALLYMATQ ISSAMEYLEK KNFFSLPLRD LAARNCLVGE 420

NHVVKVADFG LSRLMTGDTY TAHAGAKFPI KWTAPESLAY NTFSIKSDVW AFGVLLWEIA 480

TYGMSPYPGI DLSQVYDLLE KGYRMEQPEG CPPKVYELMR ACWQWSPLDR PSFAEIHQAF 540

ETMFHGSSIS EEVAEELCKT ASSDHSGPLQ SFSHDMPLLP SKSRPLHKHT ENKENIEGGL 600

DGRTDHSTHG HSGWASSLLG GDSRSGSSPA LPRKQQSRDK SPSSLLEDAQ DVGTFTRDRK 660

TGFFSSFIKH QQNLPMPPKR SSSFREMETQ PHKKYEPTPD FSAPPPLPQS DSLGGFSASP 720

SHSHGEPIQA QSRCCGAAFG QKPSGGGFGS QVTSGSSWSG LAGFFTPRLI KKTLGLRTGK 780

TCSTDEGGNI VGGPKPFPRS NSTSSMSAGL PDLERMALTL PRNRSAKPPL ERTASTTSQP 840

ENGAARPSET LLRRMDEGTA QIRERPKAKL LPRGTAVGVR APGVGGEGGD SDSLSRVREG 900

REESGGLDRQ QSWTSPSKSS GLSMSSAAAG GPPHNHKVPV LISPTLKHSP GDVHLVGLDS 960

QGNRFKLLSE HQADRDRPRL VKPKCAPPPP PTLRSLQHSY SGDGEEQVGG MPVEVNGDTL 1020

KGQRSGRMSG GMMTGRPSVP PPQVPPASSA SFSSSCSATT NTTPTKMANG ATTTAPSHTA 1080

PSAGSKVALR RTRQQVERAP LERVNREVLL ECAECLSSAL HASSESPSSS QVLDAGHQLL 1140

DYCSGYVDCI PQMRNKFAFR EAVGKLELSL QELRASSSGG GGLGGVGSNT VLDNLHSCIK 1200

EISDVVQR 1208

Nucleotide Sequence
(FASTA)

ATGGGACAGC AGGTTGGCCG AGTCGGTGAG GGTACATCGA CCGGGCTCCA GCCACCACAG 60

CCCCACGCGC CCCAACCACA CCAAGGGAAG GGGAACCGGG GGAGCGGCGT CGGGAGGAGA 120

CCCCGGGAAC CCGGCAGTAG CACCGGGACA CCACCAGGCA GGACAGCTCC AGTCAATGTG 180

CCCGATCCAG GCATCAATAT ATTCACGCAG CATTCAGTAG TGCAAAGAAT ATATGCTTGT 240

CCTTTCGTAC CAGAAGCTCT GACAGAGGCG GTGCGCTGGA GCTCCAAGGA GAACCTTCTG 300

GGCGCGGCCG AGAGCGACCC TAACCTCTTT GTTGCACTTT ATGACTTTGT TGCTAGTGGA 360

GACAACACAC TCAGCATCAC CAAAGGTGAG AAGCTGCGTG TGCTGGGCTA CAACCAGAAT 420

GGAGAGTGGA GTGAAGTGAG GTCTAAAAAC GGTCAGGGAT GGGTTCCCTC CAACTACATC 480

ACACCGGTCA ACAGCCTGGA GAAGCATAGC TGGTACCACG GGCCCGTTTC CCGCAGCGCT 540

GCAGAGTATC TGCTCTCATC ACTTATCAAT GGCAGTTTTC TGGTGCGAGA AAGCGAGAGC 600

AGCCCCGGAC AGCTGTCCAT ATCTCTGCGC TATGAGGGCA GAGTGTACCA CTACCGCATC 660

AACACAGCCA CGGATGGGAA GGTGTACGTA ACATCTGAAA GCCGATTCGC CACTCTGGCC 720

GAGCTGGTCC ATCACCACTC CACTGTACCT GATGGTCTGG TCACCACGCT GCACTACCCT 780

GCACCCAAAT GTAACAAGCC CACAGTGTAC GGTGTGTCAC CCATCCATGA TAAGTGGGAG 840

ATGGAGCGCA CAGACATCAC CATGAAGCAC AAGCTGGGAG GAGGCCAGTA TGGGGAGGTG 900

TATGTCGGAG TGTGGAAAAA GTACAACCTC ACTGTGGCTG TCAAAACACT AAAGGAAGAC 960

ACTATGGAAG TAGAAGAGTT TTTGAAAGAG GCGGCAGTTA TGAAAGAGGT TAAACACCCA 1020

AACCTTGTTC AGCTGCTGGG TGTGTGTACG TTAGAGCCTC CATTCTACAT TGTGACTGAG 1080

TATATGCCAC ATGGCAACCT ACTGGACTAC TTGAGAGAGT GTGAACGCGA TGAGGTGAAT 1140

GCTGTTGCGC TGCTATACAT GGCCACGCAG ATCTCCTCTG CCATGGAGTA TCTGGAGAAA 1200

AAGAACTTTT TTTCTTTACC TCTCAGGGAT CTCGCAGCGA GGAACTGCCT GGTCGGTGAA 1260

AATCATGTCG TGAAGGTTGC CGATTTCGGC CTGAGCCGGT TGATGACCGG TGACACCTAC 1320

ACCGCCCACG CTGGGGCCAA GTTCCCCATC AAATGGACCG CACCGGAGAG CCTTGCCTAT 1380

AACACCTTCT CCATCAAGTC TGATGTCTGG GCTTTTGGAG TGCTACTTTG GGAAATTGCC 1440

ACTTATGGCA TGTCTCCCTA CCCGGGTATC GATTTGTCTC AGGTCTACGA TCTCTTGGAG 1500

AAAGGCTATC GCATGGAGCA ACCTGAGGGA TGCCCGCCCA AAGTTTATGA ACTCATGAGG 1560

GCATGCTGGC AGTGGAGCCC GTTGGATCGA CCTTCGTTTG CAGAGATCCA CCAAGCCTTC 1620

GAAACGATGT TTCATGGCTC GAGCATTTCT GAAGAGGTGG CAGAGGAGCT CTGTAAGACA 1680

GCATCCTCTG ATCACAGCGG ACCGCTGCAG TCTTTCAGTC ATGATATGCC CCTGTTGCCT 1740

TCCAAATCTC GCCCACTCCA CAAGCACACA GAAAACAAGG AAAACATCGA GGGTGGACTG 1800

GACGGCCGCA CCGATCACAG CACGCACGGT CACTCAGGTT GGGCGTCGTC TTTGCTCGGA 1860

GGGGACAGCC GATCAGGCAG CTCCCCAGCC CTCCCCAGAA AGCAACAGTC AAGAGATAAA 1920

TCTCCCAGCA GCCTTTTAGA GGATGCACAG GATGTGGGCA CATTTACGCG AGACCGCAAG 1980

ACTGGCTTCT TTAGCTCATT TATCAAACAC CAACAGAACC TTCCAATGCC ACCCAAGAGA 2040

AGCAGTTCCT TCCGGGAGAT GGAGACACAA CCTCACAAAA AGTACGAGCC TACACCCGAT 2100

TTCAGTGCTC CTCCTCCCCT GCCCCAGTCA GACAGTTTAG GGGGCTTTTC TGCGTCTCCT 2160

TCCCACTCAC ATGGGGAACC CATCCAGGCA CAGTCTCGCT GCTGCGGGGC AGCTTTTGGA 2220

CAGAAACCCT CTGGGGGAGG CTTTGGTTCA CAGGTGACAA GTGGTAGCAG TTGGAGTGGG 2280

CTGGCTGGCT TTTTTACCCC TAGACTCATT AAAAAGACCC TGGGGCTACG GACAGGAAAG 2340

ACATGCTCCA CAGACGAGGG TGGAAACATA GTTGGTGGGC CTAAACCTTT CCCTAGGTCC 2400

AATTCTACCT CCTCAATGTC AGCTGGGCTG CCAGATTTGG AGCGCATGGC TCTGACGTTA 2460

CCCAGGAACC GCAGTGCTAA ACCGCCTCTG GAGAGGACTG CCTCAACAAC CTCTCAGCCA 2520

GAGAACGGGG CTGCACGGCC ATCAGAAACT CTGCTGAGGA GGATGGATGA GGGGACTGCA 2580

CAGATCAGGG AAAGGCCCAA AGCCAAGCTA CTACCCCGGG GCACTGCTGT AGGGGTGAGG 2640

GCACCAGGGG TTGGGGGGGA AGGTGGGGAT TCGGACAGCC TGTCCCGAGT CAGGGAGGGT 2700

AGAGAGGAGA GTGGAGGACT GGACAGGCAG CAGAGTTGGA CATCTCCTTC CAAGTCTTCT 2760

GGCTTGAGCA TGTCATCAGC TGCAGCAGGT GGGCCACCTC ACAACCACAA AGTCCCAGTC 2820

CTGATCTCTC CCACACTGAA GCACAGCCCA GGTGACGTGC ACCTGGTGGG GCTAGACTCT 2880

CAGGGGAACC GCTTTAAGCT GCTGTCTGAG CACCAAGCAG ACCGAGACAG GCCACGCCTC 2940

GTCAAACCCA AGTGTGCGCC GCCTCCTCCC CCTACTCTGC GCAGTCTGCA ACACTCCTAC 3000

AGCGGCGACG GAGAAGAGCA AGTCGGAGGA ATGCCTGTGG AAGTAAATGG GGACACATTA 3060

AAAGGTCAAA GGTCAGGGCG AATGTCAGGA GGAATGATGA CAGGCAGACC ATCAGTGCCA 3120

CCACCACAAG TGCCTCCAGC TTCTTCCGCT TCCTTTTCCT CTTCTTGCTC TGCCACCACA 3180

AACACAACCC CCACTAAAAT GGCCAATGGG GCCACCACCA CTGCCCCCTC GCACACAGCA 3240

CCGTCTGCTG GTTCCAAAGT GGCACTGCGG CGAACTAGGC AGCAAGTGGA GAGGGCGCCC 3300

TTGGAGCGGG TTAACCGCGA GGTCTTGCTG GAGTGCGCGG AATGCCTGAG CAGCGCACTC 3360

CACGCCAGCT CCGAAAGCCC CTCCAGCAGC CAGGTTCTGG ACGCTGGCCA TCAGCTGCTA 3420

GACTACTGCT CAGGTTATGT GGACTGCATC CCTCAGATGA GGAACAAATT TGCCTTTCGA 3480

GAGGCAGTGG GGAAGCTGGA GCTCAGCCTG CAGGAACTGA GAGCCTCGTC GTCAGGAGGT 3540

GGGGGGTTGG GTGGCGTGGG GTCCAACACT GTACTGGATA ACCTACACAG CTGTATTAAA 3600

GAGATTAGTG ACGTAGTGCA GAGGTAG 3627

Domain Profile

S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60

         i+mkhklgggqygevy+gvwkky+ltvavktlkedtmeveeflkeaavmke+khpnlvql

Q: 286   ITMKHKLGGGQYGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFLKEAAVMKEVKHPNLVQL  345

         89**********************************************************

S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120

         lgvct eppfyi+te+m++gnlldylre++r+ev+av+llymatqissameylekknf

Q: 346   LGVCTLEPPFYIVTEYMPHGNLLDYLRECERDEVNAVALLYMATQISSAMEYLEKKNFFS  405

         **********************************************************85

S: 121   ...rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsi  177

            rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsi

Q: 406   lplRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSI  465

         555*********************************************************

S: 178   ksdvwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkw  237

         ksdvwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracw+w

Q: 466   KSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWQW  525

         ************************************************************

S: 238   spsdrpsfaeihqal  252

         sp drpsfaeihqa+

Q: 526   SPLDRPSFAEIHQAF  540

         ************986

Domain Sequence
(FASTA)

ITMKHKLGGG QYGEVYVGVW KKYNLTVAVK TLKEDTMEVE EFLKEAAVMK EVKHPNLVQL 60

LGVCTLEPPF YIVTEYMPHG NLLDYLRECE RDEVNAVALL YMATQISSAM EYLEKKNFFS 120

LPLRDLAARN CLVGENHVVK VADFGLSRLM TGDTYTAHAG AKFPIKWTAP ESLAYNTFSI 180

KSDVWAFGVL LWEIATYGMS PYPGIDLSQV YDLLEKGYRM EQPEGCPPKV YELMRACWQW 240

SPLDRPSFAE IHQAF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

InterPros

IPR015015	; F-actin_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF08919	; F_actin_bind; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00808	; FABD; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013