EKS-ORN-00132
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00132
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec441.69.5E-133377627251
StatusUnreviewed
Ensembl ProteinENSONIP00000003101
UniProt AccessionI3J2L2;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000002479ENSONIP00000003102ENSONIT00000003103
ENSONIG00000002479ENSONIP00000003101ENSONIT00000003102
OrganismOreochromis niloticus
Functional Description
Protein Length635
Protein Sequence
(FASTA)
MSDSILEQVF IKRSQQKKKT SPLNYKERLF VLTAEKIFYY DFDTDKAKRK GLKGSVDLEK 60
IKCVETVQPE PNAPQERMYP FQVIYDEGPL YIFSKTEDIR AEWIKKLKEL VRFNSDLMQK 120
YHPCFWVDGV WLCCHQEVKQ AMGCKVLDSK NGVTSQLSRR STRKPLPPTP GEKKPTRPLP 180
PQPPDPPASS AGMTVVAEYN YTPMTTQDLE LRKDEEYTIL EKSDANWWRA RDKYGKEGYI 240
PSNYVVEAED GLERFDWYCK NMNRSQAEKL LKAENKDGGF LVRDSSKAGK YTVSLLTKGG 300
GEAVGSCRHY NICTTPQSQY YLAEKHNFNT IAELINYHQH NAAGMVSRLK HIVSNRARPP 360
STAGLGYGVW EIDPRYLTFI KELGSGQFGV VKYGKWQGQH DVAIKMIKEG SMSEDDFIEE 420
AKIMMKLRHE NLVQLYGVCT KQRPIYIVTE YLANGCLLTY LKEGLKQHPT SIQLLEMCKD 480
VAEGMAYLEA HQYIHRDLAA RNCLVDGNGT VKVTDFGLSR YVLDDEYTSS VGSKFPVRWS 540
PPEVLLYCKF SSKSDIWAYG VLMWEVYTLG RLPYERLNNT EIVDQVSRGL RLFRPQLANE 600
RVYSIMSSCW LDKAEERPNF QELALTVQDL LYELQ 635
Nucleotide Sequence
(FASTA)
ATGTCAGACT CTATACTGGA ACAAGTCTTC ATTAAAAGAT CTCAACAGAA GAAGAAGACC 60
TCACCTTTAA ACTACAAAGA GAGATTGTTT GTTCTCACAG CAGAAAAAAT ATTCTACTAT 120
GACTTTGACA CAGACAAAGC GAAGCGAAAA GGTCTGAAAG GGTCAGTTGA CCTAGAGAAG 180
ATCAAGTGTG TAGAGACAGT CCAGCCAGAG CCCAATGCCC CACAAGAGCG CATGTATCCA 240
TTCCAGGTCA TTTATGATGA AGGGCCACTG TATATATTTT CTAAGACTGA AGACATCCGG 300
GCTGAGTGGA TAAAGAAGCT CAAAGAATTG GTGCGCTTCA ACAGTGATCT GATGCAGAAG 360
TACCATCCGT GCTTCTGGGT TGATGGGGTG TGGTTGTGCT GCCACCAGGA AGTTAAACAG 420
GCCATGGGTT GCAAAGTGCT CGATAGTAAG AATGGAGTGA CATCACAGCT ATCTCGAAGG 480
TCAACAAGGA AGCCGCTTCC TCCAACCCCA GGAGAGAAAA AGCCTACTCG TCCTTTACCT 540
CCACAGCCTC CTGACCCACC AGCTTCCTCT GCAGGCATGA CAGTTGTAGC TGAGTACAAT 600
TACACACCCA TGACAACACA AGACCTGGAG CTAAGGAAGG ATGAGGAGTA CACCATCCTG 660
GAAAAGTCCG ATGCAAACTG GTGGAGAGCT CGAGACAAAT ATGGGAAAGA GGGTTATATA 720
CCAAGCAATT ATGTTGTAGA AGCTGAAGAT GGGCTAGAAA GATTCGACTG GTATTGCAAG 780
AATATGAACC GTAGTCAAGC AGAAAAACTG TTAAAGGCTG AGAACAAAGA TGGAGGCTTC 840
TTGGTACGGG ACTCCAGCAA GGCTGGGAAA TACACTGTGT CTCTGCTCAC AAAGGGTGGC 900
GGGGAAGCTG TTGGAAGCTG CCGACATTAT AACATCTGCA CCACCCCGCA GAGCCAGTAT 960
TACTTGGCAG AAAAGCATAA TTTTAACACC ATCGCAGAGC TCATCAACTA TCACCAGCAC 1020
AACGCAGCAG GCATGGTTAG CAGACTGAAA CACATCGTAT CTAACCGGGC ACGGCCCCCA 1080
TCCACAGCAG GCCTTGGTTA TGGTGTGTGG GAGATTGACC CACGCTACCT CACCTTCATC 1140
AAGGAGTTGG GATCTGGACA ATTTGGAGTG GTGAAGTATG GGAAGTGGCA GGGACAGCAT 1200
GATGTGGCCA TTAAAATGAT TAAAGAGGGC TCCATGTCAG AAGATGATTT CATAGAAGAA 1260
GCAAAAATCA TGATGAAGCT TCGCCATGAG AACCTGGTCC AGCTCTACGG CGTGTGCACC 1320
AAACAAAGGC CTATTTATAT AGTGACTGAG TACCTTGCAA ACGGCTGCCT CCTCACATAC 1380
CTCAAGGAGG GCCTGAAGCA GCACCCAACA AGCATCCAGC TGCTAGAGAT GTGTAAAGAT 1440
GTCGCTGAGG GCATGGCCTA CCTCGAGGCA CACCAGTACA TCCACAGAGA CCTGGCTGCC 1500
AGGAACTGTT TAGTAGATGG AAATGGCACT GTCAAAGTGA CTGACTTTGG GCTATCAAGG 1560
TATGTTTTAG ATGATGAATA CACAAGCTCG GTTGGCTCAA AGTTCCCTGT CCGCTGGTCG 1620
CCACCCGAAG TCCTTCTTTA CTGCAAATTC AGCAGTAAGT CTGACATCTG GGCATATGGG 1680
GTTTTAATGT GGGAGGTGTA CACTCTGGGA CGGCTTCCTT ATGAGCGCCT CAACAACACG 1740
GAAATAGTGG ACCAAGTGTC CCGGGGCCTG CGCCTCTTTC GCCCCCAGTT GGCCAACGAA 1800
AGAGTTTACA GCATTATGTC AAGCTGCTGG CTTGATAAAG CAGAGGAGAG ACCCAACTTT 1860
CAGGAGCTGG CGCTGACTGT TCAGGATCTG CTGTATGAAC TCCAGTAG 1908
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt++kelgsgqfgvvk+gkw++++dvaik+ikeg+mse+dfieeak+mmkl h++lvqly
Q: 377   LTFIKELGSGQFGVVKYGKWQGQHDVAIKMIKEGSMSEDDFIEEAKIMMKLRHENLVQLY  436
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkkl.ekelllemckdvcegmeylerksfihr  119
         gvc+kq+piyivteyl+ngcll yl+e  k+  ++ +llemckdv+egm+yle +++ihr
Q: 437   GVCTKQRPIYIVTEYLANGCLLTYLKEGLKQHpTSIQLLEMCKDVAEGMAYLEAHQYIHR  496
         **************************98766615667***********************
S: 120   dlaarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdv  179
         dlaarnclvd + +vkv+dfgl+ryvldd+y+ssvg+kfpv+wsppevl y k+ssksd+
Q: 497   DLAARNCLVDGNGTVKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYCKFSSKSDI  556
         ************************************************************
S: 180   wafgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpee  239
         wa+gvlmwev+++g+lpye+ +n+e+v++vsrglrl+rp+la+++vy++m scw +k+ee
Q: 557   WAYGVLMWEVYTLGRLPYERLNNTEIVDQVSRGLRLFRPQLANERVYSIMSSCWLDKAEE  616
         ************************************************************
S: 240   rptfkellsal  250
         rp+f+el  ++
Q: 617   RPNFQELALTV  627
         ******97666
Domain Sequence
(FASTA)
LTFIKELGSG QFGVVKYGKW QGQHDVAIKM IKEGSMSEDD FIEEAKIMMK LRHENLVQLY 60
GVCTKQRPIY IVTEYLANGC LLTYLKEGLK QHPTSIQLLE MCKDVAEGMA YLEAHQYIHR 120
DLAARNCLVD GNGTVKVTDF GLSRYVLDDE YTSSVGSKFP VRWSPPEVLL YCKFSSKSDI 180
WAYGVLMWEV YTLGRLPYER LNNTEIVDQV SRGLRLFRPQ LANERVYSIM SSCWLDKAEE 240
RPNFQELALT V 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013