EKS-ORN-00414

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00414

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	345.8	2.0E-103	254	505	252

Status

Unreviewed

Ensembl Protein

ENSONIP00000003561

UniProt Accession

I3J3X1;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK2 (2 of 2)

Gene Synonyms/Alias

PAK2 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000002841	ENSONIP00000003561	ENSONIT00000003562

Organism

Oreochromis niloticus

Functional Description

Protein Length

529

Protein Sequence
(FASTA)

MCDNGDPEDK PPAPPVRMSS TIFSTGSGKD SLSANHSSKP LPSVPEERKR NKIISIFSGA 60

EKSGRKKDRD KERPEISPPS DFEHTIHVGF DAVTGEFTGM PEQWARLLQT SNITKSEQKK 120

NPQAVLDVLK FYDSTGNGRQ KYLSFSSSEK DTFTVGPQSA AKKGTEPSSP NIKDIDDDDD 180

DEAPPPVVAP RPEHTKSVYT RSVIDPIPAP STCPDGDVAS KAADRQKRKG KMSDEEIMDK 240

LRTIVSIGDP KKKYTRYEKI GQGASGTVFT AIDVSTGQEV AIKQINLQKQ PKKELIINEI 300

LVMKELKNPN IVNFLDSFLM GEELFVVMEY LAGGSLTDVV TETCMDEAQI AAVCRECLQA 360

LDFLHANQVI HRDIKSDNVL LGMDGSVKLT DFGFCAQITP EQSKRSTMVG TPYWMAPEVV 420

TRKAYGPKVD IWSLGIMAIE MVEGEPPYLN ENPLRALYLI ATNGTPELQN PEKLSPIFRD 480

FLNLCLEMDV EKRGSGKELL QHPFLKLAKP LSSLTPLILA AKEAMKSNR 529

Nucleotide Sequence
(FASTA)

ATGTGTGATA ACGGAGATCC TGAGGATAAA CCCCCTGCCC CTCCGGTCAG GATGAGCAGC 60

ACTATCTTCA GCACTGGCTC TGGCAAAGAC TCACTTTCGG CTAACCACAG CTCTAAACCG 120

CTGCCTTCTG TGCCTGAGGA GAGGAAGCGC AATAAGATCA TCTCAATCTT CTCTGGGGCT 180

GAAAAAAGTG GTAGAAAGAA AGATCGAGAC AAAGAGCGGC CAGAAATCTC ACCGCCTTCA 240

GATTTTGAAC ATACCATACA TGTTGGGTTT GACGCTGTAA CAGGGGAGTT CACGGGTATG 300

CCAGAGCAAT GGGCTCGACT ACTCCAGACC TCAAACATTA CCAAGTCAGA GCAGAAAAAA 360

AACCCACAGG CTGTGCTTGA TGTCCTTAAG TTCTATGACT CTACAGGCAA CGGTCGCCAG 420

AAGTACCTCA GCTTCTCATC CTCTGAAAAA GACACATTTA CAGTAGGGCC TCAGTCCGCT 480

GCCAAAAAAG GCACTGAACC CTCATCTCCA AACATCAAAG ACATCGATGA TGATGACGAT 540

GATGAAGCGC CTCCACCAGT TGTGGCACCA AGACCAGAAC ACACAAAGAG TGTATATACT 600

CGCTCTGTCA TCGACCCCAT CCCTGCTCCA AGCACGTGTC CGGACGGAGA TGTGGCCTCC 660

AAGGCTGCAG ACAGGCAAAA AAGGAAGGGC AAGATGTCAG ATGAAGAGAT CATGGACAAA 720

CTGAGAACCA TAGTCAGTAT TGGGGATCCC AAGAAGAAGT ACACCCGATA TGAAAAGATT 780

GGCCAGGGGG CATCGGGAAC AGTATTCACA GCCATTGATG TATCCACGGG ACAGGAGGTC 840

GCCATTAAAC AGATCAACTT ACAAAAGCAG CCGAAGAAGG AGCTGATTAT CAACGAGATT 900

CTAGTGATGA AGGAGCTCAA GAACCCAAAC ATTGTCAACT TTTTAGACAG TTTCCTGATG 960

GGGGAGGAGT TATTTGTGGT GATGGAATAT CTTGCTGGTG GCTCGCTGAC AGATGTGGTT 1020

ACAGAGACCT GTATGGATGA GGCCCAGATA GCTGCTGTCT GCCGAGAGTG TTTACAAGCA 1080

TTGGATTTCC TACACGCAAA TCAGGTCATC CACAGAGACA TCAAAAGTGA CAATGTGTTG 1140

CTTGGGATGG ATGGTTCTGT CAAGCTAACC GATTTTGGCT TTTGCGCCCA GATCACTCCA 1200

GAGCAGAGCA AACGCAGCAC CATGGTAGGC ACGCCTTACT GGATGGCTCC TGAAGTGGTG 1260

ACCAGAAAGG CTTATGGGCC TAAAGTAGAT ATTTGGTCAC TGGGTATTAT GGCCATTGAG 1320

ATGGTTGAAG GAGAACCTCC CTACCTGAAT GAGAATCCAC TACGAGCATT ATACCTAATT 1380

GCTACAAATG GCACACCTGA GCTTCAGAAT CCTGAGAAGC TGTCTCCAAT ATTCAGAGAT 1440

TTTCTAAACC TGTGCCTGGA AATGGATGTA GAGAAAAGAG GCAGTGGCAA AGAGCTCCTG 1500

CAGCATCCAT TTTTGAAGCT GGCGAAACCC CTCTCCAGTC TCACACCTCT CATCTTGGCA 1560

GCCAAGGAGG CCATGAAGAG CAATCGTTAG 1590

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+v++a +++tg+ vaik+inl+kq+k+e++++ei v+k+lk+pniv+

Q: 254   YTRYEKIGQGASGTVFTAIDVSTGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVN  313

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l+sfl+ eel++vmeylagGsl+d+v+   ++ ++E qia+++re+l+aL++lH+++vi

Q: 314   FLDSFLMGEELFVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCRECLQALDFLHANQVI  370

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++n+Ll ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 371   HRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  428

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f++ cl+

Q: 429   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNLCLEM  488

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR s +ell+h+Fl

Q: 489   DVEKRGSGKELLQHPFL  505

         ****************7

Domain Sequence
(FASTA)

YTRYEKIGQG ASGTVFTAID VSTGQEVAIK QINLQKQPKK ELIINEILVM KELKNPNIVN 60

FLDSFLMGEE LFVVMEYLAG GSLTDVVTET CMDEAQIAAV CRECLQALDF LHANQVIHRD 120

IKSDNVLLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPIFRDFLN LCLEMDVEKR 240

GSGKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013