EKS-ORN-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	524.4	6.3E-158	1005	1272	268

Status

Unreviewed

Ensembl Protein

ENSONIP00000003709

UniProt Accession

I3J4B9;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R (2 of 2)

Gene Synonyms/Alias

IGF1R (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000002961	ENSONIP00000003710	ENSONIT00000003711
ENSONIG00000002961	ENSONIP00000003709	ENSONIT00000003710

Organism

Oreochromis niloticus

Functional Description

Protein Length

1427

Protein Sequence
(FASTA)

MRSRKERSRL TLFWGLMLGL SSCLRPATAE ICGPNIDIGN DITEFRRLEN CTVVEGYLQI 60

LLIGDKNNNI NNQEVFRSLS FPKLTMITDY LLLFRVSGLD SLSTLFPNLT VIHGRNLFYN 120

YALVIFEMTS LKDIGLYNLR NITRGAIRIE KNPELCYLDS IDWSLIMDAE FNNYIAGNKQ 180

SKECSDVCPG IMENNPQCSK TMFNNNYNYR CWNSNHCQKV SPVGCPEKCA QRACTADGEC 240

CHPQCLGSCT VPDSDTACTA CVHYYYQGRC MADCPPGTYK FEGWSCISAE LCSKAQFTDL 300

DRYVIHGGEC MPECPSGYTR AAPNSMFCTA CDGLCDKVCD GKVIDSMTAA QSLKGCTVIK 360

GNLQINIRRG HNMVAELESF TGLIQRVTGY VRIIHSHTLS SLAFLRSLRY IDGENLHEDM 420

YAFSAFDNQQ LQYLWDWKQH NLTIKTGKLF FRANPKLCMS EIRKMWNKTG IQARFDESDF 480

RNNGDRASCE STILKFKSNS TSSTRIKLTW QRYRPPDYRD LISFIVYYKE APYQNITEFE 540

GQDGCGSNSW NMVDVELRPD KESDPGVLLS NLKPWTQYAV FVKAITLTVE DRHMPGAKSK 600

VVYIRTSPSA PSMPQDVRAY SNSSTQLVVR WSPPVSANGN HTYYLVRWQQ QAEDRELYQH 660

NYCSKELKIP IRIAAIGVGD QEEETKPTKL NPDGAGKGCC PCPKSVEDLE AEAADASYRK 720

VFENFLHNSI FTPRPADRRR RDLFGIANST HSRRNQLHSN SSTAPPLQAA GNNSTPEQDP 780

ADQEFEFIEQ SVTERELQIS GLQPFTVYRI DVHACNRQVV RCSAAEFVFS RTKPAEKADD 840

IPGPVTWEGH EDWVFLRWPT PPRPNGLILM YEIKFKLGAE EVQKHECVSG QMYRAQRGVR 900

LSNLSPGNYS VRVRATSLAG NGSWTQTVDL YVAERYENIF YAMIFVPISI IIFICLLIGV 960

MVVLNRKRNS DRLGNGVLYA SVNPEYFSAA EMYVPDEWEV AREKITLSRE LGQGSFGMVY 1020

EGIAKGVVKD EPETRVAIKT VNESASMRER IEFLNEASVM KEFNCHHVVR LLGVVSQGQP 1080

TLVIMELMTR GDLKSYLRSL RPKEQQWSSL SLPPLKKMLQ MAGQIADGMA YLNANKFVHR 1140

DLAARNCMVA EDFTVKIGDF GMTRDIYETD YYRKGGKGLL PVRWMSPESL KDGVFTTNSD 1200

VWSFGVVLWE IATLAEQPYQ GLSNEQVLRF VMEGGLLEKP QNCPDMLFEL MRMCWQYNPK 1260

MRPSFVEIIS SIKDELDPCF RDVSFFYSAD NKPADAPQLH LEKLDNMEDV PLDVPSSTQL 1320

QQTPAPQQTP PSPSSEAPPG PSLAPSSPSS PCTSRAAMDK HPSGQQAANG LSGAGHAAGS 1380

GLAAGSGLGT GSSVTMRPSL DDLPPYAHMN GGRKNERAMP LPQSSAC 1427

Nucleotide Sequence
(FASTA)

ATGAGGTCTC GAAAGGAAAG GAGCCGCTTG ACCTTGTTTT GGGGTCTGAT GCTGGGTCTT 60

TCGTCCTGCC TCCGGCCCGC CACCGCAGAG ATCTGTGGAC CCAACATTGA TATTGGCAAT 120

GACATCACTG AATTCAGGCG TCTGGAGAAC TGCACAGTGG TGGAGGGCTA CTTGCAGATC 180

CTCCTCATTG GTGACAAAAA CAACAACATC AACAACCAGG AAGTCTTCCG CTCCCTCAGC 240

TTCCCCAAGC TGACCATGAT CACAGACTAC CTGCTGCTAT TCCGGGTATC CGGCCTGGAC 300

AGTCTGAGCA CGCTCTTTCC CAACCTCACT GTCATTCATG GTCGTAACCT CTTCTACAAC 360

TACGCCCTGG TGATTTTCGA GATGACCAGC CTGAAGGACA TCGGCCTGTA CAACCTGAGG 420

AACATCACCC GTGGAGCCAT CCGTATTGAG AAAAATCCTG AGCTCTGTTA CCTGGACTCC 480

ATTGACTGGT CCCTCATCAT GGATGCAGAA TTCAACAATT ACATTGCTGG GAACAAGCAG 540

TCGAAGGAGT GCAGTGATGT TTGCCCAGGT ATCATGGAGA ACAACCCCCA GTGCAGCAAG 600

ACCATGTTCA ACAACAATTA TAACTACCGT TGCTGGAACT CCAATCATTG CCAAAAAGTC 660

TCCCCAGTGG GGTGCCCAGA GAAGTGTGCA CAGCGAGCGT GCACAGCAGA CGGCGAGTGC 720

TGCCACCCTC AGTGTCTGGG CAGCTGCACA GTCCCCGATA GTGACACAGC ATGTACTGCA 780

TGTGTGCATT ACTATTACCA AGGCCGCTGC ATGGCTGACT GCCCCCCAGG CACCTACAAG 840

TTCGAGGGCT GGAGCTGCAT CAGTGCCGAG CTTTGCTCCA AAGCCCAATT TACCGACCTT 900

GACAGATACG TTATCCATGG AGGAGAGTGC ATGCCTGAAT GTCCATCTGG GTACACACGC 960

GCTGCACCAA ACAGTATGTT TTGCACAGCT TGTGATGGTC TGTGTGATAA AGTATGTGAT 1020

GGGAAGGTCA TCGACTCCAT GACTGCTGCT CAGTCTCTCA AAGGCTGCAC TGTTATCAAA 1080

GGCAACCTGC AAATCAACAT CCGCAGAGGC CATAACATGG TGGCAGAGCT GGAAAGTTTC 1140

ACAGGTCTGA TCCAAAGGGT GACTGGTTAC GTACGGATCA TACACTCGCA CACACTGAGC 1200

TCCCTTGCAT TCCTTCGGAG CCTGAGATAC ATCGATGGAG AAAACCTCCA TGAAGACATG 1260

TATGCCTTCT CTGCATTCGA CAACCAACAG TTACAGTATC TTTGGGACTG GAAGCAGCAC 1320

AATCTGACCA TCAAAACAGG AAAGCTGTTC TTCAGAGCCA ACCCGAAGCT ATGCATGTCC 1380

GAGATCCGCA AAATGTGGAA CAAAACAGGC ATCCAGGCCC GCTTTGATGA GAGTGATTTC 1440

CGAAACAACG GCGACAGAGC CAGCTGTGAA AGCACTATTC TGAAATTTAA GTCTAACAGC 1500

ACCAGCAGCA CAAGGATCAA GCTGACATGG CAGCGCTACC GGCCCCCTGA CTACAGAGAC 1560

CTCATCAGCT TCATTGTCTA CTACAAGGAA GCGCCCTACC AGAACATCAC AGAGTTTGAG 1620

GGACAGGATG GCTGTGGCTC CAACAGCTGG AACATGGTGG ATGTGGAGCT GAGGCCTGAC 1680

AAGGAGTCAG ATCCTGGAGT TCTTCTGTCC AACCTGAAGC CGTGGACACA GTATGCTGTC 1740

TTTGTTAAAG CTATCACACT CACAGTGGAG GATAGACACA TGCCAGGAGC CAAGAGCAAG 1800

GTGGTCTACA TCCGCACCAG CCCCTCAGCA CCCTCCATGC CGCAGGATGT GCGAGCGTAC 1860

TCCAACTCAT CCACTCAACT GGTGGTACGC TGGTCACCCC CTGTCTCAGC GAACGGGAAC 1920

CACACGTACT ACTTGGTAAG ATGGCAGCAG CAAGCGGAAG ACCGAGAGCT GTATCAGCAC 1980

AATTATTGCT CCAAAGAGTT GAAGATTCCC ATTAGGATCG CTGCCATAGG GGTGGGAGAC 2040

CAGGAAGAGG AGACAAAGCC GACTAAACTA AATCCCGATG GGGCAGGTAA AGGCTGTTGT 2100

CCCTGCCCCA AATCAGTGGA AGACCTGGAG GCTGAAGCTG CTGACGCCTC TTACCGAAAA 2160

GTCTTTGAAA ACTTCCTGCA CAACTCCATT TTCACACCAA GGCCAGCAGA TCGTCGCCGC 2220

AGAGATCTGT TTGGCATCGC CAACTCTACT CACTCCCGCC GCAACCAGCT GCACAGCAAC 2280

AGTAGCACTG CCCCTCCTCT TCAAGCCGCT GGCAACAACA GCACCCCCGA ACAGGATCCG 2340

GCAGACCAAG AATTTGAATT CATTGAGCAA TCAGTGACAG AACGTGAGCT GCAGATCTCT 2400

GGCTTGCAGC CTTTTACGGT TTACCGCATC GATGTTCATG CGTGCAATCG ACAGGTCGTA 2460

CGTTGCAGCG CAGCGGAGTT CGTCTTTTCC AGAACCAAGC CTGCAGAAAA GGCCGATGAC 2520

ATCCCGGGTC CAGTGACCTG GGAAGGCCAT GAGGACTGGG TGTTTCTGCG TTGGCCCACG 2580

CCGCCTCGTC CCAACGGACT TATCCTCATG TATGAGATCA AGTTTAAACT GGGTGCTGAG 2640

GAAGTTCAGA AACATGAATG TGTATCTGGT CAAATGTATC GGGCCCAGCG TGGCGTTCGG 2700

CTGTCCAACC TCAGTCCAGG AAACTACTCA GTCAGAGTGA GAGCCACGTC TCTGGCTGGC 2760

AATGGCTCCT GGACACAAAC TGTGGATCTG TATGTGGCTG AACGATATGA AAATATCTTC 2820

TACGCAATGA TCTTTGTTCC CATCTCCATC ATCATCTTCA TCTGCCTTCT GATTGGAGTG 2880

ATGGTTGTCC TCAACAGGAA AAGGAACAGT GATCGGCTCG GAAATGGAGT TCTGTACGCT 2940

TCAGTGAACC CAGAGTACTT CAGTGCAGCA GAAATGTATG TACCAGATGA GTGGGAAGTG 3000

GCACGGGAGA AGATCACCTT GAGCCGGGAG CTTGGCCAAG GGTCATTCGG GATGGTGTAC 3060

GAAGGCATAG CCAAAGGTGT GGTCAAAGAC GAACCAGAGA CGCGTGTTGC CATTAAGACT 3120

GTTAATGAGT CGGCCAGCAT GAGAGAGCGG ATCGAGTTCC TCAATGAAGC CTCCGTCATG 3180

AAGGAGTTCA ATTGTCATCA TGTGGTTCGC CTCCTGGGAG TGGTCTCTCA GGGCCAGCCC 3240

ACCCTGGTTA TCATGGAACT GATGACCCGA GGAGATCTAA AAAGTTACTT GCGCTCCTTG 3300

CGACCCAAAG AGCAACAGTG GTCCAGCCTA TCTCTCCCTC CTCTGAAGAA GATGCTTCAG 3360

ATGGCAGGGC AGATTGCTGA TGGCATGGCT TACCTCAACG CCAACAAGTT TGTCCACCGA 3420

GATCTGGCAG CCAGGAACTG CATGGTAGCC GAAGACTTTA CTGTTAAGAT CGGAGATTTT 3480

GGCATGACCA GAGACATCTA TGAGACAGAT TACTACCGCA AAGGTGGTAA AGGTTTGCTC 3540

CCCGTACGTT GGATGTCACC CGAGTCCTTG AAAGACGGAG TCTTTACCAC CAACTCGGAT 3600

GTCTGGTCAT TTGGGGTTGT GCTGTGGGAG ATTGCCACTC TGGCAGAACA GCCCTACCAA 3660

GGTCTCTCTA ATGAACAAGT TCTCCGTTTT GTCATGGAGG GGGGGCTTCT GGAGAAACCT 3720

CAGAACTGTC CCGATATGCT GTTTGAGCTG ATGCGAATGT GTTGGCAGTA CAATCCTAAG 3780

ATGCGTCCAT CCTTTGTTGA GATCATCAGC AGCATAAAGG ATGAGCTGGA CCCGTGTTTC 3840

AGAGATGTCA GTTTCTTCTA CAGCGCCGAT AACAAGCCGG CCGATGCGCC GCAGCTCCAC 3900

CTGGAAAAGC TAGACAACAT GGAAGATGTT CCTCTGGACG TTCCTTCATC GACACAACTG 3960

CAGCAGACTC CAGCTCCCCA ACAGACGCCC CCTTCCCCAA GCTCAGAAGC ACCACCTGGC 4020

CCGTCGCTAG CTCCCAGCTC ACCTTCCTCT CCCTGCACGT CGAGAGCTGC CATGGACAAG 4080

CACCCCTCCG GCCAGCAAGC AGCTAATGGG CTGTCGGGGG CGGGGCACGC AGCGGGGTCG 4140

GGGCTCGCAG CGGGGTCGGG GCTCGGGACA GGCTCGAGTG TCACAATGCG GCCGTCTCTG 4200

GACGATCTGC CACCATACGC GCACATGAAT GGAGGACGCA AAAATGAGCG TGCCATGCCT 4260

CTCCCGCAGT CCTCTGCCTG CTGA 4284

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+l+relGqGsfGmvyeG+ak+vvk+e etrvaiktvne+as+reriefl+easvmkef+

Q: 1005  ITLSRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESASMRERIEFLNEASVMKEFN  1064

         7899********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrp+e++ ++l+ p l+k+ qma++

Q: 1065  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPKEQQWSSLSLPPLKKMLQMAGQ  1124

         ***********************************************999**********

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1125  IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1184

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqGlsneqvl+fv++gg+lekp+ncp

Q: 1185  MSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLEKPQNCP  1244

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rpsf+ei++++

Q: 1245  DMLFELMRMCWQYNPKMRPSFVEIISSI  1272

         *************************876

Domain Sequence
(FASTA)

ITLSRELGQG SFGMVYEGIA KGVVKDEPET RVAIKTVNES ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPKE QQWSSLSLPP LKKMLQMAGQ 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTNSDVWSF GVVLWEIATL AEQPYQGLSN EQVLRFVMEG GLLEKPQNCP 240

DMLFELMRMC WQYNPKMRPS FVEIISSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013