EKS-ORN-00514
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00514
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR533.14.6E-160573906334
StatusUnreviewed
Ensembl ProteinENSONIP00000003734
UniProt AccessionI3J4E4;
Protein Name
Protein Synonyms/Alias
Gene NameKIT (1 of 2)
Gene Synonyms/Alias KIT (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000002981ENSONIP00000003734ENSONIT00000003735
OrganismOreochromis niloticus
Functional Description
Protein Length977
Protein Sequence
(FASTA)
MEYHWILLSV FLQLTFHPGD TKPTITPARP HIVVQLNEPF KLHCQGENRI QWKRERSKLP 60
AANEIDGMLT YSIKKALPSQ MGRYICQEEG SKEEASIYVY VKDPGNPFRK LKVYRYVTHE 120
GENASFPCLA TDPDLENMHL ETCSSKSLPP GLQFSASLEH GIYMHNTQKA YEGCYVCAGR 180
LHGKDVRSGQ FHLSVVPVPT APPVVELQPS TRVILTRGER FSLTCNTSNA NREISITWVT 240
PPGSQPAKVG SSTESLTEKF ANSHRTTLQI DAVRPQDAGS YVCEVRNGKG VSSKSVWLDV 300
YERGFIDLMP ANSSIFQVRS GESLSLKVRI VAYPKPHISW SFKGHELRNT TDHVITTHSD 360
EYSYISELRL VRLKMLEGGV YTFQASNGDA SANQTFTVFV ISKPEIVSID SPVNGQVRCV 420
AEGFPAPQIT WYYCERPHAR CSQQVNSTQE ELNVITITLV SPMFGKTEVE SRVNISRARF 480
NTLECVATVE GEQAYILYSI SEKRVPHGLF TPLLIGSISA AGILCLILIM LFYKYMQKPK 540
YQIQWKVIGN DYVDIDPTQL PYDDQWEFPR NNLRFGKTLG SGAFGKVVEA TAYGLSKADS 600
VMTVAVKMLK SSAHATEKEA LMSELKVLSY LGNHINIVNL LGACTVGGPT LVITEYCCFG 660
DLLNFLRRKR DLCICFKLED DYYNRNVMQQ RVTDGDSLNS YMTMKPSVAG NAPVSSSSEK 720
RNSLRKGGPY VEADTENEMF ADDGLSLDTE DLLSFSYQVA KGMEFLASKN CIHRDLAARN 780
ILLTEGRVAK ICDFGLARDI TTDSNYVVKG NARLPVKWMS PESIFECVYT FESDVWSYGI 840
LLWEIFSLGN SPYPGMPVDA KFYKLIKEGY RMDAPEFAPS EMYEIMRCCW DADPFNRPPF 900
RKVVETIEQQ LSDATKRIYL NFSSMLPMMP RAREEPSSQS PAFHHPNSAG TNSTPTQPLL 960
VQHEVFLEGT ILSAEWV 977
Nucleotide Sequence
(FASTA)
ATGGAATACC ACTGGATACT TCTCTCTGTG TTTTTACAGC TAACATTCCA TCCAGGTGAC 60
ACAAAGCCCA CTATCACACC TGCCAGACCC CACATCGTCG TCCAGCTCAA CGAACCCTTC 120
AAACTACATT GCCAGGGTGA AAACAGGATA CAGTGGAAGC GGGAGAGGTC AAAGCTGCCG 180
GCAGCAAACG AGATCGATGG GATGTTGACA TATTCAATTA AGAAGGCTCT GCCTAGTCAA 240
ATGGGCCGCT ATATCTGCCA GGAGGAGGGT TCCAAGGAAG AAGCCTCCAT CTACGTCTAT 300
GTGAAAGATC CTGGAAATCC CTTCAGAAAA CTAAAGGTGT ATAGATATGT TACTCATGAG 360
GGAGAAAATG CTTCCTTCCC TTGCCTGGCA ACTGATCCAG ATCTGGAGAA TATGCACCTG 420
GAAACATGCT CCAGTAAAAG TTTGCCCCCT GGTCTCCAGT TCTCCGCCAG CCTGGAGCAT 480
GGCATTTACA TGCACAACAC ACAAAAGGCC TACGAAGGTT GCTATGTGTG TGCAGGAAGA 540
CTCCATGGAA AGGACGTCAG ATCAGGCCAA TTCCACCTGA GTGTTGTACC AGTACCGACT 600
GCGCCTCCTG TAGTTGAGCT CCAACCATCC ACAAGAGTGA TTCTGACCCG AGGTGAGAGA 660
TTCTCCCTCA CCTGCAACAC CAGTAATGCC AATAGAGAAA TCAGCATCAC GTGGGTCACC 720
CCACCTGGCT CGCAACCAGC AAAGGTTGGC AGTTCTACAG AATCCCTGAC GGAAAAATTT 780
GCCAATAGCC ACAGAACGAC ACTGCAAATC GATGCAGTAC GGCCACAGGA TGCTGGGAGT 840
TACGTATGTG AAGTTAGGAA TGGAAAAGGG GTCAGCAGCA AGTCGGTGTG GCTCGATGTA 900
TATGAAAGAG GATTCATCGA CTTAATGCCC GCAAACAGCA GCATCTTTCA AGTCCGCTCC 960
GGCGAGAGTC TGTCCCTGAA AGTTCGAATA GTGGCTTATC CAAAGCCACA CATCTCCTGG 1020
AGCTTTAAAG GCCATGAGCT GAGAAACACA ACTGACCATG TGATCACCAC ACACAGTGAT 1080
GAATACAGTT ACATCAGTGA GCTGAGGCTA GTGCGGCTGA AAATGTTAGA GGGTGGAGTT 1140
TACACCTTTC AAGCCTCCAA TGGTGATGCT TCAGCAAATC AGACATTCAC CGTCTTTGTG 1200
ATCAGTAAAC CAGAAATTGT ATCGATTGAC AGCCCAGTGA ATGGACAGGT GCGCTGTGTG 1260
GCTGAGGGGT TCCCTGCTCC CCAGATCACC TGGTACTACT GTGAGCGTCC ACATGCCAGG 1320
TGCTCCCAGC AGGTAAATTC CACCCAGGAG GAGCTCAATG TCATCACCAT CACACTGGTC 1380
AGTCCCATGT TCGGGAAGAC AGAGGTGGAG AGTCGGGTGA ACATCAGCAG AGCACGGTTC 1440
AATACTCTTG AATGTGTGGC TACAGTGGAG GGAGAGCAAG CCTACATACT TTACTCTATT 1500
AGTGAGAAAA GAGTTCCACA TGGCCTGTTC ACCCCTCTGC TAATTGGCTC CATTTCAGCA 1560
GCAGGCATCC TCTGCCTCAT CCTTATCATG CTGTTCTACA AGTACATGCA GAAACCCAAA 1620
TATCAGATTC AGTGGAAAGT TATCGGAAAC GACTATGTGG ACATTGACCC CACCCAGCTA 1680
CCGTACGATG ACCAGTGGGA GTTTCCGCGA AACAACTTGC GCTTTGGGAA GACTCTGGGA 1740
TCTGGTGCAT TTGGAAAAGT GGTGGAAGCC ACTGCATATG GACTCTCCAA AGCAGATTCA 1800
GTCATGACTG TGGCTGTGAA AATGCTCAAA TCTAGCGCTC ATGCCACAGA GAAAGAAGCA 1860
CTAATGTCAG AGCTGAAAGT CCTCAGTTAC TTGGGAAACC ACATTAATAT TGTCAACCTG 1920
CTGGGAGCCT GCACAGTTGG AGGTCCTACC CTGGTGATCA CAGAGTACTG CTGTTTCGGA 1980
GATCTGCTCA ACTTTCTACG CAGAAAGAGA GACTTGTGCA TCTGCTTTAA GCTTGAGGAC 2040
GATTACTACA ACCGCAACGT CATGCAGCAG AGAGTCACAG ATGGTGACAG CTTGAACAGC 2100
TACATGACCA TGAAGCCTTC TGTTGCTGGC AACGCACCGG TCAGCTCATC CTCTGAGAAG 2160
AGAAACTCGC TACGCAAAGG TGGTCCTTAC GTTGAAGCAG ACACGGAGAA TGAGATGTTT 2220
GCTGATGATG GTCTGTCTCT GGACACCGAA GATCTCCTCA GTTTCTCATA CCAAGTTGCC 2280
AAAGGCATGG AGTTCTTAGC CTCGAAAAAT TGTATTCACA GAGACCTGGC TGCCAGAAAT 2340
ATCCTACTTA CTGAAGGAAG AGTGGCCAAA ATCTGTGATT TTGGCCTTGC CCGAGACATC 2400
ACCACAGATT CTAATTATGT CGTCAAAGGC AATGCTCGTC TGCCAGTGAA ATGGATGTCT 2460
CCAGAAAGTA TCTTTGAGTG CGTTTACACA TTCGAGAGTG ACGTGTGGTC ATATGGCATC 2520
TTGCTTTGGG AAATCTTCTC ACTGGGAAAC AGTCCGTACC CTGGTATGCC GGTGGACGCC 2580
AAGTTCTACA AACTAATAAA AGAAGGATAC AGAATGGATG CCCCAGAGTT TGCGCCCAGT 2640
GAAATGTATG AGATTATGAG GTGCTGCTGG GATGCTGACC CCTTCAACAG ACCCCCGTTC 2700
AGGAAGGTCG TGGAAACGAT TGAACAGCAG CTGTCAGATG CCACTAAGCG AATTTATCTG 2760
AACTTCAGCT CCATGCTTCC TATGATGCCT AGAGCAAGGG AGGAGCCGAG TTCTCAGAGC 2820
CCAGCGTTTC ACCATCCCAA CTCAGCCGGC ACTAACAGTA CTCCAACTCA GCCCTTACTA 2880
GTCCAACACG AGGTCTTCCT GGAGGGAACA ATCCTCTCAG CCGAGTGGGT GTAA 2934
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lGsGafGkvveatayGlsk+d+v++vavkmlks+a+++ekealmselk+ls+lG
Q: 573   LRFGKTLGSGAFGKVVEATAYGLSKADSVMTVAVKMLKSSAHATEKEALMSELKVLSYLG  632
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h nivnllGact+gGp++viteycc+Gdlln+lrrkr+  +  +le       + + ++
Q: 633   NHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRDLCICFKLE------DDYYNRN  686
         ***************************************99944443......3556665
S: 121   lladkslrsksslssesseeyvdlkkd...vsdvssskadklasekkksalerevkaale  177
         +       ++  +  +s ++y+ +k++    + vsss++++ + +k   ++e ++++++ 
Q: 687   V------MQQRVTDGDSLNSYMTMKPSvagNAPVSSSSEKRNSLRKGGPYVEADTENEMF  740
         5......3344455688899******94444568888888888888899***********
S: 178   eedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardi  237
          +d  +l+ edllsfsyqvakGmeflasknc+hrdlaarn+llteG+v+kicdfGlardi
Q: 741   ADDGLSLDTEDLLSFSYQVAKGMEFLASKNCIHRDLAARNILLTEGRVAKICDFGLARDI  800
         ************************************************************
S: 238   mkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvds  297
         ++dsnyvvkGnarlpvkwm+pesif+++yt++sdvwsyGillweifslG +pypg++vd+
Q: 801   TTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIFSLGNSPYPGMPVDA  860
         ************************************************************
S: 298   kfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         kfyklikeGyrm+ p++a++e+yeim+ cw+a+p +rp+f+++ve 
Q: 861   KFYKLIKEGYRMDAPEFAPSEMYEIMRCCWDADPFNRPPFRKVVET  906
         ******************************************9975
Domain Sequence
(FASTA)
LRFGKTLGSG AFGKVVEATA YGLSKADSVM TVAVKMLKSS AHATEKEALM SELKVLSYLG 60
NHINIVNLLG ACTVGGPTLV ITEYCCFGDL LNFLRRKRDL CICFKLEDDY YNRNVMQQRV 120
TDGDSLNSYM TMKPSVAGNA PVSSSSEKRN SLRKGGPYVE ADTENEMFAD DGLSLDTEDL 180
LSFSYQVAKG MEFLASKNCI HRDLAARNIL LTEGRVAKIC DFGLARDITT DSNYVVKGNA 240
RLPVKWMSPE SIFECVYTFE SDVWSYGILL WEIFSLGNSP YPGMPVDAKF YKLIKEGYRM 300
DAPEFAPSEM YEIMRCCWDA DPFNRPPFRK VVET 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013