EKS-ORN-00512
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORN-00512
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR577.41.5E-173589942354
StatusUnreviewed
Ensembl ProteinENSONIP00000003759
UniProt AccessionI3J4G9;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRA
Gene Synonyms/Alias PDGFRA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSONIG00000003001ENSONIP00000003759ENSONIT00000003760
OrganismOreochromis niloticus
Functional Description
Protein Length1080
Protein Sequence
(FASTA)
RVFTTYRRFM THCMCLLSAP TAGMIPSSSV PLLLPKLDEM VVTLHTPFTL TCHGQENLGW 60
ETPIDVSEQT QEDPNGLFIS TITVDSATAS HTGYYTCFYS RTFAEDTAEF SRIYIYVPDP 120
DVPFLESLIP FGYHVLSGYD EMEIQCRVSD PNANVTLINS DTQQPVPSIY DSKRGALGIF 180
TAGTYVCKAV INGHEFYSEE YIVHGSTDEL DVELTAKKTA LLVGDTITVT CVARGSEILE 240
DHWKYPGKLA NRGTKTVREN KRTQEIFYTL TIPQASTKDS GIYSCSITDI LSNSGQTKQL 300
AIQVYASEFL SVKPEFREYE SAALDEVREF KAVVNSFPSV HVSWFKDGYP LSDVTAEIST 360
SLQQTSEISY MSVLTLIRAK EEDSGNYTMR VENRNQSRDI SLILEVKVPA VIVDLMDVHH 420
GSAQGQSVVC ITRGQPTPMV EWFVCKNIKH CANDSSSWVP IPANSTEITL DSHIDEDNNL 480
ESQVMFGHLE STMAVRCLAR NEMAVVSREV KLVSNGPHPE LTVAAAVLVL LVIVIISLIV 540
LVVIWKQKPR YEIRWRVIES VSPDGHEYIY VDPMQLPYDS RWEFPRDRLV LGRILGSGAF 600
GKVVEGTAYG LSRSQPVMKV AVKMLKPTAR SSEKQALMSE LKIMTHLGPH LNIVNLLGAC 660
TKSGPIYIIT EYCFYGDLVN YLHKNRENFL SLNPEKNKKE LDIFGINPAD ESSRSYVILS 720
FESKGDYMDM KQADSTQYVP MLEMSNASKY SDIQRSNYDH PPSQKGSSEG EMEIMLSDDV 780
NEGLTTTDLL SFTYQVAKGM EFLASKNCVH RDLAARNVLL SQGKIVKICD FGLARDIMHD 840
NNYVSKGSTF LPVKWMAPES IFDNLYTTLS DVWSYGILLW EIFSLGGTPY PGMVVDSSFY 900
NKIKSGYRMS KPEHAPHDVY EMMMKCWNSE PEKRPSFLGL SETVASLLPS SYKRQYERVN 960
HEFLKSDHPA VTRVCMENED YIGIAYKNQG KLKDRESGFD EQRLSSDSGY IIPLPDLDPI 1020
SDEEYGKRNR HSSQTSEESA IETGSSSSTF AKREGETLED ITLLDEMCLD CSDLVEDSFL 1080
Nucleotide Sequence
(FASTA)
AGAGTATTTA CGACCTATAG AAGATTTATG ACCCACTGTA TGTGTCTTCT CTCAGCTCCC 60
ACTGCAGGGA TGATCCCATC ATCTTCAGTC CCTCTGCTGC TGCCAAAGCT GGACGAGATG 120
GTAGTTACTC TCCACACCCC TTTCACCTTG ACCTGTCATG GACAGGAAAA CCTGGGCTGG 180
GAGACGCCAA TCGATGTATC TGAGCAAACG CAGGAGGACC CCAACGGCTT GTTTATCAGC 240
ACCATCACAG TGGATAGTGC CACAGCAAGC CACACTGGCT ACTACACGTG CTTTTATAGT 300
AGAACTTTCG CTGAGGATAC AGCAGAATTT AGCAGAATCT ACATTTATGT TCCAGACCCC 360
GATGTCCCCT TTCTGGAATC ACTGATACCT TTTGGCTACC ACGTCCTGTC TGGATATGAT 420
GAGATGGAGA TCCAGTGTCG AGTGTCTGAT CCAAATGCTA ACGTGACTCT GATTAACAGT 480
GACACCCAGC AGCCTGTGCC TAGTATTTAT GACAGCAAGA GGGGCGCTTT GGGGATATTC 540
ACTGCTGGAA CCTATGTCTG CAAGGCCGTC ATAAATGGAC ACGAATTCTA CAGCGAGGAA 600
TACATCGTCC ATGGCTCGAC AGATGAGCTG GATGTTGAGT TGACAGCGAA AAAGACTGCT 660
CTGCTGGTGG GCGACACAAT AACTGTCACC TGTGTGGCTC GGGGATCTGA GATTCTGGAA 720
GATCACTGGA AGTATCCTGG CAAACTGGCA AATCGTGGTA CAAAAACAGT GCGAGAAAAT 780
AAGAGAACTC AGGAGATCTT TTATACCCTG ACCATCCCAC AAGCTTCAAC CAAAGACAGC 840
GGCATCTATT CTTGCTCCAT CACTGACATA CTGAGTAACA GTGGCCAGAC GAAACAACTA 900
GCTATTCAAG TTTATGCAAG TGAGTTCTTG TCCGTCAAGC CAGAGTTCAG AGAATACGAA 960
TCTGCAGCGC TGGATGAAGT CCGGGAGTTC AAGGCTGTTG TCAACTCCTT CCCAAGTGTT 1020
CATGTCAGCT GGTTTAAAGA TGGCTACCCA CTCAGCGATG TGACTGCAGA GATCTCCACC 1080
AGCCTCCAGC AGACCAGTGA AATCAGCTAC ATGAGTGTTC TCACCCTGAT CCGAGCCAAG 1140
GAGGAGGACA GCGGGAACTA CACCATGCGG GTGGAGAACA GAAACCAAAG TCGTGATATC 1200
AGTTTAATCC TTGAAGTCAA AGTGCCTGCA GTCATTGTTG ATCTGATGGA CGTCCACCAT 1260
GGCTCAGCTC AAGGCCAGTC TGTGGTTTGC ATTACCAGAG GGCAGCCGAC ACCCATGGTG 1320
GAGTGGTTTG TCTGCAAGAA TATCAAACAT TGCGCTAATG ATTCGTCTTC GTGGGTGCCC 1380
ATCCCTGCCA ACTCCACTGA GATCACATTG GACTCACACA TTGATGAAGA CAATAACCTG 1440
GAGAGCCAGG TCATGTTTGG TCATCTGGAA AGCACAATGG CAGTGCGCTG CCTGGCCAGG 1500
AACGAAATGG CTGTTGTCAG CAGGGAGGTC AAACTGGTGT CCAATGGCCC TCACCCTGAG 1560
CTGACTGTAG CTGCTGCTGT GCTGGTGCTC CTGGTCATTG TCATCATCTC ACTCATTGTC 1620
TTGGTTGTTA TCTGGAAACA GAAACCACGA TATGAAATCC GCTGGAGGGT CATAGAATCT 1680
GTGAGCCCAG ACGGTCATGA GTACATCTAT GTGGATCCCA TGCAGCTTCC CTATGACTCG 1740
AGATGGGAGT TTCCCCGTGA CAGACTTGTG CTTGGTCGTA TCTTGGGCTC TGGAGCCTTT 1800
GGGAAGGTGG TAGAGGGCAC CGCCTATGGA CTCAGCCGCT CGCAACCTGT CATGAAGGTG 1860
GCAGTGAAAA TGCTGAAACC CACAGCACGC TCCAGTGAGA AACAGGCCCT GATGTCTGAA 1920
CTCAAGATCA TGACTCATCT TGGACCCCAT CTCAACATTG TTAACCTCCT GGGAGCATGC 1980
ACCAAGTCAG GCCCTATCTA CATTATCACT GAGTACTGCT TCTATGGGGA CCTGGTTAAC 2040
TATCTGCACA AGAACAGGGA GAACTTCCTC AGTCTGAACC CCGAGAAGAA CAAGAAGGAG 2100
CTGGACATCT TTGGAATCAA CCCTGCAGAT GAAAGCAGCA GGAGTTATGT GATCCTGTCA 2160
TTTGAAAGCA AAGGGGACTA CATGGATATG AAGCAGGCTG ACAGCACTCA GTATGTGCCC 2220
ATGCTGGAGA TGAGCAATGC CTCCAAGTAC TCAGATATCC AGCGGTCTAA CTATGACCAT 2280
CCACCCTCGC AGAAAGGCTC GAGTGAAGGT GAAATGGAAA TCATGCTGTC AGACGACGTA 2340
AATGAAGGCC TCACCACCAC TGACCTGCTC AGCTTTACCT ACCAGGTGGC CAAAGGCATG 2400
GAGTTTCTTG CCTCCAAAAA TTGTGTACAT CGAGACCTTG CAGCCAGGAA TGTCCTTCTC 2460
TCTCAGGGCA AGATAGTGAA GATCTGTGAC TTTGGACTGG CTAGAGACAT CATGCATGAC 2520
AACAACTATG TGTCCAAAGG GAGCACTTTT CTCCCGGTGA AGTGGATGGC ACCAGAGAGT 2580
ATTTTTGATA ACTTGTACAC CACTCTGAGC GACGTCTGGT CTTACGGCAT CCTCCTCTGG 2640
GAGATATTCT CCCTGGGTGG CACCCCGTAC CCAGGGATGG TGGTGGACTC GAGTTTCTAC 2700
AACAAGATCA AGAGTGGATA CAGGATGTCA AAACCAGAGC ACGCACCTCA TGATGTGTAT 2760
GAGATGATGA TGAAGTGCTG GAACAGTGAG CCAGAGAAGA GGCCATCTTT CCTGGGTCTG 2820
AGTGAAACAG TAGCTTCGTT GTTACCCTCC AGCTACAAGA GGCAATACGA AAGAGTAAAC 2880
CACGAGTTCC TGAAGAGCGA CCACCCTGCT GTTACTCGGG TATGCATGGA AAATGAGGAC 2940
TACATTGGGA TCGCCTACAA AAACCAGGGG AAGCTGAAGG ACAGAGAAAG TGGCTTCGAT 3000
GAACAGCGGT TGAGCTCTGA CAGTGGCTAC ATCATTCCCC TTCCTGACCT GGACCCTATA 3060
TCTGACGAAG AATATGGAAA GAGGAACAGA CACAGCTCTC AAACATCTGA AGAGAGCGCC 3120
ATTGAGACAG GCTCCAGCAG CTCCACCTTT GCTAAGCGCG AGGGTGAGAC TCTGGAGGAC 3180
ATCACGCTGC TGGATGAGAT GTGTCTAGAC TGTAGTGACC TGGTGGAAGA CAGCTTTCTG 3240
TGA 3243
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 589   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  648
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++re+fl+   ek   +++eld+++
Q: 649   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRENFLSLNPEK---NKKELDIFG  705
         ******************************************888777...778899999
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         + +ad+s rs+++ls+es+++y+d+k++                +sd+++s++d++ s+k
Q: 706   InPADESSRSYVILSFESKGDYMDMKQAdstqyvpmlemsnaskYSDIQRSNYDHPPSQK  765
         999************************9******************************99
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
          +s    e++ +l+++ +e+l+ +dllsf+yqvakGmeflaskncvhrdlaarnvll++G
Q: 766   GSSE--GEMEIMLSDDVNEGLTTTDLLSFTYQVAKGMEFLASKNCVHRDLAARNVLLSQG  823
         6665..5556669***********************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+d nyv+kG+++lpvkwmapesifd+lyt+ sdvwsyGillweif
Q: 824   KIVKICDFGLARDIMHDNNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF  883
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         slG+tpypg++vds fy++ik+Gyrm++p++a++++ye+m kcw++epekrpsf  l+e
Q: 884   SLGGTPYPGMVVDSSFYNKIKSGYRMSKPEHAPHDVYEMMMKCWNSEPEKRPSFLGLSE  942
         ******************************************************98876
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNREN FLSLNPEKNK KELDIFGINP 120
ADESSRSYVI LSFESKGDYM DMKQADSTQY VPMLEMSNAS KYSDIQRSNY DHPPSQKGSS 180
EGEMEIMLSD DVNEGLTTTD LLSFTYQVAK GMEFLASKNC VHRDLAARNV LLSQGKIVKI 240
CDFGLARDIM HDNNYVSKGS TFLPVKWMAP ESIFDNLYTT LSDVWSYGIL LWEIFSLGGT 300
PYPGMVVDSS FYNKIKSGYR MSKPEHAPHD VYEMMMKCWN SEPEKRPSFL GLSE 354
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-RAN-00416
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013