EKS-ORN-00082

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00082

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	383.4	8.0E-115	148	429	282

Status

Unreviewed

Ensembl Protein

ENSONIP00000004135

UniProt Accession

I3J5J6;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000003295	ENSONIP00000004136	ENSONIT00000004137
ENSONIG00000003295	ENSONIP00000004135	ENSONIT00000004136

Organism

Oreochromis niloticus

Functional Description

Protein Length

478

Protein Sequence
(FASTA)

MESQLLSIMN KMKNFKRRFS LSVPRTETIE ENEFTEQINQ LNIRHTQGLT PDRLGPPSHD 60

ASPVSPEPTT PGAQSPSHLH YHSKAQHRRF SMEDVSKRMS LPMDIHLPPE FLKKLQMENE 120

NSPLCKPLSR MSRRASLSDI GFGKLETYVK LGKLGEGTYA TVFKGRSKLT ENLVALKEIR 180

LEHDEGAPCT AIREVSLLKN LKHANIVTLH DIIHTDRCLT LVFEYLDSDL KQYLDNCGNL 240

MSMHNVKIFM FQLLRGLSYC HKRKILHRDL KPQNLLINDK GELKLADFGL ARAKSVPTKT 300

YSNEVVTLWY RPPDVLLGST EYSTPIDMWG VGCILYEMAT GRPMFPGATV KEELHLIFRL 360

MGTPTEETWP GISSNEEFMS YLFPQYRPQA LINHVPRLDT EGIDLLSALL LYDTRSRLSS 420

ETALRHPYFL SLGDNIHNLA DTASVFSLRE VQLQKDPGHR SSVFQPLGRG KNRRQSIF 478

Nucleotide Sequence
(FASTA)

ATGGAGAGTC AACTACTCAG CATCATGAAC AAGATGAAGA ACTTTAAGAG ACGTTTCTCT 60

TTGTCGGTTC CTCGGACTGA GACGATTGAA GAAAATGAGT TCACTGAGCA GATCAACCAG 120

CTCAACATAC GGCACACTCA GGGCCTGACT CCAGACAGAC TGGGTCCTCC ATCTCATGAT 180

GCCAGCCCAG TGAGCCCTGA ACCAACTACT CCAGGAGCAC AGTCTCCATC CCACCTACAC 240

TACCACAGCA AGGCCCAGCA CAGACGCTTC TCCATGGAGG ACGTTAGTAA GCGCATGTCC 300

CTGCCAATGG ACATCCACCT GCCTCCAGAG TTTCTGAAGA AGTTGCAGAT GGAGAATGAA 360

AACTCACCGC TCTGCAAACC TCTCAGTCGC ATGTCTCGAC GCGCCTCACT GTCTGACATA 420

GGATTTGGGA AACTGGAAAC ATATGTTAAG CTTGGCAAAC TGGGTGAGGG GACATATGCT 480

ACAGTCTTTA AAGGGCGGAG CAAACTCACT GAGAACCTGG TTGCACTGAA GGAGATCCGG 540

CTGGAGCACG ATGAGGGGGC ACCTTGCACT GCTATCAGAG AAGTGTCTCT GCTAAAGAAC 600

CTGAAGCACG CTAATATTGT CACCCTGCAT GACATCATCC ACACCGACCG CTGCCTTACT 660

CTGGTGTTTG AGTATCTTGA CAGTGATCTT AAACAGTACT TGGACAACTG TGGGAACCTC 720

ATGAGCATGC ATAATGTCAA GATCTTCATG TTCCAGCTGC TGCGTGGTCT GTCCTATTGT 780

CACAAGAGGA AAATCCTCCA CAGAGACCTA AAGCCTCAGA ACCTGCTCAT CAATGATAAG 840

GGCGAACTGA AGTTAGCTGA TTTTGGTCTG GCCAGGGCCA AGTCCGTCCC CACTAAGACC 900

TATTCCAATG AGGTGGTAAC GCTTTGGTAT CGACCTCCTG ACGTGCTGCT AGGCTCTACA 960

GAATATTCCA CACCCATCGA CATGTGGGGC GTAGGCTGCA TCCTGTATGA GATGGCAACA 1020

GGTCGTCCCA TGTTTCCTGG TGCCACTGTG AAGGAAGAAC TACATCTAAT TTTTAGGCTC 1080

ATGGGCACTC CGACAGAGGA GACCTGGCCT GGTATCAGCA GTAATGAGGA ATTTATGTCC 1140

TACCTCTTTC CTCAGTACAG ACCTCAAGCT CTCATCAACC ATGTGCCCCG GTTGGACACA 1200

GAAGGGATTG ACCTGCTGTC TGCTCTGCTG CTGTATGACA CCCGGAGCAG ACTCTCCTCT 1260

GAAACGGCTC TACGTCACCC CTACTTCCTG AGTCTGGGAG ACAACATTCA TAACTTGGCA 1320

GACACTGCTT CAGTGTTTTC TCTCAGAGAG GTGCAGCTCC AGAAGGACCC AGGACACCGC 1380

AGCTCAGTAT TCCAGCCTTT AGGTCGAGGA AAGAACCGAA GACAAAGCAT CTTCTAG 1437

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl k+geGty++v+k+++k t+++vAlK+irle++ eg p+ta+rE+sllk+lkh+ni

Q: 148   YVKLGKLGEGTYATVFKGRSKLTENLVALKEIRLEHD-EGAPCTAIREVSLLKNLKHANI  206

         78999******************************99.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ +++ l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+gl+y+H++k

Q: 207   VTLHDIIH-TDRCLTLVFEYLDSDLKQYLDNCGN-LMSMHNVKIFMFQLLRGLSYCHKRK  264

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 265   ILHRDLKPQNLLINDKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  324

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W+vgcil e++t +p+f+g + +++l+ if+l+gtp+e++wp++s+ +e+  + fp

Q: 325   PIDMWGVGCILYEMATGRPMFPGATVKEELHLIFRLMGTPTEETWPGISSNEEFMsYLFP  384

         *****************************************************99899**

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +++++ l ++v++l+++++dll+ ll +d ++R+s+++al+h+yf

Q: 385   QYRPQALINHVPRLDTEGIDLLSALLLYDTRSRLSSETALRHPYF  429

         ********************************************9

Domain Sequence
(FASTA)

YVKLGKLGEG TYATVFKGRS KLTENLVALK EIRLEHDEGA PCTAIREVSL LKNLKHANIV 60

TLHDIIHTDR CLTLVFEYLD SDLKQYLDNC GNLMSMHNVK IFMFQLLRGL SYCHKRKILH 120

RDLKPQNLLI NDKGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGVGCILYE MATGRPMFPG ATVKEELHLI FRLMGTPTEE TWPGISSNEE FMSYLFPQYR 240

PQALINHVPR LDTEGIDLLS ALLLYDTRSR LSSETALRHP YF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013