EKS-ORN-00201

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORN-00201

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	479.7	2.6E-144	416	673	258

Status

Unreviewed

Ensembl Protein

ENSONIP00000004405

UniProt Accession

I3J6B5;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000003497	ENSONIP00000004405	ENSONIT00000004407

Organism

Oreochromis niloticus

Functional Description

Protein Length

733

Protein Sequence
(FASTA)

MEKDKRKFNL TRMLSIYLFK KNKSLTGSPA HWPEEDGDIK EINITHVVKE GSEKADASQF 60

ELLKVLGQGS FGKVFLVRKV TPPDANQLYA MKVLKKATLK VRDRVRTKME RDILADVNHP 120

FVVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVMFTEE DVKFYLAELA LGLDHLHSLG 180

IIYRDLKPEN ILLDEEGHIK LTDFGLCKEA IDHEKKAYSF CGTVEYMAPE VVNRQGHTHS 240

ADWWSFGVLM FEMLTGALPF QGKDRKETMN LILKARLGMP QFLSAEAQSL LRALFKRNPA 300

NRLGSGADGA EEIKRHGFYS TIDWNKLFRK EVKPPFRPAV ARPDDTFYFD SEFTSRTPKD 360

SPGVPPSAGA HQLFRGFSFV ASTLLEEDGS SEPVQAPPHP VVQQLHGKNV LFSDGYVLKE 420

DIGMGSFSVC KRCIHKATNT EYAVKMIDKT STDPSEEIEI LLRYGQHPNI ITLKDVYDNG 480

KQVFMVTELM RGGELLDRIL KQKFFSEREA SAVLHTITKT VEYLHSQGVV HRDLKPSNIL 540

YVDESGNPES IRICDFGFAK QLRANNGLLM TPCYTANFVA PEVLKRQGYD EGCDIWSLGV 600

LLYTMLAGFT PFANGPEDTP NEILNRIGHG HFSLTGGNWD SVSDAAKDLV SKMLHVDPHQ 660

RLTAKQVLKH PWIVRRDKLP NSQLPHQDPK LVKGAMAATY SALKNSQPPP ELKPIESSFL 720

AQRRVKKLPS TSL 733

Nucleotide Sequence
(FASTA)

ATGGAGAAGG ACAAGAGAAA GTTCAACCTG ACTCGCATGC TGTCCATCTA CCTGTTCAAA 60

AAGAACAAAT CCTTGACTGG CAGCCCTGCT CACTGGCCCG AGGAAGATGG AGACATCAAA 120

GAGATCAACA TCACCCATGT GGTCAAGGAA GGCTCAGAGA AAGCTGATGC CTCTCAGTTT 180

GAACTGCTCA AAGTCCTGGG ACAGGGATCC TTTGGCAAGG TGTTCCTGGT ACGAAAGGTG 240

ACTCCTCCCG ATGCCAACCA GCTCTATGCC ATGAAGGTCC TTAAGAAGGC CACACTAAAA 300

GTCAGAGACC GTGTGAGGAC CAAGATGGAG CGAGACATCC TGGCAGACGT CAATCACCCA 360

TTTGTTGTCA AACTGCACTA TGCATTCCAG ACTGAAGGGA AGTTGTACTT GATCCTGGAC 420

TTCCTCAGAG GAGGGGATCT TTTTACTAGA CTCTCCAAAG AGGTGATGTT CACAGAGGAG 480

GATGTGAAGT TTTACCTAGC AGAACTGGCA TTAGGACTGG ACCACCTTCA TAGCTTGGGT 540

ATCATTTACA GGGACCTCAA ACCTGAAAAC ATTCTTCTGG ATGAGGAGGG ACACATCAAA 600

CTCACAGATT TCGGCCTGTG TAAAGAAGCC ATTGATCATG AGAAGAAAGC TTATTCCTTC 660

TGTGGTACTG TGGAGTACAT GGCACCAGAG GTCGTGAACA GGCAGGGACA CACCCACAGC 720

GCCGACTGGT GGTCGTTCGG GGTACTAATG TTTGAGATGC TGACAGGAGC GTTGCCATTT 780

CAAGGGAAGG ACCGCAAAGA AACCATGAAT CTCATTCTGA AGGCTCGTCT TGGAATGCCT 840

CAGTTCCTGA GTGCAGAGGC CCAATCTTTG CTCAGGGCTT TGTTCAAAAG GAACCCTGCC 900

AACAGACTGG GATCTGGTGC CGATGGCGCT GAGGAAATAA AGCGGCACGG TTTCTACTCC 960

ACCATAGACT GGAATAAACT CTTCCGAAAA GAAGTAAAGC CTCCGTTCAG ACCAGCGGTC 1020

GCACGTCCGG ATGACACTTT CTACTTCGAC TCCGAGTTCA CTTCCCGCAC ACCTAAAGAC 1080

TCCCCTGGTG TACCCCCCAG TGCTGGAGCT CACCAGCTCT TCAGAGGCTT CAGCTTTGTT 1140

GCATCAACTC TGTTAGAGGA GGATGGTTCA TCAGAGCCAG TGCAGGCCCC ACCACATCCA 1200

GTGGTTCAGC AACTACACGG GAAAAACGTC CTTTTCAGCG ATGGCTACGT ACTGAAGGAA 1260

GATATAGGGA TGGGCTCTTT CTCCGTCTGT AAACGTTGTA TCCACAAAGC CACCAACACT 1320

GAATACGCTG TCAAGATGAT TGACAAGACT AGCACAGACC CCTCTGAGGA AATAGAGATT 1380

CTGCTTAGAT ATGGACAGCA CCCTAACATC ATAACACTCA AGGATGTGTA CGACAACGGT 1440

AAGCAGGTGT TCATGGTGAC GGAGCTGATG CGTGGAGGAG AGCTGCTGGA TCGGATCCTC 1500

AAGCAGAAGT TCTTTTCAGA GAGAGAGGCC AGCGCTGTGC TGCACACTAT CACCAAGACT 1560

GTAGAGTACC TCCACTCACA AGGGGTAGTG CACAGAGACC TGAAGCCCAG CAACATCCTC 1620

TATGTCGACG AGTCGGGGAA TCCCGAGTCA ATCAGAATCT GTGACTTTGG CTTCGCTAAG 1680

CAACTGCGTG CCAACAATGG CCTGCTAATG ACCCCGTGCT ATACTGCTAA CTTTGTAGCT 1740

CCTGAGGTGT TGAAGCGTCA GGGCTATGAT GAAGGATGTG ACATCTGGAG CCTCGGGGTT 1800

TTGCTGTACA CCATGCTGGC TGGTTTCACT CCATTTGCCA ACGGACCTGA AGACACTCCA 1860

AATGAAATCC TGAACAGGAT AGGCCACGGC CACTTCAGTC TGACTGGTGG TAACTGGGAC 1920

TCTGTGTCTG ATGCCGCCAA GGACCTGGTG TCCAAGATGC TTCACGTTGA CCCCCATCAG 1980

AGACTGACTG CTAAGCAGGT TCTCAAACAC CCATGGATTG TCCGCAGAGA CAAGCTGCCC 2040

AACAGCCAGC TCCCACACCA GGACCCCAAA CTGGTCAAGG GTGCAATGGC AGCCACCTAC 2100

TCCGCCCTGA AGAACTCTCA ACCTCCTCCA GAGCTCAAGC CCATTGAGAG CTCCTTCCTT 2160

GCTCAGAGGC GTGTCAAGAA ACTTCCCTCC ACCTCTCTGT AG 2202

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y++ked+G Gs+svckrc+hkatn+e+avk+idk+ +d+seeieillry+qhpni+tlkd

Q: 416   YVLKEDIGMGSFSVCKRCIHKATNTEYAVKMIDKTSTDPSEEIEILLRYGQHPNIITLKD  475

         679*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyd+gk v++v+el++GGelldri+k+kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 476   VYDNGKQVFMVTELMRGGELLDRILKQKFFSEREASAVLHTITKTVEYLHSQGVVHRDLK  535

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++ra+ngll+tpcyt+nfvapevlkrqGyde+cd+

Q: 536   PSNILYVDESGNPESIRICDFGFAKQLRANNGLLMTPCYTANFVAPEVLKRQGYDEGCDI  595

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytmlaG++pfangpedt++eil +i++G+fsl G++wdsvs++akdlvsk+l+

Q: 596   WSLGVLLYTMLAGFTPFANGPEDTPNEILNRIGHGHFSLTGGNWDSVSDAAKDLVSKMLH  655

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+lkh+w+

Q: 656   VDPHQRLTAKQVLKHPWI  673

         *****************8

Domain Sequence
(FASTA)

YVLKEDIGMG SFSVCKRCIH KATNTEYAVK MIDKTSTDPS EEIEILLRYG QHPNIITLKD 60

VYDNGKQVFM VTELMRGGEL LDRILKQKFF SEREASAVLH TITKTVEYLH SQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAN NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGVLLYTM LAGFTPFANG PEDTPNEILN RIGHGHFSLT GGNWDSVSDA AKDLVSKMLH 240

VDPHQRLTAK QVLKHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013