EPS-ORN-00013

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORN-00013

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	137.3	4.5E-40	146	290	145

Status

Unreviewed

Ensembl Protein

ENSONIP00000004590

UniProt Accession

I3J6V0;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSONIG00000003650	ENSONIP00000004590	ENSONIT00000004593

Organism

Oreochromis niloticus

Functional Description

Protein Length

1142

Protein Sequence
(FASTA)

MASANEHGER GDQMVPDGKE EEEEKSVRGV QSHYLRCPSP NFSMTSESRF SMISGSDAES 60

IFMEPIHLSS AIAAKKIINE ELPPRGVRSE SIPESMLETA EQLMVEDLYN RVRDMIDDRS 120

PYNTPCVLDI QRAMVQDRLE APINPVDEVW PNIFIAEKSV AVNKARLKRM GITHILNTAH 180

GTGVYTNESF YAGMNIKYMG IEVDDFPDAD ISMHFRPTAE FLDDALLTHK GKVLVVSMMG 240

ISRSAILVAC YLMIFQNMTI MEALTSMRKK RAINPNEGFL KQLREFNETL MEERDDDDDT 300

LSQCSVIDAR ARTRIFGEDD DEDTDTEEEQ SMIEVKANSI MMEEEEDGES VMSSVASSAA 360

AGALKSGLTG AQNGFNNQVS NGVQDEFVLP EQEGKEDGDD DDDDGLDSMI QEWQRRNEKY 420

QNDEWWEAQL NIDGEDEESL PGVFTKKTKE VGDTDVESVT SEDIRAVKER LKRRNRRPPS 480

DAMSTSSCMS YSDLWKQRLK EIEEQAAARY RKKEDEEGSE ITTTEDEGVK KTIDDEVDSI 540

LSDTSSMYNF CQKNKEKMSP LERWRIKRIQ FGWNKKDRED GEKSSVGDGE EEAKTPSLQD 600

VNLTAYQAWK LRQQKRLGEE NTDEILELSR GEDLATIRRR QRREEILERS KKTLEESQSV 660

CGWETESCVS GGTIPLSAFW AGAGVTGPPS IANDDNMSML SGRSSTISSV SQARSTRSSQ 720

FGIPVNPVPI LPVPTVQGPG GEPMVNLASI QNWIANVVSE TIKQKQSEMS LPPPSRAGSE 780

LSFGAPSNVM SGRSVDDDKA SLLSGASYSS SLSQDRGRAG SVLSGGSSSS ISGLSGRGSA 840

LGSNLGSTLG SKKNKITTTS VPLFSLFQDQ VNLDKLDAMD KEIKSEMRDK MSTYEKKKIL 900

EDNKRSTLFK KKKPKEDDDE EEERKKKEEE FLEETKKKEK PKRSYGLSGC LNLNPALEKD 960

KNTNIDDWLK SVRPPPRKPA SGTEAGPSED PYDDLDASAS EFDFSSRRAS YAADEDDDEE 1020

TYGITSRYRA RLHEDLSSED TEYSCNGFTQ SHSYSRPGRS YGAVHHSRYE SNETEGRRTR 1080

KQEATEEEED DISTFIAQTR QRIRARAAAE AEDDEVLTAW RAQQEAKREK QNLENTTDAD 1140

RF 1142

Nucleotide Sequence
(FASTA)

ATGGCATCGG CCAATGAACA TGGGGAGCGA GGTGATCAGA TGGTACCTGA TGGAAAGGAA 60

GAAGAGGAGG AGAAGAGCGT CCGCGGAGTC CAATCTCATT ACCTTCGCTG TCCCTCCCCA 120

AATTTCTCCA TGACCTCAGA GTCCAGGTTT TCCATGATCT CTGGGTCTGA CGCTGAGAGC 180

ATCTTCATGG AGCCCATCCA CCTCTCGTCA GCCATCGCTG CCAAGAAGAT CATCAACGAG 240

GAGTTGCCAC CTCGAGGCGT GCGGTCCGAG TCCATCCCAG AGTCCATGTT GGAAACCGCT 300

GAGCAGCTGA TGGTGGAAGA TCTCTACAAC CGTGTCAGGG ACATGATCGA TGACCGCAGC 360

CCCTACAACA CCCCCTGTGT GCTGGACATC CAGAGAGCCA TGGTGCAGGA CCGCCTAGAG 420

GCTCCCATCA ATCCTGTGGA TGAGGTGTGG CCCAACATCT TCATTGCCGA AAAGTCTGTT 480

GCAGTGAATA AGGCCCGTCT GAAGCGAATG GGCATCACAC ACATCCTGAA CACAGCTCAC 540

GGTACAGGAG TCTACACCAA CGAGTCTTTT TACGCCGGCA TGAACATTAA GTACATGGGC 600

ATTGAAGTAG ACGACTTCCC TGATGCTGAC ATCTCGATGC ACTTTAGACC CACCGCCGAA 660

TTCTTGGACG ATGCTCTGCT GACGCACAAA GGAAAGGTTC TTGTTGTTTC GATGATGGGC 720

ATCAGTCGTT CTGCTATCCT GGTGGCTTGC TACCTGATGA TCTTCCAGAA CATGACCATC 780

ATGGAGGCTC TGACCTCAAT GAGGAAAAAA CGTGCCATCA ACCCCAATGA AGGCTTCCTG 840

AAGCAGCTGA GAGAGTTCAA TGAGACCCTC ATGGAGGAGC GAGATGATGA CGACGACACA 900

CTAAGCCAGT GCTCTGTGAT TGACGCTCGA GCGCGCACTC GCATCTTTGG GGAAGATGAT 960

GATGAGGATA CGGACACAGA AGAAGAGCAG AGTATGATTG AGGTGAAAGC TAACTCCATT 1020

ATGATGGAGG AGGAGGAGGA TGGAGAAAGT GTGATGAGCA GCGTTGCCTC CTCTGCAGCT 1080

GCTGGAGCAC TTAAAAGTGG TTTGACTGGA GCTCAGAATG GGTTCAACAA CCAGGTATCC 1140

AATGGTGTCC AAGATGAGTT TGTTCTACCT GAACAGGAGG GCAAGGAAGA TGGGGATGAT 1200

GATGATGATG ATGGTCTGGA CAGCATGATT CAGGAGTGGC AGCGGAGGAA TGAAAAATAC 1260

CAGAATGATG AGTGGTGGGA GGCACAGCTG AACATTGATG GGGAGGATGA GGAGTCTCTT 1320

CCAGGGGTTT TTACAAAGAA GACAAAAGAA GTTGGAGACA CTGATGTGGA GAGCGTAACC 1380

AGTGAGGACA TACGAGCTGT GAAAGAGCGG CTGAAGCGTC GCAACAGACG CCCACCCTCT 1440

GACGCAATGT CCACCTCCAG CTGTATGAGT TACTCTGATC TTTGGAAGCA GCGGCTTAAG 1500

GAGATCGAAG AGCAAGCAGC TGCTCGGTAC CGCAAGAAAG AAGATGAAGA AGGCAGCGAG 1560

ATCACCACCA CTGAAGATGA AGGAGTGAAG AAGACAATTG ATGATGAAGT AGATAGCATC 1620

CTCTCTGACA CCAGCTCCAT GTATAACTTC TGTCAGAAGA ATAAGGAGAA GATGTCACCA 1680

TTGGAACGTT GGCGAATCAA GAGAATCCAA TTTGGGTGGA ACAAGAAAGA TCGTGAGGAT 1740

GGAGAGAAAA GTTCTGTTGG TGACGGTGAG GAAGAAGCCA AGACACCATC TCTCCAAGAC 1800

GTCAATCTAA CGGCGTATCA GGCATGGAAG CTGAGGCAGC AGAAGCGTCT CGGGGAAGAG 1860

AACACAGATG AGATTCTGGA GCTGAGCAGA GGCGAGGACT TAGCAACAAT CAGAAGAAGA 1920

CAACGACGTG AAGAGATTCT GGAGCGTTCA AAGAAAACTT TAGAAGAAAG CCAGTCTGTA 1980

TGTGGCTGGG AAACAGAGAG TTGCGTTAGC GGTGGTACGA TACCTCTATC TGCCTTCTGG 2040

GCTGGAGCTG GTGTTACAGG GCCGCCAAGT ATTGCCAATG ATGACAATAT GTCCATGCTC 2100

AGTGGTAGAT CTTCCACAAT TTCTTCAGTT TCCCAGGCTC GCAGCACAAG ATCCTCACAG 2160

TTTGGAATCC CAGTAAATCC TGTGCCGATC CTTCCAGTTC CAACTGTGCA GGGCCCCGGA 2220

GGTGAACCAA TGGTCAATCT GGCTAGCATC CAAAACTGGA TTGCTAATGT TGTTTCAGAA 2280

ACAATCAAAC AGAAGCAGAG TGAAATGAGC CTTCCTCCTC CATCACGTGC TGGGTCTGAA 2340

TTGAGCTTTG GTGCTCCATC AAACGTGATG TCAGGGCGCA GTGTCGATGA TGACAAAGCA 2400

TCCTTGCTGA GTGGTGCTTC CTACTCCAGC TCTCTGTCAC AAGATCGAGG CAGGGCAGGA 2460

TCAGTCCTCT CCGGTGGCAG TTCAAGCAGC ATCTCAGGTC TCAGTGGTAG AGGCTCAGCA 2520

TTAGGCTCTA ACCTTGGCTC CACCCTGGGC TCAAAGAAAA ACAAGATTAC CACTACCAGT 2580

GTTCCTCTCT TCAGCCTCTT CCAGGACCAA GTTAACCTGG ATAAACTGGA TGCCATGGAC 2640

AAGGAGATCA AGTCAGAGAT GAGGGACAAG ATGTCTACCT ATGAAAAGAA GAAGATCCTG 2700

GAAGACAACA AACGCAGTAC TCTGTTTAAG AAAAAGAAGC CAAAGGAAGA TGACGATGAG 2760

GAAGAGGAAA GGAAGAAGAA AGAGGAGGAG TTTCTTGAGG AGACAAAGAA AAAGGAGAAA 2820

CCAAAGAGGA GTTACGGTCT ATCAGGGTGC CTGAATCTAA ACCCAGCGCT GGAGAAAGAT 2880

AAAAACACCA ACATTGATGA CTGGCTGAAA AGTGTCAGGC CTCCCCCAAG AAAACCAGCT 2940

TCAGGAACTG AAGCTGGTCC ATCGGAGGAC CCCTATGATG ATCTTGACGC CTCAGCTTCT 3000

GAATTTGACT TCTCAAGCAG AAGAGCCTCT TATGCTGCTG ACGAAGATGA TGATGAGGAA 3060

ACGTATGGCA TTACTTCCAG ATACCGAGCC AGGTTACACG AAGATCTATC AAGTGAAGAC 3120

ACAGAATATT CCTGCAATGG CTTCACGCAA TCCCACAGCT ACAGCCGACC GGGAAGATCG 3180

TACGGCGCTG TTCATCATTC ACGATATGAA AGCAATGAGA CAGAAGGGAG AAGGACAAGG 3240

AAACAGGAAG CCACAGAAGA GGAGGAGGAT GACATCTCCA CCTTCATTGC CCAAACCAGG 3300

CAGAGGATTA GGGCTCGAGC TGCCGCGGAG GCCGAAGACG ACGAGGTTCT CACTGCTTGG 3360

AGAGCTCAGC AGGAGGCGAA GCGAGAGAAG CAAAACTTAG AAAATACTAC TGATGCAGAC 3420

AGGTTTTAG 3429

Domain Profile

S: 2     vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd  61

         v+e++p+++++++ +a+++  L+++git+++n+++++    +  +++  ++i+y++i+vd

Q: 146   VDEVWPNIFIAEKSVAVNKARLKRMGITHILNTAHGTGV-YTNESFYAGMNIKYMGIEVD  204

         89*********************************8765.68999***************

S: 62    Dsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAi  120

         D ++ d++ +f+++aef+d+a  +++gkvlv + +G+sRSa lv +YLm+++++++ +A+

Q: 205   DFPDADISMHFRPTAEFLDDAlLTHKGKVLVVSMMGISRSAILVACYLMIFQNMTIMEAL  264

         ********************988999**********************************

S: 121   eavkrkrpsiepnegfleQLlelekkl  147

         + +++kr +i+pnegfl+QL+e++++l

Q: 265   TSMRKKR-AINPNEGFLKQLREFNETL  290

         *******.***************9876

Domain Sequence
(FASTA)

VDEVWPNIFI AEKSVAVNKA RLKRMGITHI LNTAHGTGVY TNESFYAGMN IKYMGIEVDD 60

FPDADISMHF RPTAEFLDDA LLTHKGKVLV VSMMGISRSA ILVACYLMIF QNMTIMEALT 120

SMRKKRAINP NEGFLKQLRE FNETL 145

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013